Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_E15
(815 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 64 4e-10
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 60 7e-09
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 59 2e-08
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 54 7e-07
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 53 9e-07
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 48 3e-05
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 47 8e-05
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 46 1e-04
sp|Q69ZS0|PZRN3_MOUSE PDZ domain-containing RING finger pro... 46 1e-04
sp|P68907|PZRN3_RAT PDZ domain-containing RING finger prote... 45 2e-04
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 64.3 bits (155), Expect = 4e-10
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 1/127 (0%)
Frame = +1
Query: 199 MSSSKFDEMFKFISQYKYEISENVPDNFKCGKCKNILINAYCVPCGCSYCCDCVNEMVNN 378
+SSS +E I Y E + ++C C L A PCG +C C+ + + +
Sbjct: 45 LSSSFMEE----IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRD 100
Query: 379 GVENCPGKTEDCNDVLISNNIV-DFKKNREISKVVMKCPEEMCSHECAIINMEEHVRVCE 555
CP N++L+ N + D REI +++KCP E C H+ + ++E+H CE
Sbjct: 101 AGHKCPVD----NEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCE 156
Query: 556 KKSVKCP 576
+ CP
Sbjct: 157 FALMDCP 163
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 60.1 bits (144), Expect = 7e-09
Identities = 36/127 (28%), Positives = 58/127 (45%), Gaps = 1/127 (0%)
Frame = +1
Query: 199 MSSSKFDEMFKFISQYKYEISENVPDNFKCGKCKNILINAYCVPCGCSYCCDCVNEMVNN 378
+SSS +E I Y E + ++C C L A PCG +C C+ + + +
Sbjct: 45 LSSSFMEE----IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRD 100
Query: 379 GVENCPGKTEDCNDVLISNNIV-DFKKNREISKVVMKCPEEMCSHECAIINMEEHVRVCE 555
CP N++L+ N + D REI + +KCP + C + + ++E+H CE
Sbjct: 101 AGHKCPVD----NEILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCE 156
Query: 556 KKSVKCP 576
V CP
Sbjct: 157 FALVNCP 163
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/164 (25%), Positives = 78/164 (47%), Gaps = 12/164 (7%)
Frame = +1
Query: 244 YKYEISENVPDNFKCGKCKNILINAYCVPCGCSYCCDCVNEMVNNGVENCPGKTEDCNDV 423
YK + + V D +KC KC+ +L N CG +C C+ ++++ C C +
Sbjct: 38 YKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTA----CQES 93
Query: 424 LISNNIVDFKKN---REISKVVMKCPEE--MCSHECAIINMEEHVR-VCEKKSVKCPLAN 585
+I + + FK N REI + + C E C+ + + ++ H++ C+ + + C A+
Sbjct: 94 IIKDKV--FKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRAD 151
Query: 586 VGCDGKKIAREMLNDHCQ------SANFNHCKILIEMIDNMRNE 699
+K+ R+ L DH + A +HCK + MI ++E
Sbjct: 152 C---KEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHE 192
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/106 (17%), Positives = 42/106 (39%)
Frame = +1
Query: 475 VVMKCPEEMCSHECAIINMEEHVRVCEKKSVKCPLANVGCDGKKIAREMLNDHCQSANFN 654
VV+ CP + + H+ C C GC + + + H S+
Sbjct: 199 VVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQG-TNQQIKAHEASSAVQ 257
Query: 655 HCKILIEMIDNMRNEIDILKANDEKNQLKIENLEKNLKSKDEIIDK 792
H +L E +++ ++ +L+ + I++L + S + I++
Sbjct: 258 HVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIER 303
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 53.5 bits (127), Expect = 7e-07
Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 60/190 (31%)
Frame = +1
Query: 280 FKCGKCKNILINAYCVPCGCSYCCDCVNEMVNNGVENCP-----GKTEDCNDVLISNNIV 444
+ C CKNIL + CG YC C+ ++++G +NC G E+ +L S++
Sbjct: 32 YLCSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAF 91
Query: 445 -DFKKNREISKVVMKCPEEMCS-----------HE------------------------- 513
D RE+ + CP + C+ HE
Sbjct: 92 PDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHH 151
