Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_I21
(608 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07909|ROA1_DROME Heterogeneous nuclear ribonucleoprotei... 77 3e-14
sp|P21522|ROA1_SCHAM Heterogeneous nuclear ribonucleoprotei... 75 1e-13
sp|Q99383|NAB4_YEAST Nuclear polyadenylated RNA-binding pro... 74 2e-13
sp|P51990|RO22_XENLA Heterogeneous nuclear ribonucleoprotei... 73 5e-13
sp|P49312|ROA1_MOUSE Heterogeneous nuclear ribonucleoprotei... 72 1e-12
sp|P09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotei... 72 1e-12
sp|P17130|ROA1_XENLA Heterogeneous nuclear ribonucleoprotei... 71 2e-12
sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoprotei... 71 2e-12
sp|P51989|RO21_XENLA Heterogeneous nuclear ribonucleoprotei... 71 2e-12
sp|O88569|ROA2_MOUSE Heterogeneous nuclear ribonucleoprotei... 71 2e-12
>sp|P07909|ROA1_DROME Heterogeneous nuclear ribonucleoprotein A1 (hnRNP core protein
A1-A) (PEN repeat clone P9)
Length = 365
Score = 77.0 bits (188), Expect = 3e-14
Identities = 39/108 (36%), Positives = 61/108 (56%), Gaps = 15/108 (13%)
Frame = +3
Query: 9 LRQYFGEYGTIVDA-VIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKA 185
+R YF +G IVD ++I+ G+ RGF FV F+D D VDK+++ + HQL+G+ ++VKKA
Sbjct: 138 IRDYFQHFGNIVDINIVIDKETGKKRGFAFVEFDDYDPVDKVVLQKQHQLNGKMVDVKKA 197
Query: 186 LPRDDNK--------------SNSKQSNPVGNKSTPKGGYNNNTGSNN 287
LP+ +++ ++ + GN GG N N G NN
Sbjct: 198 LPKQNDQQGGGGGRGGPGGRAGGNRGNMGGGNYGNQNGGGNWNNGGNN 245
Score = 62.4 bits (150), Expect = 9e-10
Identities = 26/67 (38%), Positives = 48/67 (71%), Gaps = 1/67 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
++L+ +F ++G IVD V++ + + SRGFGF+T+ + +D+ +RPH++DG+ +E K
Sbjct: 45 ENLKAHFEKWGNIVDVVVMKDPRTKRSRGFGFITYSHSSMIDEAQKSRPHKIDGRVVEPK 104
Query: 180 KALPRDD 200
+A+PR D
Sbjct: 105 RAVPRQD 111
>sp|P21522|ROA1_SCHAM Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog
Length = 342
Score = 75.5 bits (184), Expect = 1e-13
Identities = 39/93 (41%), Positives = 55/93 (59%), Gaps = 1/93 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDA-VIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+DLR YF +YGT+V A ++++ + RGF FV F+D D VDKI ++R HQ+ G+ I+VK
Sbjct: 122 NDLRDYFKQYGTVVSAAIVVDKETRKKRGFAFVEFDDYDPVDKICLSRNHQIRGKHIDVK 181
Query: 180 KALPRDDNKSNSKQSNPVGNKSTPKGGYNNNTG 278
KALP+ D P G +GG G
Sbjct: 182 KALPKGD--------APGGRGGGGRGGVGGGAG 206
Score = 59.7 bits (143), Expect = 6e-09
Identities = 27/67 (40%), Positives = 45/67 (67%), Gaps = 1/67 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ L+Q+F ++G IVD V++ + + SRGFGF+T+ VD RPH++DG+ +E K
Sbjct: 31 ESLKQHFEQWGEIVDVVVMKDPKTKRSRGFGFITYSRAHMVDDAQNARPHKVDGRVVEPK 90
Query: 180 KALPRDD 200
+A+PR +
Sbjct: 91 RAVPRTE 97
>sp|Q99383|NAB4_YEAST Nuclear polyadenylated RNA-binding protein 4
Length = 534
Score = 74.3 bits (181), Expect = 2e-13
Identities = 35/73 (47%), Positives = 53/73 (72%), Gaps = 1/73 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
D+LR+YFG+YGT+ D I+ + + G SRGFGF++FE SVD+++ T+ H LDG+ I+ K
Sbjct: 173 DNLREYFGKYGTVTDLKIMKDPATGRSRGFGFLSFEKPSSVDEVVKTQ-HILDGKVIDPK 231
Query: 180 KALPRDDNKSNSK 218
+A+PRD+ K
Sbjct: 232 RAIPRDEQDKTGK 244
Score = 70.5 bits (171), Expect = 3e-12
Identities = 35/101 (34%), Positives = 60/101 (59%), Gaps = 2/101 (1%)
Frame = +3
Query: 6 DLRQYFGEYGTIVDA-VIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKK 182
+ ++F ++GTI+DA ++++ G+SRGFGFVT++ D+VD++ + + IE+K+
Sbjct: 258 EFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSADAVDRVCQNKFIDFKDRKIEIKR 317
Query: 183 ALPRD-DNKSNSKQSNPVGNKSTPKGGYNNNTGSNNRYSQD 302
A PR KS++ N GN +GG N G N+ Q+
Sbjct: 318 AEPRHMQQKSSNNGGNNGGNNMNRRGGNFGNQGDFNQMYQN 358
