Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_E08
(766 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P41570|6PGD_CERCA 6-phosphogluconate dehydrogenase, deca... 304 2e-82
sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, deca... 295 7e-80
sp|P00349|6PGD_SHEEP 6-phosphogluconate dehydrogenase, deca... 295 1e-79
sp|Q9DCD0|6PGD_MOUSE 6-phosphogluconate dehydrogenase, deca... 293 3e-79
sp|P41572|6PGD_DROME 6-phosphogluconate dehydrogenase, deca... 292 6e-79
sp|P41573|6PGD_DROSI 6-phosphogluconate dehydrogenase, deca... 290 2e-78
sp|O60037|6PGD_CUNEL 6-phosphogluconate dehydrogenase, deca... 289 5e-78
sp|P14332|6PGD_PIG 6-phosphogluconate dehydrogenase, decarb... 288 9e-78
sp|Q17761|6PGD_CAEEL 6-phosphogluconate dehydrogenase, deca... 282 6e-76
sp|P38720|6PGD1_YEAST 6-phosphogluconate dehydrogenase, dec... 266 3e-71
>sp|P41570|6PGD_CERCA 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 304 bits (779), Expect = 2e-82
Identities = 156/239 (65%), Positives = 179/239 (74%)
Frame = +1
Query: 1 NDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRF 180
+D YL+E I D+AGQKGTGKWTAI+AL +GVPVTLI E+VF+R LSALK RV ASK+
Sbjct: 243 DDRGYLLERIRDTAGQKGTGKWTAISALQYGVPVTLIGEAVFSRCLSALKDERVAASKQL 302
Query: 181 PSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRG 360
N+ D KFLN IK+ALY SKI+SY QGFM+M+ A+ E WNL+ G IALMWRG
Sbjct: 303 KGPNVNAKVEDLPKFLNHIKHALYCSKIVSYAQGFMLMREAAKENNWNLNYGGIALMWRG 362
Query: 361 GCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFS 540
GCIIRS FL NIKDAY +N LS LL D FF+ I Q SWR VVANA L GIP PA S
Sbjct: 363 GCIIRSVFLGNIKDAYTRNPQLSNLLLDDFFKKAIEVGQNSWRQVVANAFLWGIPVPALS 422
Query: 541 CALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
AL+FYDG RTEKLPANL+QAQRD FGAH Y+LL G + HT+WTG GGN +ASTYQA
Sbjct: 423 TALSFYDGYRTEKLPANLLQAQRDYFGAHTYELLGAEGKFVHTNWTGTGGNVSASTYQA 481
>sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 295 bits (756), Expect = 7e-80
Identities = 143/238 (60%), Positives = 175/238 (73%)
Frame = +1
Query: 4 DGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFP 183
DG +L+ I DSAGQKGTGKWTAI+AL++GVPVTLI E+VFAR LS+LK R++ASK+
Sbjct: 246 DGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLK 305
Query: 184 SNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRGG 363
F GDK FL I+ ALYASKIISY QGFM+++ A+ EF W L+ G IALMWRGG
Sbjct: 306 GPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGG 365
Query: 364 CIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFSC 543
CIIRS FL IKDA+++N L LL D FF+S + CQ+SWR V+ GIP P F+
Sbjct: 366 CIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTT 425
Query: 544 ALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
AL+FYDG R E LPA+LIQAQRD FGAH Y+LL PG + HT+WTGHGG ++S+Y A
Sbjct: 426 ALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA 483
>sp|P00349|6PGD_SHEEP 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 295 bits (754), Expect = 1e-79
Identities = 142/238 (59%), Positives = 176/238 (73%)
Frame = +1
Query: 4 DGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFP 183
DG +L+ I DSAGQKGTGKWTAI+AL++GVPVTLI E+VFAR LS+LK R++ASK+
Sbjct: 246 DGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLK 305
Query: 184 SNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRGG 363
+ F GDK FL I+ ALYASKIISY QGFM+++ A+ EF W L+ G IALMWRGG
Sbjct: 306 GPQNIPFEGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGG 365
Query: 364 CIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFSC 543
CIIRS FL IKDA+++N L LL D FF+S + CQ+SWR ++ GIP P F+
Sbjct: 366 CIIRSVFLGKIKDAFDRNPGLQNLLLDDFFKSAVENCQDSWRRAISTGVQAGIPMPCFTT 425
Query: 544 ALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
AL+FYDG R LPANLIQAQRD FGAH Y+LL PG + HT+WTGHGG+ ++S+Y A
Sbjct: 426 ALSFYDGYRHAMLPANLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGSVSSSSYNA 483
