Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_H05-1
(724 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q15075|EEA1_HUMAN Early endosome antigen 1 (Endosome-ass... 120 3e-27
sp|Q8BL66|EEA1_MOUSE Early endosome antigen 1 117 2e-26
sp|Q96T51|RUFY1_HUMAN RUN and FYVE domain containing protei... 94 3e-19
sp|P34657|YOTB_CAEEL Hypothetical protein ZK632.12 in chrom... 71 3e-12
sp|Q13615|MTMR3_HUMAN Myotubularin-related protein 3 (FYVE ... 70 7e-12
sp|Q6ZV73|FGD6_HUMAN FYVE, RhoGEF and PH domain containing ... 70 7e-12
sp|Q9HCC9|ZFY28_HUMAN Zinc finger FYVE domain-containing pr... 69 2e-11
sp|Q69ZL1|FGD6_MOUSE FYVE, RhoGEF and PH domain containing ... 65 2e-10
sp|Q80U44|ZFY16_MOUSE Zinc finger FYVE domain-containing pr... 65 2e-10
sp|Q7Z3T8|ZFY16_HUMAN Zinc finger FYVE domain-containing pr... 64 5e-10
>sp|Q15075|EEA1_HUMAN Early endosome antigen 1 (Endosome-associated protein p162) (Zinc
finger FYVE domain-containing protein 2)
Length = 1411
Score = 120 bits (302), Expect = 3e-27
Identities = 65/207 (31%), Positives = 110/207 (53%), Gaps = 8/207 (3%)
Frame = +3
Query: 27 DELKNNFENMKKSLHRTEEDLETEKNLRESERNNMMEKISQLSEQIVVLENMRNDYEQKM 206
+ELK F + LH ++ E E + +I+ L+E + ++ ++++
Sbjct: 1205 EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264
Query: 207 EVIE--TDNIENKLRLETANXXXXXXXXXIIQVENNLKKQTELFSKKC------REFDQL 362
+E TD++ ++ + A + +E LK + E+ + R+ D
Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRAL-LERCLKGEGEIEKLQTKVLELQRKLDNT 1323
Query: 363 QSAILDLGRENQSLQISKEKLTNRQWIGDVEAIECFTCHKPFSLTLRKHHCRNCGQVYCQ 542
+A+ +LGRENQSLQI + NR+W D E C C K FS+T+R+HHCR CG ++C
Sbjct: 1324 TAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCA 1383
Query: 543 DCSSKSASLAVSRKPVRVCDSCYMEVQ 623
+CS+K+A S+KPVRVCD+C+ ++Q
Sbjct: 1384 ECSAKNALTPSSKKPVRVCDACFNDLQ 1410
Score = 39.7 bits (91), Expect = 0.008
Identities = 35/146 (23%), Positives = 74/146 (50%), Gaps = 4/146 (2%)
Frame = +3
Query: 12 LISQCDELKNNFENMKKSLHR--TEEDLETEKNLRESERNNMMEK-ISQLSEQIVVLENM 182
L + D +N ++ ++ L++ T+ D T K + E + +E + + E+ + LE
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 183 RNDYEQKMEVIETDNIENKLRLETANXXXXXXXXXIIQVENNLK-KQTELFSKKCREFDQ 359
+ E +++ +E D++E K E A Q+ +L+ + TEL + E +
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQR----QLNTDLELRATELSKQLEMEKEI 780
Query: 360 LQSAILDLGRENQSLQISKEKLTNRQ 437
+ S LDL +++++L+ K+KLT ++
Sbjct: 781 VSSTRLDLQKKSEALESIKQKLTKQE 806
Score = 32.0 bits (71), Expect = 1.7
Identities = 32/136 (23%), Positives = 53/136 (38%), Gaps = 3/136 (2%)
Frame = +3
Query: 27 DELKNNFENMKKSLHRTEE---DLETEKNLRESERNNMMEKISQLSEQIVVLENMRNDYE 197
+ L + + K L ++ LET N S+ N EK+SQL QI + E
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Query: 198 QKMEVIETDNIENKLRLETANXXXXXXXXXIIQVENNLKKQTELFSKKCREFDQLQSAIL 377
D ++N L+TA + ++ L + T K QL+S +
Sbjct: 656 AAKTAQRAD-LQN--HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 378 DLGRENQSLQISKEKL 425
+ + SL+ E+L
Sbjct: 713 EYKEKYLSLEQKTEEL 728
>sp|Q8BL66|EEA1_MOUSE Early endosome antigen 1
Length = 1411
Score = 117 bits (294), Expect = 2e-26
Identities = 62/207 (29%), Positives = 110/207 (53%), Gaps = 8/207 (3%)
Frame = +3
Query: 27 DELKNNFENMKKSLHRTEEDLETEKNLRESERNNMMEKISQLSEQIVVLENMRNDYEQKM 206
