Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_I20
(891 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 281 2e-75
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 281 2e-75
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 280 4e-75
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 278 1e-74
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 271 1e-72
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 271 2e-72
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 268 1e-71
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 268 2e-71
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 266 6e-71
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 266 6e-71
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 281 bits (719), Expect = 2e-75
Identities = 133/220 (60%), Positives = 166/220 (75%), Gaps = 3/220 (1%)
Frame = +1
Query: 88 KLPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSND 267
++P +V+W +KG VT VKNQGQCGSCWAFS +G +EGQ F +L+S SEQ LVDCS+D
Sbjct: 113 QIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHD 172
Query: 268 FGNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQDGDCEYSKEKVVAHCQGFTDISHGS 444
GNQGCNGGLMD AFQYI + GL+ E YPY A+DG C+Y E VA+ GF DI
Sbjct: 173 QGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-Q 231
Query: 445 EEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYGND--EDS 618
E+ L + +ATVGPISV +DAS+PS QFY +G+Y E NCSS LDHGVL VGYG + + +
Sbjct: 232 EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSN 291
Query: 619 QQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 738
+ YWLVKNSWGK WG++GYIK++KD++N CG+AT ASYP
Sbjct: 292 KDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYP 331
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 281 bits (718), Expect = 2e-75
Identities = 135/221 (61%), Positives = 162/221 (73%), Gaps = 3/221 (1%)
Frame = +1
Query: 91 LPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSNDF 270
LP SV+W KKGYVT VKNQ QCGSCWAFS TG++EGQ F+ +LVS SEQ LVDCS
Sbjct: 114 LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ 173
Query: 271 GNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQDGDCEYSKEKVVAHCQGFTDISHGSE 447
GNQGCNGG M AFQY+ + GL+ E YPY A D C+Y E VA+ GFT ++ G E
Sbjct: 174 GNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKE 233
Query: 448 EDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYGNDEDSQQN 627
+ L + +ATVGPISV +DA + SFQFYK+G+Y E +CSS LDHGVL VGYG + + N
Sbjct: 234 KALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNN 293
Query: 628 --YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 744
YWLVKNSWG WG NGY+K++KDK+N CGIAT ASYPN+
Sbjct: 294 SKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 280 bits (716), Expect = 4e-75
Identities = 137/220 (62%), Positives = 164/220 (74%), Gaps = 3/220 (1%)
Frame = +1
Query: 88 KLPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSND 267
K+P SV+W +KG VT VKNQGQCGSCWAFS +G +EGQ F +L+S SEQ LVDCS+
Sbjct: 113 KIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHA 172
Query: 268 FGNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQDGDCEYSKEKVVAHCQGFTDISHGS 444
GNQGCNGGLMD AFQYI + GL+ E YPY A+DG C+Y E VA+ GF DI
Sbjct: 173 QGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-Q 231
Query: 445 EEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYGND-EDSQ 621
E+ L + +ATVGPISV +DAS+PS QFY +G+Y E NCSS LDHGVL VGYG + DS
Sbjct: 232 EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSN 291
Query: 622 QN-YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 738
+N YWLVKNSWG WG+ GYIK++KD+DN CG+AT ASYP
Sbjct: 292 KNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYP 331
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 278 bits (712), Expect = 1e-74
Identities = 134/243 (55%), Positives = 172/243 (70%), Gaps = 3/243 (1%)
Frame = +1
Query: 19 YLQYKPMVKLDHPIKSANYSTKTK--LPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSM 192
Y +K + D K + + LP SV+W KG VT VK+QG CGSCWAFS+TG++
Sbjct: 98 YTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGAL 157
Query: 193 EGQYFKNNKQLVSFSEQQLVDCSNDFGNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQ 369
EGQ+F+ + LVS SEQ LVDCS +GN GCNGGLMD+AF+YI G++ E+ YPY A
Sbjct: 158 EGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAI 217
Query: 370 DGDCEYSKEKVVAHCQGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDE 549
D C ++K V A +GFTDI G E+ +AE +ATVGP+SV IDAS+ SFQFY GVY+E
Sbjct: 218 DDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNE 277
Query: 550 ENCSSTQLDHGVLAVGYGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMA 729
C + LDHGVL VG+G DE S ++YWLVKNSWG +WG G+IKM ++K+NQCGIA+ +
Sbjct: 278 PQCDAQNLDHGVLVVGFGTDE-SGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASAS 336
Query: 730 SYP 738
SYP
Sbjct: 337 SYP 339
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 271 bits (694), Expect = 1e-72
Identities = 132/219 (60%), Positives = 157/219 (71%), Gaps = 1/219 (0%)
Frame = +1
Query: 91 LPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSNDF 270
+P SV+W KKGYVT VKNQGQCGSCWAFS TG++EGQ F+ +LVS SEQ LVD S
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 271 GNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQDGDCEYSKEKVVAHCQGFTDISHGSE 447
GNQGCNGGLMD+AFQYI + GL+ E YPY A D C Y E A GF DI E
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIPQ-RE 119
