Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_F20
(896 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UN37|VPS4A_HUMAN Vacuolar sorting protein 4a (SKD2 pro... 364 e-100
sp|Q8VEJ9|VPS4A_MOUSE Vacuolar sorting protein 4a 364 e-100
sp|O75351|VPS4B_HUMAN Vacuolar sorting protein 4b (SKD1 pro... 352 1e-96
sp|P46467|VPS4B_MOUSE Vacuolar sorting protein 4b (SKD1 pro... 351 2e-96
sp|Q09803|VPS4_SCHPO Suppressor protein of bem1/bed5 double... 289 6e-78
sp|P52917|VPS4_YEAST Vacuolar protein sorting-associated pr... 278 1e-74
sp|Q9BW62|KATL1_HUMAN Katanin p60 ATPase-containing subunit... 185 1e-46
sp|Q8K0T4|KATL1_MOUSE Katanin p60 ATPase-containing subunit... 185 1e-46
sp|Q5XIK7|KATL1_RAT Katanin p60 ATPase-containing subunit A... 185 1e-46
sp|O61577|KTNA1_STRPU Katanin p60 ATPase-containing subunit... 185 2e-46
>sp|Q9UN37|VPS4A_HUMAN Vacuolar sorting protein 4a (SKD2 protein) (hVPS4) (VPS4-1)
Length = 437
Score = 364 bits (935), Expect = e-100
Identities = 185/277 (66%), Positives = 209/277 (75%), Gaps = 2/277 (0%)
Frame = +1
Query: 70 IELITKAAIEDKNKNYEEALKLYEHALEYFLHALKYESPTDKTKESIRAKCTQYLDRAEK 249
I+L+TKA EDK KNYEEAL+LY+HA+EYFLHA+KYE+ +DK KESIRAKC QYLDRAEK
Sbjct: 10 IDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEK 69
Query: 250 LKKYLA--DXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLAGAIVMEKPNVHWNDI 423
LK YL + L GA+VMEKPN+ WND+
Sbjct: 70 LKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDV 129
Query: 424 AGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYLAKAVATEAENSTF 603
AGL GAKE+L+EAVILP+KFP LFTGKR PWRGILL+GPPGTGKSYLAKAVATEA NSTF
Sbjct: 130 AGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTF 189
Query: 604 FAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCGXXXXXXXXXXXXIKT 783
F++SSSDL+SKWLGESEKLVKNLFELAR+H+PSIIFIDE+DS+CG IKT
Sbjct: 190 FSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKT 249
Query: 784 EFLVQMEGVGAQNDKILVLAATNIPWTLDSAIRRRFE 894
EFLVQM+GVG ND LVL ATNIPW LDSAIRRRFE
Sbjct: 250 EFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFE 286
>sp|Q8VEJ9|VPS4A_MOUSE Vacuolar sorting protein 4a
Length = 437
Score = 364 bits (934), Expect = e-100
Identities = 185/277 (66%), Positives = 209/277 (75%), Gaps = 2/277 (0%)
Frame = +1
Query: 70 IELITKAAIEDKNKNYEEALKLYEHALEYFLHALKYESPTDKTKESIRAKCTQYLDRAEK 249
I+L+TKA EDK KNYEEAL+LY+HA+EYFLHA+KYE+ +DK KESIRAKC QYLDRAEK
Sbjct: 10 IDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYLDRAEK 69
Query: 250 LKKYLA--DXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLAGAIVMEKPNVHWNDI 423
LK YL + L GA+VMEKPN+ WND+
Sbjct: 70 LKDYLRNKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDV 129
Query: 424 AGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYLAKAVATEAENSTF 603
AGL GAKE+L+EAVILP+KFP LFTGKR PWRGILL+GPPGTGKSYLAKAVATEA NSTF
Sbjct: 130 AGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTF 189
Query: 604 FAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCGXXXXXXXXXXXXIKT 783
