Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_G17
(932 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q11136|PEPD_MOUSE Xaa-Pro dipeptidase (X-Pro dipeptidase... 361 2e-99
sp|P12955|PEPD_HUMAN Xaa-Pro dipeptidase (X-Pro dipeptidase... 359 5e-99
sp|P44881|AMPP_HAEIN Xaa-Pro aminopeptidase (X-Pro aminopep... 117 6e-26
sp|P43590|YFH6_YEAST Hypothetical 61.8 kDa peptidase in MPR... 104 3e-22
sp|P15034|AMPP_ECOLI Xaa-Pro aminopeptidase (X-Pro aminopep... 103 5e-22
sp|P81535|PEPQ_PYRFU Xaa-Pro dipeptidase (X-Pro dipeptidase... 72 2e-12
sp|P40051|YEQ8_YEAST Hypothetical 58.0 kDa peptidase in PTP... 70 6e-12
sp|Q10439|YDE5_SCHPO Probable peptidase C12B10.05 66 1e-10
sp|P54518|YQHT_BACSU Putative peptidase yqhT 61 4e-09
sp|O58885|PEPQ_PYRHO Xaa-Pro dipeptidase (X-Pro dipeptidase... 61 4e-09
>sp|Q11136|PEPD_MOUSE Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase) (Peptidase 4)
Length = 493
Score = 361 bits (926), Expect = 2e-99
Identities = 171/309 (55%), Positives = 229/309 (74%), Gaps = 1/309 (0%)
Frame = +1
Query: 1 ARRVVPAYQLG-DALSVPMTLHTENRKRLCAKMKATNKINNNAFILLQGGTDHYLGGSDS 177
A V P++ LG + L VP+ L NR+RLC +++ + + ++LQGG + +D+
Sbjct: 2 ASTVRPSFSLGNETLKVPLALFALNRQRLCERLRKNGAVQAASAVVLQGGEEMQRYCTDT 61
Query: 178 ALTFRQESYFHWAFGVLEPDFYGLIHIDSTKTILFMPRLDERYAIFMGALETKDDVKQKY 357
++ FRQES+FHWAFGV+E YG+I +D+ K+ LF+PRL + YA +MG + +K+ K+KY
Sbjct: 62 SIIFRQESFFHWAFGVVESGCYGVIDVDTGKSTLFVPRLPDSYATWMGKIHSKEYFKEKY 121
Query: 358 AVDEVYYTDEILNVLEELKPSEIHTLHGLNTDSNNYTMEASFTGIANFQVINSVLHNEIT 537
AVD+V YTDEI +VL PS + TL G+NTDS + EASF GI+ F V N++LH EI
Sbjct: 122 AVDDVQYTDEIASVLTSRNPSVLLTLRGVNTDSGSVCREASFEGISKFNVNNTILHPEIV 181
Query: 538 ECRVIKTNQELEVLRYANKASSKAHRDIMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAY 717
ECRV KT+ ELEVLRY N+ SS+AHR++M++V GM EY++ESLF H+CY G MR+ +Y
Sbjct: 182 ECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSRGGMRHTSY 241
Query: 718 TSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKD 897
T I +G N +VLHYGHAGAPNDR I+DGD+CLFDMGGEYYC++SDITCSFP NG FT+D
Sbjct: 242 TCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTED 301
Query: 898 QKIVYEAVL 924
QK +YEAVL
Sbjct: 302 QKAIYEAVL 310
>sp|P12955|PEPD_HUMAN Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase)
Length = 493
Score = 359 bits (922), Expect = 5e-99
Identities = 171/304 (56%), Positives = 225/304 (74%), Gaps = 1/304 (0%)
Frame = +1
Query: 16 PAYQLG-DALSVPMTLHTENRKRLCAKMKATNKINNNAFILLQGGTDHYLGGSDSALTFR 192
P++ LG + L VP+ L NR+RLC +++ + + ++LQGG + +D+ + FR
Sbjct: 7 PSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFR 66
Query: 193 QESYFHWAFGVLEPDFYGLIHIDSTKTILFMPRLDERYAIFMGALETKDDVKQKYAVDEV 372
QES+FHWAFGV EP YG+I +D+ K+ LF+PRL +A +MG + +K+ K+KYAVD+V
Sbjct: 67 QESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDV 126
Query: 373 YYTDEILNVLEELKPSEIHTLHGLNTDSNNYTMEASFTGIANFQVINSVLHNEITECRVI 552
Y DEI +VL KPS + TL G+NTDS + EASF GI+ F+V N++LH EI ECRV
Sbjct: 127 QYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVF 186
Query: 553 KTNQELEVLRYANKASSKAHRDIMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGA 732
KT+ ELEVLRY NK SS+AHR++M++V GM EY++ESLF H+CY G MR+ +YT I
