Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_F08
(946 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (... 297 3e-80
sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC) 293 4e-79
sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cy... 292 8e-79
sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (... 292 1e-78
sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC) 232 1e-60
sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC) 202 9e-52
sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (... 192 2e-48
sp|P78716|DYHC_FUSSO Dynein heavy chain, cytosolic (DYHC) 64 5e-10
sp|P45443|DYHC_NEUCR Dynein heavy chain, cytosolic (DYHC) 64 8e-10
sp|Q8VHE6|DYH5_MOUSE Ciliary dynein heavy chain 5 (Axonemal... 60 1e-08
>sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
Length = 4644
Score = 297 bits (760), Expect = 3e-80
Identities = 147/313 (46%), Positives = 207/313 (66%), Gaps = 3/313 (0%)
Frame = +1
Query: 1 QRLLNSFLEYLFNEKCFSNNFALTFENDDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWL 180
QRLLN+FLE LF + F + F L + D +I P+ + +QW+ LPD+QTPSWL
Sbjct: 4260 QRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDAQTPSWL 4319
Query: 181 GLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLY 360
GLPN+AE+VLLT G +I +LKMQ ++D+ + K RT D RP WMR L+
Sbjct: 4320 GLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKARTDSTSDGRPAWMRTLH 4379
Query: 361 QSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLEDISEVCSGT 540
+ WL L+P+ + PL+RT ENIKDP++R FEREV G+ LL VR+DL D+ +VC G
Sbjct: 4380 TTASNWLHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGK 4439
Query: 541 KKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISNTAINSGA 720
KK TN+ R+++ L KGI+P SW Y + +G+TVIQW+ DF++R+KQL +IS A + GA
Sbjct: 4440 KKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISQAAASGGA 4499
Query: 721 AGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGEGK---IDKNTCIVT 891
L+++ + LGGLF+ EAY TA RQ VAQ+N W+LEEL L+V + + +D + VT
Sbjct: 4500 KELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTASQSATLDACSFGVT 4559
Query: 892 GLRLMGSEIVDSK 930
GL+L G+ ++K
Sbjct: 4560 GLKLQGATCSNNK 4572
>sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC)
Length = 4639
Score = 293 bits (751), Expect = 4e-79
Identities = 161/326 (49%), Positives = 206/326 (63%), Gaps = 11/326 (3%)
Frame = +1
Query: 1 QRLLNSFLEYLFNEKCFSNNFALTFENDDKT----EIVFPEFNNHGDILQWIYKLPDSQT 168
QRLL SFL+ LF + F +FAL D + I P+ L+WI L D QT
Sbjct: 4246 QRLLTSFLKKLFTARSFEADFALVANVDGASGGLRHITMPDGTRRDHFLKWIENLTDRQT 4305
Query: 169 PSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEI---VVDQRKSKRTIELGDSRP 339
PSWLGLPN+AEKVLLT G L+ +LKMQQ LEDD+E+ V DQ + D RP
Sbjct: 4306 PSWLGLPNNAEKVLLTTRGTDLVSKLLKMQQ-LEDDDELAYSVEDQSEQSAVGRGEDGRP 4364
Query: 340 VWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLEDI 519
WM+ L+ S WL+LLPK + L+RT ENIKDP+YR FEREV SGS LL V DL+D+
Sbjct: 4365 SWMKTLHNSATAWLELLPKNLQVLKRTVENIKDPLYRYFEREVTSGSRLLQTVILDLQDV 4424
Query: 520 SEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISN 699
+C G KK TNHHRSM++ L +GIIP W +Y + +G TVIQWI DF++RV+QL +S
Sbjct: 4425 VLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAGCTVIQWITDFSNRVQQLQKVSQ 4484