Query: 514 ------------------CAIINMEEHVRVCEKKSVKCPLANVGCDGKKIAREMLNDHCQ 639
C+ +++E H VC K + C GC KKI RE DH +
Sbjct: 152 TEQECPKRSLSCQHCRAPCSHVDLEVHYEVCPKFPLTCD----GCGKKKIpreTFQDHVR 207
Query: 640 SANFNHCKIL 669
+ + C++L
Sbjct: 208 AC--SKCRVL 215
Score = 39.3 bits (90), Expect = 0.013
Identities = 30/151 (19%), Positives = 61/151 (40%)
Frame = +1
Query: 358 VNEMVNNGVENCPGKTEDCNDVLISNNIVDFKKNREISKVVMKCPEEMCSHECAIINMEE 537
++E ++ + CP ++ C + VD + + E+ + + ++
Sbjct: 145 LSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYEVCPKFPLTCDGCGKKKIpreTFQD 204
Query: 538 HVRVCEKKSVKCPLANVGCDGKKIAREMLNDHCQSANFNHCKILIEMIDNMRNEIDILKA 717
HVR C K V C VGC + + E L DH H +L+ + L
Sbjct: 205 HVRACSKCRVLCRFHTVGC-SEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQ 263
Query: 718 NDEKNQLKIENLEKNLKSKDEIIDKINQEIE 810
+ + + LE+ + + + I+ +N+E+E
Sbjct: 264 VGPELLQRCQILEQKIATFENIVCVLNREVE 294
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 53.1 bits (126), Expect = 9e-07
Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 12/164 (7%)
Frame = +1
Query: 244 YKYEISENVPDNFKCGKCKNILINAYCVPCGCSYCCDCVNEMVNNGVENCPGKTEDCNDV 423
YK + + V D +KC KC +L + CG +C C+ ++++ C C +
Sbjct: 39 YKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQES 94
Query: 424 LISNNIVDFKKN---REISKVVMKCPEEM--CSHECAIINMEEHVR-VCEKKSVKCPLAN 585
++ + + FK N REI + + C E C+ + + ++ H++ C + + C
Sbjct: 95 IVKDKV--FKDNCCKREILALQIYCRNESRGCAEQLTLGHLLVHLKNDCHFEELPC--VR 150
Query: 586 VGCDGKKIAREMLNDHCQ------SANFNHCKILIEMIDNMRNE 699
C +K+ R+ L DH + A +HCK + MI ++E
Sbjct: 151 PDCK-EKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHE 193
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/106 (17%), Positives = 42/106 (39%)
Frame = +1
Query: 475 VVMKCPEEMCSHECAIINMEEHVRVCEKKSVKCPLANVGCDGKKIAREMLNDHCQSANFN 654
VV+ CP + + H+ C C GC + + + H S+
Sbjct: 200 VVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQG-TNQQIKAHEASSAVQ 258
Query: 655 HCKILIEMIDNMRNEIDILKANDEKNQLKIENLEKNLKSKDEIIDK 792
H +L E +++ ++ +L+ + I++L + S + I++
Sbjct: 259 HVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIER 304
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 48.1 bits (113), Expect = 3e-05
Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 8/139 (5%)
Frame = +1
Query: 247 KYEISENVPDNFKCGKCKNILINAYCVPCGCSYCCDCVNEMVN-NGVENCPGKTEDCNDV 423
+Y+ E + + +KC C ++L N + CG +C C+ + N V CP E V
Sbjct: 32 EYQFVEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKE----V 87
Query: 424 LISNNIVDFKKN---REISKVVMKCPEEM-CSHECAIINMEEHVRVCEKKSVKCPLANVG 591
+ + FK N RE+ + + C C+ + ++H++ C ++V CP N
Sbjct: 88 IKPQEV--FKDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCP--NES 143
Query: 592 CDG---KKIAREMLNDHCQ 639
C +K +E L+ +C+
Sbjct: 144 CREAMLRKDVKEHLSAYCR 162
Score = 43.5 bits (101), Expect = 7e-04
Identities = 30/130 (23%), Positives = 58/130 (44%)
Frame = +1
Query: 412 CNDVLISNNIVDFKKNREISKVVMKCPEEMCSHECAIINMEEHVRVCEKKSVKCPLANVG 591
C ++ N+ D ++N + CP C + EH+ VC + CP + G
Sbjct: 171 CKRDIVVTNLQDHEEN-SCPAYPVSCPNR-CVQTIPRARVNEHLTVCPEAEQDCPFKHYG 228
Query: 592 CDGKKIAREMLNDHCQSANFNHCKILIEMIDNMRNEIDILKANDEKNQLKIENLEKNLKS 771
C K R L +H ++A +H +++E + I L + E+ + KI+ L + +K
Sbjct: 229 CTVKG-KRGNLLEHERAALQDHMLLVLEKNYQLEQRISDLYQSLEQKESKIQQLAETVKK 287
Query: 772 KDEIIDKINQ 801
++ + + Q
Sbjct: 288 FEKELKQFTQ 297
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 46.6 bits (109), Expect = 8e-05
Identities = 41/177 (23%), Positives = 67/177 (37%), Gaps = 56/177 (31%)
Frame = +1
Query: 280 FKCGKCKNILINAYCVPCGCSYCCDCVNEMVNNGVENC-----PGKTEDCNDVLISNN-I 441
+ C C+N+L + CG YC C+ ++++G +NC G E+ +L S++
Sbjct: 32 YLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAF 91
