Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_J22
(335 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P36423|THAS_MOUSE Thromboxane-A synthase (TXA synthase) ... 62 3e-10
sp|P49430|THAS_RAT Thromboxane-A synthase (TXA synthase) (TXS) 61 7e-10
sp|P08684|CP3A4_HUMAN Cytochrome P450 3A4 (Quinine 3-monoox... 60 1e-09
sp|P05184|CP3A3_HUMAN Cytochrome P450 3A3 (CYPIIIA3) (HLp) 60 1e-09
sp|P79152|CP3AJ_CAPAE Cytochrome P450 3A19 (CYPIIIA19) 59 3e-09
sp|P24463|CP3AC_CANFA Cytochrome P450 3A12 (CYPIIIA12) (P45... 59 5e-09
sp|O18993|CP3AL_CALJA Cytochrome P450 3A21 (CYPIIIA21) (P45... 59 5e-09
sp|P24557|THAS_HUMAN Thromboxane-A synthase (TXA synthase) ... 59 5e-09
sp|P33268|CP3A8_MACFA Cytochrome P450 3A8 (CYPIIIA8) (P450-... 58 6e-09
sp|P47787|THAS_PIG Thromboxane-A synthase (TXA synthase) (TXS) 58 8e-09
>sp|P36423|THAS_MOUSE Thromboxane-A synthase (TXA synthase) (TXS) (TS)
Length = 533
Score = 62.4 bits (150), Expect = 3e-10
Identities = 25/62 (40%), Positives = 43/62 (69%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAPVNG 198
P ++PFGAGPR+C+G RL ++++KLT+ + ++ F S +T+ PL+L+ + P NG
Sbjct: 466 PFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNG 525
Query: 199 VH 204
V+
Sbjct: 526 VY 527
>sp|P49430|THAS_RAT Thromboxane-A synthase (TXA synthase) (TXS)
Length = 533
Score = 61.2 bits (147), Expect = 7e-10
Identities = 25/62 (40%), Positives = 42/62 (67%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAPVNG 198
P ++PFGAGPR+C+G RL ++++KLTL + ++ F +T+ PL+L+ + P NG
Sbjct: 466 PFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNG 525
Query: 199 VH 204
V+
Sbjct: 526 VY 527
>sp|P08684|CP3A4_HUMAN Cytochrome P450 3A4 (Quinine 3-monooxygenase) (CYPIIIA4)
(Nifedipine oxidase) (NF-25) (P450-PCN1)
Length = 503
Score = 60.5 bits (145), Expect = 1e-09
Identities = 27/57 (47%), Positives = 37/57 (64%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAP 189
P + PFG+GPRNCIG R A+M +KL L R + +F +T+ PLKL +GG + P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQP 485
>sp|P05184|CP3A3_HUMAN Cytochrome P450 3A3 (CYPIIIA3) (HLp)
Length = 504
Score = 60.5 bits (145), Expect = 1e-09
Identities = 27/57 (47%), Positives = 37/57 (64%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAP 189
P + PFG+GPRNCIG R A+M +KL L R + +F +T+ PLKL +GG + P
Sbjct: 430 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQP 486
>sp|P79152|CP3AJ_CAPAE Cytochrome P450 3A19 (CYPIIIA19)
Length = 218
Score = 59.3 bits (142), Expect = 3e-09
Identities = 26/58 (44%), Positives = 36/58 (62%)
Frame = +1
Query: 16 HPMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAP 189
+P ++PFG GPRNC+G R A+M IKL L R + +F + +T+ PLKL G P
Sbjct: 139 NPYVYLPFGTGPRNCVGMRFALMNIKLALVRILQNFSFIPCKETQIPLKLYTQGLTQP 196
>sp|P24463|CP3AC_CANFA Cytochrome P450 3A12 (CYPIIIA12) (P450-PBD-1)
Length = 503
Score = 58.5 bits (140), Expect = 5e-09
Identities = 27/58 (46%), Positives = 36/58 (62%)
Frame = +1
Query: 16 HPMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAP 189
+P ++PFG GPRNCIG R A+M +KL L R + +F +T+ PLKL G I P
Sbjct: 428 NPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQP 485
>sp|O18993|CP3AL_CALJA Cytochrome P450 3A21 (CYPIIIA21) (P450 CM3A-10)
Length = 503
Score = 58.5 bits (140), Expect = 5e-09
Identities = 26/55 (47%), Positives = 36/55 (65%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTI 183
P + PFG GPRNCIG R A+M +KL L R + +F +T+ PLKL++GG +
Sbjct: 429 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLRLGGLL 483
>sp|P24557|THAS_HUMAN Thromboxane-A synthase (TXA synthase) (TXS)
Length = 533
Score = 58.5 bits (140), Expect = 5e-09
Identities = 25/62 (40%), Positives = 40/62 (64%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAPVNG 198
P ++PFGAGPR+C+G RL ++ +KLTL ++ F +T+ PL+L+ + P NG
Sbjct: 466 PFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNG 525
Query: 199 VH 204
V+
Sbjct: 526 VY 527
>sp|P33268|CP3A8_MACFA Cytochrome P450 3A8 (CYPIIIA8) (P450-MKNF2) (P-450-MK2)
Length = 503
Score = 58.2 bits (139), Expect = 6e-09
Identities = 25/55 (45%), Positives = 37/55 (67%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTI 183
P + PFG+GPRNCIG R A+M +KL + R + +F +T+ PLKL++GG +
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLL 483
>sp|P47787|THAS_PIG Thromboxane-A synthase (TXA synthase) (TXS)
Length = 534
Score = 57.8 bits (138), Expect = 8e-09
Identities = 25/62 (40%), Positives = 40/62 (64%)
Frame = +1
Query: 19 PMAWIPFGAGPRNCIGQRLAMMIIKLTLGRFINHFELVCSNKTENPLKLKIGGTIAPVNG 198
P ++PFGAGPR+C+G +L ++ IKLTL + F +T+ PL+L+ ++P NG
Sbjct: 467 PFTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACPETQVPLQLESKSALSPKNG 526
Query: 199 VH 204
V+
Sbjct: 527 VY 528
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,007,038
Number of Sequences: 369166
Number of extensions: 530720
Number of successful extensions: 1800
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1786
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1799
length of database: 68,354,980
effective HSP length: 79
effective length of database: 53,760,915
effective search space used: 1720349280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)