Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_C12
(601 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P24156|L2CC_DROME L(2)37Cc protein 220 2e-57
sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated ... 208 7e-54
sp|P35232|PHB_HUMAN Prohibitin 207 2e-53
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex prote... 204 2e-52
sp|P40961|PHB_YEAST Prohibitin 179 6e-45
sp|P50085|PHB2_YEAST Prohibitin-2 143 4e-34
sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associat... 142 5e-34
sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated... 142 5e-34
sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex prote... 134 2e-31
sp|O28852|Y1420_ARCFU Hypothetical protein AF1420 40 0.006
>sp|P24156|L2CC_DROME L(2)37Cc protein
Length = 276
Score = 220 bits (561), Expect = 2e-57
Identities = 112/185 (60%), Positives = 142/185 (76%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNITLRILY+P+ + LPKIYT LG D++ERVLPSI EVLK VVAQFDA +LITQRE+VS
Sbjct: 88 VNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAVVAQFDAGELITQREMVS 147
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
Q+V++ LT RA FG LDDISLTHLTFG EF+ ++VEKAEQ+K
Sbjct: 148 QRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEKARFVVEKAEQQK 207
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 543
LA+IISAEGD++AA LLAKSF + G+G +EL+RI+ +E+IA+ LS++R + YLP Q TL
Sbjct: 208 LASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLSRSRGVAYLPSGQSTL 267
Query: 544 INLPA 558
+NLP+
Sbjct: 268 LNLPS 272
>sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated protein 32) (BAP 32)
sp|P67779|PHB_RAT Prohibitin
Length = 272
Score = 208 bits (530), Expect = 7e-54
Identities = 107/184 (58%), Positives = 140/184 (76%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNITLRIL++PVA LP+IYT++G D++ERVLPSIT E+LK+VVA+FDA +LITQRELVS
Sbjct: 88 VNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVS 147
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
++V++ LT RA FGL LDD+SLTHLTFG EF+ ++VEKAEQ+K
Sbjct: 148 RQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQK 207
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 543
AAIISAEGDS+AA L+A S G+G IEL++++ +E+IA+ LS++RNI YLP Q L
Sbjct: 208 KAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVL 267
Query: 544 INLP 555
+ LP
Sbjct: 268 LQLP 271
>sp|P35232|PHB_HUMAN Prohibitin
Length = 272
Score = 207 bits (526), Expect = 2e-53
Identities = 106/184 (57%), Positives = 140/184 (76%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNITLRIL++PVA LP+I+T++G D++ERVLPSIT E+LK+VVA+FDA +LITQRELVS
Sbjct: 88 VNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVS 147
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
++V++ LT RA FGL LDD+SLTHLTFG EF+ ++VEKAEQ+K
Sbjct: 148 RQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQK 207
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 543
AAIISAEGDS+AA L+A S G+G IEL++++ +E+IA+ LS++RNI YLP Q L
Sbjct: 208 KAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVL 267
Query: 544 INLP 555
+ LP
Sbjct: 268 LQLP 271
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 (Prohibitin-1)
Length = 275
Score = 204 bits (518), Expect = 2e-52
Identities = 104/183 (56%), Positives = 133/183 (72%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNITLRIL++P + LP IY N+GLD+ ERVLPSIT EVLK VVAQFDA ++ITQRE+VS
Sbjct: 91 VNITLRILHRPSPDRLPNIYLNIGLDYAERVLPSITNEVLKAVVAQFDAHEMITQREVVS 150
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
Q+ + L RA FGL LDDI++THL FG EF+ YLVEKAEQ K
Sbjct: 151 QRASVALRERAAQFGLLLDDIAITHLNFGREFTEAVEMKQVAQQEAEKARYLVEKAEQMK 210
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 543
+AA+ +AEGD+QAA LLAK+F G+G +EL++I+ +EEIA ++KN+N+ YLP Q TL
Sbjct: 211 IAAVTTAEGDAQAAKLLAKAFASAGDGLVELRKIEAAEEIAERMAKNKNVTYLPGNQQTL 270
Query: 544 INL 552
+NL
Sbjct: 271 LNL 273
>sp|P40961|PHB_YEAST Prohibitin
Length = 287
Score = 179 bits (453), Expect = 6e-45
Identities = 84/176 (47%), Positives = 131/176 (74%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
V++TLR+L++P LP IY NLGLD++ERVLPSI EVLK++VAQFDA++LITQRE++S
Sbjct: 90 VSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSIVAQFDAAELITQREIIS 149
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
QK+ + L+TRA+ FG+ L+D+S+TH+TFG EF+ +LVEKAEQE+
Sbjct: 150 QKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAERAKFLVEKAEQER 209
