Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_J12
(764 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P21708|MK03_RAT Mitogen-activated protein kinase 3 (Extr... 234 1e-61
sp|Q63844|MK03_MOUSE Mitogen-activated protein kinase 3 (Ex... 234 1e-61
sp|P27361|MK03_HUMAN Mitogen-activated protein kinase 3 (Ex... 233 3e-61
sp|P26696|MK01_XENLA Mitogen-activated protein kinase 1 (My... 232 7e-61
sp|P46196|MK01_BOVIN Mitogen-activated protein kinase 1 (Ex... 232 9e-61
sp|P28482|MK01_HUMAN Mitogen-activated protein kinase 1 (Ex... 231 1e-60
sp|P63086|MK01_RAT Mitogen-activated protein kinase 1 (Extr... 231 1e-60
sp|P39745|SUR1_CAEEL Mitogen-activated protein kinase mpk-1... 227 2e-59
sp|P40417|ERKA_DROME Mitogen-activated protein kinase ERK-A... 219 8e-57
sp|Q00859|MAPK_FUSSO Mitogen-activated protein kinase (FsMAPK) 189 5e-48
>sp|P21708|MK03_RAT Mitogen-activated protein kinase 3 (Extracellular signal-regulated
kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP
kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK)
(Microtubule-associated protein 2 kinase) (MNK1)
Length = 380
Score = 234 bits (598), Expect = 1e-61
Identities = 106/171 (61%), Positives = 138/171 (80%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ +L
Sbjct: 203 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 262
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P++ED I+N KAR++++ +KTK W +L+P +D + +L+ ++TFNP KR+TV
Sbjct: 263 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 322
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFR 513
E ALA PYL QYY+PTDEPVA PFTF+ ELDDLP E+L+E+I++ F+
Sbjct: 323 EEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQ 373
>sp|Q63844|MK03_MOUSE Mitogen-activated protein kinase 3 (Extracellular signal-regulated
kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP
kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK)
(Microtubule-associated protein 2 kinase) (MNK1)
Length = 380
Score = 234 bits (598), Expect = 1e-61
Identities = 106/171 (61%), Positives = 138/171 (80%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ +L
Sbjct: 203 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 262
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P++ED I+N KAR++++ +KTK W +L+P +D + +L+ ++TFNP KR+TV
Sbjct: 263 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 322
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFR 513
E ALA PYL QYY+PTDEPVA PFTF+ ELDDLP E+L+E+I++ F+
Sbjct: 323 EEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQ 373
>sp|P27361|MK03_HUMAN Mitogen-activated protein kinase 3 (Extracellular signal-regulated
kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP
kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK)
(Microtubule-associated protein 2 kinase)
Length = 379
Score = 233 bits (595), Expect = 3e-61
Identities = 106/171 (61%), Positives = 137/171 (80%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ +L
Sbjct: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P++ED I+N KAR++++ +KTK W +L+P +D + +L+ ++TFNP KR+TV
Sbjct: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFR 513
E ALA PYL QYY+PTDEPVA PFTF ELDDLP E+L+E+I++ F+
Sbjct: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372
>sp|P26696|MK01_XENLA Mitogen-activated protein kinase 1 (Myelin xP42 protein kinase)
(Myelin basic protein kinase) (MBP kinase) (M phase MAP
kinase)
Length = 361
Score = 232 bits (592), Expect = 7e-61
Identities = 108/171 (63%), Positives = 135/171 (78%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ +L
Sbjct: 188 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 247
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P++ED I+N KAR+++ K K PW +L+PNAD + +L+ ++TFNP KR+ V
Sbjct: 248 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADPKALDLLDKMLTFNPHKRIEV 307
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFR 513
EAALA PYL QYY+P+DEPVA PF FE ELDDLP E L+E+I+E F+
Sbjct: 308 EAALAHPYLEQYYDPSDEPVAEAPFKFEMELDDLPKETLKELIFEETARFQ 358
>sp|P46196|MK01_BOVIN Mitogen-activated protein kinase 1 (Extracellular signal-regulated
kinase 2) (ERK-2) (Mitogen-activated protein kinase 2)
(MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)
Length = 360
Score = 232 bits (591), Expect = 9e-61
Identities = 107/171 (62%), Positives = 135/171 (78%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ +L
Sbjct: 185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 244
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P++ED I+N KAR+++ K K PW +L+PNAD + +L+ ++TFNP KR+ V
