Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_B09
(900 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q94887|NRX4_DROME Neurexin-4 precursor (Neurexin IV) 173 5e-43
sp|Q99P47|CNTP4_MOUSE Contactin-associated protein-like 4 p... 122 1e-27
sp|Q9C0A0|CNTP4_HUMAN Contactin-associated protein-like 4 p... 117 6e-26
sp|Q9BZ76|CNTP3_HUMAN Contactin-associated protein-like 3 p... 112 1e-24
sp|Q5RD64|CNTP2_PONPY Contactin-associated protein-like 2 p... 106 1e-22
sp|Q9UHC6|CNTP2_HUMAN Contactin-associated protein-like 2 p... 103 7e-22
sp|Q9CPW0|CNTP2_MOUSE Contactin-associated protein-like 2 p... 103 7e-22
sp|P97846|CNTP1_RAT Contactin-associated protein 1 precurso... 93 1e-18
sp|P78357|CNTP1_HUMAN Contactin-associated protein 1 precur... 92 2e-18
sp|O54991|CNTP1_MOUSE Contactin-associated protein 1 precur... 90 1e-17
>sp|Q94887|NRX4_DROME Neurexin-4 precursor (Neurexin IV)
Length = 1284
Score = 173 bits (439), Expect = 5e-43
Identities = 100/286 (34%), Positives = 149/286 (52%), Gaps = 2/286 (0%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTL 180
N +TF DA INLPP + D+ F+TT N+VI + + + ++ + G L
Sbjct: 796 NVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTD--YIKLSLNGGNKL 853
Query: 181 RVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTT 357
+ + DN WH V ERNRKE+RL++D + E P P
Sbjct: 854 QFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPG-PVRA 912
Query: 358 FNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKS-AITDYYGISNGCNPKCNSKPCL 534
+ SDL++G++ + DGYVGC L++NG + DLK + YGIS GC +C S PCL
Sbjct: 913 LHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCL 972
Query: 535 NRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKLDYFDQKISTLEEYIEI 714
N G C E Y GY C+C + ++G +C E+G + S I+ ++ ST+ E I +
Sbjct: 973 NNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSI--IRYEFEGSFRSTIAENIRV 1030
Query: 715 GFKTKDKQGTLLQVSSYDYKKYIIIKVNNNGGITIEFDVGFTRYEV 852
GF T +G LL SS +Y+ I+++N+G + FD GF R E+
Sbjct: 1031 GFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEI 1076
Score = 47.0 bits (110), Expect = 7e-05
Identities = 51/217 (23%), Positives = 83/217 (38%), Gaps = 15/217 (6%)
Frame = +1
Query: 7 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 186
+TFT + + L ++ F F+T V+L +G + +V + G
Sbjct: 377 VTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHH-DFYSGGYLKVFLEFGKVKID 435
Query: 187 TFXXXXXXXXXXXXXXXXXDNFWH--VVRFERNRKESRLILDENAPVTHSEDPDRPFTTF 360
D WH V+ E+NR LIL+ + RP TT
Sbjct: 436 LKVKDKARIILDNYDDQFNDGKWHSFVISIEKNR----LILNID---------QRPMTTT 482
Query: 361 NFDSDLLLGSSQSFT-----DGYVGCFSNLIVNG---VVQDLKSAITDYYG---ISNGCN 507
+ G+ +G+VGC + V+G + QD G + + C
Sbjct: 483 K-SMQVATGAQYYIAGGKDKNGFVGCMRLISVDGNYKLPQDWVKGEEVCCGDDVVVDACQ 541
Query: 508 --PKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVC 612
+CN PC ++G C++ ++C+CG T Y G VC
Sbjct: 542 MIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVC 578
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/123 (25%), Positives = 50/123 (40%), Gaps = 6/123 (4%)
Frame = +1
Query: 85 FKTTVANAVILQSVSKLNGQFFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXXDNFWHVV 264
F TT+ +L S L G++ ++I LR F +H +
Sbjct: 1032 FTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDM 1091
Query: 265 RFERNRKESRLIL--DENAPVTHSED----PDRPFTTFNFDSDLLLGSSQSFTDGYVGCF 426
F R S ++L D PV ++ D D F + + +G ++S TDG+VGC
Sbjct: 1092 HFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQY---MYIGKNESMTDGFVGCV 1148
Query: 427 SNL 435
S +
Sbjct: 1149 SRV 1151
Score = 34.7 bits (78), Expect = 0.37
Identities = 29/128 (22%), Positives = 50/128 (39%), Gaps = 6/128 (4%)
Frame = +1
Query: 79 FLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXXDNFWH 258
F FKT AN V++ S G ++ +++++ + + DN WH