Query: 700 TAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGEG--KIDK 873
+GA L+ +WLGGL EAY TA RQ VAQ+N W+LEEL LDV + + K D+
Sbjct: 4485 LVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQANSWSLEELALDVTITDAGLKNDQ 4544
Query: 874 NTCI--VTGLRLMGSEIVDSKTLKLS 945
C VTGL+L G++ +++ L S
Sbjct: 4545 KDCCFGVTGLKLQGAQCKNNELLLAS 4570
>sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
(MAP 1C)
Length = 4644
Score = 292 bits (748), Expect = 8e-79
Identities = 146/313 (46%), Positives = 205/313 (65%), Gaps = 3/313 (0%)
Frame = +1
Query: 1 QRLLNSFLEYLFNEKCFSNNFALTFENDDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWL 180
QRLLN+FLE LF + F + F L + D +I P+ + +QW+ LPD+QTPSWL
Sbjct: 4260 QRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDAQTPSWL 4319
Query: 181 GLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLY 360
GLPN+AE+VLLT G +I +LKMQ ++D+ + K RT D RP WMR L+
Sbjct: 4320 GLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDFTSDGRPAWMRTLH 4379
Query: 361 QSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLEDISEVCSGT 540
+ WL L+P+ + PL+RT ENIKDP++R FEREV G+ LL VR+DL D+ +VC G
Sbjct: 4380 TTASNWLHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGK 4439
Query: 541 KKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISNTAINSGA 720
KK TN+ R+++ L KGI+P SW Y + +G+TVIQW+ DF++R+KQL +IS A GA
Sbjct: 4440 KKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISQAAAAGGA 4499
Query: 721 AGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGEGK---IDKNTCIVT 891
L+++ + LG LF+ EAY TA RQ VAQ+N W+LEEL L+V + + +D + VT
Sbjct: 4500 KELKNIHVCLGALFVPEAYITATRQYVAQANSWSLEELCLEVNVTASQSTTLDACSFGVT 4559
Query: 892 GLRLMGSEIVDSK 930
GL+L G+ ++K
Sbjct: 4560 GLKLQGATCSNNK 4572
>sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain
1) (DHC1)
Length = 4646
Score = 292 bits (747), Expect = 1e-78
Identities = 146/313 (46%), Positives = 206/313 (65%), Gaps = 3/313 (0%)
Frame = +1
Query: 1 QRLLNSFLEYLFNEKCFSNNFALTFENDDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWL 180
QRLLN+FLE LF + F + F L + D +I P+ + +QW+ LPD+QTPSWL
Sbjct: 4262 QRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSWL 4321
Query: 181 GLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLY 360
GLPN+AE+VLLT G +I +LKMQ ++D+ + K RT D RP WMR L+
Sbjct: 4322 GLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLH 4381
Query: 361 QSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLEDISEVCSGT 540
+ WL L+P+ + L+RT ENIKDP++R FEREV G+ LL VR+DL D+ +VC G
Sbjct: 4382 TTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGK 4441
Query: 541 KKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISNTAINSGA 720
KK TN+ R+++ L KGI+P SW Y + +G+TVIQW+ DF++R+KQL +IS A + GA
Sbjct: 4442 KKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGGA 4501
Query: 721 AGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGEGK---IDKNTCIVT 891
L+++ + LGGLF+ EAY TA RQ VAQ+N W+LEEL L+V + + +D + VT
Sbjct: 4502 KELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGVT 4561
Query: 892 GLRLMGSEIVDSK 930
GL+L G+ ++K
Sbjct: 4562 GLKLQGATCNNNK 4574
>sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC)