Sbjct: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFR 513
E ALA PYL QYY+P+DEPVA PF F+ ELDDLP EKL+E+I+E F+
Sbjct: 305 EQALAHPYLEQYYDPSDEPVAEAPFKFDMELDDLPKEKLKELIFEETARFQ 355
>sp|P28482|MK01_HUMAN Mitogen-activated protein kinase 1 (Extracellular signal-regulated
kinase 2) (ERK-2) (Mitogen-activated protein kinase 2)
(MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)
Length = 360
Score = 231 bits (590), Expect = 1e-60
Identities = 106/171 (61%), Positives = 135/171 (78%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ +L
Sbjct: 185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 244
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P++ED I+N KAR+++ K K PW +L+PNAD + +L+ ++TFNP KR+ V
Sbjct: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFR 513
E ALA PYL QYY+P+DEP+A PF F+ ELDDLP EKL+E+I+E F+
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQ 355
>sp|P63086|MK01_RAT Mitogen-activated protein kinase 1 (Extracellular signal-regulated
kinase 2) (ERK-2) (Mitogen-activated protein kinase 2)
(MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)
sp|P63085|MK01_MOUSE Mitogen-activated protein kinase 1 (Extracellular signal-regulated
kinase 2) (ERK-2) (Mitogen-activated protein kinase 2)
(MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)
Length = 358
Score = 231 bits (590), Expect = 1e-60
Identities = 106/171 (61%), Positives = 135/171 (78%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ +L
Sbjct: 183 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 242
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P++ED I+N KAR+++ K K PW +L+PNAD + +L+ ++TFNP KR+ V
Sbjct: 243 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 302
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFR 513
E ALA PYL QYY+P+DEP+A PF F+ ELDDLP EKL+E+I+E F+
Sbjct: 303 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQ 353
>sp|P39745|SUR1_CAEEL Mitogen-activated protein kinase mpk-1 (MAP kinase sur-1)
Length = 444
Score = 227 bits (579), Expect = 2e-59
Identities = 104/175 (59%), Positives = 133/175 (76%), Gaps = 1/175 (0%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+ID+WSVGCILAEML+ +P+FPGKHY++QL LI+ V+
Sbjct: 256 TEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVV 315
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P+ D I+N+KAR ++ K K PW +LYP AD + +L+ ++TFNP R+ +
Sbjct: 316 GSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDI 375
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVK-YFRQLE 522
E ALA PYL QYY+P DEPV PFT E E DDLP EKL+E+IWE + + R++E
Sbjct: 376 EQALAHPYLEQYYDPGDEPVCEEPFTLEMEFDDLPKEKLKELIWEEAEAHHRRME 430
>sp|P40417|ERKA_DROME Mitogen-activated protein kinase ERK-A (Extracellular-regulated
kinase A) (Rolled protein)
Length = 376
Score = 219 bits (557), Expect = 8e-57
Identities = 102/172 (59%), Positives = 129/172 (75%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIMLNSKGYTK+IDIWSVGCILAEML+ +PIFPGKHY++QL I+ VL
Sbjct: 198 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVL 257
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G P+ +D I+NEKAR+++E K PW +L+PNAD L + +L ++TFNP KR+ V
Sbjct: 258 GSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPV 317
Query: 361 EAALAMPYLSQYYEPTDEPVASTPFTFEHELDDLPIEKLREMIWERVKYFRQ 516
E ALA PYL QYY+P DEPVA PF E DD+ + L+ +I+E F++
Sbjct: 318 EEALAHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKE 369
>sp|Q00859|MAPK_FUSSO Mitogen-activated protein kinase (FsMAPK)
Length = 355
Score = 189 bits (481), Expect = 5e-48
Identities = 93/171 (54%), Positives = 119/171 (69%), Gaps = 4/171 (2%)
Frame = +1
Query: 1 TEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVL 180
TEYVATRWYRAPEIML K YTKAID+WSVGCILAEML+GKP+FPGK Y QLTLI+ VL
Sbjct: 183 TEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVL 242
Query: 181 GYPTEEDKAWIVNEKARHFVEKFVTKTKTPWKQLYPNADDLCIQMLEGLMTFNPGKRLTV 360
G PT ED I + +AR ++ K K P++ L+P DL + +LE L+ FNP KR+TV
Sbjct: 243 GTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFPKTSDLALDLLEKLLAFNPVKRITV 302
Query: 361 EAALAMPYLSQYYEPTDEPVA----STPFTFEHELDDLPIEKLREMIWERV 501
E AL PYL Y++P DEP A F F+ D+L E+L+++I++ +
Sbjct: 303 EEALKHPYLEPYHDPEDEPTAPPIPEEFFDFDKHKDNLSKEQLKQLIYQEI 353
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,483,341
Number of Sequences: 369166
Number of extensions: 1687478
Number of successful extensions: 5631
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5165
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5358
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7066925600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)