Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_L05
(270 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5EA46|CREL1_BOVIN Cysteine-rich with EGF-like domain pr... 56 3e-08
sp|Q62919|NELL1_RAT Protein kinase C-binding protein NELL1 ... 55 5e-08
sp|Q99435|NELL2_HUMAN Protein kinase C-binding protein NELL... 55 7e-08
sp|Q62918|NELL2_RAT Protein kinase C-binding protein NELL2 ... 54 9e-08
sp|Q61220|NELL2_MOUSE Protein kinase C-binding protein NELL... 54 9e-08
sp|Q91XD7|CREL1_MOUSE Cysteine-rich with EGF-like domain pr... 54 1e-07
sp|Q96HD1|CREL1_HUMAN Cysteine-rich with EGF-like domain pr... 54 1e-07
sp|Q92832|NELL1_HUMAN Protein kinase C-binding protein NELL... 54 1e-07
sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related... 53 3e-07
sp|Q90827|NEL_CHICK NEL protein precursor (93 kDa protein) 53 3e-07
>sp|Q5EA46|CREL1_BOVIN Cysteine-rich with EGF-like domain protein 1 precursor
Length = 420
Score = 55.8 bits (133), Expect = 3e-08
Identities = 23/59 (38%), Positives = 36/59 (61%)
Frame = +1
Query: 7 KCVSCNTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
+C C+ G+Q++ + C D++EC ++ +C Q+C N GSY C C D Y KQ +G C
Sbjct: 288 RCKKCSPGYQQVGSKCLDVDEC--ETAVCPGENQQCENTEGSYRCICADGY-KQMEGIC 343
Score = 37.4 bits (85), Expect = 0.011
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Frame = +1
Query: 10 CVSCNTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSC-DC 147
C+ C G+ + C DI+EC + C Q C N GSY C DC
Sbjct: 229 CLQCKKGWALHHLKCVDIDECGTERASC-GADQFCVNTEGSYECRDC 274
>sp|Q62919|NELL1_RAT Protein kinase C-binding protein NELL1 precursor (NEL-like protein
1)
Length = 810
Score = 55.1 bits (131), Expect = 5e-08
Identities = 23/58 (39%), Positives = 31/58 (53%), Gaps = 3/58 (5%)
Frame = +1
Query: 19 CNTGFQKINNN---CEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
C G+ + N CEDI+EC+A C C N+PG Y CDC+ Y++ D SC
Sbjct: 418 CKNGYISVQGNSAYCEDIDECAAKMHYCH-ANTVCVNLPGLYRCDCVPGYIRVDDFSC 474
Score = 37.4 bits (85), Expect = 0.011
Identities = 20/49 (40%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Frame = +1
Query: 4 DKCVSCNTGFQKINNNCE-DINECSADSELCREVGQKCTNIPGSYSCDC 147
+KCV C +GF ++CE DI+EC+ C +C N+PG Y C+C
Sbjct: 533 NKCV-CPSGFT--GSHCEKDIDECAEGFVECHNYS-RCVNLPGWYHCEC 577
Score = 28.1 bits (61), Expect = 6.6
Identities = 13/49 (26%), Positives = 25/49 (51%), Gaps = 1/49 (2%)
Frame = +1
Query: 19 CNTGFQKINN-NCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYV 162
C G+ ++++ +C + ++C + C + CTN +SC C YV
Sbjct: 462 CVPGYIRVDDFSCTEHDDCGSGQHNC-DKNAICTNTVQGHSCTCQPGYV 509
>sp|Q99435|NELL2_HUMAN Protein kinase C-binding protein NELL2 precursor (NEL-like protein
2) (Nel-related protein 2)
Length = 816
Score = 54.7 bits (130), Expect = 7e-08
Identities = 28/65 (43%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Frame = +1
Query: 1 NDKCV-SCNTGFQKI---NNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQ 168
ND+ V SC GF+ + N CEDI+EC+ CRE C N PGS+ C C Y++
Sbjct: 417 NDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRE-NTMCVNTPGSFMCICKTGYIRI 475
Query: 169 SDGSC 183
D SC
Sbjct: 476 DDYSC 480
Score = 36.2 bits (82), Expect = 0.024
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Frame = +1
Query: 16 SCNTGFQKINNNCE-DINECSADSELCREVGQKCTNIPGSYSCDCIDNY 159
+C GF +CE DI+ECS C + C N+PG Y C+C D Y
Sbjct: 542 ACPQGFT--GPSCETDIDECSDGFVQC-DSRANCINLPGWYHCECRDGY 587
Score = 33.9 bits (76), Expect = 0.12
Identities = 18/54 (33%), Positives = 22/54 (40%)
Frame = +1
Query: 22 NTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
N F +CEDI+EC C C N+ G Y C C + K G C
Sbjct: 590 NGMFSPSGESCEDIDECGTGRHSCAN-DTICFNLDGGYDCRC--PHGKNCTGDC 640
>sp|Q62918|NELL2_RAT Protein kinase C-binding protein NELL2 precursor (NEL-like protein
2)
Length = 816
