Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_P11
(893 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein ... 288 1e-77
sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1) 286 4e-77
sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein ... 284 3e-76
sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2) 256 5e-68
sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2) 248 2e-65
sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-bindi... 61 4e-09
sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-bin... 60 6e-09
sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-bin... 55 2e-07
sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-bin... 55 2e-07
sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-bin... 55 2e-07
>sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein 1) (Melanoma
differentiation-associated protein 9) (MDA-9) (Scaffold
protein Pbp1) (Pro-TGF-alpha cytoplasmic
domain-interacting protein 18) (TACIP18)
Length = 298
Score = 288 bits (738), Expect = 1e-77
Identities = 150/297 (50%), Positives = 201/297 (67%), Gaps = 18/297 (6%)
Frame = +3
Query: 3 LYPTLEDLKVDELKSVQHNFINTVVNEPAGSQGS------------LYPALDDYLGLDMR 146
LYP+LEDLKVD++ Q F N S+ S LYP L Y+GL +
Sbjct: 3 LYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLN 62
Query: 147 AAQ---NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCKDS 308
+ N V S G + G + +S+ VAPVT NDVGI RAEIKQG+R +LCKD
Sbjct: 63 EEEIRANVAVVS-GAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQ 121
Query: 309 KGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA 488
G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K A
Sbjct: 122 DGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQA 181
Query: 489 GSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEI 668
IT+ +RDRPFERTITM+KDS G++GF+FKNG IT +VKDSSAARNGLL +H + EI
Sbjct: 182 FGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEI 241
Query: 669 NGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKNHMHHSIPEI 839
NGQNVIGLKD +I I+ + +VT+TIMP F++EH++K ++ ++K+ M H+IPE+
Sbjct: 242 NGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV 298
>sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1)
Length = 300
Score = 286 bits (733), Expect = 4e-77
Identities = 150/299 (50%), Positives = 202/299 (67%), Gaps = 20/299 (6%)
Frame = +3
Query: 3 LYPTLEDLKVDELKSVQH-------------NFINTVVNEPAGS-QGSLYPALDDYLGLD 140
LYP+LEDLKVD++ Q N +++ P G+ LYP L Y+GL
Sbjct: 3 LYPSLEDLKVDKVIQAQTASSANPASQAFFLNVVDSAAFPPGGNLYPKLYPELSQYMGLS 62
Query: 141 MRAAQ---NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCK 302
+ A+ N V S G G + +SV VAPVT ND GI RAEIKQG+R +LCK
Sbjct: 63 LSEAEICENMPVVS-GAPTQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCK 121
Query: 303 DSKGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFK 482
D G IGLR+++V+ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K
Sbjct: 122 DQDGKIGLRLKSVDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLK 181
Query: 483 AAGSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLI 662
A IT+ +RDRPFERT+TM+KDS+G++GF+FK+G IT +VKDSSAARNGLL DH +
Sbjct: 182 QAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHIC 241
Query: 663 EINGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKNHMHHSIPEI 839
EINGQNVIGLKD +I I+ +VT+TIMP F++EH++K ++ ++K+ M H+IPE+
Sbjct: 242 EINGQNVIGLKDAQIADILSTAGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV 300
>sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein 1) (Scaffold protein Pbp1)
Length = 299
Score = 284 bits (726), Expect = 3e-76
Identities = 146/297 (49%), Positives = 199/297 (67%), Gaps = 18/297 (6%)
Frame = +3
Query: 3 LYPTLEDLKVDELKSVQHNFINTVVNE------------PAGS-QGSLYPALDDYLGLDM 143
LYP+LEDLKVD++ Q + ++ P G+ LYP L Y+GL +
Sbjct: 3 LYPSLEDLKVDKVIQAQTAYSANPASQAFVLVDASAALPPDGNLYPKLYPELSQYMGLSL 62
Query: 144 RAAQ--NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCKDS 308
A+ M G G + +SV VAPVT ND GI RAEIKQG+R +LCKD
Sbjct: 63 NEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQ 122
Query: 309 KGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA 488
G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K A
Sbjct: 123 DGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQA 182
Query: 489 GSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEI 668
IT+ +RDRPFERT+TM+KDS+G++GF+FK+G IT +VKDSSAARNGLL DH + EI
Sbjct: 183 FGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEI 242
Query: 669 NGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKNHMHHSIPEI 839
NGQNVIGLKD +I I+ +VT+TIMP F++EH++K ++ ++K+ M H+IPE+
Sbjct: 243 NGQNVIGLKDAQIADILSTAGTVVTITIMPTFIFEHIIKRMAPSIMKSLMDHTIPEV 299
>sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 256 bits (655), Expect = 5e-68
Identities = 141/293 (48%), Positives = 190/293 (64%), Gaps = 15/293 (5%)
Frame = +3
Query: 3 LYPTLEDLKVDELKSVQHNFINTVVNEPAGSQGS-----LYP---ALDDYLGLDMRAAQN 158
LYP+LEDLKV ++ Q T+ PA + LYP L+ Y+GL + + +
Sbjct: 4 LYPSLEDLKVGQVIQAQGRASPTMPTLPAPMASAPPLSELYPNLAELESYMGLSLSSQEV 63
Query: 159 Q----MVQSYGNSVV---GYGWRQNTSVVAPVTKNDVGISRAEIKQGLRRAVLCKDSKGI 317
Q + N VV G G VVAPV+ N++GI RAEIK G+R LCKD +G
Sbjct: 64 QKNLTQIPDSDNMVVTSPGPG-----QVVAPVSGNNLGILRAEIKPGVREIHLCKDERGK 118
