Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_J13
(788 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 271 1e-72
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 271 2e-72
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 270 3e-72
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 270 3e-72
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 269 6e-72
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 268 2e-71
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 266 6e-71
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 263 4e-70
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 258 1e-68
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 258 1e-68
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 271 bits (693), Expect = 1e-72
Identities = 132/233 (56%), Positives = 164/233 (70%), Gaps = 2/233 (0%)
Frame = +3
Query: 27 TLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRL 206
+ +G T+++P ++ LP SVDWR KG VT VK+Q CGSCW+FS+TG+LEGQ+FRK+ L
Sbjct: 110 SFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVL 168
Query: 207 ISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKI 383
+S SEQ LVDCS LMDNAFRYIKD GI++E YPY A D +C N +
Sbjct: 169 VSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTV 228
Query: 384 VTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHG 563
GFTDI +E +A AVATVGPVSVAIDA H SFQ Y G+YNE C LDHG
Sbjct: 229 GATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHG 288
Query: 564 VLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
VL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 289 VLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 271 bits (692), Expect = 2e-72
Identities = 135/241 (56%), Positives = 164/241 (68%), Gaps = 2/241 (0%)
Frame = +3
Query: 3 RHEVKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQ 182
R ++ + L G+TY+ P ++ V P SVDWR+ G VT VK+Q CGSCW+FS+TG+LEGQ
Sbjct: 100 RQLMRERTGLVGATYIPPAHVTV-PKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQ 158
Query: 183 YFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGT 359
+FRK L+S SEQ LVDCS LMDNAFRYIKD G I++E YPY D +
Sbjct: 159 HFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDS 218
Query: 360 CKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESC 539
C N + I TGF DI +E + AVAT+GPVSVAIDA H SFQLY G+YNE C
Sbjct: 219 CHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPEC 278
Query: 540 STTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPL 716
LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++ NQCGIAT +SYP
Sbjct: 279 DEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPT 338
Query: 717 V 719
V
Sbjct: 339 V 339
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 270 bits (691), Expect = 3e-72
Identities = 134/218 (61%), Positives = 154/218 (70%), Gaps = 2/218 (0%)
Frame = +3
Query: 72 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 251
+P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVD S
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 252 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 428
LMDNAF+YIK+ G++SE YPY ATD +C P K TGF DI Q E
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDI-PQRE 119
Query: 429 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKY 605
L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+
Sbjct: 120 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKF 179
Query: 606 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
WIVKNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 180 WIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 270 bits (690), Expect = 3e-72
Identities = 134/220 (60%), Positives = 154/220 (70%), Gaps = 5/220 (2%)
Frame = +3
Query: 75 PASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXX 254
P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 255 XXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNET 431
LMD AF+Y++D G++SE YPY AT+ +CK NP V TGF DI Q E
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EK 233
Query: 432 DLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GK 599
L AVATVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG +
Sbjct: 234 ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 600 KYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
KYW+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 269 bits (688), Expect = 6e-72
Identities = 131/221 (59%), Positives = 152/221 (68%), Gaps = 5/221 (2%)
Frame = +3
Query: 72 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 251
LP SVDWR+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ 173
Query: 252 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 428
M AF+Y+K+ G++SE YPY A D CK P V TGFT + E
Sbjct: 174 GNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKE 233
Query: 429 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIG 596
L AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG
Sbjct: 234 KALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNN 293
Query: 597 KKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
KYW+VKNSW WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 294 SKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 268 bits (684), Expect = 2e-71
Identities = 134/221 (60%), Positives = 153/221 (69%), Gaps = 5/221 (2%)
Frame = +3
Query: 72 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 251
+P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 IPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 252 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 425
LMDNAFRY+KD G++SE YPY D TC P TGF D+ Q
Sbjct: 174 GNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQR 232
Query: 426 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIG 596
E L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT
Sbjct: 233 EKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSN 292
Query: 597 KKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 293 NKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 266 bits (679), Expect = 6e-71
Identities = 135/222 (60%), Positives = 153/222 (68%), Gaps = 6/222 (2%)
Frame = +3
Query: 72 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 251
+P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 252 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 425
LMDNAF+YIKD G++SE YPY ATD +C P TGF DI Q
Sbjct: 174 GNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQR 232
Query: 426 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----I 593
E L AVATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG +
Sbjct: 233 EKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSN 292
Query: 594 GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 293 NNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 263 bits (672), Expect = 4e-70
Identities = 124/228 (54%), Positives = 160/228 (70%), Gaps = 1/228 (0%)
Frame = +3
Query: 39 STYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFS 218
S + + G VDWR KG VTPVK+Q QCGSCW+FS TGSLEGQ+F K LIS +
Sbjct: 96 SVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLA 155
Query: 219 EQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKC 395
EQQLVDCS M++AF YIK + GI++E YPY A DG+C+ + + + C
Sbjct: 156 EQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATC 215
Query: 396 TGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAV 575
+G T+I S +ET L AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAV
Sbjct: 216 SGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAV 275
Query: 576 GYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
GYG++ G+ +W+VKNSW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 276 GYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 258 bits (660), Expect = 1e-68
Identities = 125/219 (57%), Positives = 156/219 (71%), Gaps = 1/219 (0%)
Frame = +3
Query: 66 GVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSX 245
G + A VDWR K VTPVK+Q+QCGSCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS
Sbjct: 104 GPMAADVDWRTKALVTPVKDQEQCGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCST 163
Query: 246 XXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQ 422
M +AF YIKD G I++E YPY A D +C+ + + I CTG ++Q
Sbjct: 164 DYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHT 223
Query: 423 NETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKK 602
E L AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K
Sbjct: 224 EEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKD 282
Query: 603 YWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
YW+VKNSW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 283 YWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 258 bits (659), Expect = 1e-68
Identities = 129/222 (58%), Positives = 153/222 (68%), Gaps = 6/222 (2%)
Frame = +3
Query: 72 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 251
+P SVDWR+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 VPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ 173
Query: 252 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 425
LMDNAF+Y+KD G+++E YPY + +C P TGF DI Q
Sbjct: 174 GNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQR 232
Query: 426 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----I 593
E L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG +
Sbjct: 233 EKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSN 292
Query: 594 GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 719
K+WIVKNSW WG +GY+KM+KD+ N CGI+T ASYP V
Sbjct: 293 SSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,633,292
Number of Sequences: 369166
Number of extensions: 1736942
Number of successful extensions: 5354
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4712
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4873
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)