Score = 54.3 bits (129), Expect = 9e-08
Identities = 28/65 (43%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Frame = +1
Query: 1 NDKCV-SCNTGFQKI---NNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQ 168
ND+ V SC GF+ + N CEDI+EC+ CRE C N PGS+ C C Y++
Sbjct: 417 NDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRE-NTMCVNTPGSFLCICQTGYIRI 475
Query: 169 SDGSC 183
D SC
Sbjct: 476 DDYSC 480
Score = 36.6 bits (83), Expect = 0.019
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Frame = +1
Query: 16 SCNTGFQKINNNCE-DINECSADSELCREVGQKCTNIPGSYSCDCIDNY 159
+C GF +CE DI+ECS C + C N+PG Y C+C D Y
Sbjct: 542 ACPQGFT--GPSCETDIDECSEGFVQC-DSRANCINLPGWYHCECRDGY 587
Score = 32.7 bits (73), Expect = 0.27
Identities = 18/54 (33%), Positives = 22/54 (40%)
Frame = +1
Query: 22 NTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
N F +CEDI+EC C C N+ G Y C C + K G C
Sbjct: 590 NGMFAPGGESCEDIDECGTGRHSCAN-DTICFNLDGGYDCRC--PHGKNCTGDC 640
>sp|Q61220|NELL2_MOUSE Protein kinase C-binding protein NELL2 precursor (NEL-like protein
2) (MEL91 protein)
Length = 816
Score = 54.3 bits (129), Expect = 9e-08
Identities = 28/65 (43%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Frame = +1
Query: 1 NDKCV-SCNTGFQKI---NNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQ 168
ND+ V SC GF+ + N CEDI+EC+ CRE C N PGS+ C C Y++
Sbjct: 417 NDRVVCSCRDGFRALREDNAYCEDIDECAEGRHYCRE-NTMCVNTPGSFMCVCKTGYIRI 475
Query: 169 SDGSC 183
D SC
Sbjct: 476 DDYSC 480
Score = 36.6 bits (83), Expect = 0.019
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Frame = +1
Query: 16 SCNTGFQKINNNCE-DINECSADSELCREVGQKCTNIPGSYSCDCIDNY 159
+C GF +CE DI+ECS C + C N+PG Y C+C D Y
Sbjct: 542 ACPQGFT--GPSCETDIDECSEGFVQC-DSRANCINLPGWYHCECRDGY 587
Score = 32.7 bits (73), Expect = 0.27
Identities = 18/54 (33%), Positives = 22/54 (40%)
Frame = +1
Query: 22 NTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
N F +CEDI+EC C C N+ G Y C C + K G C
Sbjct: 590 NGMFAPGGESCEDIDECGTGRHSCTN-DTICFNLDGGYDCRC--PHGKNCTGDC 640
>sp|Q91XD7|CREL1_MOUSE Cysteine-rich with EGF-like domain protein 1 precursor
Length = 420
Score = 53.5 bits (127), Expect = 1e-07
Identities = 21/59 (35%), Positives = 35/59 (59%)
Frame = +1
Query: 7 KCVSCNTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
+C C+ G+Q++ + C D++EC ++ +C +KC N G Y C C + Y +Q DG C
Sbjct: 288 RCKKCSRGYQQVGSKCLDVDEC--ETVVCPGENEKCENTEGGYRCVCAEGY-RQEDGIC 343
Score = 38.1 bits (87), Expect = 0.006
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Frame = +1
Query: 10 CVSCNTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSC-DC 147
C+ C G+ + C DI+EC + C Q C N GSY C DC
Sbjct: 229 CLQCKKGWALHHLKCVDIDECGTEQATC-GADQFCVNTEGSYECRDC 274
>sp|Q96HD1|CREL1_HUMAN Cysteine-rich with EGF-like domain protein 1 precursor
Length = 420
Score = 53.5 bits (127), Expect = 1e-07
Identities = 21/59 (35%), Positives = 36/59 (61%)
Frame = +1
Query: 7 KCVSCNTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
+C C+ G+Q++ + C D++EC ++E+C ++C N G Y C C + Y KQ +G C
Sbjct: 288 RCKKCSPGYQQVGSKCLDVDEC--ETEVCPGENKQCENTEGGYRCICAEGY-KQMEGIC 343
Score = 37.4 bits (85), Expect = 0.011
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Frame = +1
Query: 10 CVSCNTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSC-DC 147
C+ C G+ + C DI+EC + C Q C N GSY C DC
Sbjct: 229 CLQCKKGWALHHLKCVDIDECGTEGANC-GADQFCVNTEGSYECRDC 274
>sp|Q92832|NELL1_HUMAN Protein kinase C-binding protein NELL1 precursor (NEL-like protein
1) (Nel-related protein 1)
Length = 810
Score = 53.5 bits (127), Expect = 1e-07
Identities = 22/58 (37%), Positives = 32/58 (55%), Gaps = 3/58 (5%)
Frame = +1
Query: 19 CNTGFQKINNN---CEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
C +G+ + + CEDI+EC+A C C N+PG Y CDC+ Y++ D SC