Sbjct: 218 FRFKTAFANGVMMYSRGT-QGDYYALQLKDN-KMVLNLDLGSRVMTSLSVGSLLDDNVWH 275
Query: 259 VVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSFTDGYV------G 420
V RN+++ +D V FT N + +L LG + +G + G
Sbjct: 276 DVVISRNQRDIIFSVDR---VIVRGRIQGEFTRLNLNRELYLGGVPNVQEGLIVQQNFSG 332
Query: 421 CFSNLIVN 444
C N+ N
Sbjct: 333 CLENIYFN 340
>sp|Q99P47|CNTP4_MOUSE Contactin-associated protein-like 4 precursor (Cell recognition
molecule Caspr4)
Length = 1310
Score = 122 bits (306), Expect = 1e-27
Identities = 83/294 (28%), Positives = 133/294 (45%), Gaps = 19/294 (6%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTL 180
N +F + ++ P E D+ F FKTT + V L+++ + F + +R T+
Sbjct: 795 NAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITD--FIRIELRSPTTV 852
Query: 181 RVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTT 357
+F DN WH VR ERN KE+ L +DE P + D
Sbjct: 853 TFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKIQAAPTDG-HVL 911
Query: 358 FNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPKCNS--KPC 531
+S L +G + + G++GC +L +NG+ DL+ T G+ GC C S K C
Sbjct: 912 LQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLC 971
Query: 532 LNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKLD-------------- 669
+ G+C E SG++C+C + + G C +E+ A F GS++
Sbjct: 972 RHGGKCREKPSGFFCDCSSSAFAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAA 1031
Query: 670 --YFDQKISTLEEYIEIGFKTKDKQGTLLQVSSYDYKKYIIIKVNNNGGITIEF 825
+ D K+S E I+ F+T LL +SS+ YK+Y+ I + NG + I +
Sbjct: 1032 SFHGDMKLS--REMIKFSFRTTRAPSLLLHMSSF-YKEYLSIIIAKNGSLQIRY 1082
Score = 48.1 bits (113), Expect = 3e-05
Identities = 50/219 (22%), Positives = 88/219 (40%), Gaps = 13/219 (5%)
Frame = +1
Query: 7 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 186
+TF + + LP E F F+T ++L S +L + + +G L++
Sbjct: 374 LTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDG-KLKL 432
Query: 187 TFXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILDEN-APVTHSEDPDRPFT--T 357
T D WH V R +++D + +P + P++ +
Sbjct: 433 TLYQPGKSPSDITAGAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGV 492
Query: 358 FNFDS--DLLLGSS-QSFTDGYVGCFSNLIVNGVVQDL----KSAITDYYGI---SNGCN 507
F F D GS +S G+ GC + +N + DL + A+ ++ + S G +
Sbjct: 493 FYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSCGIS 552
Query: 508 PKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 624
+C C + GEC + +S ++C C T Y G C V
Sbjct: 553 DRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSV 591
>sp|Q9C0A0|CNTP4_HUMAN Contactin-associated protein-like 4 precursor (Cell recognition
molecule Caspr4)
Length = 1308
Score = 117 bits (292), Expect = 6e-26
Identities = 81/294 (27%), Positives = 131/294 (44%), Gaps = 19/294 (6%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTL 180
N+ +F + ++ P E D+ F FKTT ++ V L+++ + F + +R +
Sbjct: 793 NSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIAD--FIRIELRSPTVV 850
Query: 181 RVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTT 357
+F DN WH VR ERN KE+ L +D+ P T D
Sbjct: 851 TFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADG-HVL 909
Query: 358 FNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPKCNS--KPC 531
+S L +G + + G++GC +L +NG+ DL+ + GC C+S K C
Sbjct: 910 LQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLC 969
Query: 532 LNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKLD-------------- 669
N G+C E G++C+C + Y G C E+ A F GS++
Sbjct: 970 RNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAA 1029
Query: 670 --YFDQKISTLEEYIEIGFKTKDKQGTLLQVSSYDYKKYIIIKVNNNGGITIEF 825
+ D K+S E I+ F+T LL VSS+ YK+Y+ + + NG + I +
Sbjct: 1030 SFHGDMKLS--REMIKFSFRTTRTPSLLLFVSSF-YKEYLSVIIAKNGSLQIRY 1080
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/219 (23%), Positives = 85/219 (38%), Gaps = 13/219 (5%)