++ K F + LH ++ E E + +++ L+E + ++ ++++
Sbjct: 1205 EKRKEEFSEKEAKLHSEIKEKEAGMKKHEENEAKLTMQVTTLNENLGTVKKEWQSSQRRV 1264
Query: 207 EVIE--TDNIENKLRLETANXXXXXXXXXIIQVENNLKKQTELFSKKC------REFDQL 362
+E TD++ ++ + A + +E LK + E+ + R+ D
Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRAL-LERCLKGEGEIEKLQTKALELQRKLDNT 1323
Query: 363 QSAILDLGRENQSLQISKEKLTNRQWIGDVEAIECFTCHKPFSLTLRKHHCRNCGQVYCQ 542
+A+ +LGRENQSLQI + NR+W D E C +C K FS+T+R+HHCR CG ++C
Sbjct: 1324 TAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKCFSVTVRRHHCRQCGNIFCA 1383
Query: 543 DCSSKSASLAVSRKPVRVCDSCYMEVQ 623
+CS+K+A S+KPVRVCD+C+ ++Q
Sbjct: 1384 ECSTKNALTPSSKKPVRVCDACFNDLQ 1410
Score = 32.7 bits (73), Expect = 1.0
Identities = 36/149 (24%), Positives = 60/149 (40%), Gaps = 3/149 (2%)
Frame = +3
Query: 27 DELKNNFENMKKSLHRTEE---DLETEKNLRESERNNMMEKISQLSEQIVVLENMRNDYE 197
+ L + + K L ++ LET + S+ N EK+SQL QI + E
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVSELSSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Query: 198 QKMEVIETDNIENKLRLETANXXXXXXXXXIIQVENNLKKQTELFSKKCREFDQLQSAIL 377
D ++N L+TA + +V L + T F +K QL+S +
Sbjct: 656 AAKAAQRAD-LQN--HLDTAQHALQDKQQELNKVSVQLDQLTAKFQEKQEHCIQLESHLK 712
Query: 378 DLGRENQSLQISKEKLTNRQWIGDVEAIE 464
D ++ SL+ E L + +A+E
Sbjct: 713 DHKEKHLSLEQKVEDLEGHIKKLEADALE 741
>sp|Q96T51|RUFY1_HUMAN RUN and FYVE domain containing protein 1 (FYVE-finger protein EIP1)
(Zinc finger FYVE domain containing protein 12)
Length = 600
Score = 94.4 bits (233), Expect = 3e-19
Identities = 74/234 (31%), Positives = 112/234 (47%), Gaps = 33/234 (14%)
Frame = +3
Query: 9 SLISQCDELKNNFEN----MKKSLHRTEEDLETEKNLRES--ERNNMMEK---------- 140
S + Q +E +FE + S+ + EE L+ + R+ ER++ +++
Sbjct: 367 SSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQ 426
Query: 141 --ISQLSEQIVVLEN-MRNDYEQKM----EVIETDNIENKLRLETANXXXXXXXXXIIQV 299
+SQL EQ LE ++++ EQ+ E+ + + LR+E + QV
Sbjct: 427 LQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRME------------LQQV 474
Query: 300 ENNLKKQTELFSKK------CREFDQ-LQSAILDLGRENQSLQISKE---KLTNRQWIGD 449
E K+ EL +K C E +Q LQ L L + ++ KE L W+ D
Sbjct: 475 EGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKD 534
Query: 450 VEAIECFTCHKPFSLTLRKHHCRNCGQVYCQDCSSKSASLAVSRKPVRVCDSCY 611
EA C C K FS++ RKHHCRNCG ++C CSS +L KPVRVCDSC+
Sbjct: 535 DEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCH 588
>sp|P34657|YOTB_CAEEL Hypothetical protein ZK632.12 in chromosome III
Length = 266
Score = 71.2 bits (173), Expect = 3e-12
Identities = 31/60 (51%), Positives = 42/60 (70%), Gaps = 2/60 (3%)
Frame = +3
Query: 438 WIGDVEAIECFTCHKP-FSLTLRKHHCRNCGQVYCQDCSSKSASL-AVSRKPVRVCDSCY 611
W+ D EA++C C K F+L R+HHCRNCG+V C CSS++ + V +KPVRVCD C+
Sbjct: 149 WVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVHKKPVRVCDHCF 208
>sp|Q13615|MTMR3_HUMAN Myotubularin-related protein 3 (FYVE domain-containing dual
specificity protein phosphatase 1) (FYVE-DSP1) (Zinc
finger FYVE domain containing protein 10)
Length = 1198
Score = 69.7 bits (169), Expect = 7e-12
Identities = 46/163 (28%), Positives = 70/163 (42%), Gaps = 16/163 (9%)
Frame = +3
Query: 171 LENMRNDYEQKMEVIETDNIENKLRLETA--------NXXXXXXXXXIIQVENNLKKQ-- 320
L + + ++Q++E ++ E K RLE+ N I E+NL +