Sbjct: 187 KTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICG 246
Query: 733 TGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVY 912
+G N +VLHYGHAGAPNDR I++GDMCLFDMGGEYYC++SDITCSFP NG FT DQK VY
Sbjct: 247 SGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVY 306
Query: 913 EAVL 924
EAVL
Sbjct: 307 EAVL 310
>sp|P44881|AMPP_HAEIN Xaa-Pro aminopeptidase (X-Pro aminopeptidase) (Aminopeptidase P II)
(APP-II) (Aminoacylproline aminopeptidase)
Length = 430
Score = 117 bits (292), Expect = 6e-26
Identities = 92/308 (29%), Positives = 150/308 (48%), Gaps = 6/308 (1%)
Frame = +1
Query: 25 QLGDALSVPMTLHTENRKRLCAKMKATNKINNNAFILLQGGTDHYLGGSDSALTFRQESY 204
+L +P E R R+ A+M+ N+A +L +D FRQ+SY
Sbjct: 2 ELAYMAKLPKEEFEERRTRVFAQMQP-----NSALLLFSEIEKRR--NNDCTYPFRQDSY 54
Query: 205 FHWAFGVLEPDFYGLIHIDST--KTILFMPRLDERYAIFMGALETKDDVKQKYAVDEVYY 378
F + G EP+ L+ K I+F+ D + G + Q+ V+E Y
Sbjct: 55 FWYLTGFNEPNAALLLLKTEQVEKAIIFLRPRDPLLETWNGRRLGVERAPQQLNVNEAYS 114
Query: 379 TDEILNVLEELKPSEIHTLH--GLNTDSNNYTMEAS--FTGIANFQVINSVLHNEITECR 546
+E VL ++ + H ++T + E++ F+ I +++ + ++E R
Sbjct: 115 IEEFATVLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWRPM-------LSEMR 167
Query: 547 VIKTNQELEVLRYANKASSKAHRDIMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSI 726
+IK+ E+ +++ A + ++ H M++ P +EY+IES LH H A R +Y SI
Sbjct: 168 LIKSPNEIRLMQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCA-RFPSYNSI 226
Query: 727 GATGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKI 906
A G N +LHY NDR + DGD+ L D G E+ Y+ DIT +FPVNG F++ Q+
Sbjct: 227 VAGGSNACILHY----TENDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQRE 282
Query: 907 VYEAVLAA 930
+YE VL A
Sbjct: 283 IYELVLKA 290
>sp|P43590|YFH6_YEAST Hypothetical 61.8 kDa peptidase in MPR1-GCN20 intergenic region
Length = 535
Score = 104 bits (260), Expect = 3e-22
Identities = 77/251 (30%), Positives = 115/251 (45%)
Frame = +1
Query: 172 DSALTFRQESYFHWAFGVLEPDFYGLIHIDSTKTILFMPRLDERYAIFMGALETKDDVKQ 351
D+ FRQ YF+ GV P L + + K LF+P +DE I+ G + D+ +
Sbjct: 113 DTNKDFRQNRYFYHLSGVDIPASAILFNCSTDKLTLFLPNIDEEDVIWSGMPLSLDEAMR 172
Query: 352 KYAVDEVYYTDEILNVLEELKPSEIHTLHGLNTDSNNYTMEASFTGIANFQVINSVLHNE 531
+ +DE Y ++ +EL+ I T N N + NF
Sbjct: 173 VFDIDEALYISDLGKKFKELQDFAIFTTDLDNVHDENIA-RSLIPSDPNF-------FYA 224
Query: 532 ITECRVIKTNQELEVLRYANKASSKAHRDIMRSVHPGMYEYQIESLFLHHCYFHGAMRNV 711
+ E R IK E+E +R A + S K+H +M ++ + E QI++ F +H G R++
Sbjct: 225 MDETRAIKDWYEIESIRKACQISDKSHLAVMSALPIELNELQIQAEFEYHATRQGG-RSL 283
Query: 712 AYTSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFT 891
Y I +G C LHY N I+ L D G E+ Y+SDIT FP +G FT
Sbjct: 284 GYDPICCSGPACGTLHY----VKNSEDIKGKHSILIDAGAEWRQYTSDITRCFPTSGKFT 339
Query: 892 KDQKIVYEAVL 924
+ + VYE VL
Sbjct: 340 AEHREVYETVL 350
>sp|P15034|AMPP_ECOLI Xaa-Pro aminopeptidase (X-Pro aminopeptidase) (Aminopeptidase P II)
(APP-II) (Aminoacylproline aminopeptidase)
Length = 441
Score = 103 bits (258), Expect = 5e-22
Identities = 86/275 (31%), Positives = 128/275 (46%), Gaps = 23/275 (8%)
Frame = +1
Query: 169 SDSALTFRQESYFHWAFGVLEPD-FYGLIHIDSTK--TILFMPRLDERYAIFMGALETKD 339