Frame = +1
Query: 7 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 186
+TF + + LP E E F F+T ++L S +L + + +G L+
Sbjct: 372 VTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDG-KLKS 430
Query: 187 TFXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILD-ENAPVTHSEDPDRPFT--T 357
D WH V + + +D + A P++ ++ T
Sbjct: 431 NLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGT 490
Query: 358 FNFDS--DLLLGSS-QSFTDGYVGCFSNLIVNGVVQDLKSA-------ITDYYGISNGCN 507
+ F D GS +S G+ GC + ++G V DL S +D S G +
Sbjct: 491 YYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGIS 550
Query: 508 PKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 624
+C C + GEC + +S ++C C T YRG C +
Sbjct: 551 DRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSI 589
Score = 32.0 bits (71), Expect = 2.4
Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 7/76 (9%)
Frame = +1
Query: 244 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLL------GSSQSFT 405
D WH V +R K+ +DE+ H+ F N D ++ G S SF
Sbjct: 269 DQHWHSVLIQRLGKQVNFTVDEHRHHFHARG---EFNLMNLDYEISFGGIPAPGKSVSFP 325
Query: 406 D-GYVGCFSNLIVNGV 450
+ GC NL NGV
Sbjct: 326 HRNFHGCLENLYYNGV 341
>sp|Q9BZ76|CNTP3_HUMAN Contactin-associated protein-like 3 precursor (Cell recognition
molecule Caspr3)
Length = 1288
Score = 112 bits (281), Expect = 1e-24
Identities = 77/292 (26%), Positives = 128/292 (43%), Gaps = 17/292 (5%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTL 180
N+ +F + ++ P E D+ F FKTTV++ V ++++ + F + +R +
Sbjct: 793 NSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITD--FIRIELRAPTEV 850
Query: 181 RVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTT 357
+F DN WH VR ERN K + L +D+ P P
Sbjct: 851 TFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQ-LPQKMQPAPADGHVR 909
Query: 358 FNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPKCNSKP--C 531
+S L +G + + G++GC +L +NGV DL+ T G+ GC C++ C
Sbjct: 910 LQLNSQLFIGGTATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLC 969
Query: 532 LNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIK--------------LD 669
N G C E G C+C + Y G C E+ A F GS++ +
Sbjct: 970 RNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVS 1029
Query: 670 YFDQKISTLEEYIEIGFKTKDKQGTLLQVSSYDYKKYIIIKVNNNGGITIEF 825
+ ++ E I + F+T LL VSS+ Y++Y+ + + NNG + I +
Sbjct: 1030 SLHRDVTLTREMITLSFRTTRTPSLLLYVSSF-YEEYLSVILANNGSLQIRY 1080
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/220 (20%), Positives = 78/220 (35%), Gaps = 18/220 (8%)
Frame = +1
Query: 7 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 186
+TF + + LP E++ + F F+T +L + F + +++G L++
Sbjct: 372 VTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDG-KLKL 430
Query: 187 TFXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNF 366
+ D WH V F +++D++ V +P
Sbjct: 431 SLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAV-------QPLVAVLI 483
Query: 367 DS----------DLLLGSS-QSFTDGYVGCFSNLIVNG-------VVQDLKSAITDYYGI 492
DS D GS +S G+ GC + + V Q + D
Sbjct: 484 DSGDTYYFGGCLDNSSGSGCKSPLGGFQGCLRLITIGDKAVDPILVQQGALGSFRDLQID 543
Query: 493 SNGCNPKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVC 612
S G +C C + GEC + + + C+C T Y G C
Sbjct: 544 SCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETC 583
>sp|Q5RD64|CNTP2_PONPY Contactin-associated protein-like 2 precursor
Length = 1331
Score = 106 bits (264), Expect = 1e-22
Identities = 84/323 (26%), Positives = 137/323 (42%), Gaps = 23/323 (7%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTL 180
N +F + ++ E D+ F FKT V L+++ K + F ++ ++ +
Sbjct: 799 NAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKED--FIKLELKSATEV 856
Query: 181 RVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTT 357