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDK 531
A++I AEG++++A ++K+ + G+G + ++R++ S++IA L+ + N+VYLP +
Sbjct: 210 QASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSSNVVYLPSQ 265
>sp|P50085|PHB2_YEAST Prohibitin-2
Length = 315
Score = 143 bits (360), Expect = 4e-34
Identities = 77/182 (42%), Positives = 115/182 (63%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNIT R+L +P LP IY LG D++ERVLPSI EVLK VVAQF+AS LITQRE VS
Sbjct: 119 VNITCRVLSRPDVVQLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFNASQLITQREKVS 178
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
+ + E L RA F + LDD+S+T++TF EF+ ++V+KA QEK
Sbjct: 179 RLIRENLVRRASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQRAAFVVDKARQEK 238
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 543
++ A+G++++A L+ ++ + ++EL+R+ T+ +IA +L+ + N V L D + L
Sbjct: 239 QGMVVRAQGEAKSAELIGEAIKK-SRDYVELKRLDTARDIAKILASSPNRVIL-DNEALL 296
Query: 544 IN 549
+N
Sbjct: 297 LN 298
>sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity)
sp|Q99623|PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity) (D-prohibitin)
Length = 299
Score = 142 bits (359), Expect = 5e-34
Identities = 75/173 (43%), Positives = 117/173 (67%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNI+LR+L +P A+ LP +Y LGLD+EERVLPSI EVLK+VVA+F+AS LITQR VS
Sbjct: 102 VNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVS 161
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
+ LT RA +F L LDD+++T L+F E++ +LVEKA+QE+
Sbjct: 162 LLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQ 221
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYL 522
I+ AEG+++AA +L ++ ++ G+I+L++I+ ++ I+ ++ ++N +YL
Sbjct: 222 RQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37)
Length = 299
Score = 142 bits (359), Expect = 5e-34
Identities = 75/173 (43%), Positives = 117/173 (67%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNI+LR+L +P A+ LP +Y LGLD+EERVLPSI EVLK+VVA+F+AS LITQR VS
Sbjct: 102 VNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVS 161
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
+ LT RA +F L LDD+++T L+F E++ +LVEKA+QE+
Sbjct: 162 LLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQ 221
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYL 522
I+ AEG+++AA +L ++ ++ G+I+L++I+ ++ I+ ++ ++N +YL
Sbjct: 222 RQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273
>sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 (Prohibitin-2)
Length = 286
Score = 134 bits (336), Expect = 2e-31
Identities = 77/183 (42%), Positives = 116/183 (63%)
Frame = +1
Query: 4 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 183
VNI LR+L +P E L IY LG ++EERVLPSI EVLK VVA+F+AS LITQR+ VS
Sbjct: 93 VNIGLRVLSRPNPEHLVHIYRTLGQNWEERVLPSICNEVLKGVVAKFNASQLITQRQQVS 152
Query: 184 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 363
V + L RA +F + LDD+SLT L F ++S + VE+A+Q+K
Sbjct: 153 MLVRKTLIERALDFNIILDDVSLTELAFSPQYSAAVEAKQVAAQEAQRATFYVERAKQQK 212
Query: 364 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 543
I+ AEG++++A LL ++ GF++L++I+ +++IA ++S++ N YLP G +
Sbjct: 213 QEKIVQAEGEAESAKLLGEAMKN-DPGFLKLRKIRAAQKIARIVSESGNKTYLP-TGGLM 270
Query: 544 INL 552
+N+
Sbjct: 271 LNI 273
>sp|O28852|Y1420_ARCFU Hypothetical protein AF1420
Length = 249
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/124 (20%), Positives = 63/124 (50%), Gaps = 2/124 (1%)
Frame = +1
Query: 121 LKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXX 300
L++++ Q + +++++R+ ++ K+ +++ + +G+ + + + + E
Sbjct: 115 LRSIIGQAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKDVELPEEMRRIMA-- 172
Query: 301 XXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQC--GEGFIELQRIQTS 474
+ +AE+E+ + II AEG+ QAA+ L ++ + EG I L+ +QT
Sbjct: 173 ------------MQAEAERERRSKIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTL 220
Query: 475 EEIA 486
EI+
Sbjct: 221 NEIS 224
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,100,279
Number of Sequences: 369166
Number of extensions: 1069821
Number of successful extensions: 2582
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2546
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2568
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4602033670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)