Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_J14
(722 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P34657|YOTB_CAEEL Hypothetical protein ZK632.12 in chrom... 113 4e-25
sp|Q6ZV73|FGD6_HUMAN FYVE, RhoGEF and PH domain containing ... 95 2e-19
sp|Q69ZL1|FGD6_MOUSE FYVE, RhoGEF and PH domain containing ... 92 1e-18
sp|O95405|ZFYV9_HUMAN Zinc finger FYVE domain-containing pr... 72 2e-12
sp|Q80U44|ZFY16_MOUSE Zinc finger FYVE domain-containing pr... 70 4e-12
sp|Q8BY35|FGD2_MOUSE FYVE, RhoGEF and PH domain containing ... 70 7e-12
sp|Q7Z6J4|FGD2_HUMAN FYVE, RhoGEF and PH domain containing ... 69 1e-11
sp|Q7Z3T8|ZFY16_HUMAN Zinc finger FYVE domain-containing pr... 69 1e-11
sp|Q9HCC9|ZFY28_HUMAN Zinc finger FYVE domain-containing pr... 66 8e-11
sp|Q96M96|FGD4_HUMAN FYVE, RhoGEF and PH domain containing ... 65 2e-10
>sp|P34657|YOTB_CAEEL Hypothetical protein ZK632.12 in chromosome III
Length = 266
Score = 113 bits (283), Expect = 4e-25
Identities = 53/127 (41%), Positives = 79/127 (62%), Gaps = 3/127 (2%)
Frame = +3
Query: 72 GFCVKSPKKSFAMYAVSTEEKEQWINHLKKCSDECSKKRGLVGLSAAKSPVWIPDAMAPK 251
G+ +K+P KSFA+YA + EK +W+ H+++C + + RG + A + VW+PD A K
Sbjct: 99 GWIIKTPAKSFAVYAATETEKREWMLHIERCVTDLLE-RGNKQAATAHAAVWVPDGEAVK 157
Query: 252 CMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLPYQSVVPVRVCDLCYEQLKT---G 422
CMVC T F ++ RRHHCR+CG VVC +CS + + + PVRVCD C++ L + G
Sbjct: 158 CMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVHKKPVRVCDHCFDSLSSATPG 217
Query: 423 NEYISPR 443
E P+
Sbjct: 218 QEESEPK 224
>sp|Q6ZV73|FGD6_HUMAN FYVE, RhoGEF and PH domain containing protein 6 (Zinc finger FYVE
domain containing protein 24)
Length = 1430
Score = 94.7 bits (234), Expect = 2e-19
Identities = 47/138 (34%), Positives = 76/138 (55%), Gaps = 17/138 (12%)
Frame = +3
Query: 81 VKSPKKSFAMYAVSTEEKEQWINHLKKCSDECSKKRGL-----------------VGLSA 209
++S ++SF + A S E+++W+ + + +E +KKR V
Sbjct: 1154 IESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLG 1213
Query: 210 AKSPVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLPYQSVVPVRV 389
+K+P+WIPD A CM+C + FT+ RRHHCR CG +VC +CS ++ L Y P RV
Sbjct: 1214 SKAPIWIPDTRATMCMICT-SEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARV 1272
Query: 390 CDLCYEQLKTGNEYISPR 443
C+ C+++L+ + SPR
Sbjct: 1273 CEHCFQELQKLDHQHSPR 1290
>sp|Q69ZL1|FGD6_MOUSE FYVE, RhoGEF and PH domain containing protein 6
Length = 1399
Score = 92.4 bits (228), Expect = 1e-18
Identities = 47/137 (34%), Positives = 74/137 (54%), Gaps = 16/137 (11%)
Frame = +3
Query: 81 VKSPKKSFAMYAVSTEEKEQWINHLKKCSDECSKKRGL----------------VGLSAA 212
++S ++SF + A S E++ W+ + +E +KKR V A
Sbjct: 1124 IESVERSFILSASSAAERDDWLEAISSSIEEYAKKRITFCPSRSLDEDSERKEEVSPLGA 1183
Query: 213 KSPVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLPYQSVVPVRVC 392
K+P+WIPD A CM+C + FT+ RRHHCR CG +VC +CS ++ L Y RVC
Sbjct: 1184 KAPIWIPDTRATMCMICT-SEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKGQLARVC 1242
Query: 393 DLCYEQLKTGNEYISPR 443
+ C+++L+ + +SPR
Sbjct: 1243 EHCFQELQKLDHQLSPR 1259
>sp|O95405|ZFYV9_HUMAN Zinc finger FYVE domain-containing protein 9 (Mothers against
decapentaplegic homolog interacting protein)
(Madh-interacting protein) (Smad anchor for receptor
activation) (Receptor activation anchor) (hSARA) (Novel
serine protease) (NSP)
Length = 1425
Score = 71.6 bits (174), Expect = 2e-12
Identities = 36/85 (42%), Positives = 45/85 (52%), Gaps = 8/85 (9%)
Frame = +3
Query: 183 KRGLVGLSAAK--------SPVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSC 338
+ G G+SA K +PVW+PD+ AP CM C FT RRHHCR CG V C+SC
Sbjct: 674 RAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEAR-FTFTKRRHHCRACGKVFCASC 732
Query: 339 SLKRWLLPYQSVVPVRVCDLCYEQL 413
+ L Y RVC +C+ L
Sbjct: 733 CSLKCKLLYMDRKEARVCVICHSVL 757
>sp|Q80U44|ZFY16_MOUSE Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal
associated FYVE domain protein)
Length = 1528
Score = 70.5 bits (171), Expect = 4e-12