+DS +RQ S F + G EP+ LI D T ++LF D I+ G +D
Sbjct: 38 ADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQD 97
Query: 340 DVKQKYAVDEVYYTDEILNVLEELKPSEIHTLHGLNTDSNNYTMEASFTGIANFQVINSV 519
+K VD EI L +L L+GL+ + E ++ + ++NS
Sbjct: 98 AAPEKLGVDRALAFSEINQQLYQL-------LNGLDVVYHAQG-EYAYADV----IVNSA 145
Query: 520 LHN--------------------EITECRVIKTNQELEVLRYANKASSKAHRDIMRSVHP 639
L + E R+ K+ +E+ VLR A + ++ AH M P
Sbjct: 146 LEKLRKGSRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRP 205
Query: 640 GMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLF 819
GM+EY +E H HGA R +Y +I +G N +LHY N+ ++ DGD+ L
Sbjct: 206 GMFEYHLEGEIHHEFNRHGA-RYPSYNTIVGSGENGCILHY----TENECEMRDGDLVLI 260
Query: 820 DMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVL 924
D G EY Y+ DIT +FPVNG FT+ Q+ +Y+ VL
Sbjct: 261 DAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVL 295
>sp|P81535|PEPQ_PYRFU Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase)
Length = 348
Score = 72.0 bits (175), Expect = 2e-12
Identities = 63/229 (27%), Positives = 113/229 (49%)
Frame = +1
Query: 244 GLIHIDSTKTILFMPRLDERYAIFMGALETKDDVKQKYAVDEVYYTDEILNVLEELKPSE 423
G I +D + L++P L+ M E+K V + DE+Y E LK +E
Sbjct: 40 GYIIVDGDEATLYVPELEYE----MAKEESKLPVVKFKKFDEIY---------EILKNTE 86
Query: 424 IHTLHGLNTDSNNYTMEASFTGIANFQVINSVLHNEITECRVIKTNQELEVLRYANKASS 603
+ G + +Y+M +F +N + + + I + R+IKT +E+E++ A + +
Sbjct: 87 TLGIEG----TLSYSMVENFKEKSNVKEFKKI-DDVIKDLRIIKTKEEIEIIEKACEIAD 141
Query: 604 KAHRDIMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPN 783
KA + + G E ++ + + +GA + A+ +I A+G ++ H G +
Sbjct: 142 KAVMAAIEEITEGKREREVAAKVEYLMKMNGAEKP-AFDTIIASGHRSALPH----GVAS 196
Query: 784 DRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAA 930
D++IE GD+ + D+G Y Y+SDIT + V G + Q+ +YE VL A
Sbjct: 197 DKRIERGDLVVIDLGALYNHYNSDITRTIVV-GSPNEKQREIYEIVLEA 244
>sp|P40051|YEQ8_YEAST Hypothetical 58.0 kDa peptidase in PTP3-ILV1 intergenic region
Length = 511
Score = 70.5 bits (171), Expect = 6e-12
Identities = 78/291 (26%), Positives = 122/291 (41%), Gaps = 27/291 (9%)
Frame = +1
Query: 133 LLQGGTDHYLGGSDSALTFRQESYFHWAFGVLEPDFYGLIHIDSTKTILFMPRLDERYAI 312
++ G D F+QE+ + G EP+ + IL P I
Sbjct: 87 VILAGNDIQFASGAVFYPFQQENDLFYLSGWNEPN---------SVMILEKPTDSLSDTI 137
Query: 313 FMGALETKDDVKQK--------YAVDEVYYTDEI--LNVLEELKPSEIHT--------LH 438
F + KD +K Y V E++ DE +N L + P I+ L
Sbjct: 138 FHMLVPPKDAFAEKWEGFRSGVYGVQEIFNADESASINDLSKYLPKIINRNDFIYFDMLS 197
Query: 439 GLNTDSNNYT-MEASFTGIANF-QVINSV-------LHNEITECRVIKTNQELEVLRYAN 591
N S+N+ +++ G N + +NS+ + I E R IK+ QEL ++R A
Sbjct: 198 TSNPSSSNFKHIKSLLDGSGNSNRSLNSIANKTIKPISKRIAEFRKIKSPQELRIMRRAG 257
Query: 592 KASSKAHRDIMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHA 771
+ S ++ E ++S FLH+ + G AY + ATG N +HY
Sbjct: 258 QISGRSFNQAFAKRFRN--ERTLDS-FLHYKFISGGCDKDAYIPVVATGSNSLCIHYTR- 313
Query: 772 GAPNDRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVL 924
ND + D +M L D G Y +DI+ ++P +G FT Q+ +YEAVL
Sbjct: 314 ---NDDVMFDDEMVLVDAAGSLGGYCADISRTWPNSGKFTDAQRDLYEAVL 361
>sp|Q10439|YDE5_SCHPO Probable peptidase C12B10.05
Length = 486
