Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_M09
(875 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 119 8e-27
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 119 1e-26
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 119 1e-26
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 116 9e-26
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 113 6e-25
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 108 2e-23
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 105 2e-22
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 104 4e-22
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 97 4e-20
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 97 6e-20
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 119 bits (299), Expect = 8e-27
Identities = 86/285 (30%), Positives = 142/285 (49%), Gaps = 8/285 (2%)
Frame = +3
Query: 45 CDEQTRKIDLLNEDIVKLR-NVDKLMREDLDKLKLGGERDKKSIESLQKKCEQQNKQIEQ 221
C E +L + ++ +LR ++ L+ L+ G ++ E LQ+ C+ ++I
Sbjct: 223 CSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQR-CQILEQKIAT 281
Query: 222 FNNKY----QQIENKFVNAKLERENKEKDLMRNIDEMKNKQIEMTTISNKIDETMKNVEN 389
F N +++E V A+ D I+ + NK ++ D M ++E
Sbjct: 282 FENIVCVLNREVERVAVTAEACSRQHRLD-QDKIEALSNKVQQLERSIGLKDLAMADLEQ 340
Query: 390 KLLEIEINQNKMRNGEFVWRIDKINDKMKDAKNGINTYIYSDSFYTHKHGYKMCLRVDPD 569
K+ E+E++ +G F+W+I K ++A G I+S +FYT ++GYKMCLRV +
Sbjct: 341 KVSELEVSTY---DGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLN 397
Query: 570 GHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLINQQTRLDHVNKKIKYNDFPND- 746
G G G GTHLSL+F +M G D +LQWPF V L L LDH N++ + F D
Sbjct: 398 GDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLML------LDHNNREHVIDAFRPDV 451
Query: 747 --ELWNKPVNERNIGFGRSKFIELKELSTNANLILNNQIFIKCSV 875
+ +PV++ NI G F + ++ + + ++ IFIK V
Sbjct: 452 TSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIV 496
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor 1)
(CRAF1) (CD40 binding protein) (CD40BP) (LMP1 associated
protein) (LAP1) (CAP-1)
Length = 568
Score = 119 bits (297), Expect = 1e-26
Identities = 84/296 (28%), Positives = 147/296 (49%), Gaps = 24/296 (8%)
Frame = +3
Query: 60 RKIDLL-NEDIVKLRNVDKLMREDLDKLKLGGERDKKSIESLQKKCEQQNKQIEQFNNKY 236
+K+ LL NE + K +++ L + + ++ ER K+ + + + K + I+ K
Sbjct: 272 KKVSLLQNESVEKNKSIQSLHNQ-ICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
Query: 237 QQIENKFVNAKLEREN-KEKDLMRN-IDEMKNKQIEMTTISNKIDETMKN---VENKL-- 395
++++ + + R+N +E D M++ ++ ++N+ E+ ++ + +N +E++L
Sbjct: 331 KELDKEI---RPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSR 387
Query: 396 ----------------LEIEINQNKMRNGEFVWRIDKINDKMKDAKNGINTYIYSDSFYT 527
L ++ + NG +W+I + ++A G +YS FYT
Sbjct: 388 HDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYT 447
Query: 528 HKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLINQQTRLDH 707
GYKMC RV +G G G+GTHLSL+F +M GE+D +L WPFK V L L++Q + H
Sbjct: 448 GYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH 507
Query: 708 VNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNANLILNNQIFIKCSV 875
+ K + PN + KP E NI G F+ L N I ++ IFIK V
Sbjct: 508 LGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFIKVIV 560
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor 1)
(CRAF1) (TRAFAMN)
Length = 567
Score = 119 bits (297), Expect = 1e-26
Identities = 84/296 (28%), Positives = 147/296 (49%), Gaps = 24/296 (8%)
Frame = +3
Query: 60 RKIDLL-NEDIVKLRNVDKLMREDLDKLKLGGERDKKSIESLQKKCEQQNKQIEQFNNKY 236
+K+ LL NE + K +++ L + + ++ ER K+ + + + K + I+ K
Sbjct: 271 KKVSLLQNESVEKNKSIQSLHNQ-ICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 329
Query: 237 QQIENKFVNAKLEREN-KEKDLMRN-IDEMKNKQIEMTTISNKIDETMKN---VENKL-- 395
++++ + + R+N +E D M++ ++ ++N+ E+ ++ + +N +E++L
Sbjct: 330 KELDKEI---RPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSR 386
Query: 396 ----------------LEIEINQNKMRNGEFVWRIDKINDKMKDAKNGINTYIYSDSFYT 527
L ++ + NG +W+I + ++A G +YS FYT
