Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_I24
(498 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26563|CATC_SCHMA Cathepsin C precursor 195 4e-50
sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 189 2e-48
sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 186 3e-47
sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 179 2e-45
sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 178 7e-45
sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 175 5e-44
sp|Q8IIJ9|CATC_PLAF7 Probable cathepsin C precursor 102 5e-22
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 101 9e-22
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 98 1e-20
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 97 2e-20
>sp|Q26563|CATC_SCHMA Cathepsin C precursor
Length = 454
Score = 195 bits (496), Expect = 4e-50
Identities = 88/140 (62%), Positives = 106/140 (75%), Gaps = 1/140 (0%)
Frame = +1
Query: 16 GKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGGVY 195
GKC+ +K+C RY+ T+Y YIGGYYGATNE LM++EL+ NGP VGFEVY+DF Y G+Y
Sbjct: 319 GKCTVSKNCTRYYTTDYSYIGGYYGATNEKLMQLELISNGPFPVGFEVYEDFQFYKEGIY 378
Query: 196 HHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGENGYFRI 372
HH + T + FNPFELTNHAVL+VGYG + SGE +W VKNSWG WGE GYFRI
Sbjct: 379 HHT----TVQTDHYNFNPFELTNHAVLLVGYGVDKLSGEPYWKVKNSWGVEWGEQGYFRI 434
Query: 373 RRGNDECGIESLGVASEPIL 432
RG DECG+ESLGV +P+L
Sbjct: 435 LRGTDECGVESLGVRFDPVL 454
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 189 bits (481), Expect = 2e-48
Identities = 86/144 (59%), Positives = 107/144 (74%), Gaps = 1/144 (0%)
Frame = +1
Query: 1 YKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSY 180
Y G + C +DC RY+++ Y Y+GG+YG NE LM++ELV +GP+AV FEVYDDF+ Y
Sbjct: 324 YTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHY 383
Query: 181 SGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGEN 357
G+YHH T + FNPFELTNHAVL+VGYG +++SG +WIVKNSWG GWGEN
Sbjct: 384 KKGIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGEN 436
Query: 358 GYFRIRRGNDECGIESLGVASEPI 429
GYFRIRRG DEC IES+ VA+ PI
Sbjct: 437 GYFRIRRGTDECAIESIAVAATPI 460
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 186 bits (472), Expect = 3e-47
Identities = 84/144 (58%), Positives = 106/144 (73%), Gaps = 1/144 (0%)
Frame = +1
Query: 1 YKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSY 180
Y G + C +DC RY+++ Y Y+GG+YG NE LM++ELV +GP+AV FEVYDDF+ Y
Sbjct: 324 YTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVYHGPLAVAFEVYDDFLHY 383
Query: 181 SGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGEN 357
G+YHH T + FNPFELTNHAVL+VGYG +++SG +WIVKNSWG WGE+
Sbjct: 384 QNGIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTSWGED 436
Query: 358 GYFRIRRGNDECGIESLGVASEPI 429
GYFRIRRG DEC IES+ VA+ PI
Sbjct: 437 GYFRIRRGTDECAIESIAVAATPI 460
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain 1;
Dipeptidyl-peptidase I heavy chain 2;
Dipeptidyl-peptidase I heavy chain 3;
Dipeptidyl-peptidase I heavy chain 4;
Dipeptidyl-peptidase I light chain]
Length = 435
Score = 179 bits (455), Expect = 2e-45
Identities = 84/144 (58%), Positives = 107/144 (74%), Gaps = 1/144 (0%)
Frame = +1
Query: 1 YKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSY 180
Y G + C DC RY+++ Y Y+GG+YGA NE LM++ELV++GP+AV FEVYDDF Y
Sbjct: 297 YAGSDSPCKPN-DCFRYYSSEYYYVGGFYGACNEALMKLELVRHGPMAVAFEVYDDFFHY 355
Query: 181 SGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGEN 357
G+Y+H T + FNPFELTNHAVL+VGYG +++SG +WIVKNSWG+ WGE+
Sbjct: 356 QKGIYYH-------TGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGSRWGED 408
Query: 358 GYFRIRRGNDECGIESLGVASEPI 429
GYFRIRRG DEC IES+ VA+ PI
Sbjct: 409 GYFRIRRGTDECAIESIAVAATPI 432
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 178 bits (451), Expect = 7e-45
Identities = 80/144 (55%), Positives = 106/144 (73%), Gaps = 1/144 (0%)
Frame = +1
Query: 1 YKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSY 180
Y + C ++C RY++++Y Y+GG+YG NE LM++ELVK+GP+AV FEV+DDF+ Y
Sbjct: 323 YTAKDSPCKpreNCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHY 382
