Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_L11
(834 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxid... 170 4e-42
sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxid... 169 7e-42
sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide ... 169 9e-42
sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxid... 168 2e-41
sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 ... 152 8e-37
sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 ... 150 3e-36
sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Ju... 128 2e-29
sp|Q06816|HYEP_STIAU Epoxide hydrolase (Epoxide hydratase) 70 5e-12
sp|P44248|Y1543_HAEIN Hypothetical protein HI1543 32 2.2
>sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 170 bits (431), Expect = 4e-42
Identities = 93/217 (42%), Positives = 138/217 (63%), Gaps = 3/217 (1%)
Frame = +1
Query: 4 VAGIHINFVETPYHDMRYLTQVFIGSMLPAKLHFLTQKELDMVYPWSDKI-NTILSSMGY 180
V G+H+N + Y + +G + L + T+++++++YP+ +K+ +++ GY
Sbjct: 243 VKGLHLNMALILRN--HYTLTLLLGRRIGGLLGY-TERDMELLYPFKEKVFYSLMRESGY 299
Query: 181 FGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLT 360
+++T+P T+G AL+DSP GLAAYILEKF W+N+ L +GGLE K + ++LT
Sbjct: 300 MHIRATKPDTVGCALNDSPVGLAAYILEKFSTWTNSEFRDLE--DGGLER-KFSLQDLLT 356
Query: 361 NVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFK 534
N+MIY+ T +I SS R YKE L + HK + V VPT A FP EI+ VP+ +V K
Sbjct: 357 NIMIYWTTGSIVSSQRYYKENLGQGFMAHKHERLKVHVPTGFAAFPCEIMHVPEKWVRTK 416
Query: 535 YRNVRQFNYMPRGGHFAALEEPELLANDIRSFINLME 645
Y + ++YMPRGGHFAA EEPELLA DI F+ L+E
Sbjct: 417 YPQLISYSYMPRGGHFAAFEEPELLARDICKFVGLVE 453
>sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 169 bits (429), Expect = 7e-42
Identities = 96/221 (43%), Positives = 139/221 (62%), Gaps = 7/221 (3%)
Frame = +1
Query: 4 VAGIHINF--VETPYHDMRYLTQVFIGSMLPAKLHFLTQKELDMVYPWSDKI-NTILSSM 174
V G+H+N V + + + L G L LT+++++++YP +K+ +++
Sbjct: 243 VKGLHLNMALVLSNFSTLTLLLGQRFGRFLG-----LTERDVELLYPVKEKVFYSLMRES 297
Query: 175 GYFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEM 354
GY +Q T+P T+G AL+DSP GLAAYILEKF W+N +L +GGLE K + D++
Sbjct: 298 GYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLE--DGGLER-KFSLDDL 354
Query: 355 LTNVMIYYITNTISSSVRLYKEMLNE----QNHKLFKTPVRVPTAIAMFPNEIIQVPKPF 522
LTNVM+Y+ T TI SS R YKE L + Q H+ K V VPT + FP E++ P+ +
Sbjct: 355 LTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMK--VYVPTGFSAFPFELLHTPEKW 412
Query: 523 VHFKYRNVRQFNYMPRGGHFAALEEPELLANDIRSFINLME 645
V FKY + ++YM RGGHFAA EEPELLA DIR F++++E
Sbjct: 413 VRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLE 453
>sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 169 bits (428), Expect = 9e-42
Identities = 94/219 (42%), Positives = 136/219 (62%), Gaps = 5/219 (2%)
Frame = +1
Query: 4 VAGIHIN--FVETPYHDMRYLTQVFIGSMLPAKLHFLTQKELDMVYPWSDKI-NTILSSM 174
V G+H+N F+ ++ M L G L T+K+++++YP+ +K+ +I+
Sbjct: 243 VKGLHLNMAFISRSFYTMTPLLGQRFGRFLG-----YTEKDIELLYPYKEKVFYSIMRES 297
