Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_E22
(858 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31319|KAPR_APLCA cAMP-dependent protein kinase regulato... 325 8e-89
sp|P12849|KAP1_MOUSE cAMP-dependent protein kinase type I-b... 322 1e-87
sp|Q9DBC7|KAP0_MOUSE cAMP-dependent protein kinase type I-a... 321 1e-87
sp|P00514|KAP0_BOVIN cAMP-dependent protein kinase type I-a... 321 1e-87
sp|P31321|KAP1_HUMAN cAMP-dependent protein kinase type I-b... 321 2e-87
sp|P81377|KAP1_RAT cAMP-dependent protein kinase type I-bet... 321 2e-87
sp|P07802|KAP0_PIG cAMP-dependent protein kinase type I-alp... 319 5e-87
sp|P10644|KAP0_HUMAN cAMP-dependent protein kinase type I-a... 317 2e-86
sp|P09456|KAP0_RAT cAMP-dependent protein kinase type I-alp... 314 2e-85
sp|P16905|KAPR1_DROME cAMP-dependent protein kinase type I ... 307 2e-83
>sp|P31319|KAPR_APLCA cAMP-dependent protein kinase regulatory subunit (N4 subunit of
protein kinase A)
Length = 378
Score = 325 bits (834), Expect = 8e-89
Identities = 173/285 (60%), Positives = 212/285 (74%), Gaps = 1/285 (0%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEK-QLQKDXXXXXXXXXXXXXXX 181
Y++KHNI QLLK+C+V+L ++KP SP++F+R++F LEK Q+ K+
Sbjct: 17 YVQKHNIQQLLKECIVQLVVNKPESPLAFLRDHFDRLEKEQVAKEK-------------- 62
Query: 182 HHKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVY 361
S S +E E+ M+ + A +K R+RRGAVS EVY
Sbjct: 63 ------SKSATPPSDEKEEDMSSTP------------PQMHPAMNK--RMRRGAVSAEVY 102
Query: 362 TEDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETII 541
E+DAA YVKKVVPKDYKTM+ALSKAI KNVLFSHLD+ ERSDIFDAMFP+H+ A E II
Sbjct: 103 REEDAAQYVKKVVPKDYKTMAALSKAISKNVLFSHLDDNERSDIFDAMFPVHRHAGEVII 162
Query: 542 QQGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWG 721
QQGD+GDNFY+IDQGEV++YVN+ ++ EGGSFGELALIYGTPRAATVKA TDVKLWG
Sbjct: 163 QQGDEGDNFYVIDQGEVDVYVNNVHVTSIGEGGSFGELALIYGTPRAATVKAKTDVKLWG 222
Query: 722 IDRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
IDRDSYRRILMGSTI+KRK+Y++FLS+V ILE+LDKWE+LTVADA
Sbjct: 223 IDRDSYRRILMGSTIRKRKIYEDFLSKVSILENLDKWERLTVADA 267
Score = 63.9 bits (154), Expect = 5e-10
Identities = 47/152 (30%), Positives = 75/152 (49%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + K + +LD+ ER + DA+ P+ + E I++QG
Sbjct: 224 DRDSYRRILMGSTIRKRKIYEDFLSKVSILENLDKWERLTVADALEPVQFEDKEEIVRQG 283
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ G++F+II +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 284 EPGEDFFIILEGSAAVLQRRSENEEPVEVGRLGPSDYFGEIALLLDRPRAATVVARGPLK 343
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 344 CVKLDRARFERVLGPCSDILKRNISQYNSFVS 375
>sp|P12849|KAP1_MOUSE cAMP-dependent protein kinase type I-beta regulatory subunit
Length = 381
Score = 322 bits (824), Expect = 1e-87
Identities = 165/284 (58%), Positives = 204/284 (71%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++KH I Q+LK+C+V LC++KP P+ F+RE+F+ LEK+ +
Sbjct: 21 YVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHFEKLEKEENRQI--------------- 65
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
+ S ++ + H DE S KAR RRG VS EVYT
Sbjct: 66 ------LARQKSNSQCDSH-------------DEEISPTPPNPVVKARRRRGGVSAEVYT 106
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DA SYV+KV+PKDYKTM+AL+KAI KNVLFSHLD+ ERSDIFDAMFP+ ET+IQ
Sbjct: 107 EEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIGGETVIQ 166
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QG++GDNFY+IDQGEV++YVN E N+SEGGSFGELALIYGTPRAATVKA TD+KLWGI
Sbjct: 167 QGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGI 226
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
DRDSYRRILMGST++KRK+Y+EFLS+V ILE L+KWE+LTVADA
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADA 270
Score = 66.6 bits (161), Expect = 8e-11
Identities = 48/152 (31%), Positives = 74/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + K + L++ ER + DA+ P+ + E I+ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ GD+FYII +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378
>sp|Q9DBC7|KAP0_MOUSE cAMP-dependent protein kinase type I-alpha regulatory subunit
Length = 381
Score = 321 bits (823), Expect = 1e-87