+F D+ WH + ERN K++ L +D P + P T
Sbjct: 857 SFSFDVGNGPVEIVVRSPTPLNDDQWHRITAERNVKQASLQVDR-LPQQIRKAPTEGHTR 915
Query: 358 FNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPKCNS--KPC 531
S L +G + G++GC +L +NGV DL+ G +GC+ C S C
Sbjct: 916 LELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNC 974
Query: 532 LNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDG------------------SALE 657
N G+C E Y GY C+C T Y G C ++VGA F +G S +E
Sbjct: 975 ENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVE 1034
Query: 658 IKLDYFDQKISTLEEYIEIGFKTKDKQGTLLQVSSYDYKKYIIIKVNNNGGITIEFDVGF 837
D + +E I F T LL +SS+ ++ + V G + I +++G
Sbjct: 1035 NAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFT-TDFLAVLVKPTGSLQIRYNLGG 1093
Query: 838 TR--YEVTTDYIVDLCNDQHHTL 900
TR Y + TD+ ++ N Q H++
Sbjct: 1094 TREPYNIDTDH-RNMANGQPHSV 1115
Score = 30.4 bits (67), Expect = 7.0
Identities = 38/218 (17%), Positives = 71/218 (32%), Gaps = 14/218 (6%)
Frame = +1
Query: 13 FTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFT-LRVT 189
F + + +P ++ F + F F+T N +++ S N E+ + E + +
Sbjct: 377 FFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHIN 436
Query: 190 FXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILD-ENAPVTHSEDP-----DRPF 351
D WH VRF + L +D + A + P +
Sbjct: 437 ITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKY 496
Query: 352 TTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCN-------P 510
F + + S + GC + V+ + +L G +
Sbjct: 497 FFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIID 556
Query: 511 KCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 624
+C C G+C + + + C C T Y G C +
Sbjct: 557 RCVPNHCERGGKCSQTWDSFKCTCDETGYTGATCHNSI 594
>sp|Q9UHC6|CNTP2_HUMAN Contactin-associated protein-like 2 precursor (Cell recognition
molecule Caspr2)
Length = 1331
Score = 103 bits (257), Expect = 7e-22
Identities = 83/323 (25%), Positives = 136/323 (42%), Gaps = 23/323 (7%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTL 180
N +F + ++ E D+ F FKT V L+++ K + F ++ ++ +
Sbjct: 799 NAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKED--FIKLELKSATEV 856
Query: 181 RVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTT 357
+F D+ WH V ERN K++ L +D P + P T
Sbjct: 857 SFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDR-LPQQIRKAPTEGHTR 915
Query: 358 FNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPKCNS--KPC 531
S L +G + G++GC +L +NGV DL+ G +GC+ C S C
Sbjct: 916 LELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNC 974
Query: 532 LNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDG------------------SALE 657
N G+C E Y GY C+C T Y G C ++VGA F +G S ++
Sbjct: 975 ENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVD 1034
Query: 658 IKLDYFDQKISTLEEYIEIGFKTKDKQGTLLQVSSYDYKKYIIIKVNNNGGITIEFDVGF 837
D + +E I F T LL +SS+ ++ + V G + I +++G
Sbjct: 1035 NAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFT-TDFLAVLVKPTGSLQIRYNLGG 1093
Query: 838 TR--YEVTTDYIVDLCNDQHHTL 900
TR Y + D+ ++ N Q H++
Sbjct: 1094 TREPYNIDVDH-RNMANGQPHSV 1115
Score = 30.8 bits (68), Expect = 5.4
Identities = 38/218 (17%), Positives = 72/218 (33%), Gaps = 14/218 (6%)
Frame = +1
Query: 13 FTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFT-LRVT 189
F + + +P ++ F + F F+T N +++ S N E+ + E + +
Sbjct: 377 FFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHIN 436
Query: 190 FXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILD-ENAPVTHSEDP-----DRPF 351
D WH VRF + L +D + A + P +
Sbjct: 437 ITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKY 496
Query: 352 TTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCN-------P 510
F + + S + GC + V+ + +L G +
Sbjct: 497 FFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIID 556