Query: 175 GYFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEM 354
GY +Q+T+P T+G AL+DSP GLAAYILEKF W+ + L +GGLE K + D++
Sbjct: 298 GYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELE--DGGLER-KFSLDDL 354
Query: 355 LTNVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVH 528
L N+MIY+ T TI SS R YKE L + HK V VPT + FP+E++ P+ +V
Sbjct: 355 LVNIMIYWTTGTIVSSQRYYKENLGQGIMVHKHEGMKVFVPTGFSAFPSELLHAPEKWVK 414
Query: 529 FKYRNVRQFNYMPRGGHFAALEEPELLANDIRSFINLME 645
KY + ++YM RGGHFAA EEP+LLA DIR F++L E
Sbjct: 415 VKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAE 453
>sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 168 bits (425), Expect = 2e-41
Identities = 95/219 (43%), Positives = 135/219 (61%), Gaps = 5/219 (2%)
Frame = +1
Query: 4 VAGIHIN--FVETPYHDMRYLTQVFIGSMLPAKLHFLTQKELDMVYPWSDKI-NTILSSM 174
V G+H+N F+ + + L G L T+K+L+++YP+ +K+ I+
Sbjct: 243 VKGLHLNMSFISRNIYSLTPLLGQRFGRFLG-----YTEKDLELLYPFKEKVFYNIMRES 297
Query: 175 GYFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEM 354
GY +Q+T+P T+G AL+DSP GLAAYILEKF W+ + L +GGLE K + +++
Sbjct: 298 GYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELE--DGGLER-KFSLEDL 354
Query: 355 LTNVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVH 528
LTN+MIY+ T TI SS R YKE L + H+ V VPT + FP+EI+ PK +V
Sbjct: 355 LTNIMIYWTTGTIVSSQRFYKENLGQGVMVHRHEGMKVFVPTGYSAFPSEILHAPKKWVK 414
Query: 529 FKYRNVRQFNYMPRGGHFAALEEPELLANDIRSFINLME 645
KY + ++YM RGGHFAA EEP+LLA DIR F++L E
Sbjct: 415 VKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAE 453
>sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 (Juvenile hormone epoxide
hydrolase I) (Juvenile hormone-specific epoxide
hydrolase I) (JHEH I) (CfEH1)
Length = 464
Score = 152 bits (385), Expect = 8e-37
Identities = 95/210 (45%), Positives = 122/210 (58%), Gaps = 4/210 (1%)
Frame = +1
Query: 4 VAGIHIN--FVETPYHDMRYLTQVFIGSMLPAKLHFLTQKELDMVYPWSDKINTILSSMG 177
V G H N FV TP +++ + IGS P F +YP S+ T+L MG
Sbjct: 241 VLGQHSNMCFVNTPSSNIKAI----IGSFFPES--FAGTGNAHKMYPMSEHFFTLLEEMG 294
Query: 178 YFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEML 357
Y LQ+T+P T+G+AL DSPAGLAAYILEKF W+N + S G +K E+L
Sbjct: 295 YLHLQATKPDTVGVALRDSPAGLAAYILEKFSTWTNRS---WRSVKDGNLLLKYNIPELL 351
Query: 358 TNVMIYYITNTISSSVRLYKEMLNEQNHKLFKTPVR--VPTAIAMFPNEIIQVPKPFVHF 531
NVMIYY+T++I++S+RLY E + + L VR VP A A FPNE+ V +
Sbjct: 352 DNVMIYYVTDSITTSMRLYAESFTKAHLALNLDRVRNHVPAACAKFPNELAYVTDCQLAE 411
Query: 532 KYRNVRQFNYMPRGGHFAALEEPELLANDI 621
KY+ + Q N MP GGHFAA EEP LLA DI
Sbjct: 412 KYKTLLQSNDMPSGGHFAAFEEPGLLAEDI 441
>sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 (Juvenile hormone epoxide
hydrolase II) (Juvenile hormone-specific epoxide
hydrolase II) (JHEH II) (CfEH2)
Length = 465
Score = 150 bits (380), Expect = 3e-36
Identities = 87/190 (45%), Positives = 119/190 (62%), Gaps = 2/190 (1%)
Frame = +1
Query: 70 FIGSMLPAKLHFLTQKELDMVYPWSDKINTILSSMGYFGLQSTRPSTIGIALSDSPAGLA 249