>sp|P51990|RO22_XENLA Heterogeneous nuclear ribonucleoprotein A2 homolog 2 (hnRNP A2(B))
Length = 358
Score = 73.2 bits (178), Expect = 5e-13
Identities = 41/106 (38%), Positives = 59/106 (55%), Gaps = 6/106 (5%)
Frame = +3
Query: 9 LRQYFGEYGTIVDAVIINNS-NGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKA 185
LR+YF EYG I II + +G+ RGFGFVTF D D VDKI++ + H ++G + EV+KA
Sbjct: 116 LREYFEEYGKIESTEIITDKQSGKKRGFGFVTFNDHDPVDKIVLQKYHTINGHNAEVRKA 175
Query: 186 LPRDD-----NKSNSKQSNPVGNKSTPKGGYNNNTGSNNRYSQDDF 308
L + + N N++ N S G + + G N R D +
Sbjct: 176 LSKQEMQDVQNTRNNRGGNFGFGDSRGGGNFGSGPGGNFRGGSDGY 221
Score = 58.9 bits (141), Expect = 1e-08
Identities = 31/92 (33%), Positives = 54/92 (58%), Gaps = 1/92 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ LR ++ ++G + D V++ + ++ SRGFGFVTF + VD + RPH +DG+ +E K
Sbjct: 23 ESLRNFYEQWGQLTDCVVMRDPASKRSRGFGFVTFSCMNEVDAAMSARPHTIDGRVVEPK 82
Query: 180 KALPRDDNKSNSKQSNPVGNKSTPKGGYNNNT 275
+A+ R++ ++K V K GG +T
Sbjct: 83 RAVAREE---SAKPGAHVTVKKLFVGGIKEDT 111
>sp|P49312|ROA1_MOUSE Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing
protein) (Single-strand binding protein) (hnRNP core
protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed)
Length = 320
Score = 71.6 bits (174), Expect = 1e-12
Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 1/98 (1%)
Frame = +3
Query: 9 LRQYFGEYGTI-VDAVIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKA 185
LR YF +YG I V ++ + +G+ RGF FVTF+D DSVDKI++ + H ++G + EV+KA
Sbjct: 121 LRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKA 180
Query: 186 LPRDDNKSNSKQSNPVGNKSTPKGGYNNNTGSNNRYSQ 299
L + + S S GG G N+ + +
Sbjct: 181 LSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGR 218
Score = 65.1 bits (157), Expect = 1e-10
Identities = 28/69 (40%), Positives = 49/69 (71%), Gaps = 1/69 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ LR +F ++GT+ D V++ + N + SRGFGFVT+ + VD + RPH++DG+ +E K
Sbjct: 28 ESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPK 87
Query: 180 KALPRDDNK 206
+A+ R+D++
Sbjct: 88 RAVSREDSQ 96
>sp|P09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing
protein) (Single-strand binding protein) (hnRNP core
protein A1)
Length = 372
Score = 71.6 bits (174), Expect = 1e-12
Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 1/98 (1%)
Frame = +3
Query: 9 LRQYFGEYGTI-VDAVIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKA 185
LR YF +YG I V ++ + +G+ RGF FVTF+D DSVDKI++ + H ++G + EV+KA
Sbjct: 121 LRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKA 180
Query: 186 LPRDDNKSNSKQSNPVGNKSTPKGGYNNNTGSNNRYSQ 299
L + + S S GG G N+ + +
Sbjct: 181 LSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGR 218
Score = 65.1 bits (157), Expect = 1e-10
Identities = 28/69 (40%), Positives = 49/69 (71%), Gaps = 1/69 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ LR +F ++GT+ D V++ + N + SRGFGFVT+ + VD + RPH++DG+ +E K
Sbjct: 28 ESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPK 87
Query: 180 KALPRDDNK 206
+A+ R+D++
Sbjct: 88 RAVSREDSQ 96
>sp|P17130|ROA1_XENLA Heterogeneous nuclear ribonucleoproteins A1 homolog (hnRNP A1)
(Helix-destabilizing protein) (Single-strand binding
protein) (hnRNP core protein A1)
Length = 365
Score = 71.2 bits (173), Expect = 2e-12
Identities = 39/103 (37%), Positives = 60/103 (58%), Gaps = 1/103 (0%)
Frame = +3
Query: 3 DDLRQYFGEYGTI-VDAVIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
D LR+YF +YG I V ++ + +G+ RGF FVTFED DSVDKI++ + H ++ + +V+
Sbjct: 119 DHLREYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFEDHDSVDKIVIQKYHTVNNHNSQVR 178
Query: 180 KALPRDDNKSNSKQSNPVGNKSTPKGGYNNNTGSNNRYSQDDF 308
KAL + + S V +GG + N GS + D+F
Sbjct: 179 KALSKQEMAS-------VSGSQRERGG-SGNYGSRGGFGNDNF 213