Length = 4568
Score = 232 bits (591), Expect = 1e-60
Identities = 125/314 (39%), Positives = 183/314 (58%)
Frame = +1
Query: 1 QRLLNSFLEYLFNEKCFSNNFALTFENDDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWL 180
Q LL+ LE LF K F + L + D + P + ++ W+ +L + Q P+WL
Sbjct: 4210 QVLLDCVLENLFTAKSFEQDHVLIPKYDGDDSLFTPNMSKKDQMIGWVEELKNEQLPAWL 4269
Query: 181 GLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLY 360
GLPN+AEKVLLT G+S++ N+LK+ DEE+ ++ + +P WM QL
Sbjct: 4270 GLPNNAEKVLLTKRGESMLRNMLKVT-----DEELAFNEDGKEEV------KPQWMAQLG 4318
Query: 361 QSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLEDISEVCSGT 540
+ + WLQLLPK ++ ++RT ENIKDP++R FEREVN GS LL +R+DL +IS VC
Sbjct: 4319 ELAKQWLQLLPKEIVKMRRTVENIKDPLFRFFEREVNLGSQLLKDIRRDLNEISAVCRAE 4378
Query: 541 KKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISNTAINSGA 720
KK N R++ +L KG +P W +Y + +TV+ W+ D +R+KQLI I GA
Sbjct: 4379 KKQNNETRALAASLQKGEVPTGWKRYTVpreVTVMDWMTDLNERLKQLIRI------GGA 4432
Query: 721 AGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGEGKIDKNTCIVTGLR 900
L+ WLGG F EAY TA RQ VAQ+N W+LE+L L + +G + ++G+
Sbjct: 4433 DNLKRETFWLGGTFSPEAYITATRQQVAQANTWSLEQLNLHIHIGRTD-STDVFRISGID 4491
Query: 901 LMGSEIVDSKTLKL 942
+ G++ V L+L
Sbjct: 4492 IRGAKSVGGNKLEL 4505
>sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC)
Length = 4725
Score = 202 bits (515), Expect = 9e-52
Identities = 111/279 (39%), Positives = 164/279 (58%)
Frame = +1
Query: 4 RLLNSFLEYLFNEKCFSNNFALTFENDDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWLG 183
RLL SFLE LF F+ +F L + PE ++WI LP+ TP WLG
Sbjct: 4349 RLLYSFLEQLFTPSAFNPDFPLV----PSIGLSVPEGTTRAHFMKWIEALPEISTPIWLG 4404
Query: 184 LPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLYQ 363
LP +AE +LL+N + +I ++ KMQ + ED E+ V SK+ S +L
Sbjct: 4405 LPENAESLLLSNKARKMINDLQKMQSSEEDGEDDQVSG-SSKKESSSSSSEDKGKAKLRA 4463
Query: 364 STQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLEDISEVCSGTK 543
+ W +LLPK + L+RTT+NIKDP++RCFERE+++G L+ + DL ++ E+ SG
Sbjct: 4464 TITEWTKLLPKPLKQLKRTTQNIKDPLFRCFEREISTGGKLVKKITNDLANLLELISGNI 4523
Query: 544 KPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISNTAINSGAA 723
K TN+ RS+ T+++KGI+P W Y + +++ WI DF+ R++QL IS ++ S
Sbjct: 4524 KSTNYLRSLTTSISKGIVPKEWKWYSVPETISLSVWISDFSKRMQQLSEISESSDYS--- 4580
Query: 724 GLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFL 840
S+++WLGGL EAY TA RQ+ +Q N W+LE L L
Sbjct: 4581 ---SIQVWLGGLLNPEAYITATRQSASQLNGWSLENLRL 4616
>sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (DHC08)
Length = 4540
Score = 192 bits (487), Expect = 2e-48
Identities = 103/315 (32%), Positives = 177/315 (56%), Gaps = 1/315 (0%)
Frame = +1
Query: 1 QRLLNSFLEYLFNEKCFSNNFALTFENDDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWL 180
Q++L S +E F E+ F++N L F + K I PE + D +QWI +LP +++P W
Sbjct: 4163 QKILQSLVEQFFTEQSFNHNHPLFFTLEGKEAITVPEGRTYLDFMQWIEQLPKTESPEWS 4222
Query: 181 GLPNSAEKVLLTNLGQSLIGNILKMQQTLEDD-EEIVVDQRKSKRTIELGDSRPVWMRQL 357
GLP++ E+V L Q LI + +QQ E++ +I V K+++ + W++ L
Sbjct: 4223 GLPSNVERVQRDQLTQKLITKVQNLQQEGEEEITQIEVQTEKTQKKDNKKSDQVQWLQDL 4282
Query: 358 YQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLEDISEVCSG 537