Sbjct: 387 HDQTLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYT 446
Query: 528 HKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLINQQTRLDH 707
GYKMC RV +G G G+GTHLSL+F +M GE+D +L WPFK V L L++Q + H
Sbjct: 447 GYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH 506
Query: 708 VNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNANLILNNQIFIKCSV 875
+ K + PN + KP E NI G F+ L N I ++ IFIK V
Sbjct: 507 LGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFIKVIV 559
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 116 bits (290), Expect = 9e-26
Identities = 77/257 (29%), Positives = 129/257 (50%), Gaps = 3/257 (1%)
Frame = +3
Query: 114 LMREDLDKLKLGGERDKKSIESLQKKCEQQNKQIEQFNNKYQQIENKFVNAKLERENKEK 293
L+ L+ L G++ E LQ+ CE K+ F N + + + E +
Sbjct: 247 LLSSVLEAKPLLGDQSHAGSELLQR-CESLEKKTATFENIVCVLNREVERVAMTAEACSR 305
Query: 294 DLMRNIDEMKNKQIEMTTISNKI---DETMKNVENKLLEIEINQNKMRNGEFVWRIDKIN 464
+ D+++ ++ + I D M ++E K+LE+E + +G F+W+I
Sbjct: 306 QHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY---DGVFIWKISDFA 362
Query: 465 DKMKDAKNGINTYIYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDIL 644
K ++A G I+S +FYT ++GYKMCLR+ +G G G GTHLSL+F +M G D +L
Sbjct: 363 RKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALL 422
Query: 645 QWPFKYDVRLSLINQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELS 824
+WPF V L L++Q R +HV + + + +PVN+ NI G F + ++
Sbjct: 423 RWPFNQKVTLMLLDQNNR-EHVIDAFRPD--VTSSSFQRPVNDMNIASGCPLFCPVSKME 479
Query: 825 TNANLILNNQIFIKCSV 875
+ + ++ IFIK V
Sbjct: 480 AKNSYVRDDAIFIKAIV 496
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 113 bits (283), Expect = 6e-25
Identities = 71/281 (25%), Positives = 140/281 (49%), Gaps = 40/281 (14%)
Frame = +3
Query: 153 ERDKKSIESLQKKCEQQNKQIEQFNNKYQQIENKFVNAKLERENKEKDL-----MRNIDE 317
E+ + I+ L + ++ K+++QF + + N + + +K +R + +
Sbjct: 272 EQKESKIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALTSHTDKSAWLEAQVRQLLQ 331
Query: 318 MKNKQ---IEMTTISNKIDETMKNV------ENKLLEIE----------------INQNK 422
+ N+Q +++ ++ + +D + + + +L+ +E +N+N+
Sbjct: 332 IVNQQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGETSKHDAHINIHKAQLNKNE 391
Query: 423 MR---------NGEFVWRIDKINDKMKDAKNGINTYIYSDSFYTHKHGYKMCLRVDPDGH 575
R +G+ +W++ K ++A G ++S FYT + GY++C R +G
Sbjct: 392 ERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGD 451
Query: 576 GDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLINQQTRLDHVNKKIKYNDFPNDELW 755
G G+GTHLSLYF +M GEFD +LQWPF+ V L L++Q + +H+ + K + PN +
Sbjct: 452 GSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFKAD--PNSSSF 509
Query: 756 NKPVNERNIGFGRSKFIELKELSTNAN-LILNNQIFIKCSV 875
+P E NI G +F+ L + N I ++ +F+K +V
Sbjct: 510 KRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLFLKVAV 550
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 108 bits (270), Expect = 2e-23
Identities = 71/237 (29%), Positives = 118/237 (49%), Gaps = 15/237 (6%)
Frame = +3
Query: 210 QIEQFNNKYQQIENKFVNAKLERENKEKDLMRNIDEMKNKQIEMTTISNKI----DETMK 377
Q+ Q Q +NKF + LM +D +K K + ++ +ET K
Sbjct: 325 QVHQLLQMVNQQQNKF---------DLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNK 375
Query: 378 NVEN-KLLEIEINQNKMR---------NGEFVWRIDKINDKMKDAKNGINTYIYSDSFYT 527
+ + + + ++++N+ R NG+ +W++ K ++A +G I+S SFYT
Sbjct: 376 HDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYT 435
Query: 528 HKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLINQQTRLDH 707
+ GY++C R +G G G G+HLSLYF +M GEFD +LQWPF+ V L L++Q +
Sbjct: 436 SRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGK--- 492
Query: 708 VNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNAN-LILNNQIFIKCSV 875
N + PN + +P E NI G +F+ L N I ++ +F+K +V
Sbjct: 493 KNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAV 549
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 105 bits (261), Expect = 2e-22
Identities = 58/202 (28%), Positives = 111/202 (54%), Gaps = 9/202 (4%)
Frame = +3