Score = 70.5 bits (171), Expect = 3e-12
Identities = 30/68 (44%), Positives = 50/68 (73%), Gaps = 1/68 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ LR++F ++GT+ D V++ + N + SRGFGFVT+ TD VD + RPH++DG+ +E K
Sbjct: 28 ESLREHFEQWGTLTDCVVMRDPNSKRSRGFGFVTYLSTDEVDAAMTARPHKVDGRVVEPK 87
Query: 180 KALPRDDN 203
+A+ R+D+
Sbjct: 88 RAVSREDS 95
>sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2 / hnRNP
B1)
Length = 353
Score = 70.9 bits (172), Expect = 2e-12
Identities = 44/107 (41%), Positives = 61/107 (57%), Gaps = 7/107 (6%)
Frame = +3
Query: 9 LRQYFGEYGTI-VDAVIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKA 185
LR YF EYG I +I + +G+ RGFGFVTF+D D VDKI++ + H ++G + EV+KA
Sbjct: 128 LRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKA 187
Query: 186 LPRDD-NKSNSKQSNPVGN--KSTPKGGYNN---NTGSNNRYSQDDF 308
L R + + S +S GN +GG N GSN R D +
Sbjct: 188 LSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGY 234
Score = 61.2 bits (147), Expect = 2e-09
Identities = 26/68 (38%), Positives = 45/68 (66%), Gaps = 1/68 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ LR Y+ ++G + D V++ + ++ SRGFGFVTF VD + RPH +DG+ +E K
Sbjct: 35 ESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPK 94
Query: 180 KALPRDDN 203
+A+ R+++
Sbjct: 95 RAVAREES 102
>sp|P51989|RO21_XENLA Heterogeneous nuclear ribonucleoprotein A2 homolog 1 (hnRNP A2(A))
Length = 346
Score = 70.9 bits (172), Expect = 2e-12
Identities = 40/106 (37%), Positives = 59/106 (55%), Gaps = 6/106 (5%)
Frame = +3
Query: 9 LRQYFGEYGTIVDAVIINNS-NGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKA 185
LR+YF EYG I II + +G+ RGF FVTF+D D VDKI++ + H ++G + EV+KA
Sbjct: 116 LREYFEEYGKIDSIEIITDKQSGKKRGFAFVTFDDHDPVDKIVLQKYHTINGHNAEVRKA 175
Query: 186 LPRDD-----NKSNSKQSNPVGNKSTPKGGYNNNTGSNNRYSQDDF 308
L + + N N++ N S G + + G N R D +
Sbjct: 176 LSKQEMQDVQNTRNNRGGNFGFGDSRGGGNFGSGPGGNFRGGSDGY 221
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/92 (36%), Positives = 56/92 (60%), Gaps = 1/92 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ LR Y+ ++GT+ D V++ + ++ SRGFGFVTF + VD + TRPH +DG+ +E K
Sbjct: 23 ESLRNYYEQWGTLTDCVVMRDPASKRSRGFGFVTFSCMNEVDAAMATRPHTIDGRVVEPK 82
Query: 180 KALPRDDNKSNSKQSNPVGNKSTPKGGYNNNT 275
+A+ R++ ++K V K GG +T
Sbjct: 83 RAVAREE---SAKPGAHVTVKKLFVGGIKEDT 111
>sp|O88569|ROA2_MOUSE Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2 / hnRNP
B1)
Length = 341
Score = 70.9 bits (172), Expect = 2e-12
Identities = 44/107 (41%), Positives = 61/107 (57%), Gaps = 7/107 (6%)
Frame = +3
Query: 9 LRQYFGEYGTI-VDAVIINNSNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKA 185
LR YF EYG I +I + +G+ RGFGFVTF+D D VDKI++ + H ++G + EV+KA
Sbjct: 116 LRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKA 175
Query: 186 LPRDD-NKSNSKQSNPVGN--KSTPKGGYNN---NTGSNNRYSQDDF 308
L R + + S +S GN +GG N GSN R D +
Sbjct: 176 LSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGY 222
Score = 61.2 bits (147), Expect = 2e-09
Identities = 26/68 (38%), Positives = 45/68 (66%), Gaps = 1/68 (1%)
Frame = +3
Query: 3 DDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVTRPHQLDGQSIEVK 179
+ LR Y+ ++G + D V++ + ++ SRGFGFVTF VD + RPH +DG+ +E K
Sbjct: 23 ESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPK 82
Query: 180 KALPRDDN 203
+A+ R+++
Sbjct: 83 RAVAREES 90
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,591,258
Number of Sequences: 369166
Number of extensions: 853099
Number of successful extensions: 3861
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2777
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3472
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4748907085
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)