Identities = 37/102 (36%), Positives = 50/102 (49%)
Frame = +3
Query: 126 EEKEQWINHLKKCSDECSKKRGLVGLSAAKSPVWIPDAMAPKCMVCRLTVFTVLNRRHHC 305
E+ ++ K E +K LV K P W+PD+ AP CM C++ FT RRHHC
Sbjct: 701 EDGSSFVTANKDSLPENKRKESLV--LGQKQPTWVPDSEAPNCMNCQVK-FTFTKRRHHC 757
Query: 306 RHCGVVVCSSCSLKRWLLPYQSVVPVRVCDLCYEQLKTGNEY 431
R CG V C C ++ L Y RVC +CYE + +
Sbjct: 758 RACGKVFCGVCCNRKCKLQYLE-KEARVCVICYETINKAQAF 798
>sp|Q8BY35|FGD2_MOUSE FYVE, RhoGEF and PH domain containing protein 2
Length = 655
Score = 69.7 bits (169), Expect = 7e-12
Identities = 43/135 (31%), Positives = 59/135 (43%), Gaps = 18/135 (13%)
Frame = +3
Query: 75 FCVKSPKKSFAMYAVSTEEKEQWINHLKKCSDECSKK------------------RGLVG 200
F V +++ + A S +E W+ + D+ K+ + V
Sbjct: 387 FLVSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVE 446
Query: 201 LSAAKSPVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLPYQSVVP 380
++P W+ D M CM C+ + RRHHCR CG VVC+ CS R L Y S P
Sbjct: 447 ELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRP 506
Query: 381 VRVCDLCYEQLKTGN 425
RVC CY L TGN
Sbjct: 507 NRVCLTCYTFL-TGN 520
>sp|Q7Z6J4|FGD2_HUMAN FYVE, RhoGEF and PH domain containing protein 2 (Zinc finger FYVE
domain containing protein 4)
Length = 655
Score = 69.3 bits (168), Expect = 1e-11
Identities = 43/135 (31%), Positives = 58/135 (42%), Gaps = 18/135 (13%)
Frame = +3
Query: 75 FCVKSPKKSFAMYAVSTEEKEQWINHLKKCSDECSKKRGLVGLSAA-------------- 212
F V +++ + A S EE W+ + D+ K+ +A
Sbjct: 387 FLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSE 446
Query: 213 ----KSPVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLPYQSVVP 380
++P W+ D M CM C+ + RRHHCR CG VVC+ CS R L Y P
Sbjct: 447 ELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRP 506
Query: 381 VRVCDLCYEQLKTGN 425
RVC CY L TGN
Sbjct: 507 NRVCLHCYAFL-TGN 520
>sp|Q7Z3T8|ZFY16_HUMAN Zinc finger FYVE domain-containing protein 16 (Endofin)
(Endosome-associated FYVE domain protein)
Length = 1539
Score = 69.3 bits (168), Expect = 1e-11
Identities = 35/83 (42%), Positives = 44/83 (53%)
Frame = +3
Query: 183 KRGLVGLSAAKSPVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLP 362
K GLV K P W+PD+ AP CM C++ FT RRHHCR CG V C C ++ L
Sbjct: 732 KEGLV--LGQKQPTWVPDSEAPNCMNCQVK-FTFTKRRHHCRACGKVFCGVCCNRKCKLQ 788
Query: 363 YQSVVPVRVCDLCYEQLKTGNEY 431
Y RVC +CYE + +
Sbjct: 789 YLE-KEARVCVVCYETISKAQAF 810
>sp|Q9HCC9|ZFY28_HUMAN Zinc finger FYVE domain-containing protein 28
Length = 887
Score = 66.2 bits (160), Expect = 8e-11
Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 1/63 (1%)
Frame = +3
Query: 219 PVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLP-YQSVVPVRVCD 395
P W+PD C C+ FTV+ R+HHCR CG + CS CS LP Y V PVRVC
Sbjct: 812 PEWVPDEACGFCTACKAP-FTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCT 870
Query: 396 LCY 404
CY
Sbjct: 871 HCY 873
>sp|Q96M96|FGD4_HUMAN FYVE, RhoGEF and PH domain containing protein 4 (Actin-filament
binding protein frabin) (FGD1-related F-actin-binding
protein) (Zinc finger FYVE domain containing protein 6)
Length = 766
Score = 65.1 bits (157), Expect = 2e-10
Identities = 38/127 (29%), Positives = 56/127 (44%), Gaps = 16/127 (12%)
Frame = +3
Query: 75 FCVKSPKKSFAMYAVSTEEKEQWINHLKKCSDECSKKRGLVGLSAAK------------- 215
F V +++ + A S ++KE+WI L++ D ++ + AK
Sbjct: 490 FQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAEL 549
Query: 216 ---SPVWIPDAMAPKCMVCRLTVFTVLNRRHHCRHCGVVVCSSCSLKRWLLPYQSVVPVR 386
+P WI D CM C+ + RRHHCR CG VVC CS + L Y +
Sbjct: 550 GKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSK 609
Query: 387 VCDLCYE 407
VC CY+
Sbjct: 610 VCKDCYQ 616
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,247,363
Number of Sequences: 369166
Number of extensions: 1591113
Number of successful extensions: 3949
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3769
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3911
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6462248555
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)