Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_F13
(888 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P29349|CSW_DROME Tyrosine-protein phosphatase corkscrew 345 1e-94
sp|Q90687|PTN11_CHICK Tyrosine-protein phosphatase, non-rec... 331 1e-90
sp|P35235|PTN11_MOUSE Tyrosine-protein phosphatase, non-rec... 330 3e-90
sp|Q06124|PTN11_HUMAN Tyrosine-protein phosphatase, non-rec... 330 3e-90
sp|P41499|PTN11_RAT Tyrosine-protein phosphatase, non-recep... 330 3e-90
sp|P29350|PTN6_HUMAN Tyrosine-protein phosphatase, non-rece... 274 2e-73
sp|P29351|PTN6_MOUSE Tyrosine-protein phosphatase, non-rece... 273 6e-73
sp|P81718|PTN6_RAT Tyrosine-protein phosphatase, non-recept... 270 4e-72
sp|Q24708|CSW_DROVI Tyrosine-protein phosphatase corkscrew 180 5e-45
sp|Q05876|FYN_CHICK Proto-oncogene tyrosine-protein kinase ... 66 1e-10
>sp|P29349|CSW_DROME Tyrosine-protein phosphatase corkscrew
Length = 845
Score = 345 bits (885), Expect = 1e-94
Identities = 182/292 (62%), Positives = 217/292 (74%)
Frame = +1
Query: 10 ISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLYGGEK 189
ISG+++EKLL E+G GSFLAR S S+PG+FTLSVRRGNEVTHIKIQN DF DLYGGEK
Sbjct: 11 ISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDLYGGEK 70
Query: 190 FATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKMLLEKG 369
FATLPELV YYM++G ELKEKNGQ IELK PL +PTTERWFHG+++GKEAEK++LE+G
Sbjct: 71 FATLPELVQYYMENG-ELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERG 129
Query: 370 INGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDNKKFDIGGGRQFDTLKDLIDFYVT 549
NGSFLVRES K G +V+SV T D V HVMI +D KK+D+GGG F TL +LID Y
Sbjct: 130 KNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQD-KKYDVGGGESFGTLSELIDHYKR 188
Query: 550 TPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQPGFLEEFDELQQDAR 729
PMVE GT+V L PFNATR+ I R+ QL K GF EEF+ LQQD+R
Sbjct: 189 NPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKG---------GFWEEFESLQQDSR 239
Query: 730 SKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYINANYIK 885
+R EG+K N KNRYRNILP+D RVKL D + ++ G++YINANYI+
Sbjct: 240 D-TFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIR 290
Score = 83.6 bits (205), Expect = 7e-16
Identities = 44/95 (46%), Positives = 63/95 (66%), Gaps = 1/95 (1%)
Frame = +1
Query: 1 FH-HISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH ++SG ++EKL+LERG +GSFL R S S PG F LSVR ++VTH+ I+ D D+
Sbjct: 112 FHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVG 171
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYP 282
GGE F TL EL+ +Y ++ + E G ++ L+ P
Sbjct: 172 GGESFGTLSELIDHYKRN--PMVETCGTVVHLRQP 204
Score = 76.3 bits (186), Expect = 1e-13
Identities = 40/100 (40%), Positives = 61/100 (61%), Gaps = 1/100 (1%)
Frame = +1
Query: 301 TTERWFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDN 480
++ RWFH I+G EAEK+L E+G +GSFL R S G++ +SV G+ V H+ I +
Sbjct: 2 SSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQ-NNG 60
Query: 481 KKFDIGGGRQFDTLKDLIDFYVTT-PMVEKSGTLVSLIHP 597
FD+ GG +F TL +L+ +Y+ + EK+G + L P
Sbjct: 61 DFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQP 100
>sp|Q90687|PTN11_CHICK Tyrosine-protein phosphatase, non-receptor type 11 (cSH-PTP2)
Length = 593
Score = 331 bits (849), Expect = 1e-90
Identities = 175/305 (57%), Positives = 213/305 (69%), Gaps = 11/305 (3%)
Frame = +1
Query: 1 FH-HISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH +I+GV++E LLL RG GSFLARPS S+PG FTLSVRR VTHIKIQNT D+ DLY
Sbjct: 7 FHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRTGAVTHIKIQNTGDYYDLY 66
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKML 357
GGEKFATL ELV YYM+ +LKEKNG +IELKYPL DPT+ERWFHG ++G+EAEK+L
Sbjct: 67 GGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLL 126