Identities = 168/284 (59%), Positives = 207/284 (72%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++KHNI LLKD +V+LC ++P P++F+REYF+ LEK+ +
Sbjct: 21 YVQKHNIQALLKDSIVQLCTTRPERPMAFLREYFERLEKEEARQIQ-------------- 66
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
C + ED ++ + VV K R RRGA+S EVYT
Sbjct: 67 ----CLQKTGIRTDSREDEISP----------PPPNPVV------KGRRRRGAISAEVYT 106
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DAASYV+KV+PKDYKTM+AL+KAIEKNVLFSHLD+ ERSDIFDAMFP+ A ET+IQ
Sbjct: 107 EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQ 166
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QGD+GDNFY+IDQGE+++YVN+E +V EGGSFGELALIYGTPRAATVKA T+VKLWGI
Sbjct: 167 QGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGI 226
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
DRDSYRRILMGST++KRK+Y+EFLS+V ILE LDKWE+LTVADA
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADA 270
Score = 63.2 bits (152), Expect = 9e-10
Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + K + LD+ ER + DA+ P+ + + I+ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ GD F+II +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 287 EPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378
>sp|P00514|KAP0_BOVIN cAMP-dependent protein kinase type I-alpha regulatory subunit
Length = 379
Score = 321 bits (823), Expect = 1e-87
Identities = 167/284 (58%), Positives = 204/284 (71%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++KHNI LLKD +V+LC ++P P++F+REYF+ LEK+ K
Sbjct: 19 YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFEKLEKEEAKQIQNLQKAG-------- 70
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
S DS + ++ K R RRGA+S EVYT
Sbjct: 71 -------SRADSREDEISPPPPNPVV-------------------KGRRRRGAISAEVYT 104
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DAASYV+KV+PKDYKTM+AL+KAIEKNVLFSHLD+ ERSDIFDAMFP+ A ET+IQ
Sbjct: 105 EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQ 164
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QGD+GDNFY+IDQGE+++YVN+E +V EGGSFGELALIYGTPRAATVKA T+VKLWGI
Sbjct: 165 QGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGI 224
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
DRDSYRRILMGST++KRK+Y+EFLS+V ILE LDKWE+LTVADA
Sbjct: 225 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADA 268
Score = 63.5 bits (153), Expect = 7e-10
Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + K + LD+ ER + DA+ P+ + + I+ QG
Sbjct: 225 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 284
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ GD F+II +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 285 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 344
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 345 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 376
>sp|P31321|KAP1_HUMAN cAMP-dependent protein kinase type I-beta regulatory subunit
Length = 381
Score = 321 bits (822), Expect = 2e-87
Identities = 164/283 (57%), Positives = 203/283 (71%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++ H I Q+LKDC+V LC+SKP P+ F+RE+F+ LEK+ +
Sbjct: 21 YVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQI--------------- 65
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
+ S ++ + H DE S KAR RRG VS EVYT
Sbjct: 66 ------LARQKSNSQSDSH-------------DEEVSPTPPNPVVKARRRRGGVSAEVYT 106
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DA SYV+KV+PKDYKTM+AL+KAI KNVLF+HLD+ ERSDIFDAMFP+ A ET+IQ
Sbjct: 107 EEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQ 166
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QG++GDNFY++DQGEV++YVN E N+SEGGSFGELALIYGTPRAATVKA TD+KLWGI
Sbjct: 167 QGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGI 226
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVAD 853
DRDSYRRILMGST++KRK+Y+EFLS+V ILE L+KWE+LTVAD
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVAD 269
Score = 64.7 bits (156), Expect = 3e-10
Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + K + L++ ER + D + P+ + E I+ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADRLEPVQFEDGEKIVVQG 286
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ GD+FYII +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378