>sp|Q9DCD0|6PGD_MOUSE 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 293 bits (750), Expect = 3e-79
Identities = 142/238 (59%), Positives = 176/238 (73%)
Frame = +1
Query: 4 DGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFP 183
DG L+ I DSAGQKGTGKWTAI+AL++G+PVTLI E+VFAR LS+LK RV+AS++
Sbjct: 246 DGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLK 305
Query: 184 SNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRGG 363
++ G K FL I+ ALYASKIISY QGFM+++ A+ EF W L+ G IALMWRGG
Sbjct: 306 GPKVVQLEGSKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGG 365
Query: 364 CIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFSC 543
CIIRS FL IKDA+E+N L LL D FF+S + CQ+SWR V++ GIP P F+
Sbjct: 366 CIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVISTGVQAGIPMPCFTT 425
Query: 544 ALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
AL+FYDG R E LPANLIQAQRD FGAH Y+LL PG + HT+WTGHGG+ ++S+Y A
Sbjct: 426 ALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFIHTNWTGHGGSVSSSSYNA 483
>sp|P41572|6PGD_DROME 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 292 bits (748), Expect = 6e-79
Identities = 148/235 (62%), Positives = 173/235 (73%)
Frame = +1
Query: 13 YLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFPSNN 192
YL+E I D+AGQKGTGKWTAI AL +GVPVTLI E+VF+R LSALK RV+AS +
Sbjct: 247 YLLERIRDTAGQKGTGKWTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGPS 306
Query: 193 LLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRGGCII 372
+ TKFL+ IK+ALY +KI+SY QGFM+M+ A+ E KW L+ G IALMWRGGCII
Sbjct: 307 TKAQVANLTKFLDDIKHALYCAKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCII 366
Query: 373 RSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFSCALA 552
RS FL NIKDAY LS LL D FF+ I + Q+SWR VVANA GIP PA S AL+
Sbjct: 367 RSVFLGNIKDAYTSQPELSNLLLDDFFKKAIERGQDSWREVVANAFRWGIPVPALSTALS 426
Query: 553 FYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
FYDG RT KLPANL+QAQRD FGAH Y+LL G + HT+WTG GGN +ASTYQA
Sbjct: 427 FYDGYRTAKLPANLLQAQRDYFGAHTYELLGQEGQFHHTNWTGTGGNVSASTYQA 481
>sp|P41573|6PGD_DROSI 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 290 bits (743), Expect = 2e-78
Identities = 147/235 (62%), Positives = 173/235 (73%)
Frame = +1
Query: 13 YLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFPSNN 192
+L+E I D+AGQKGTGKWTAI AL +GVPVTLI E+VF+R LSALK RV+AS +
Sbjct: 247 HLLERIRDTAGQKGTGKWTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGPS 306
Query: 193 LLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRGGCII 372
+ TKFL+ IK+ALY +KI+SY QGFM+M+ A+ E KW L+ G IALMWRGGCII
Sbjct: 307 TKAEVANLTKFLDDIKHALYCAKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCII 366
Query: 373 RSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFSCALA 552
RS FL NIKDAY LS LL D FF+ I + Q+SWR VVANA GIP PA S AL+
Sbjct: 367 RSVFLGNIKDAYTSQPQLSNLLLDDFFKKAIERGQDSWREVVANAFRWGIPVPALSTALS 426
Query: 553 FYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
FYDG RT KLPANL+QAQRD FGAH Y+LL G + HT+WTG GGN +ASTYQA
Sbjct: 427 FYDGYRTAKLPANLLQAQRDYFGAHTYELLGQEGQFHHTNWTGTGGNVSASTYQA 481
>sp|O60037|6PGD_CUNEL 6-phosphogluconate dehydrogenase, decarboxylating
Length = 485
Score = 289 bits (740), Expect = 5e-78
Identities = 144/238 (60%), Positives = 174/238 (73%)
Frame = +1
Query: 4 DGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFP 183
DG LV I D+AGQKGTGKWTAI +LD G+PVTLI E+V++R LS+LK RV ASK
Sbjct: 248 DGQPLVTKIRDTAGQKGTGKWTAIDSLDRGIPVTLIGEAVYSRCLSSLKDERVRASKILQ 307
Query: 184 SNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRGG 363
+ FTGDK F+ Q+ ALYA+KI+SY QG+M+M+ A+ +++W L+ IALMWRGG
Sbjct: 308 GPSSSKFTGDKKTFIAQLGQALYAAKIVSYAQGYMLMRQAAKDYEWKLNNAGIALMWRGG 367
Query: 364 CIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFSC 543
CIIRS FL I+DAY KN L LLFD FF+ K Q++WR+V A A L GIPTPA S
Sbjct: 368 CIIRSVFLGKIRDAYTKNPELENLLFDDFFKDATAKAQDAWRNVTAQAVLMGIPTPALST 427