F++SSSDL+SKWLGESEKLVKNLFELAR+H+PSIIFIDE+DS+CG IKT
Sbjct: 190 FSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKT 249
Query: 784 EFLVQMEGVGAQNDKILVLAATNIPWTLDSAIRRRFE 894
EFLVQM+GVG ND LVL ATNIPW LDSAIRRRFE
Sbjct: 250 EFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFE 286
>sp|O75351|VPS4B_HUMAN Vacuolar sorting protein 4b (SKD1 protein)
Length = 444
Score = 352 bits (902), Expect = 1e-96
Identities = 183/282 (64%), Positives = 209/282 (74%), Gaps = 7/282 (2%)
Frame = +1
Query: 70 IELITKAAIEDKNKNYEEALKLYEHALEYFLHALKYESPTDKTKESIRAKCTQYLDRAEK 249
I+L +KAA EDK NYEEAL+LY+HA++YFLH +KYE+ DK K+SIRAKCT+YLDRAEK
Sbjct: 12 IDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEK 71
Query: 250 LKKYLADXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------LAGAIVMEKPNV 408
LK+YL + L GAIV+E+PNV
Sbjct: 72 LKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNV 131
Query: 409 HWNDIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYLAKAVATEA 588
W+D+AGL GAKE+L+EAVILP+KFP LFTGKR PWRGILL+GPPGTGKSYLAKAVATEA
Sbjct: 132 KWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEA 191
Query: 589 ENSTFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCGXXXXXXXXXX 768
NSTFF+ISSSDLVSKWLGESEKLVKNLF+LARE++PSIIFIDEIDS+CG
Sbjct: 192 NNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAA 251
Query: 769 XXIKTEFLVQMEGVGAQNDKILVLAATNIPWTLDSAIRRRFE 894
IKTEFLVQM+GVG ND ILVL ATNIPW LDSAIRRRFE
Sbjct: 252 RRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFE 293
>sp|P46467|VPS4B_MOUSE Vacuolar sorting protein 4b (SKD1 protein)
Length = 444
Score = 351 bits (900), Expect = 2e-96
Identities = 183/282 (64%), Positives = 208/282 (73%), Gaps = 7/282 (2%)
Frame = +1
Query: 70 IELITKAAIEDKNKNYEEALKLYEHALEYFLHALKYESPTDKTKESIRAKCTQYLDRAEK 249
I+L +KAA EDK NYEEAL+LY+HA++YFLH +KYE+ DK K+SIRAKCT+YLDRAEK
Sbjct: 12 IDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEK 71
Query: 250 LKKYLADXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------LAGAIVMEKPNV 408
LK+YL L GAIV+E+PNV
Sbjct: 72 LKEYLKKKEKKPQKPVKEEQSGPVDEKGNDSDGEAESDDPEKKKLQNQLQGAIVIERPNV 131
Query: 409 HWNDIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYLAKAVATEA 588
W+D+AGL GAKE+L+EAVILP+KFP LFTGKR PWRGILL+GPPGTGKSYLAKAVATEA
Sbjct: 132 KWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEA 191
Query: 589 ENSTFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCGXXXXXXXXXX 768
NSTFF+ISSSDLVSKWLGESEKLVKNLF+LARE++PSIIFIDEIDS+CG
Sbjct: 192 NNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAA 251
Query: 769 XXIKTEFLVQMEGVGAQNDKILVLAATNIPWTLDSAIRRRFE 894
IKTEFLVQM+GVG ND ILVL ATNIPW LDSAIRRRFE
Sbjct: 252 RRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFE 293
>sp|Q09803|VPS4_SCHPO Suppressor protein of bem1/bed5 double mutants
Length = 432
Score = 289 bits (740), Expect = 6e-78
Identities = 158/279 (56%), Positives = 185/279 (66%), Gaps = 4/279 (1%)
Frame = +1
Query: 70 IELITKAAIEDKNKNYEEALKLYEHALEYFLHALKYESPTDKTKESIRAKCTQYLDRAEK 249