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/288 (23%), Positives = 126/288 (43%), Gaps = 12/288 (4%)
Frame = +1
Query: 97 KATNKINNNAFILLQGGTDHYLGGSDSALTFRQESYFHWAFGVLEPDFYGLIHID----S 264
+ + + +N F+++ ++ G+ + + Q+ F++ G LEP+ L+ + S
Sbjct: 73 RVASLLEDNDFMIVTSAPVRHMCGA-AFYEYHQDPNFYYLTGCLEPNAVLLMFKNGASGS 131
Query: 265 TKTILFMPRLDERYAIFMGALETKDDVKQKYAVDEVYYTDEILNVLEELKPSEIHTLHGL 444
L++P + + G K+ + ++ VY + +V+ L +
Sbjct: 132 YDCSLYLPSKNPYIEKWEGLRTGSTLGKKLFQIENVYDSSLASSVINALGKKSNRIFYNY 191
Query: 445 NTDSNNYTMEAS---FTGIANFQVINSVLHNEITEC----RVIKTNQELEVLRYANKASS 603
T + AS F ++ + + E R IK+ ELE ++ A SS
Sbjct: 192 QTGYLSKMPAASAPEFIQDTLTKLFRTSTQRSVDELLHPLRSIKSTAELECMKEAANISS 251
Query: 604 KAHRDIMRSVHPGMYEYQIE-SLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAP 780
+R+IMR +E + E S ++ + G AY + A G N +HY
Sbjct: 252 NVYREIMRK----RFEKEAEMSAEFNYRFCIGGCDRSAYVPVVAGGKNGLTIHY----TI 303
Query: 781 NDRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVL 924
N+ +M L D GGE+ Y +DI+ ++P+NG F+ Q+ +Y+AVL
Sbjct: 304 NNDIFRPDEMVLVDAGGEFGGYVTDISRTWPINGKFSTVQRDLYQAVL 351
>sp|P54518|YQHT_BACSU Putative peptidase yqhT
Length = 353
Score = 61.2 bits (147), Expect = 4e-09
Identities = 46/164 (28%), Positives = 81/164 (49%)
Frame = +1
Query: 439 GLNTDSNNYTMEASFTGIANFQVINSVLHNEITECRVIKTNQELEVLRYANKASSKAHRD 618
G +S Y AS++ + + + V + + + R+IK+++E+++L A K + A R
Sbjct: 91 GFEQNSMTYGTYASYSAVISDAELVPVAES-VEKLRLIKSSEEIKILEEAAKIADDAFRH 149
Query: 619 IMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIE 798
I+ + PG+ E + + + GA + ++ I A+G S+ H G +D+ IE
Sbjct: 150 ILTFMKPGISEIAVANELEFYMRSQGADSS-SFDMIVASGLRSSLPH----GVASDKLIE 204
Query: 799 DGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAA 930
GD+ D G Y Y SDIT + V G + K +Y+ V A
Sbjct: 205 SGDLVTLDFGAYYKGYCSDITRTVAV-GQPSDQLKEIYQVVFDA 247
>sp|O58885|PEPQ_PYRHO Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase)
Length = 351
Score = 61.2 bits (147), Expect = 4e-09
Identities = 59/229 (25%), Positives = 102/229 (44%)
Frame = +1
Query: 244 GLIHIDSTKTILFMPRLDERYAIFMGALETKDDVKQKYAVDEVYYTDEILNVLEELKPSE 423
G I I L++P L+ A + V++ DE LE +K
Sbjct: 43 GYILITGESATLYVPELEYEMA----------KEESNIPVEKFKKMDEFYKALEGIKSLG 92
Query: 424 IHTLHGLNTDSNNYTMEASFTGIANFQVINSVLHNEITECRVIKTNQELEVLRYANKASS 603
I + S Y AN + V + I + R+IK+ +E++++ A + +
Sbjct: 93 IES-------SLPYGFIEELKKKANIKEFKKV-DDVIRDMRIIKSEKEIKIIEKACEIAD 144
Query: 604 KAHRDIMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPN 783
KA + + G E ++ + + +GA + A+ +I A+G ++ H G +
Sbjct: 145 KAVMAAIEEITEGKKEREVAAKVEYLMKMNGAEKP-AFDTIIASGYRSALPH----GVAS 199
Query: 784 DRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAA 930
D++IE GD+ + D+G Y Y+SDIT + V G + QK +YE VL A
Sbjct: 200 DKRIERGDLVVIDLGALYQHYNSDITRTIVV-GSPNEKQKEIYEIVLEA 247
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,804,071
Number of Sequences: 369166
Number of extensions: 1964080
Number of successful extensions: 4594
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4447
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4572
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9606826000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)