Query: 544 ALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
AL FYDGLR E LPANL+QAQRD FGAH Y+LL PG + HT+WTG GGN +ASTY A
Sbjct: 428 ALNFYDGLRHEILPANLLQAQRDYFGAHTYELLHTPGKWVHTNWTGRGGNVSASTYDA 485
>sp|P14332|6PGD_PIG 6-phosphogluconate dehydrogenase, decarboxylating
Length = 250
Score = 288 bits (738), Expect = 9e-78
Identities = 142/238 (59%), Positives = 176/238 (73%)
Frame = +1
Query: 4 DGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFP 183
DG +L+ I DSAGQKGTGKWTAI+AL++GVPVTLI E+VFAR LS+LK RV+ASK+
Sbjct: 14 DGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERVQASKKLK 73
Query: 184 SNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRGG 363
+ F+GDK FL I+ ALYASKIISYTQGFM+++ A+ EF W+ + LMWRGG
Sbjct: 74 GPQKIQFSGDKKSFLEDIRKALYASKIISYTQGFMLLRQAAAEFGWS-STTEHRLMWRGG 132
Query: 364 CIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFSC 543
CIIRS FL IKDA+++N L LL D FF+S + CQ+SWR V+ GIP P F+
Sbjct: 133 CIIRSVFLGKIKDAFDRNPGLQNLLLDDFFKSAVEDCQDSWRRAVSTGVQTGIPMPCFTT 192
Query: 544 ALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
AL+FYDG R E LPANLIQAQRD FGAH Y+LL PG + HT+WTGHGG+ ++S+Y A
Sbjct: 193 ALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLAKPGHFVHTNWTGHGGSVSSSSYNA 250
>sp|Q17761|6PGD_CAEEL 6-phosphogluconate dehydrogenase, decarboxylating
Length = 484
Score = 282 bits (722), Expect = 6e-76
Identities = 144/239 (60%), Positives = 171/239 (71%), Gaps = 2/239 (0%)
Frame = +1
Query: 7 GTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFPS 186
G +V I DSAGQKGTGKWT AL++G+PVTLI E+VFAR LSALK RV ASK+ P
Sbjct: 246 GEPIVPKIRDSAGQKGTGKWTCFAALEYGLPVTLIGEAVFARCLSALKDERVRASKQLPR 305
Query: 187 NNLLNFT--GDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRG 360
+ T DK F+ QI ALYASKI+SY QGFM++ AS +F WNL+ G IALMWRG
Sbjct: 306 PQVSPDTVVQDKRVFIKQISKALYASKIVSYAQGFMLLAEASKQFNWNLNFGAIALMWRG 365
Query: 361 GCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFS 540
GCIIRSRFL +I+ A++KNK LS LL D FF I + Q+SWR VV A GIP PAFS
Sbjct: 366 GCIIRSRFLGDIEHAFQKNKQLSNLLLDDFFTKAITEAQDSWRVVVCAAVRLGIPVPAFS 425
Query: 541 CALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGHGGNAAASTYQA 717
ALAFYDG +E +PANL+QAQRD FGAH Y+LL PGT+ HT+WTG GG ++ Y A
Sbjct: 426 SALAFYDGYTSEVVPANLLQAQRDYFGAHTYELLAKPGTWVHTNWTGTGGRVTSNAYNA 484
>sp|P38720|6PGD1_YEAST 6-phosphogluconate dehydrogenase, decarboxylating 1
Length = 489
Score = 266 bits (681), Expect = 3e-71
Identities = 137/246 (55%), Positives = 173/246 (70%), Gaps = 8/246 (3%)
Frame = +1
Query: 4 DGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSALKSLRVEASKRFP 183
DG LVE I D+AGQKGTGKWTAI ALD G+PVTLI E+VFAR LSALK+ R+ ASK P
Sbjct: 244 DGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLP 303
Query: 184 SNNL-LNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWNLDLGKIALMWRG 360
+ + D+ +F++ ++ ALYASKIISY QGFM+++ A+ + W L+ IALMWRG
Sbjct: 304 GPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRG 363
Query: 361 GCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVANAALHGIPTPAFS 540
GCIIRS FL I AY + +L LLF+KFF + K Q WR +A A +GIPTPAFS
Sbjct: 364 GCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFS 423
Query: 541 CALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYE-------HTDWTGHGGNAA 699
AL+FYDG R+E+LPANL+QAQRD FGAH +++L + H +WTGHGGN +
Sbjct: 424 TALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPECASDNLPVDKDIHINWTGHGGNVS 483
Query: 700 ASTYQA 717
+STYQA
Sbjct: 484 SSTYQA 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,570,834
Number of Sequences: 369166
Number of extensions: 1877538
Number of successful extensions: 4755
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4565
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4697
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7066925600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)