Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_A05
(797 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydra... 143 5e-34
sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 138 2e-32
sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydra... 137 3e-32
sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydra... 137 3e-32
sp|P28651|CAH8_MOUSE Carbonic anhydrase-related protein (CA... 135 1e-31
sp|P27139|CAH2_RAT Carbonic anhydrase II (Carbonate dehydra... 135 1e-31
sp|P35219|CAH8_HUMAN Carbonic anhydrase-related protein (CA... 135 2e-31
sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydr... 133 6e-31
sp|P35217|CAH1_MACNE Carbonic anhydrase 1 (Carbonic anhydra... 132 1e-30
sp|P00915|CAH1_HUMAN Carbonic anhydrase 1 (Carbonic anhydra... 131 2e-30
>sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 143 bits (361), Expect = 5e-34
Identities = 82/204 (40%), Positives = 117/204 (57%), Gaps = 4/204 (1%)
Frame = +3
Query: 3 GHSFKVEVGLDSMSVTGVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLV 182
GHSF+V D+ S ++L QFHFHWG ++ G+GSEH ++GK +P ELHLV
Sbjct: 63 GHSFQVTFADDNDSSMLTEGPISGKYRLKQFHFHWGASD-GKGSEHTVDGKCYPAELHLV 121
Query: 183 HYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVRENPTINLHEKNAY 362
H+N TKY+S EA N+ DGL V+GV +QI N Q + + +++ + +
Sbjct: 122 HWN-TKYASFGEAANKPDGLAVVGVFLQIGEDNPKLQKILDAMDAIKSKGK----QTSFT 176
Query: 363 XXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNV----HCDD 530
+ Y+TY GSLTTPP ESV WIV + PI++S EQ+ +F+++ +
Sbjct: 177 NFDPTCLLPKSLEYWTYPGSLTTPPLYESVTWIVCKQPISVSSEQMKKFRSLLFTAEEEK 236
Query: 531 GCETHSNYRPVCPVNDRKVKRSFK 602
C +NYRP P+ DRKV SFK
Sbjct: 237 ACCMVNNYRPPQPLKDRKVCASFK 260
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase)
Length = 260
Score = 138 bits (348), Expect = 2e-32
Identities = 83/208 (39%), Positives = 115/208 (55%), Gaps = 8/208 (3%)
Frame = +3
Query: 3 GHSFKVEVGLDSMSVTGVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLV 182
GHSF+V+ D S T +++L QFHFHWG++++ +GSEH I G +PCELHLV
Sbjct: 63 GHSFQVDFVDDDNSSTLAGGPITGIYRLRQFHFHWGSSDD-KGSEHTIAGTKFPCELHLV 121
Query: 183 HYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSV----RENPTINLHE 350
H+N TKY + EA ++ DGL V+GV ++I N Q + L + R+ N
Sbjct: 122 HWN-TKYPNFGEAASKPDGLAVVGVFLKIGAANPRLQKVLDALDDIKSKGRQTTFANFDP 180
Query: 351 KNAYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCDD 530
K Y+TY GSLTTPP ESV WIV + PI++S Q+ +F+++
Sbjct: 181 KTLLPASLD--------YWTYEGSLTTPPLLESVTWIVLKEPISVSPAQMAKFRSLLFSS 232
Query: 531 GCETH----SNYRPVCPVNDRKVKRSFK 602
ET NYRP P+ RKV+ SFK
Sbjct: 233 EGETPCCMVDNYRPPQPLKGRKVRASFK 260
>sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 137 bits (346), Expect = 3e-32
Identities = 82/206 (39%), Positives = 116/206 (56%), Gaps = 6/206 (2%)
Frame = +3
Query: 3 GHSFKVEV--GLDSMSVTGVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELH 176
GHSF VE D+ + G P D ++L+QFHFHWG+++ G+GSEH +N K + ELH
Sbjct: 63 GHSFNVEFDDSQDNAVLKGGP--LSDSYRLIQFHFHWGSSD-GQGSEHTVNKKKYAAELH 119
Query: 177 LVHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVRENPTINLHEKN 356
LVH+N TKY +AV + DGL VLG ++I + Q ++ L S++ T
Sbjct: 120 LVHWN-TKYGDFGKAVQQPDGLAVLGYFLKIGPASQGLQKVLEALHSIK---TKGKRAAF 175
Query: 357 AYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCDDGC 536
A D Y+TY GSLTTPP E V WIV PIT+S EQ+ F+ ++ ++
Sbjct: 176 ANFDPCSLLPGNLD-YWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEEG 234
Query: 537 ETH----SNYRPVCPVNDRKVKRSFK 602
+ N+RP P+ +RK+K SFK
Sbjct: 235 DAEEAMVDNWRPAQPLKNRKIKASFK 260
>sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 259