Query: 297 LMRNIDE-MKNKQIEMTTISNKIDETMKNVENKLLEIEINQNKMRNGEFVWRIDKINDKM 473
+ R+++E +K M + ++ + ++ + +L E+ + + G +W+I ++
Sbjct: 266 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSD----GVLIWKIGSYGRRL 321
Query: 474 KDAKNGINTYIYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWP 653
++AK N +S +FYTHK+GYK+ + +G+G GEGTHLSLY ++ G FD++L+WP
Sbjct: 322 QEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWP 381
Query: 654 FKYDVRLSLINQQ----TRLDHVNKKI----KYNDFPNDELWNKPVNERNIGFGRSKFIE 809
F V SL++Q + HV + + +F W ++E ++GFG KFI
Sbjct: 382 FARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFIS 441
Query: 810 LKELSTNANLILNNQIFIKCSV 875
+++ N + ++ +FI+ +V
Sbjct: 442 HQDI-RKRNYVRDDAVFIRAAV 462
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 104 bits (259), Expect = 4e-22
Identities = 58/200 (29%), Positives = 109/200 (54%), Gaps = 9/200 (4%)
Frame = +3
Query: 303 RNIDE-MKNKQIEMTTISNKIDETMKNVENKLLEIEINQNKMRNGEFVWRIDKINDKMKD 479
R+++E +K M + ++ + ++ + +L E+ I + G +W+I ++++
Sbjct: 268 RHVEESVKPHLAMMCALVSRQRQELQELRRELEELSIGSD----GVLIWKIGSYGRRLQE 323
Query: 480 AKNGINTYIYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFK 659
AK N +S +FYTHK+GYK+ + +G+G GEGTHLS+Y ++ G FD++L+WP
Sbjct: 324 AKAKPNLECFSPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLA 383
Query: 660 YDVRLSLINQQ----TRLDHVNKKI----KYNDFPNDELWNKPVNERNIGFGRSKFIELK 815
V SL++Q + HV + + +F W ++E ++GFG KFI +
Sbjct: 384 RRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQ 443
Query: 816 ELSTNANLILNNQIFIKCSV 875
++ N + ++ +FI+ SV
Sbjct: 444 DI-RKRNYVRDDAVFIRASV 462
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 97.4 bits (241), Expect = 4e-20
Identities = 62/245 (25%), Positives = 118/245 (48%), Gaps = 8/245 (3%)
Frame = +3
Query: 165 KSIESLQKKCEQQNKQIEQFNNKYQQIENKFVNAKLERENKEKDLMRNIDEMKNKQIEMT 344
+S E L + + K + + K + EN E E L +I + + + +
Sbjct: 171 ESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERIL 230
Query: 345 TISNKIDETMKNVENKLLEIEINQNKMR-------NGEFVWRIDKINDKMKDAKNGINTY 503
++ ++ E + + K + + +R +G F+W+I + + ++ G
Sbjct: 231 SLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVS 290
Query: 504 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 683
++S +FYT K+GYK+CLR+ +G G G+ THLSL+ +M GE+D +L WPF+ V L+
Sbjct: 291 LFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLL 350
Query: 684 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKEL-STNANLILNNQIF 860
+Q R ++ + + + +P +E N+ G F L +L S + ++ +F
Sbjct: 351 DQNNREHAID---AFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMF 407
Query: 861 IKCSV 875
+KC V
Sbjct: 408 LKCIV 412
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 97.1 bits (240), Expect = 6e-20
Identities = 55/217 (25%), Positives = 114/217 (52%), Gaps = 1/217 (0%)
Frame = +3
Query: 228 NKYQQIENKFVNAKLERENKEKDLMRNIDEMKNKQIEMTTISNKIDETMKNVENKLLEIE 407
NK + + + A + + +++ + ++++ + +E+ + D+ + +E+ L
Sbjct: 198 NKEVEASHLALAASIHQSQLDREHLLSLEQ---RVVELQQTLAQKDQVLGKLEHSL---R 251
Query: 408 INQNKMRNGEFVWRIDKINDKMKDAKNGINTYIYSDSFYTHKHGYKMCLRVDPDGHGDGE 587
+ + +G F+W+I + + ++ G ++S +FYT K+GYK+CLR+ +G G G+
Sbjct: 252 LMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGK 311
Query: 588 GTHLSLYFCLMIGEFDDILQWPFKYDVRLSLINQQTRLDHVNKKIKYNDFPNDELWNKPV 767
THLSL+ +M GE+D +L WPF+ V L++Q R ++ + + + +P
Sbjct: 312 KTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAID---AFRPDLSSASFQRPQ 368
Query: 768 NERNIGFGRSKFIELKEL-STNANLILNNQIFIKCSV 875
+E N+ G F L +L S + ++ +F+KC V
Sbjct: 369 SETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIV 405
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,655,077
Number of Sequences: 369166
Number of extensions: 1475765
Number of successful extensions: 8418
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6915
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8158
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8694177530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)