Query: 511 KCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 624
+C C + G+C + + + C C T Y G C +
Sbjct: 557 RCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSI 594
>sp|Q9CPW0|CNTP2_MOUSE Contactin-associated protein-like 2 precursor (Cell recognition
molecule Caspr2)
Length = 1332
Score = 103 bits (257), Expect = 7e-22
Identities = 85/324 (26%), Positives = 134/324 (41%), Gaps = 24/324 (7%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTL 180
N +F + ++ E D+ F FKT + V L+++ N F ++ ++ +
Sbjct: 799 NAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLG--NTDFIKLELKSATEV 856
Query: 181 RVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTT 357
+F D+ WH V ERN K++ L +D P + P T
Sbjct: 857 SFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDR-LPQQIRKAPTEGHTR 915
Query: 358 FNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPKCNS--KPC 531
S L +G + G++GC +L +NGV DL+ G +GC+ C S C
Sbjct: 916 LELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSGCSGHCTSYGANC 974
Query: 532 LNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFID------------------GSALE 657
N G+C E Y GY C+C T Y G C ++VGA F + GS E
Sbjct: 975 ENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAE 1034
Query: 658 IKLDYFDQKISTL-EEYIEIGFKTKDKQGTLLQVSSYDYKKYIIIKVNNNGGITIEFDVG 834
D L +E I F T LL VSS ++ + V G + I +++G
Sbjct: 1035 NSADQQQHLAPDLAQEQIHFSFSTTKAPCILLYVSSLT-TDFLAVLVKPTGNLQIRYNLG 1093
Query: 835 FTR--YEVTTDYIVDLCNDQHHTL 900
TR + + D+ ++ N Q H++
Sbjct: 1094 GTREPFNIDVDH-RNMANGQPHSV 1116
Score = 30.8 bits (68), Expect = 5.4
Identities = 29/144 (20%), Positives = 50/144 (34%), Gaps = 17/144 (11%)
Frame = +1
Query: 244 DNFWHVVRFERNRKESRLILD-ENAPVTHSEDP-----DRPFTTFNFDSDLLLGSSQSFT 405
D WH VRF + L +D + A + P + F + + S +
Sbjct: 455 DGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQ 514
Query: 406 DGYVGCFSNLIVNGVVQDL-----------KSAITDYYGISNGCNPKCNSKPCLNRGECY 552
+ GC + V+ + +L + D I + C P C + G+C
Sbjct: 515 PSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVTIDMCAIIDRCVPN----HCEHGGKCS 570
Query: 553 EMYSGYYCECGLTPYRGYVCGREV 624
+ + + C C T Y G C +
Sbjct: 571 QTWDSFKCTCDETGYSGATCHNSI 594
>sp|P97846|CNTP1_RAT Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin
4) (Neurexin IV) (p190) (Paranodin)
Length = 1381
Score = 92.8 bits (229), Expect = 1e-18
Identities = 65/233 (27%), Positives = 103/233 (44%), Gaps = 11/233 (4%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFE-----VRIR 165
NTI+F + A + PP+ A + D+ F F+T+ + V L++ + G F + VR+
Sbjct: 787 NTISF-RTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN---MGGPFCQWRRPYVRVE 842
Query: 166 EGFTLRVTFXXXXXXXXXXXXXXXXX----DNFWHVVRFERNRKESRLILDENAPVTHSE 333
+ V F D+ WH+VR E N K++RL +D P
Sbjct: 843 LNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHR-PWVLRP 901
Query: 334 DPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPK 513
P + + +D L +GS++ +VGC + +NGV +L+ G C
Sbjct: 902 MPLQTYIWLEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTFPNCTGH 961
Query: 514 CNSK--PCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKL 666
C PC + G C E YS Y C+C LT + G C ++G F G+ + L
Sbjct: 962 CTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNL 1014
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 26/149 (17%)
Frame = +1
Query: 244 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSF------- 402
D FWH V F + EN V +D + ++ + G+S F
Sbjct: 442 DGFWHEVNF---------VAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPA 492
Query: 403 --------TDGYVGCFSNLIVNGVVQDLK-----------SAITDYYGISNGCNPKCNSK 525
+ GC L V+G + +L + D GI++ C+P
Sbjct: 493 SRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNM--- 549
Query: 526 PCLNRGECYEMYSGYYCECGLTPYRGYVC 612
C + G CY+ + + C C LT Y+G C