+ + + +LP + PL+RT ++I DP++R +RE+ S LL VR+++E++ ++ G
Sbjct: 4283 LEKVEKFKAILPNKISPLERTADSINDPLFRFLDREITVASKLLKAVRQNIEELIQLAQG 4342
Query: 538 TKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISNTAINSG 717
TN R + ++ I+P W KY + + + + W+ DF R+ Q + T
Sbjct: 4343 KILATNILRQLAKDVFNNIVPAQWNKYNVIT-MPLNDWVGDFKRRIDQFDLLGKT----- 4396
Query: 718 AAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGEGKIDKNTCIVTGL 897
+ ++W GGL EAY TA RQ VAQ+NKW+LEEL L + + ID+++ ++ G+
Sbjct: 4397 -KDFQKGQVWFGGLLFPEAYLTATRQYVAQANKWSLEELELQMIPEDQGIDEDSFVIEGV 4455
Query: 898 RLMGSEIVDSKTLKL 942
+ G + DSKTL++
Sbjct: 4456 SMEGGHL-DSKTLQV 4469
>sp|P78716|DYHC_FUSSO Dynein heavy chain, cytosolic (DYHC)
Length = 4349
Score = 64.3 bits (155), Expect = 5e-10
Identities = 28/66 (42%), Positives = 47/66 (71%)
Frame = +1
Query: 97 IVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDD 276
+V P + D WI++LP+ + P++LGLP +AEK+LL LG+SLIGN+ K+ + L++
Sbjct: 4283 LVVPSGTSFQDFNAWIHRLPEREPPTYLGLPANAEKLLLGGLGRSLIGNLRKVTELLDEG 4342
Query: 277 EEIVVD 294
E++V +
Sbjct: 4343 EQLVTE 4348
>sp|P45443|DYHC_NEUCR Dynein heavy chain, cytosolic (DYHC)
Length = 4367
Score = 63.5 bits (153), Expect = 8e-10
Identities = 28/67 (41%), Positives = 46/67 (68%)
Frame = +1
Query: 94 EIVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLED 273
++V P + + + WI KLP+ + P++LGLP +AEK+LL LG+SLIGN+ K+ L++
Sbjct: 4296 DLVVPSGTSLQEFMSWIQKLPEREPPTYLGLPANAEKLLLVGLGKSLIGNLKKVTDLLDE 4355
Query: 274 DEEIVVD 294
E I+ +
Sbjct: 4356 GEAIMAE 4362
>sp|Q8VHE6|DYH5_MOUSE Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5)
(Mdnah5)
Length = 4621
Score = 59.7 bits (143), Expect = 1e-08
Identities = 67/285 (23%), Positives = 113/285 (39%), Gaps = 5/285 (1%)
Frame = +1
Query: 1 QRLLNSFLEYLFNEKCFSNNFALTFENDDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWL 180
+RLLN+F + F+E F +F TF P+ + LQ+I LP +P
Sbjct: 4258 KRLLNTFAKVWFSENMFGPDF--TFYQGYN----IPKCSTVDGYLQYIQSLPAYDSPEVF 4311
Query: 181 GLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLY 360
GL +A+ + L + ++ IL +Q D D+ + L D
Sbjct: 4312 GLHPNADITYQSKLAKDVLDTILGIQPK---DSSGGGDETREAVVARLADDM-------- 4360
Query: 361 QSTQTWLQLLPKVVIPLQRTTENIK----DPIYRCFEREVNSGSNLLLIVRKDLEDISEV 528
L+ LP+ P + K P+ +E++ +L +VR L ++
Sbjct: 4361 ------LEKLPEDYSPFEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELKLA 4414
Query: 529 CSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVKQLIHISNTAI 708
GT + + R + + IP W K S T+ W + +R N
Sbjct: 4415 VDGTIIMSENLRDALDCMFDARIPARWKKASWVSS-TLGFWFTELLER--------NCQF 4465
Query: 709 NSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNK-WALEELFL 840
S + R W+ G F + + TA+RQ + ++NK WAL+ + L
Sbjct: 4466 TSWVSNGRPHCFWMTGFFNPQGFLTAMRQEITRANKGWALDNMVL 4510
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,809,067
Number of Sequences: 369166
Number of extensions: 2064343
Number of successful extensions: 5501
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5305
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5482
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9798962520
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)