Query: 358 LEKGINGSFLVRESMRKIGSYVVSVLTGD----------HVDHVMIYCRDNKKFDIGGGR 507
EKG +GSFLVRES G +V+SV TGD V HVMI+C+D K+D+GGG
Sbjct: 127 TEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIHCQD-LKYDVGGGE 185
Query: 508 QFDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQP 687
+FD+L DL++ Y PMVE GT++ L P N TR+N I+ R+ +L K +
Sbjct: 186 KFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQ 245
Query: 688 GFLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYI 867
GF EEF+ LQQ +R+EG + N +KNRY+NILPFD RV L DGDPN P SDYI
Sbjct: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYI 305
Query: 868 NANYI 882
NAN I
Sbjct: 306 NANII 310
Score = 75.1 bits (183), Expect = 2e-13
Identities = 39/103 (37%), Positives = 60/103 (58%), Gaps = 2/103 (1%)
Frame = +1
Query: 301 TTERWFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDN 480
T+ RWFH +I G EAE +LL +G++GSFL R S G + +SV V H+ I
Sbjct: 2 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRTGAVTHIKIQ-NTG 60
Query: 481 KKFDIGGGRQFDTLKDLIDFYVT--TPMVEKSGTLVSLIHPFN 603
+D+ GG +F TL +L+ +Y+ + EK+G ++ L +P N
Sbjct: 61 DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103
>sp|P35235|PTN11_MOUSE Tyrosine-protein phosphatase, non-receptor type 11
(Protein-tyrosine phosphatase SYP)
Length = 585
Score = 330 bits (846), Expect = 3e-90
Identities = 175/305 (57%), Positives = 212/305 (69%), Gaps = 11/305 (3%)
Frame = +1
Query: 1 FH-HISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH +I+GV++E LLL RG GSFLARPS S+PG FTLSVRR VTHIKIQNT D+ DLY
Sbjct: 7 FHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLY 66
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKML 357
GGEKFATL ELV YYM+ +LKEKNG +IELKYPL DPT+ERWFHG ++GKEAEK+L
Sbjct: 67 GGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLL 126
Query: 358 LEKGINGSFLVRESMRKIGSYVVSVLTGD----------HVDHVMIYCRDNKKFDIGGGR 507
EKG +GSFLVRES G +V+SV TGD V HVMI C++ K+D+GGG
Sbjct: 127 TEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQE-LKYDVGGGE 185
Query: 508 QFDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQP 687
+FD+L DL++ Y PMVE GT++ L P N TR+N I+ R+ +L K +
Sbjct: 186 RFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQ 245
Query: 688 GFLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYI 867
GF EEF+ LQQ +R+EG + N +KNRY+NILPFD RV L DGDPN P SDYI
Sbjct: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYI 305
Query: 868 NANYI 882
NAN I
Sbjct: 306 NANII 310
Score = 75.9 bits (185), Expect = 1e-13
Identities = 39/103 (37%), Positives = 60/103 (58%), Gaps = 2/103 (1%)
Frame = +1
Query: 301 TTERWFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDN 480
T+ RWFH +I G EAE +LL +G++GSFL R S G + +SV V H+ I
Sbjct: 2 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQ-NTG 60
Query: 481 KKFDIGGGRQFDTLKDLIDFYVT--TPMVEKSGTLVSLIHPFN 603
+D+ GG +F TL +L+ +Y+ + EK+G ++ L +P N
Sbjct: 61 DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103
>sp|Q06124|PTN11_HUMAN Tyrosine-protein phosphatase, non-receptor type 11
(Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D)
(SH-PTP3) (SH-PTP2) (SHP-2)
Length = 593
Score = 330 bits (846), Expect = 3e-90
Identities = 175/305 (57%), Positives = 212/305 (69%), Gaps = 11/305 (3%)
Frame = +1
Query: 1 FH-HISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH +I+GV++E LLL RG GSFLARPS S+PG FTLSVRR VTHIKIQNT D+ DLY
Sbjct: 7 FHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLY 66
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKML 357
GGEKFATL ELV YYM+ +LKEKNG +IELKYPL DPT+ERWFHG ++GKEAEK+L
Sbjct: 67 GGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLL 126
Query: 358 LEKGINGSFLVRESMRKIGSYVVSVLTGD----------HVDHVMIYCRDNKKFDIGGGR 507
EKG +GSFLVRES G +V+SV TGD V HVMI C++ K+D+GGG