>sp|P81377|KAP1_RAT cAMP-dependent protein kinase type I-beta regulatory subunit
Length = 381
Score = 321 bits (822), Expect = 2e-87
Identities = 165/284 (58%), Positives = 204/284 (71%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++KH I Q+LK+C+V LC++KP P+ F+RE+F+ LEK+ +
Sbjct: 21 YVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHFEKLEKEENRQI--------------- 65
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
+ S ++ + H DE S KAR RRG VS EVYT
Sbjct: 66 ------LARQKSNSQCDSH-------------DEEISPTPPNPVVKARRRRGGVSAEVYT 106
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DA SYV+KV+PKDYKTM+AL+KAI KNVLFSHLD+ ERSDIFDAMFP+ ET+IQ
Sbjct: 107 EEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIDGETVIQ 166
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QG++GDNFY+IDQGEV++YVN E N+SEGGSFGELALIYGTPRAATVKA TD+KLWGI
Sbjct: 167 QGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGI 226
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
DRDSYRRILMGST++KRK+Y+EFLS+V ILE L+KWE+LTVADA
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADA 270
Score = 66.6 bits (161), Expect = 8e-11
Identities = 48/152 (31%), Positives = 74/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + K + L++ ER + DA+ P+ + E I+ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ GD+FYII +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378
>sp|P07802|KAP0_PIG cAMP-dependent protein kinase type I-alpha regulatory subunit
Length = 380
Score = 319 bits (818), Expect = 5e-87
Identities = 167/284 (58%), Positives = 206/284 (72%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++KHNI LLKD +V+LC ++P P++F+REYF+ LEK+ K
Sbjct: 20 YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQ---------------- 63
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
+ L+ A + + + VV K R RRGA+S EVYT
Sbjct: 64 ------------IQNLQKASARADSREDEISPPPPNPVV------KGRRRRGAISAEVYT 105
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DAASYV+KV+PKDYKTM+AL+KAIEKNVLFSHLD+ ERSDIFDAMFP+ A ET+IQ
Sbjct: 106 EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQ 165
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QGD+GDNFY+IDQGE+++YVN+E +V EGGSFGELALIYGTPRAATVKA T+VKLWG
Sbjct: 166 QGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGN 225
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
DRDSYRRILMGST++KRK+Y+EFLS+V ILE LDKWE+LTVADA
Sbjct: 226 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADA 269
Score = 63.9 bits (154), Expect = 5e-10
Identities = 47/153 (30%), Positives = 74/153 (48%), Gaps = 9/153 (5%)
Frame = +2
Query: 368 DDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQ 547
+D SY + ++ + + + K + LD+ ER + DA+ P+ + + I+ Q
Sbjct: 225 NDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQ 284
Query: 548 GDDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDV 709
G+ GD F+II +G + N E G FGE+AL+ PRAATV A +
Sbjct: 285 GEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPL 344
Query: 710 KLWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
K +DR + R+L S I KR + Y F+S
Sbjct: 345 KCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 377
>sp|P10644|KAP0_HUMAN cAMP-dependent protein kinase type I-alpha regulatory subunit
(Tissue-specific extinguisher 1) (TSE1)
Length = 381
Score = 317 bits (813), Expect = 2e-86
Identities = 165/284 (58%), Positives = 202/284 (71%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++KHNI LLKD +V+LC ++P P++F+REYF+ LEK+ K
Sbjct: 21 YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAG-------- 72
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
+ DS + ++ K R RRGA+S EVYT
Sbjct: 73 -------TRTDSREDEISPPPPNPVV-------------------KGRRRRGAISAEVYT 106
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DAASYV+KV+PKDYKTM+AL+KAIEKNVLFSHLD+ ERSDIFDAMF + A ET+IQ
Sbjct: 107 EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQ 166
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QGD+GDNFY+IDQGE ++YVN+E +V EGGSFGELALIYGTPRAATVKA T+VKLWGI
Sbjct: 167 QGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGI 226
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