F+GS+ P F ++ + +YP S+ T+L GYF +Q+T+P T+G+AL DSPAGLA
Sbjct: 261 FVGSLFPE--WFAGKQNVHKIYPLSEHFFTLLEESGYFHIQATKPDTVGVALRDSPAGLA 318
Query: 250 AYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEMLN 429
AYILEKF + N S+ +G L+ K T E+L NVMIYY+T +I++S+R+Y E +
Sbjct: 319 AYILEKFS--TGTNKAWRSAKDGNLQS-KFTFTELLDNVMIYYVTGSITTSMRIYAESYS 375
Query: 430 EQNHKL--FKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEPE 603
+ L + P VPTA A FP+EI + KY+ + Q MPRGGHFAALEEP
Sbjct: 376 WDHLSLNMDRVPTIVPTACAKFPHEIAYKTDFQLAEKYKTLLQSTIMPRGGHFAALEEPL 435
Query: 604 LLANDIRSFI 633
LLA DI S +
Sbjct: 436 LLAEDIFSAV 445
>sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Juvenile hormone-specific
epoxide hydrolase) (JHEH)
Length = 462
Score = 128 bits (321), Expect = 2e-29
Identities = 79/209 (37%), Positives = 122/209 (58%), Gaps = 2/209 (0%)
Frame = +1
Query: 1 KVAGIHINFVETPYHDMRYLT-QVFIGSMLPAKLHFLTQKELDMVYPWSDKINTILSSMG 177
+V G+H N P T ++FIG++ P+ + + K +D +YP + + IL G
Sbjct: 243 QVLGLHTNM---PLSSRPLSTVKLFIGALFPSLI--VDAKYMDRIYPLKNLFSYILRETG 297
Query: 178 YFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEML 357
YF +Q+T+P TIG+AL+DSPAGLA Y++EK SN + L +P+GGLE++ + D++L
Sbjct: 298 YFHIQATKPDTIGVALTDSPAGLAGYLIEKMAICSNRD--QLDTPHGGLENLNL--DDVL 353
Query: 358 TNVMIYYITNTISSSVRLYKEMLN-EQNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFK 534
V I +I N I +S RLY E + + + + P VPTA F E++ P + K
Sbjct: 354 DTVTINWINNCIVTSTRLYAEGFSWPEVLIVHRIPSMVPTAGINFKYEVLYQPDWILRDK 413
Query: 535 YRNVRQFNYMPRGGHFAALEEPELLANDI 621
+ N+ + + GGHFAAL P+ LA+DI
Sbjct: 414 FPNLVRSTVLDFGGHFAALHTPQALADDI 442
>sp|Q06816|HYEP_STIAU Epoxide hydrolase (Epoxide hydratase)
Length = 232
Score = 70.5 bits (171), Expect = 5e-12
Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 2/98 (2%)
Frame = +1
Query: 337 ITKDEMLTNVMIYYITNTISSSVRLYKEML--NEQNHKLFKTPVRVPTAIAMFPNEIIQV 510
+++DEML N+ +Y++T+T +SS R+Y E N KL +P +++FP E+ +
Sbjct: 131 LSQDEMLDNISLYWLTDTAASSARIYWENAGSNFSGGKL-----DLPVGVSVFpreLFRA 185
Query: 511 PKPFVHFKYRNVRQFNYMPRGGHFAALEEPELLANDIR 624
PK + Y + +N RGGHFAA E+P L A+++R
Sbjct: 186 PKRWAEQTYSKLIYWNEPDRGGHFAAFEQPALFAHELR 223
>sp|P44248|Y1543_HAEIN Hypothetical protein HI1543
Length = 184
Score = 32.0 bits (71), Expect = 2.2
Identities = 23/66 (34%), Positives = 35/66 (53%)
Frame = +1
Query: 394 SSSVRLYKEMLNEQNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRG 573
S V++ +LNE+ KLF T +V TAI+ + ++ + FV+F R VR +
Sbjct: 59 SLQVKIDLNLLNEEYQKLFATNGKVMTAISAYGIDV----EEFVNF--RLVRNMPEVESA 112
Query: 574 GHFAAL 591
HFA L
Sbjct: 113 DHFALL 118
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,356,373
Number of Sequences: 369166
Number of extensions: 1912886
Number of successful extensions: 4429
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 4287
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4411
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8100769320
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)