Sbjct: 127 TEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQE-LKYDVGGGE 185
Query: 508 QFDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQP 687
+FD+L DL++ Y PMVE GT++ L P N TR+N I+ R+ +L K +
Sbjct: 186 RFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQ 245
Query: 688 GFLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYI 867
GF EEF+ LQQ +R+EG + N +KNRY+NILPFD RV L DGDPN P SDYI
Sbjct: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYI 305
Query: 868 NANYI 882
NAN I
Sbjct: 306 NANII 310
Score = 75.9 bits (185), Expect = 1e-13
Identities = 39/103 (37%), Positives = 60/103 (58%), Gaps = 2/103 (1%)
Frame = +1
Query: 301 TTERWFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDN 480
T+ RWFH +I G EAE +LL +G++GSFL R S G + +SV V H+ I
Sbjct: 2 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQ-NTG 60
Query: 481 KKFDIGGGRQFDTLKDLIDFYVT--TPMVEKSGTLVSLIHPFN 603
+D+ GG +F TL +L+ +Y+ + EK+G ++ L +P N
Sbjct: 61 DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103
>sp|P41499|PTN11_RAT Tyrosine-protein phosphatase, non-receptor type 11
(Protein-tyrosine phosphatase SYP)
Length = 593
Score = 330 bits (846), Expect = 3e-90
Identities = 175/305 (57%), Positives = 212/305 (69%), Gaps = 11/305 (3%)
Frame = +1
Query: 1 FH-HISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH +I+GV++E LLL RG GSFLARPS S+PG FTLSVRR VTHIKIQNT D+ DLY
Sbjct: 7 FHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLY 66
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKML 357
GGEKFATL ELV YYM+ +LKEKNG +IELKYPL DPT+ERWFHG ++GKEAEK+L
Sbjct: 67 GGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLL 126
Query: 358 LEKGINGSFLVRESMRKIGSYVVSVLTGD----------HVDHVMIYCRDNKKFDIGGGR 507
EKG +GSFLVRES G +V+SV TGD V HVMI C++ K+D+GGG
Sbjct: 127 TEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDSKSKVTHVMIRCQE-LKYDVGGGE 185
Query: 508 QFDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQP 687
+FD+L DL++ Y PMVE GT++ L P N TR+N I+ R+ +L K +
Sbjct: 186 RFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQ 245
Query: 688 GFLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYI 867
GF EEF+ LQQ +R+EG + N +KNRY+NILPFD RV L DGDPN P SDYI
Sbjct: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYI 305
Query: 868 NANYI 882
NAN I
Sbjct: 306 NANII 310
Score = 75.9 bits (185), Expect = 1e-13
Identities = 39/103 (37%), Positives = 60/103 (58%), Gaps = 2/103 (1%)
Frame = +1
Query: 301 TTERWFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDN 480
T+ RWFH +I G EAE +LL +G++GSFL R S G + +SV V H+ I
Sbjct: 2 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQ-NTG 60
Query: 481 KKFDIGGGRQFDTLKDLIDFYVT--TPMVEKSGTLVSLIHPFN 603
+D+ GG +F TL +L+ +Y+ + EK+G ++ L +P N
Sbjct: 61 DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103
>sp|P29350|PTN6_HUMAN Tyrosine-protein phosphatase, non-receptor type 6 (Protein-tyrosine
phosphatase 1C) (PTP-1C) (Hematopoietic cell
protein-tyrosine phosphatase) (SH-PTP1)
(Protein-tyrosine phosphatase SHP-1)
Length = 595
Score = 274 bits (701), Expect = 2e-73
Identities = 150/305 (49%), Positives = 197/305 (64%), Gaps = 10/305 (3%)
Frame = +1
Query: 1 FHH-ISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH +SG+D+E LL RG GSFLARPS + G F+LSVR G++VTHI+IQN+ DF DLY
Sbjct: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKML 357
GGEKFATL ELV YY Q L++++G II LKYPL DPT+ERW+HG ++G +AE +L
Sbjct: 65 GGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLL 124
Query: 358 LEKGINGSFLVRESMRKIGSYVVSVLTGD---------HVDHVMIYCRDNKKFDIGGGRQ 510
KG +FLVRES+ + G +V+SVL+ V H+ + C + ++ +GG
Sbjct: 125 QAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMC-EGGRYTVGGLET 183
Query: 511 FDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQPG 690