DRDSYRRILMGST++KRK+Y+EFLS+V ILE LDKWE+LTVADA
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADA 270
Score = 63.5 bits (153), Expect = 7e-10
Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + K + LD+ ER + DA+ P+ + + I+ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ GD F+II +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 287 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378
>sp|P09456|KAP0_RAT cAMP-dependent protein kinase type I-alpha regulatory subunit
Length = 381
Score = 314 bits (804), Expect = 2e-85
Identities = 165/284 (58%), Positives = 204/284 (71%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEKQLQKDXXXXXXXXXXXXXXXH 184
Y++KHNI LLKD +V+LC ++P P++F+REYF+ +L+K+
Sbjct: 21 YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFE----RLEKEEARQIQSLQK------ 70
Query: 185 HKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVYT 364
S DS + ++ K R RRGA+S EVYT
Sbjct: 71 -----SGIRTDSREDEISPPPPNPVV-------------------KGRRRRGAISAEVYT 106
Query: 365 EDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQ 544
E+DAASYV+KV+PKDYKTM+AL+KAIEKNVLFSHLD+ ERSDIFDAMFP+ A ET+IQ
Sbjct: 107 EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQ 166
Query: 545 QGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWGI 724
QGD+GDNFY+IDQGE+++YVN+E +V EGGSFGELALIYGTPRAATVKA T+VKLWGI
Sbjct: 167 QGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGI 226
Query: 725 DRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
DRDSYRRILMGST++KRK+Y+EFLS+V ILE LDKWE+LTVADA
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADA 270
Score = 63.2 bits (152), Expect = 9e-10
Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + K + LD+ ER + DA+ P+ + + I+ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
+ GD F+II +G + N E G FGE+AL+ PRAATV A +K
Sbjct: 287 EPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L S I KR + Y F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378
>sp|P16905|KAPR1_DROME cAMP-dependent protein kinase type I regulatory subunit (DRI class
I to class IV)
Length = 376
Score = 307 bits (787), Expect = 2e-83
Identities = 164/285 (57%), Positives = 203/285 (71%), Gaps = 1/285 (0%)
Frame = +2
Query: 5 YIKKHNIHQLLKDCVVKLCLSKPVSPVSFIREYFQNLEK-QLQKDXXXXXXXXXXXXXXX 181
YI+ H I ++LKDC+V+LC+ +P +PV F+R+YFQ LE+ Q++ D
Sbjct: 20 YIQTHGIQRVLKDCIVQLCVCRPENPVQFLRQYFQKLEREQVKLD--------------- 64
Query: 182 HHKKCCSFSHNDSLNELEDHMAGMEIIGLACNVDEYSSVVCSAKDKKARLRRGAVSGEVY 361
A ++I + ++ S + +A R RG +S E
Sbjct: 65 ---------------------ASRQVIS-PDDCEDLSPMPQTAAPPVRR--RGGISAEPV 100
Query: 362 TEDDAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETII 541
TE+DA +YVKKVVPKDYKTM+ALSKAI KNVLF+HLDE ERSDIFDAMFP++ A E II
Sbjct: 101 TEEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENII 160
Query: 542 QQGDDGDNFYIIDQGEVEIYVNDELNCNVSEGGSFGELALIYGTPRAATVKASTDVKLWG 721
QQGD+GDNFY+ID GEV+++VN EL +SEGGSFGELALIYGTPRAATV+A TDVKLWG
Sbjct: 161 QQGDEGDNFYVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWG 220
Query: 722 IDRDSYRRILMGSTIKKRKLYQEFLSRVPILEDLDKWEQLTVADA 856
IDRDSYRRILMGSTI+KRK+Y+EFLSRV ILE LDKWE+LTVAD+
Sbjct: 221 IDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADS 265
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 9/152 (5%)
Frame = +2
Query: 371 DAASYVKKVVPKDYKTMSALSKAIEKNVLFSHLDEKERSDIFDAMFPLHKKAYETIIQQG 550
D SY + ++ + + + + + LD+ ER + D++ ETI++QG
Sbjct: 222 DRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQG 281
Query: 551 DDGDNFYIIDQGEVEIYVNDELNCNVSEGGS------FGELALIYGTPRAATVKASTDVK 712
GD+FYII +G + + +E G FGE+AL+ PRAATV A +K
Sbjct: 282 AAGDDFYIILEGCAVVLQQRSEGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVARGPLK 341
Query: 713 LWGIDRDSYRRIL-MGSTIKKRKL--YQEFLS 799
+DR + R+L + I KR + Y F+S
Sbjct: 342 CVKLDRARFERVLGPCADILKRNITQYNSFVS 373
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,312,273
Number of Sequences: 369166
Number of extensions: 1663147
Number of successful extensions: 4691
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4399
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4587
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)