Score = 137 bits (346), Expect = 3e-32
Identities = 81/205 (39%), Positives = 118/205 (57%), Gaps = 6/205 (2%)
Frame = +3
Query: 3 GHSFKVEVGLDSMSVTGVPEHKGD-VFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHL 179
GHSF VE DS T + E + ++L+QFHFHWG+++ G+GSEH +N K + ELHL
Sbjct: 62 GHSFNVEFD-DSHDKTVLKEGPLEGTYRLIQFHFHWGSSD-GQGSEHTVNKKKYAAELHL 119
Query: 180 VHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVR-ENPTINLHEKN 356
VH+N TKY +AV DGL VLG+ ++I Q + L S++ + +++ + +
Sbjct: 120 VHWN-TKYGDFGKAVKHPDGLAVLGIFLKIGSATPGLQKVVDTLSSIKTKGKSVDFTDFD 178
Query: 357 AYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCDDGC 536
Y+TY GSLTTPP E V WIV + PIT+S EQ+L+F+N++ +
Sbjct: 179 PRGLLPESLD-----YWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMLKFRNLNFNKEA 233
Query: 537 ETH----SNYRPVCPVNDRKVKRSF 599
E N+RP P+ R+VK SF
Sbjct: 234 EPEEPMVDNWRPTQPLKGRQVKASF 258
>sp|P28651|CAH8_MOUSE Carbonic anhydrase-related protein (CARP) (CA-VIII)
Length = 291
Score = 135 bits (341), Expect = 1e-31
Identities = 76/213 (35%), Positives = 122/213 (57%), Gaps = 13/213 (6%)
Frame = +3
Query: 3 GHSFKVEVGLDSMSV-TGVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHL 179
GH+ ++V L S SV +G P +G F+L + FHWG EN GSEH +N K++P ELHL
Sbjct: 87 GHT--IQVILKSKSVLSGGPLPQGQEFELYEVRFHWGR-ENQRGSEHTVNFKAFPMELHL 143
Query: 180 VHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVR---ENPTINLHE 350
+H+NST + S+ EAV + G+ ++ + +QI +++ + + LQ ++ ++ TI
Sbjct: 144 IHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFN 203
Query: 351 KNAYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCD- 527
N Y+ Y GSLT PPC+E V WI+F YP+T+SQ QI +F+ +
Sbjct: 204 PNTLLPDPLLRD-----YWVYEGSLTIPPCSEGVTWILFRYPLTISQMQIEEFRRLRTHV 258
Query: 528 ------DGCE--THSNYRPVCPVNDRKVKRSFK 602
+GC+ N+RP P++DR ++ +F+
Sbjct: 259 KGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ 291
>sp|P27139|CAH2_RAT Carbonic anhydrase II (Carbonate dehydratase II) (CA-II)
Length = 260
Score = 135 bits (340), Expect = 1e-31
Identities = 82/205 (40%), Positives = 113/205 (55%), Gaps = 5/205 (2%)
Frame = +3
Query: 3 GHSFKVEVGLDSMSVTGVPEHK-GDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHL 179
GHSF VE DS + E ++L+QFHFHWG+++ G+GSEH +N K + ELHL
Sbjct: 63 GHSFNVEFD-DSQDFAVLKEGPLSGSYRLIQFHFHWGSSD-GQGSEHTVNKKKYAAELHL 120
Query: 180 VHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVRENPTINLHEKNA 359
VH+N TKY +AV DGL VLG+ ++I + Q + L S++ T A
Sbjct: 121 VHWN-TKYGDFGKAVQHPDGLAVLGIFLKIGPASQGLQKITEALHSIK---TKGKRAAFA 176
Query: 360 YXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCDDGCE 539
D Y+TY GSLTTPP E V WIV + PIT+S EQ+ F+ ++ + E
Sbjct: 177 NFDPCSLLPGNLD-YWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMSHFRKLNFNSEGE 235
Query: 540 TH----SNYRPVCPVNDRKVKRSFK 602
N+RP P+ +RK+K SFK
Sbjct: 236 AEELMVDNWRPAQPLKNRKIKASFK 260
>sp|P35219|CAH8_HUMAN Carbonic anhydrase-related protein (CARP) (CA-VIII)
Length = 290
Score = 135 bits (339), Expect = 2e-31
Identities = 76/213 (35%), Positives = 122/213 (57%), Gaps = 13/213 (6%)
Frame = +3
Query: 3 GHSFKVEVGLDSMSV-TGVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHL 179
GH+ ++V L S SV +G P +G F+L + FHWG EN GSEH +N K++P ELHL
Sbjct: 86 GHT--IQVILKSKSVLSGGPLPQGHEFELYEVRFHWGR-ENQRGSEHTVNFKAFPMELHL 142
Query: 180 VHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVR---ENPTINLHE 350
+H+NST + S+ EAV + G+ ++ + +QI +++ + + LQ ++ ++ TI
Sbjct: 143 IHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFN 202
Query: 351 KNAYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCD- 527