FD+L DL++ + T + E SG V L P+ ATRVN I+ R+ +L K + G
Sbjct: 184 FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAG 243
Query: 691 FLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYIN 870
F EEF+ LQ+ R EG + N KNRY+NILPFD +RV L+ D NIPGSDYIN
Sbjct: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303
Query: 871 ANYIK 885
ANYIK
Sbjct: 304 ANYIK 308
Score = 78.6 bits (192), Expect = 2e-14
Identities = 38/102 (37%), Positives = 62/102 (60%), Gaps = 2/102 (1%)
Frame = +1
Query: 310 RWFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDNKKF 489
RWFH D++G +AE +L +G++GSFL R S + G + +SV GD V H+ I +
Sbjct: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQ-NSGDFY 61
Query: 490 DIGGGRQFDTLKDLIDFYVTTPMV--EKSGTLVSLIHPFNAT 609
D+ GG +F TL +L+++Y V ++ GT++ L +P N +
Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCS 103
>sp|P29351|PTN6_MOUSE Tyrosine-protein phosphatase, non-receptor type 6 (Protein-tyrosine
phosphatase 1C) (PTP-1C) (Hematopoietic cell
protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1)
(SHP-1) (PTPTY-42)
Length = 595
Score = 273 bits (697), Expect = 6e-73
Identities = 149/305 (48%), Positives = 194/305 (63%), Gaps = 10/305 (3%)
Frame = +1
Query: 1 FHH-ISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH +SG D+E LL RG GSFLARPS + G F+LSVR ++VTHI+IQN+ DF DLY
Sbjct: 5 FHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLY 64
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKML 357
GGEKFATL ELV YY Q L++++G II LKYPL DPT+ERW+HG I+G +AE +L
Sbjct: 65 GGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQAESLL 124
Query: 358 LEKGINGSFLVRESMRKIGSYVVSVLTGD---------HVDHVMIYCRDNKKFDIGGGRQ 510
KG +FLVRES+ + G +V+SVL V H+ + C + ++ +GG
Sbjct: 125 QAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMC-EGGRYTVGGSET 183
Query: 511 FDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQPG 690
FD+L DL++ + T + E SG V L P+ ATRVN I+ R+ +L K + G
Sbjct: 184 FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAG 243
Query: 691 FLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYIN 870
F EEF+ LQ+ R EG + N KNRY+NILPFD +RV L+ D NIPGSDYIN
Sbjct: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303
Query: 871 ANYIK 885
ANY+K
Sbjct: 304 ANYVK 308
Score = 74.7 bits (182), Expect = 3e-13
Identities = 36/102 (35%), Positives = 60/102 (58%), Gaps = 2/102 (1%)
Frame = +1
Query: 310 RWFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDNKKF 489
RWFH D++G +AE +L +G+ GSFL R S + G + +SV D V H+ I +
Sbjct: 3 RWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQ-NSGDFY 61
Query: 490 DIGGGRQFDTLKDLIDFYVTTP--MVEKSGTLVSLIHPFNAT 609
D+ GG +F TL +L+++Y + ++ GT++ L +P N +
Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCS 103
>sp|P81718|PTN6_RAT Tyrosine-protein phosphatase, non-receptor type 6 (Protein-tyrosine
phosphatase SHP-1)
Length = 613
Score = 270 bits (690), Expect = 4e-72
Identities = 147/305 (48%), Positives = 193/305 (63%), Gaps = 10/305 (3%)
Frame = +1
Query: 1 FHH-ISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH +SG D+E LL RG GSFLARPS + G F+LSVR ++VTHI+IQN+ DF DLY
Sbjct: 7 FHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLY 66
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYPLYSVDPTTERWFHGDINGKEAEKML 357
GGEKFAT ELV YY Q L++++G II LKYPL DPT+ERW+HG ++G +AE +L
Sbjct: 67 GGEKFATSTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAESLL 126
Query: 358 LEKGINGSFLVRESMRKIGSYVVSVLTGD---------HVDHVMIYCRDNKKFDIGGGRQ 510
KG +FLVRES+ + G +V+SVL V H+ + C + ++ +GG
Sbjct: 127 QAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAAPGSPLRVTHIKVMC-EGGRYTVGGSET 185
Query: 511 FDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRGPNCQPG 690
FD+L DL++ + T + E SG V L P+ ATRVN I+ R+ +L K + G