I L+ A D + Y +A K Y+ AL+YF+ ALKYE +K+KE IR+K +YLDRAEK
Sbjct: 11 ISLVKTAIDNDNAEQYPDAYKYYQSALDYFMMALKYEK-NEKSKEIIRSKVIEYLDRAEK 69
Query: 250 LKKYLADXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXL----AGAIVMEKPNVHWN 417
LK YL + L AI++EKPNV W+
Sbjct: 70 LKVYLQEKNNQISSKSRVSNGNVEGSNSPTANEALDSDAKKLRSALTSAILVEKPNVRWD 129
Query: 418 DIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYLAKAVATEAENS 597
DIAGL AKE+L+E V+LP+K P LF+ RKPW GILLYGPPGTGKSYLAKAVATEA S
Sbjct: 130 DIAGLENAKEALKETVLLPIKLPQLFSHGRKPWSGILLYGPPGTGKSYLAKAVATEA-GS 188
Query: 598 TFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCGXXXXXXXXXXXXI 777
TFF+ISSSDLVSKW+GESE+LV+ LFE+ARE +PSIIFIDEIDS+CG I
Sbjct: 189 TFFSISSSDLVSKWMGESERLVRQLFEMAREQKPSIIFIDEIDSLCGSRSEGESESSRRI 248
Query: 778 KTEFLVQMEGVGAQNDKILVLAATNIPWTLDSAIRRRFE 894
KTEFLVQM GVG +LVL ATNIPWTLDSAIRRRFE
Sbjct: 249 KTEFLVQMNGVGKDESGVLVLGATNIPWTLDSAIRRRFE 287
>sp|P52917|VPS4_YEAST Vacuolar protein sorting-associated protein VPS4 (END13 protein)
(DOA4-independent degradation protein 6)
Length = 437
Score = 278 bits (712), Expect = 1e-74
Identities = 157/283 (55%), Positives = 184/283 (65%), Gaps = 8/283 (2%)
Frame = +1
Query: 70 IELITKAAIEDKNKNYEEALKLYEHALEYFLHALKYESPTDKTKESIRAKCTQYLDRAEK 249
IEL+ KA D YEEA Y + L+Y + ALKYE K+K+ IRAK T+YL+RAE+
Sbjct: 11 IELVQKAIDLDTATQYEEAYTAYYNGLDYLMLALKYEK-NPKSKDLIRAKFTEYLNRAEQ 69
Query: 250 LKKYLADXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------LAGAIVMEKPN 405
LKK+L L+ AI+ EKPN
Sbjct: 70 LKKHLESEEANAAKKSPSAGSGSNGGNKKISQEEGEDNGGEDNKKLRGALSSAILSEKPN 129
Query: 406 VHWNDIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYLAKAVATE 585
V W D+AGL GAKE+L+EAVILP+KFP LF G RKP GILLYGPPGTGKSYLAKAVATE
Sbjct: 130 VKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVATE 189
Query: 586 AENSTFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCGXXXXXXXXX 765
A NSTFF++SSSDLVSKW+GESEKLVK LF +ARE++PSIIFIDE+D++ G
Sbjct: 190 A-NSTFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDEVDALTGTRGEGESEA 248
Query: 766 XXXIKTEFLVQMEGVGAQNDKILVLAATNIPWTLDSAIRRRFE 894
IKTE LVQM GVG + +LVL ATNIPW LDSAIRRRFE
Sbjct: 249 SRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSAIRRRFE 291
>sp|Q9BW62|KATL1_HUMAN Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 490
Score = 185 bits (470), Expect = 1e-46
Identities = 97/177 (54%), Positives = 125/177 (70%), Gaps = 7/177 (3%)
Frame = +1
Query: 385 IVMEKPNVHWNDIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYL 564
IV P++HW+DIA L AK+ L+EAV+LPM PD F G R+PW+G+L+ GPPGTGK+ L
Sbjct: 198 IVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTML 257
Query: 565 AKAVATEAENSTFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCG-X 741
AKAVATE +TFF +SSS L SK+ GESEKLV+ LFE+AR + P+ IFIDEIDS+C
Sbjct: 258 AKAVATEC-GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR 316
Query: 742 XXXXXXXXXXXIKTEFLVQMEGVGA--QND----KILVLAATNIPWTLDSAIRRRFE 894
+K+E L+QM+GVG +ND ++VLAATN PW +D A+RRR E