Sbjct: 1031 LRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCL 1090
Query: 321 ----TELFSKKCREFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDVEAIECFTCHKPF 488
TE+FS+ E Q+ K+ +W+ D A C+ C F
Sbjct: 1091 SRCSTEIFSEASWE------------------QVDKQDTEMTRWLPDHLAAHCYACDSAF 1132
Query: 489 SLTLRKHHCRNCGQVYCQDCSSKSASLAVSR--KPVRVCDSCY 611
L RKHHCRNCG V+C C ++ + + +P RVC SCY
Sbjct: 1133 WLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCY 1175
>sp|Q6ZV73|FGD6_HUMAN FYVE, RhoGEF and PH domain containing protein 6 (Zinc finger FYVE
domain containing protein 24)
Length = 1430
Score = 69.7 bits (169), Expect = 7e-12
Identities = 29/63 (46%), Positives = 38/63 (60%), Gaps = 1/63 (1%)
Frame = +3
Query: 438 WIGDVEAIECFTCHKPFSLTLRKHHCRNCGQVYCQDCSSKSASL-AVSRKPVRVCDSCYM 614
WI D A C C F+LT R+HHCR CG++ CQ CSS L + +P RVC+ C+
Sbjct: 1219 WIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQ 1278
Query: 615 EVQ 623
E+Q
Sbjct: 1279 ELQ 1281
>sp|Q9HCC9|ZFY28_HUMAN Zinc finger FYVE domain-containing protein 28
Length = 887
Score = 68.6 bits (166), Expect = 2e-11
Identities = 30/62 (48%), Positives = 38/62 (61%), Gaps = 2/62 (3%)
Frame = +3
Query: 435 QWIGDVEAIECFTCHKPFSLTLRKHHCRNCGQVYCQDCSSKSASLA--VSRKPVRVCDSC 608
+W+ D C C PF++ RKHHCR+CG+++C CSS SA L KPVRVC C
Sbjct: 813 EWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHC 872
Query: 609 YM 614
YM
Sbjct: 873 YM 874
>sp|Q69ZL1|FGD6_MOUSE FYVE, RhoGEF and PH domain containing protein 6
Length = 1399
Score = 65.1 bits (157), Expect = 2e-10
Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 1/63 (1%)
Frame = +3
Query: 438 WIGDVEAIECFTCHKPFSLTLRKHHCRNCGQVYCQDCSSKSASL-AVSRKPVRVCDSCYM 614
WI D A C C F+LT R+HHCR CG++ CQ CSS L + + RVC+ C+
Sbjct: 1188 WIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKGQLARVCEHCFQ 1247
Query: 615 EVQ 623
E+Q
Sbjct: 1248 ELQ 1250
>sp|Q80U44|ZFY16_MOUSE Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal
associated FYVE domain protein)
Length = 1528
Score = 64.7 bits (156), Expect = 2e-10
Identities = 28/75 (37%), Positives = 41/75 (54%)
Frame = +3
Query: 387 RENQSLQISKEKLTNRQWIGDVEAIECFTCHKPFSLTLRKHHCRNCGQVYCQDCSSKSAS 566
+ +SL + +++ T W+ D EA C C F+ T R+HHCR CG+V+C C ++
Sbjct: 718 KRKESLVLGQKQPT---WVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCK 774
Query: 567 LAVSRKPVRVCDSCY 611
L K RVC CY
Sbjct: 775 LQYLEKEARVCVICY 789
>sp|Q7Z3T8|ZFY16_HUMAN Zinc finger FYVE domain-containing protein 16 (Endofin)
(Endosome-associated FYVE domain protein)
Length = 1539
Score = 63.5 bits (153), Expect = 5e-10
Identities = 25/58 (43%), Positives = 32/58 (55%)
Frame = +3
Query: 438 WIGDVEAIECFTCHKPFSLTLRKHHCRNCGQVYCQDCSSKSASLAVSRKPVRVCDSCY 611
W+ D EA C C F+ T R+HHCR CG+V+C C ++ L K RVC CY
Sbjct: 744 WVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCY 801
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,918,308
Number of Sequences: 369166
Number of extensions: 1388664
Number of successful extensions: 5992
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5336
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5924
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6462248555
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)