Query: 448 EDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYGNDEDSQQN 627
+ L + +ATVGPISV IDA + SFQFYK+G+Y + +CSS LDHGVL VGYG E +
Sbjct: 120 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYG-FEGTNNK 178
Query: 628 YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 744
+W+VKNSWG WG GY+KM+KD++N CGIAT ASYP +
Sbjct: 179 FWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 271 bits (693), Expect = 2e-72
Identities = 135/222 (60%), Positives = 159/222 (71%), Gaps = 4/222 (1%)
Frame = +1
Query: 91 LPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSNDF 270
+P SV+W KKGYVT VKNQGQCGSCWAFS TG++EGQ F+ +LVS SEQ LVDCS
Sbjct: 114 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 271 GNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQD-GDCEYSKEKVVAHCQGFTDISHGS 444
GNQGCNGGLMD+AFQYI GL+ E YPY A D C Y E A+ GF DI
Sbjct: 174 GNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQ-R 232
Query: 445 EEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYG-NDEDSQ 621
E+ L + +ATVGPISV IDA + SFQFYK+G+Y + +CS LDHGVL VGYG DS
Sbjct: 233 EKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSN 292
Query: 622 QN-YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 744
N +W+VKNSWG WG NGY+KM+KD++N CGIAT ASYP +
Sbjct: 293 NNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 268 bits (686), Expect = 1e-71
Identities = 128/220 (58%), Positives = 158/220 (71%), Gaps = 3/220 (1%)
Frame = +1
Query: 94 PDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSNDFG 273
P SV+W +KGYVT VKNQGQCGSCWAFS TG++EGQ F+ +L+S SEQ LVDCS G
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 274 NQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQDGDCEYSKEKVVAHCQGFTDISHGSEE 450
N+GCNGGLMD AFQY+ GL+ E YPY A + C+Y+ + VA+ GF DI E+
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEK 233
Query: 451 DLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYG--NDEDSQQ 624
L + +ATVGPISV IDA + SF FYK G+Y E +CSS +DHGVL VGYG + E
Sbjct: 234 ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 625 NYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 744
YWLVKNSWG+ WG+ GY+KM+KD+ N CGIA+ ASYP +
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 268 bits (684), Expect = 2e-71
Identities = 128/222 (57%), Positives = 161/222 (72%), Gaps = 3/222 (1%)
Frame = +1
Query: 88 KLPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSND 267
++P SV+W +KGYVT VKNQGQCGSCWAFS TG++EGQ F+ +LVS SEQ LVDCS
Sbjct: 113 EIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRA 172
Query: 268 FGNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQDGD-CEYSKEKVVAHCQGFTDISHG 441
GN+GCNGGLMD+AF+Y+ GL+ E YPY +D + C Y E A+ GF D+
Sbjct: 173 QGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ- 231
Query: 442 SEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYG-NDEDS 618
E+ L + +AT+GPISV IDA + SFQFYK+G+Y + +CSS LDHGVL VGYG DS
Sbjct: 232 REKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDS 291
Query: 619 QQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 744
+W+VKNSWG WG NGY+KM+KD++N CGIAT ASYP +
Sbjct: 292 NNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 266 bits (680), Expect = 6e-71
Identities = 124/219 (56%), Positives = 158/219 (72%), Gaps = 1/219 (0%)
Frame = +1
Query: 91 LPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSNDF 270
+P SV+W + G VT VK+QG CGSCWAFS+TG++EGQ+F+ LVS SEQ LVDCS +
Sbjct: 122 VPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKY 181
Query: 271 GNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQDGDCEYSKEKVVAHCQGFTDISHGSE 447
GN GCNGGLMD+AF+YI G++ E+ YPY D C ++K + A GF DI G E
Sbjct: 182 GNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDE 241
Query: 448 EDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYGNDEDSQQN 627
E + + +AT+GP+SV IDAS+ SFQ Y GVY+E C LDHGVL VGYG DE S +
Sbjct: 242 EKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDE-SGMD 300
Query: 628 YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 744
YWLVKNSWG +WG GYIKM+++++NQCGIAT +SYP +
Sbjct: 301 YWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 266 bits (680), Expect = 6e-71
Identities = 128/223 (57%), Positives = 160/223 (71%), Gaps = 4/223 (1%)
Frame = +1
Query: 88 KLPDSVNWVKKGYVTQVKNQGQCGSCWAFSTTGSMEGQYFKNNKQLVSFSEQQLVDCSND 267
++P SV+W +KGYVT VKNQGQCGSCWAFS TG++EGQ F+ +LVS SEQ LVDCS
Sbjct: 113 EVPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRP 172
Query: 268 FGNQGCNGGLMDSAFQYIMQY-GLEKERDYPYTAQD-GDCEYSKEKVVAHCQGFTDISHG 441
GNQGCNGGLMD+AFQY+ GL+ E YPY ++ C Y E A+ GF DI
Sbjct: 173 QGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ- 231
Query: 442 SEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVGYG--NDED 615
E+ L + +ATVGPISV IDA + SFQFYK+G+Y + +CSS LDHGVL VGYG +
Sbjct: 232 REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDS 291
Query: 616 SQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 744
+ +W+VKNSWG WG NGY+KM+KD++N CGI+T ASYP +
Sbjct: 292 NSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,371,015
Number of Sequences: 369166
Number of extensions: 2062493
Number of successful extensions: 6090
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5226
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5486
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8934348180
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)