Sbjct: 186 FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAG 245
Query: 691 FLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIPGSDYIN 870
F EEF+ LQ+ R EG + N KNRY+NILPFD +RV L+ D NIPGSDYIN
Sbjct: 246 FWEEFESLQKQEAKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 305
Query: 871 ANYIK 885
ANY+K
Sbjct: 306 ANYVK 310
Score = 70.5 bits (171), Expect = 6e-12
Identities = 34/101 (33%), Positives = 58/101 (57%), Gaps = 2/101 (1%)
Frame = +1
Query: 313 WFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDNKKFD 492
WFH D++G +AE +L +G+ GSFL R S + G + +SV D V H+ I +D
Sbjct: 6 WFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQ-NSGDFYD 64
Query: 493 IGGGRQFDTLKDLIDFYVTTP--MVEKSGTLVSLIHPFNAT 609
+ GG +F T +L+++Y + ++ GT++ L +P N +
Sbjct: 65 LYGGEKFATSTELVEYYTQQQGILQDRDGTIIHLKYPLNCS 105
>sp|Q24708|CSW_DROVI Tyrosine-protein phosphatase corkscrew
Length = 764
Score = 180 bits (456), Expect = 5e-45
Identities = 100/191 (52%), Positives = 126/191 (65%)
Frame = +1
Query: 313 WFHGDINGKEAEKMLLEKGINGSFLVRESMRKIGSYVVSVLTGDHVDHVMIYCRDNKKFD 492
WFHG+++GKEAEK++LE+G NGSFLVRES K G +V+SV T D V HVMI +D KK+D
Sbjct: 1 WFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQD-KKYD 59
Query: 493 IGGGRQFDTLKDLIDFYVTTPMVEKSGTLVSLIHPFNATRVNVLCIKERMSQLEKNNGRG 672
+GGG F TL +LI+ Y PMVE GT+V L PFNATR+ I R+ QL K
Sbjct: 60 VGGGESFATLSELIEHYKRHPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKG---- 115
Query: 673 PNCQPGFLEEFDELQQDARSKNLTREEGFKLYNADKNRYRNILPFDVNRVKLKDGDPNIP 852
GF EEF+ LQQD+R +R EG+K N KNRY D RVKL+D + + P
Sbjct: 116 -----GFWEEFESLQQDSRD-TFSRHEGYKDENRLKNRYH-----DHTRVKLQDVERSAP 164
Query: 853 GSDYINANYIK 885
G++YINANYI+
Sbjct: 165 GAEYINANYIR 175
Score = 84.0 bits (206), Expect = 5e-16
Identities = 45/95 (47%), Positives = 63/95 (66%), Gaps = 1/95 (1%)
Frame = +1
Query: 1 FH-HISGVDSEKLLLERGTSGSFLARPSYSSPGSFTLSVRRGNEVTHIKIQNTDDFLDLY 177
FH ++SG ++EKL+LERG +GSFL R S S PG F LSVR ++VTH+ I+ D D+
Sbjct: 2 FHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVG 61
Query: 178 GGEKFATLPELVGYYMQDGKELKEKNGQIIELKYP 282
GGE FATL EL+ +Y + + E G ++ L+ P
Sbjct: 62 GGESFATLSELIEHYKR--HPMVETCGTVVHLRQP 94
>sp|Q05876|FYN_CHICK Proto-oncogene tyrosine-protein kinase Fyn (p59-Fyn)
Length = 534
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/165 (32%), Positives = 77/165 (46%), Gaps = 12/165 (7%)
Frame = +1
Query: 85 SSPGSFTLSVRRGNEVTHIKI-----QNTDDFLDLYGGEKFATLPELVGYYMQDGKELKE 249
SS + TL R G VT + T+D L + GEKF L G + +
Sbjct: 69 SSSHTGTLRTRGGTGVTLFEALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTG 128
Query: 250 KNGQI-IELKYPLYSVDPTTERWFHGDINGKEAEKMLLEKGI-NGSFLVRESMRKIGSYV 423
+ G I P+ S+ E W+ G + K+AE+ LL G G+FL+RES G+Y
Sbjct: 129 ETGYIPSNYVAPVDSIQ--AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYS 186
Query: 424 VSV-----LTGDHVDHVMIYCRDNKKFDIGGGRQFDTLKDLIDFY 543
+S+ + GDHV H I DN + I QF+TL+ L+ Y
Sbjct: 187 LSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
Score = 39.3 bits (90), Expect = 0.015
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 12/88 (13%)
Frame = +1
Query: 1 FHHISGVDSEKLLLERGTS-GSFLARPSYSSPGSFTLSVR-----RGNEVTHIKIQNTDD 162
F + D+E+ LL G G+FL R S ++ G+++LS+R +G+ V H KI+ D+
Sbjct: 151 FGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDN 210
Query: 163 FLDLYGG------EKFATLPELVGYYMQ 228
GG +F TL +LV +Y +
Sbjct: 211 -----GGYYITTRAQFETLQQLVQHYSE 233
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,778,995
Number of Sequences: 369166
Number of extensions: 1828920
Number of successful extensions: 5059
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4539
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4870
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8886314050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)