N Y+ Y GSLT PPC+E V WI+F YP+T+SQ QI +F+ +
Sbjct: 203 PNTLLPDPLLRD-----YWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHV 257
Query: 528 ------DGCE--THSNYRPVCPVNDRKVKRSFK 602
+GC+ N+RP P++DR ++ +F+
Sbjct: 258 KGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ 290
>sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 261
Score = 133 bits (334), Expect = 6e-31
Identities = 82/209 (39%), Positives = 113/209 (54%), Gaps = 10/209 (4%)
Frame = +3
Query: 3 GHSFKVEV-GLDSMSVT-GVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELH 176
GHSF V D+ SV G P D ++L QFHFHWG+T N GSEH ++G + ELH
Sbjct: 64 GHSFHVTFEDNDNRSVLKGGP--LSDSYRLFQFHFHWGST-NEHGSEHTVDGVKYSAELH 120
Query: 177 LVHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVREN----PTINL 344
L H+NS KYSSL+EA ++ DGL V+GV++++ N Q + LQ+++ P N
Sbjct: 121 LTHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKILDALQAIKTKGKRAPFTNF 180
Query: 345 HEKNAYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQ---- 512
++TY GSLT PP ESV WI+ + I++S EQ+ QF+
Sbjct: 181 DPSTLLPSSLD--------FWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLS 232
Query: 513 NVHCDDGCETHSNYRPVCPVNDRKVKRSF 599
NV D+ N RP P+ R V+ SF
Sbjct: 233 NVEGDNAVPMQHNNRPTQPLKGRTVRASF 261
>sp|P35217|CAH1_MACNE Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 132 bits (332), Expect = 1e-30
Identities = 82/209 (39%), Positives = 116/209 (55%), Gaps = 10/209 (4%)
Frame = +3
Query: 3 GHSFKVEV-GLDSMSVT-GVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELH 176
GHSF V D+ SV G P D ++L QFHFHWG++ N GSEH ++G + ELH
Sbjct: 64 GHSFHVNFEDNDNRSVLKGGPF--SDSYRLFQFHFHWGSS-NEYGSEHTVDGVKYSSELH 120
Query: 177 LVHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVREN----PTINL 344
+VH+NS KYSSL+EAV++ DGL V+GV++++ N Q + L +++ P N
Sbjct: 121 IVHWNSAKYSSLAEAVSKADGLAVIGVLMKVGEANPKLQKVLDALHAIKTKGKRAPFTNF 180
Query: 345 HEKNAYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQ---- 512
++TYSGSLT PP ESV WI+ + I++S EQ+ QF+
Sbjct: 181 DPSTLLPSSLD--------FWTYSGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLS 232
Query: 513 NVHCDDGCETHSNYRPVCPVNDRKVKRSF 599
NV D+ + N RP P+ R V+ SF
Sbjct: 233 NVEGDNPVPSQRNNRPTQPLKGRTVRASF 261
>sp|P00915|CAH1_HUMAN Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 131 bits (330), Expect = 2e-30
Identities = 81/209 (38%), Positives = 113/209 (54%), Gaps = 10/209 (4%)
Frame = +3
Query: 3 GHSFKVEV-GLDSMSVT-GVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELH 176
GHSF V D+ SV G P D ++L QFHFHWG+T N GSEH ++G + ELH
Sbjct: 64 GHSFHVNFEDNDNRSVLKGGPF--SDSYRLFQFHFHWGST-NEHGSEHTVDGVKYSAELH 120
Query: 177 LVHYNSTKYSSLSEAVNETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVREN----PTINL 344
+ H+NS KYSSL+EA ++ DGL V+GV++++ N Q + LQ+++ P N
Sbjct: 121 VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF 180
Query: 345 HEKNAYXXXXXXXXXXTDRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQ---- 512
++TY GSLT PP ESV WI+ + I++S EQ+ QF+
Sbjct: 181 DPSTLLPSSLD--------FWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLS 232
Query: 513 NVHCDDGCETHSNYRPVCPVNDRKVKRSF 599
NV D+ N RP P+ R V+ SF
Sbjct: 233 NVEGDNAVPMQHNNRPTQPLKGRTVRASF 261
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,992,669
Number of Sequences: 369166
Number of extensions: 1548962
Number of successful extensions: 3583
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3298
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3412
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7522142940
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)