Sbjct: 317 GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLE 373
>sp|Q8K0T4|KATL1_MOUSE Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 488
Score = 185 bits (470), Expect = 1e-46
Identities = 97/177 (54%), Positives = 125/177 (70%), Gaps = 7/177 (3%)
Frame = +1
Query: 385 IVMEKPNVHWNDIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYL 564
IV P++HW+DIA L AK+ L+EAV+LPM PD F G R+PW+G+L+ GPPGTGK+ L
Sbjct: 196 IVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTML 255
Query: 565 AKAVATEAENSTFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCG-X 741
AKAVATE +TFF +SSS L SK+ GESEKLV+ LFE+AR + P+ IFIDEIDS+C
Sbjct: 256 AKAVATEC-GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR 314
Query: 742 XXXXXXXXXXXIKTEFLVQMEGVGA--QND----KILVLAATNIPWTLDSAIRRRFE 894
+K+E L+QM+GVG +ND ++VLAATN PW +D A+RRR E
Sbjct: 315 GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLE 371
>sp|Q5XIK7|KATL1_RAT Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 488
Score = 185 bits (470), Expect = 1e-46
Identities = 97/177 (54%), Positives = 125/177 (70%), Gaps = 7/177 (3%)
Frame = +1
Query: 385 IVMEKPNVHWNDIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYL 564
IV P++HW+DIA L AK+ L+EAV+LPM PD F G R+PW+G+L+ GPPGTGK+ L
Sbjct: 196 IVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTML 255
Query: 565 AKAVATEAENSTFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCG-X 741
AKAVATE +TFF +SSS L SK+ GESEKLV+ LFE+AR + P+ IFIDEIDS+C
Sbjct: 256 AKAVATEC-GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR 314
Query: 742 XXXXXXXXXXXIKTEFLVQMEGVGA--QND----KILVLAATNIPWTLDSAIRRRFE 894
+K+E L+QM+GVG +ND ++VLAATN PW +D A+RRR E
Sbjct: 315 GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLE 371
>sp|O61577|KTNA1_STRPU Katanin p60 ATPase-containing subunit (Katanin p60 subunit) (p60
katanin)
Length = 516
Score = 185 bits (469), Expect = 2e-46
Identities = 98/177 (55%), Positives = 124/177 (70%), Gaps = 7/177 (3%)
Frame = +1
Query: 385 IVMEKPNVHWNDIAGLHGAKESLQEAVILPMKFPDLFTGKRKPWRGILLYGPPGTGKSYL 564
IV PNVHW DIAGL AK L+EAV+LP+ PD F G R+PW+G+L+ GPPGTGK+ L
Sbjct: 224 IVQRNPNVHWADIAGLTEAKRLLEEAVVLPLWMPDYFKGIRRPWKGVLMVGPPGTGKTML 283
Query: 565 AKAVATEAENSTFFAISSSDLVSKWLGESEKLVKNLFELAREHRPSIIFIDEIDSMCG-X 741
AKAVATE +TFF +SS+ L SK+ GESEKLV+ LFE+AR + PS IFIDEIDS+C
Sbjct: 284 AKAVATEC-GTTFFNVSSASLTSKYHGESEKLVRLLFEMARFYAPSTIFIDEIDSICSKR 342
Query: 742 XXXXXXXXXXXIKTEFLVQMEGV-----GAQNDK-ILVLAATNIPWTLDSAIRRRFE 894
+K+E L+QM+GV G ++ K ++VLAATN PW +D A+RRR E
Sbjct: 343 GTGSEHEASRRVKSELLIQMDGVSGPSAGEESSKMVMVLAATNFPWDIDEALRRRLE 399
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,009,889
Number of Sequences: 369166
Number of extensions: 1787857
Number of successful extensions: 8376
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7237
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7823
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9030416440
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)