Sbjct: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCH-ANTVCVNLPGLYRCDCVPGYIRVDDFSC 474
Score = 37.7 bits (86), Expect = 0.008
Identities = 21/49 (42%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Frame = +1
Query: 4 DKCVSCNTGFQKINNNCE-DINECSADSELCREVGQKCTNIPGSYSCDC 147
+KCV C +GF ++CE DI+ECS C +C N+PG Y C+C
Sbjct: 533 NKCV-CPSGFT--GSHCEKDIDECSEGIIECHN-HSRCVNLPGWYHCEC 577
Score = 30.4 bits (67), Expect = 1.3
Identities = 15/49 (30%), Positives = 25/49 (51%), Gaps = 1/49 (2%)
Frame = +1
Query: 19 CNTGFQKINN-NCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYV 162
C G+ ++++ +C + +EC + C E CTN +SC C YV
Sbjct: 462 CVPGYIRVDDFSCTEHDECGSGQHNCDE-NAICTNTVQGHSCTCKPGYV 509
>sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 precursor
(Megalin) (Glycoprotein 330) (gp330)
Length = 4660
Score = 52.8 bits (125), Expect = 3e-07
Identities = 25/62 (40%), Positives = 38/62 (61%), Gaps = 3/62 (4%)
Frame = +1
Query: 16 SCNTGFQKINN--NCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDG-SCK 186
SC G++ +++ +C DI+EC +LC QKC N+ GSY C C Y+++ DG SC+
Sbjct: 3138 SCLPGYKLMSDKRSCVDIDECKESPQLC---SQKCENVVGSYICKCAPGYIREPDGKSCR 3194
Query: 187 FN 192
N
Sbjct: 3195 QN 3196
Score = 44.7 bits (104), Expect = 7e-05
Identities = 25/59 (42%), Positives = 31/59 (52%), Gaps = 3/59 (5%)
Frame = +1
Query: 19 CNTGFQKINNN--CEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDG-SCK 186
C G+Q N+ CEDINEC C Q C N+ GS+ C C Y +SDG +CK
Sbjct: 1376 CPLGYQLANDTKTCEDINECDIPG-FC---SQHCVNMRGSFRCACDPEYTLESDGRTCK 1430
Score = 42.7 bits (99), Expect = 3e-04
Identities = 22/55 (40%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Frame = +1
Query: 16 SCNTGFQKIN---NNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQS 171
SC GF+ N+C+DINEC + +C Q C N GSY C C+D + S
Sbjct: 3992 SCRPGFKPSTSDKNSCQDINECE-EFGICP---QSCRNSKGSYECFCVDGFKSMS 4042
Score = 30.0 bits (66), Expect = 1.7
Identities = 16/56 (28%), Positives = 27/56 (48%), Gaps = 4/56 (7%)
Frame = +1
Query: 40 INNN----CEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSCKFNE 195
IN+N C D ++C ++ QKC N G + C C + Y+ + CK ++
Sbjct: 337 INSNDSRTCIDFDDC----QIWGICDQKCENRQGRHQCLCEEGYILERGQHCKSSD 388
>sp|Q90827|NEL_CHICK NEL protein precursor (93 kDa protein)
Length = 816
Score = 52.8 bits (125), Expect = 3e-07
Identities = 26/65 (40%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Frame = +1
Query: 1 NDKCV-SCNTGFQKI---NNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQ 168
+D+ V SC GF+ + N CED++EC+ CRE C N PGS+ C C Y++
Sbjct: 417 DDRAVCSCRDGFRALREDNAYCEDVDECAEGQHYCRE-NTMCVNTPGSFMCICKTGYIRI 475
Query: 169 SDGSC 183
D SC
Sbjct: 476 DDYSC 480
Score = 36.2 bits (82), Expect = 0.024
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Frame = +1
Query: 16 SCNTGFQKINNNCE-DINECSADSELCREVGQKCTNIPGSYSCDCIDNY 159
+C GF +CE DI+ECS C + C N+PG Y C+C D Y
Sbjct: 542 ACPQGFT--GPSCETDIDECSDGFVQC-DSRANCINLPGWYHCECRDGY 587
Score = 34.7 bits (78), Expect = 0.071
Identities = 18/54 (33%), Positives = 23/54 (42%)
Frame = +1
Query: 22 NTGFQKINNNCEDINECSADSELCREVGQKCTNIPGSYSCDCIDNYVKQSDGSC 183
N F +CEDI+EC+ C C N+ G Y C C + K G C
Sbjct: 590 NGMFSPSGESCEDIDECATGRHSCAN-DTVCFNLDGGYDCRC--PHGKNCTGDC 640
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.314 0.132 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,156,716
Number of Sequences: 369166
Number of extensions: 390568
Number of successful extensions: 2480
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1138
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2075
length of database: 68,354,980
effective HSP length: 59
effective length of database: 57,455,615
effective search space used: 1723668450
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)