Query: 442 VDFKKNREISKVVMKCPEEMCS-----------HE--CAII--------------NMEEH 540
D RE+ + CP + C+ HE C ++ E H
Sbjct: 92 PDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERH 151
Query: 541 V-RVCEKKSVKC----------------------PLANVGCDGKKIAREMLNDHCQS 642
+ C ++S+ C PL GC KKI RE DH ++
Sbjct: 152 LEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIpreKFQDHVKT 208
Score = 30.8 bits (68), Expect = 4.6
Identities = 24/94 (25%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Frame = +1
Query: 532 EEHVRVCEKKSVKCPLANVGCDGKKIAREMLNDHCQSANFNHCKILIEMIDNMRNEI-DI 708
++HV+ C K V C +GC + + E +H H +L+ + + + D
Sbjct: 203 QDHVKTCGKCRVPCRFHAIGC-LETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQ 261
Query: 709 LKANDEKNQLKIENLEKNLKSKDEIIDKINQEIE 810
A E Q + E+LEK + + I+ +N+E+E
Sbjct: 262 SHAGSELLQ-RCESLEKKTATFENIVCVLNREVE 294
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Frame = +1
Query: 487 CPEE--MCSHECAII----NMEEHVRVCEKKSVKCPLANVGCDGKKIAREMLNDHCQSAN 648
CPE C + CA I ++EH+ VC + CP + GC R L H SA
Sbjct: 188 CPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGC-AVTDKRRNLQQHEHSAL 246
Query: 649 FNHCKILIEMIDNMRNEIDILKANDEKNQLKIENLEKNLKSKDE 780
H ++++E + +I L + E+ + KI+ L + +K ++
Sbjct: 247 REHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/144 (25%), Positives = 66/144 (45%), Gaps = 8/144 (5%)
Frame = +1
Query: 232 FISQYKYEISENVPDNFKCGKCKNILINAYCVPCGCSYCCDCVNEMVN-NGVENCPGKTE 408
F +Y+ E + + +KC C ++L N + CG +C C+ + N V CP E
Sbjct: 27 FEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKE 86
Query: 409 DCNDVLISNNIVDFKKN---REISKVVMKCPEEM-CSHECAIINMEEHVRVCEKKSVKCP 576
V+ S + FK N RE+ + + C C+ + + ++H++ C + V+C
Sbjct: 87 ----VIKSQEV--FKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQC- 139
Query: 577 LANVGCDG---KKIAREMLNDHCQ 639
+N C +K +E L+ CQ
Sbjct: 140 -SNEKCREPVLRKDLKEHLSASCQ 162
>sp|Q69ZS0|PZRN3_MOUSE PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic
domain-associated protein 3) (SEMACAP3 protein)
Length = 1063
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/139 (23%), Positives = 59/139 (42%), Gaps = 6/139 (4%)
Frame = +1
Query: 265 NVPDNFKCGKCKNILINAYCVPCGCSYCCDCVNE-MVNNGVENCPGKTEDCNDVLISNNI 441
+V + KC C +L + PCG +C CV +V G +CP + N++
Sbjct: 11 DVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEG--SCPARCRGRLSAKELNHV 68
Query: 442 VDFKKNREISKVVMKCPEEM--CSHECAIINMEEHVRVCEKKSVKCPLANVGCDGKKIAR 615
+ K R I K+ +KC C + ++ EH+ C+ +C + GC + R
Sbjct: 69 LPLK--RLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARC--RHAGCGQLLLRR 124
Query: 616 EM---LNDHCQSANFNHCK 663
++ + D C + C+
Sbjct: 125 DVEAHMRDACDARPVGRCQ 143
>sp|P68907|PZRN3_RAT PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic
domain-associated protein 3) (SEMACAP3 protein)
Length = 1062
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/138 (23%), Positives = 58/138 (42%), Gaps = 6/138 (4%)
Frame = +1
Query: 268 VPDNFKCGKCKNILINAYCVPCGCSYCCDCVNE-MVNNGVENCPGKTEDCNDVLISNNIV 444
V + KC C +L + PCG +C CV +V G +CP + N+++
Sbjct: 12 VDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEG--SCPSRCRGRLSAKELNHVL 69
Query: 445 DFKKNREISKVVMKCPEEM--CSHECAIINMEEHVRVCEKKSVKCPLANVGCDGKKIARE 618
K R I K+ +KC C + ++ EH+ C+ +C + GC + R+
Sbjct: 70 PLK--RLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARC--RHAGCGQLLLRRD 125
Query: 619 M---LNDHCQSANFNHCK 663
+ + D C + C+
Sbjct: 126 VEAHMRDACDARPVGRCQ 143
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,321,534
Number of Sequences: 369166
Number of extensions: 1571560
Number of successful extensions: 6877
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6130
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6760
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)