Sbjct: 550 -CEHDGRCYQSWDDFICYCELTGYKGVTC 577
>sp|P78357|CNTP1_HUMAN Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin
4) (Neurexin IV) (p190)
Length = 1384
Score = 92.4 bits (228), Expect = 2e-18
Identities = 65/230 (28%), Positives = 102/230 (44%), Gaps = 8/230 (3%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFE--VRIREGF 174
NTI+F A + PP+ A + D+ F F+T+ + V L+++ Q+ VR+
Sbjct: 786 NTISFHT-GAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNT 844
Query: 175 TLRVTFXXXXXXXXXXXXXXXXX----DNFWHVVRFERNRKESRLILDENAPVTHSEDPD 342
+ V F D+ WH+VR E N K++RL +D P P
Sbjct: 845 SRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHR-PWVLRPMPL 903
Query: 343 RPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPKCNS 522
+ + +D L +GS++ +VGC + +NGV +L+ G S C C
Sbjct: 904 QTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAH 963
Query: 523 K--PCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKL 666
PC + G C E YS Y C+C LT + G C ++G F G+ + L
Sbjct: 964 PRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNL 1013
Score = 43.5 bits (101), Expect = 8e-04
Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 26/149 (17%)
Frame = +1
Query: 244 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSF------- 402
D FWH V F + EN V +D + ++ + G+S F
Sbjct: 441 DGFWHEVNF---------VAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPA 491
Query: 403 --------TDGYVGCFSNLIVNGVVQDLK-----------SAITDYYGISNGCNPKCNSK 525
+ GC L V+G + +L + D GI++ C+P
Sbjct: 492 SRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNM--- 548
Query: 526 PCLNRGECYEMYSGYYCECGLTPYRGYVC 612
C + G CY+ + + C C LT Y+G C
Sbjct: 549 -CEHDGRCYQSWDDFICYCELTGYKGETC 576
>sp|O54991|CNTP1_MOUSE Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin
4) (Neurexin IV) (Paranodin) (NCP1) (MHDNIV)
Length = 1385
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/233 (27%), Positives = 101/233 (43%), Gaps = 11/233 (4%)
Frame = +1
Query: 1 NTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFE-----VRIR 165
NTI+F A + PP+ A + D+ F F+T+ + V L++ + G F VR+
Sbjct: 787 NTISFHT-GAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN---MGGPFCRWRRPYVRVE 842
Query: 166 EGFTLRVTFXXXXXXXXXXXXXXXXX----DNFWHVVRFERNRKESRLILDENAPVTHSE 333
+ V F D+ WH+VR E N K++RL +D P
Sbjct: 843 LNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHR-PWVLRP 901
Query: 334 DPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCNPK 513
P + + +D L +GS++ +VGC + +NGV +L+ G C
Sbjct: 902 MPLQTYIWLVYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTFPNCTGH 961
Query: 514 CNSK--PCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKL 666
C PC + G C E YS Y C+C LT + G C ++G F G+ + L
Sbjct: 962 CTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNL 1014
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 26/149 (17%)
Frame = +1
Query: 244 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSF------- 402
D FWH V F + EN V +D + ++ + G+S F
Sbjct: 442 DGFWHEVNF---------VAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPA 492
Query: 403 --------TDGYVGCFSNLIVNGVVQDLK-----------SAITDYYGISNGCNPKCNSK 525
+ GC L V+G + +L + D GI++ C+P
Sbjct: 493 SRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNM--- 549
Query: 526 PCLNRGECYEMYSGYYCECGLTPYRGYVC 612
C + G CY+ + + C C LT Y+G C
Sbjct: 550 -CEHDGRCYQSWDDFICYCELTGYKGVTC 577
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,260,885
Number of Sequences: 369166
Number of extensions: 1877092
Number of successful extensions: 6101
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4834
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6002
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9078450570
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)