Query: 181 SGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGEN 357
G+YHH T FNPFELTNHAVL+VGYG + +G ++WI+KNSWG+ WGE+
Sbjct: 383 HSGIYHH-------TGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGES 435
Query: 358 GYFRIRRGNDECGIESLGVASEPI 429
GYFRIRRG DEC IES+ VA+ PI
Sbjct: 436 GYFRIRRGTDECAIESIAVAAIPI 459
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 175 bits (444), Expect = 5e-44
Identities = 80/144 (55%), Positives = 104/144 (72%), Gaps = 1/144 (0%)
Frame = +1
Query: 1 YKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSY 180
Y + C ++C RY+++ Y Y+GG+YG NE LM++ELVK+GP+AV FEV+DDF+ Y
Sbjct: 323 YTATDAPCKPKENCLRYYSSEYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHY 382
Query: 181 SGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGEN 357
G+YHH T FNPFELTNHAVL+VGYG + +G +WIVKNSWG+ WGE+
Sbjct: 383 HSGIYHH-------TGLSDPFNPFELTNHAVLLVGYGKDPVTGLDYWIVKNSWGSQWGES 435
Query: 358 GYFRIRRGNDECGIESLGVASEPI 429
GYFRIRRG DEC IES+ +A+ PI
Sbjct: 436 GYFRIRRGTDECAIESIAMAAIPI 459
>sp|Q8IIJ9|CATC_PLAF7 Probable cathepsin C precursor
Length = 700
Score = 102 bits (254), Expect = 5e-22
Identities = 54/140 (38%), Positives = 82/140 (58%), Gaps = 13/140 (9%)
Frame = +1
Query: 46 RYFATNYKYIGGYYGATN---EPLMRMELVKNGPIAVGFEVYDDFMSYSGGVYH-HNFGT 213
R++A ++ Y+GG YG E +M E+ +NGPI FE DF Y+ GVY +F
Sbjct: 541 RWYAKDFNYVGGCYGCNQCNGEKIMMNEIYRNGPIVSSFEASPDFYDYADGVYFVEDFPH 600
Query: 214 RKLTTSK------FGFNPFELTNHAVLVVGYGETS-SGE--KFWIVKNSWGNGWGENGYF 366
+ T + + ++ NHA++++G+GE +G+ K+WI +NSWGNGWG+ GYF
Sbjct: 601 ARRCTIEPKNDGVYNITGWDRVNHAIVLLGWGEEEINGKLYKYWIGRNSWGNGWGKEGYF 660
Query: 367 RIRRGNDECGIESLGVASEP 426
+I RG + GIES + EP
Sbjct: 661 KILRGQNFSGIESQSLFIEP 680
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 101 bits (252), Expect = 9e-22
Identities = 54/138 (39%), Positives = 77/138 (55%), Gaps = 5/138 (3%)
Frame = +1
Query: 25 STTKDCKRYFATNY---KYIG--GYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGG 189
S + C+ ++T Y K+ G Y N ++ E+ NGP+ F VY+DF Y G
Sbjct: 203 SCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDFYKYKSG 262
Query: 190 VYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWGENGYFR 369
VY H T K+ L HA+ ++G+G T SG +W+V NSWG WGE+G+F+
Sbjct: 263 VYKH-------TAGKY------LGGHAIKIIGWG-TESGSPYWLVANSWGVNWGESGFFK 308
Query: 370 IRRGNDECGIESLGVASE 423
I RG+D+CGIES VA +
Sbjct: 309 IYRGDDQCGIESAVVAGK 326
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 97.8 bits (242), Expect = 1e-20
Identities = 54/146 (36%), Positives = 75/146 (51%), Gaps = 5/146 (3%)
Frame = +1
Query: 4 KGMNGKCSTTKDCKRYFATNYKY-----IGGYYGATNEPLMRMELVKNGPIAVGFEVYDD 168
+G KC+ T C+ ++ +YK Y A NE + E+ KNGP+ F VY D
Sbjct: 201 EGDTPKCNKT--CEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSD 258
Query: 169 FMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGW 348
F+ Y GVY H G + HA+ ++G+G +G +W+V NSW W
Sbjct: 259 FLLYKSGVYQHVSGEI-------------MGGHAIRILGWG-VENGTPYWLVGNSWNTDW 304
Query: 349 GENGYFRIRRGNDECGIESLGVASEP 426
G+NG+F+I RG D CGIES VA P
Sbjct: 305 GDNGFFKILRGQDHCGIESEIVAGMP 330
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 97.4 bits (241), Expect = 2e-20
Identities = 57/143 (39%), Positives = 75/143 (52%), Gaps = 5/143 (3%)
Frame = +1
Query: 19 KCSTTKDCKRYFATNY---KYIGGYYGATNEPL--MRMELVKNGPIAVGFEVYDDFMSYS 183
KC + K +AT Y K+ G A + + ++ E++ NGPI V F VY+DF Y+
Sbjct: 212 KCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAFTVYEDFYQYT 271
Query: 184 GGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWGENGY 363
GVY H G L HAV ++G+G +G +W+V NSW WGE GY
Sbjct: 272 TGVYVHTAGA-------------SLGGHAVKILGWG-VDNGTPYWLVANSWNVAWGEKGY 317
Query: 364 FRIRRGNDECGIESLGVASEPIL 432
FRI RG +ECGIE VA P L
Sbjct: 318 FRIIRGLNECGIEHSAVAGIPDL 340
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,729,215
Number of Sequences: 369166
Number of extensions: 1288864
Number of successful extensions: 3783
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3513
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3603
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3119256630
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)