Query: 318 IGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSN 497
GLR+QAV+KG+FV V N+PAS+ GLRFGDQIL+++ AGW T K HK K A +
Sbjct: 119 TGLRLQAVDKGLFVQLVQANTPASLVGLRFGDQILQIDGCDCAGWNTHKAHKVLKKASAE 178
Query: 498 NITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQ 677
I + +RDRPF+RT+TM+KDS+G +GF K G I +VK SSAARNGLL +H + E+NGQ
Sbjct: 179 KIVMVIRDRPFQRTVTMHKDSSGQVGFSIKKGKIVSVVKGSSAARNGLLTNHYVCEVNGQ 238
Query: 678 NVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKNHMHHSIPE 836
NVIGLKDK++ +I+ +++T+TI+P +YEHM+K LS LL + M HSIP+
Sbjct: 239 NVIGLKDKKVTEILTTAGDVITLTIIPTVIYEHMIKRLSPLLLHHTMDHSIPD 291
>sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 248 bits (633), Expect = 2e-65
Identities = 136/291 (46%), Positives = 189/291 (64%), Gaps = 13/291 (4%)
Frame = +3
Query: 3 LYPTLEDLKVDELKSVQHNFINTVVNEPAGSQGS-----LYP---ALDDYLGLDMRAAQN 158
LYP+LEDLKVD+ Q + P + LYP L++Y+GL + + +
Sbjct: 4 LYPSLEDLKVDQAIQAQVRASPKMPALPVQATAISPPPVLYPNLAELENYMGLSLSSQEV 63
Query: 159 Q-----MVQSYGNSVVGYGWRQNTSVVAPVTKNDVGISRAEIKQGLRRAVLCKDSKGIIG 323
Q + + +V G G Q +VAPVT +G+ RAEIK G+R LCKD +G G
Sbjct: 64 QESLLQIPEGDSTAVSGPGPGQ---MVAPVTGYSLGVRRAEIKPGVREIHLCKDERGKTG 120
Query: 324 LRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSNNI 503
LR++ V++G+FV V N+PAS+ GLRFGDQ+L+++ + AGW++ K H+ K A + I
Sbjct: 121 LRLRKVDQGLFVQLVQANTPASLVGLRFGDQLLQIDGRDCAGWSSHKAHQVVKKASGDKI 180
Query: 504 TVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNV 683
V +RDRPF+RT+TM+KDS G++GFV K G I LVK SSAARNGLL +H + E++GQNV
Sbjct: 181 VVVVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDGQNV 240
Query: 684 IGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKNHMHHSIPE 836
IGLKDK+I +I+ N+VT+TI+P +YEHMVK L LL + M HSIP+
Sbjct: 241 IGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKLPPVLLHHTMDHSIPD 291
>sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 839
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/144 (26%), Positives = 68/144 (47%), Gaps = 4/144 (2%)
Frame = +3
Query: 351 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGW---TTEKVHKFFKAAGSNNITVALR 518
+ ++ + PA +G L GDQI+ +N + G T + + K K + + +R
Sbjct: 685 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI-VR 743
Query: 519 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 698
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 744 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 803
Query: 699 KEIQKIIDKTPNIVTVTIMPMFVY 770
++I I+ + + MP +Y
Sbjct: 804 EKIVHILSNAVGEIHMKTMPAAMY 827
>sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 837
Score = 60.5 bits (145), Expect = 6e-09
Identities = 39/144 (27%), Positives = 64/144 (44%), Gaps = 4/144 (2%)
Frame = +3
Query: 351 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSNNITVAL---R 518
+ ++ + PA +G L GDQI+ +N + G K N V L R
Sbjct: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGL-ENQSRVKLNIVR 741
Query: 519 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 698
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 742 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 801
Query: 699 KEIQKIIDKTPNIVTVTIMPMFVY 770
++I I+ + + MP +Y
Sbjct: 802 EKIVHILSNAVGEIHMKTMPAAMY 825
>sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter protein
X11beta)
Length = 749
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +3
Query: 351 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 527
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 528 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 704
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 705 IQKIIDKTPNIVTVTIMPMFVY 770
I + + + + + MP ++
Sbjct: 716 IVQALSNSVGEIHMKTMPAAMF 737
>sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-binding family A member 2
Length = 749
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +3
Query: 351 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 527
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 528 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 704
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 705 IQKIIDKTPNIVTVTIMPMFVY 770
I + + + + + MP ++
Sbjct: 716 IVQALSNSVGEIHMKTMPAAMF 737
>sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter protein
X11beta)
Length = 750
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +3
Query: 351 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 527
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 597 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 656
Query: 528 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 704
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 657 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 716
Query: 705 IQKIIDKTPNIVTVTIMPMFVY 770
I + + + + + MP ++
Sbjct: 717 IVQALSNSVGEIHMKTMPAAMF 738
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,454,773
Number of Sequences: 369166
Number of extensions: 2034743
Number of successful extensions: 5678
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5328
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5641
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8982382310
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)