Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_C13
(404 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P06882|THYG_RAT Thyroglobulin precursor 58 8e-09
sp|O08710|THYG_MOUSE Thyroglobulin precursor 57 2e-08
sp|P31226|SAX_RANCA Saxiphilin precursor (SAX) 56 2e-08
sp|P01267|THYG_BOVIN Thyroglobulin precursor 55 4e-08
sp|P01266|THYG_HUMAN Thyroglobulin precursor 55 5e-08
sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2) 52 3e-07
sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonido... 49 3e-06
sp|P81439|EQST_ACTEQ Equistatin 49 3e-06
sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonect... 43 2e-04
sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonect... 43 2e-04
>sp|P06882|THYG_RAT Thyroglobulin precursor
Length = 2768
Score = 57.8 bits (138), Expect = 8e-09
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE-YSQRKI 228
P C G Y+ +QC CWCV G E+EG ++G C + +++ + +
Sbjct: 618 PSCTAEGSYEDIQCYAGECWCVNSQGKEVEGSRVSGGHPRCPTKCEKQRAQMQNLAGAQP 677
Query: 229 VGRTF---RCDHLGNYEKVQCHGSICYCADLSGNKIP 330
G +F C G + VQC S CYC D G IP
Sbjct: 678 AGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIP 714
Score = 48.1 bits (113), Expect = 6e-06
Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 13/108 (12%)
Frame = +1
Query: 43 DVTFPFCEDTGMYKPVQCV--GAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYS 216
D P C + G ++ VQC G +CWCV+ G E+ G G+ C +
Sbjct: 47 DEYVPQCSEDGSFQTVQCQNDGQSCWCVDSDGTEVPG-----SRQLGRPTACLSFCQLHK 101
Query: 217 QRKIVGRTF---------RCDHLGNYEKVQC--HGSICYCADLSGNKI 327
QR ++ +C GNY VQC C+C D G ++
Sbjct: 102 QRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEV 149
Score = 45.1 bits (105), Expect = 6e-05
Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 10/102 (9%)
Frame = +1
Query: 7 LDARRLIKSGAVDVT----FPFCEDTGMYKPVQC--VGAACWCVEESGDEIEGYITGIEE 168
L +R++ S ++ T P C+D+G Y PVQC CWCV+ G E+ G
Sbjct: 99 LHKQRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEVYG-----TR 153
Query: 169 SYGKTCNCAKDKLEYSQRKIVG----RTFRCDHLGNYEKVQC 282
G+ C + S+R + G +CD G + VQC
Sbjct: 154 QQGRPTRCPRSCEIRSRRLLHGVGDKSPPQCDADGEFMPVQC 195
Score = 45.1 bits (105), Expect = 6e-05
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 4/103 (3%)
Frame = +1
Query: 34 GAVDVTFPFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEY 213
G D+ P C TG Y Q G WCV+ S E T C+ K ++
Sbjct: 1100 GPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGEGVPTNTNSSAQCPGLCDALKSRV-L 1158
Query: 214 SQRKIVGRTFRCDHL-GNYEKVQC---HGSICYCADLSGNKIP 330
S++ +G T C+ L G + VQC GS C+C SG ++P
Sbjct: 1159 SRKVGLGYTPVCEALDGGFSPVQCDLAQGS-CWCVLASGEEVP 1200
Score = 38.9 bits (89), Expect = 0.004
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 1/58 (1%)
Frame = +1
Query: 55 PFCEDTGMYKPVQC-VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 225
P C G Y+ VQC + CWCV+ G EI G G+ CAKD+ S+R+
Sbjct: 318 PSCHRDGHYQTVQCQMERMCWCVDAQGIEIPG-----TRQQGQPLFCAKDQSCASERQ 370
Score = 37.0 bits (84), Expect = 0.015
Identities = 31/110 (28%), Positives = 44/110 (40%), Gaps = 16/110 (14%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYI-----------TGIEESYGKTCNCA 195
P C G ++PVQC CWCV+ G+ I G + T E S A
Sbjct: 1030 PQCNTIGGWEPVQCHPGTGQCWCVDGWGELIPGSLMARSSQMPQCPTSCELSRANGLISA 1089
Query: 196 KDKLEYSQRKIVGRTFR--CDHLGNYEKVQCHGSICYCAD-LSGNKIPTS 336
+ + + G F C G Y + Q G+ +C D SG +PT+
Sbjct: 1090 WKQAGHQRNPGPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGEGVPTN 1139
Score = 35.8 bits (81), Expect = 0.033
Identities = 15/38 (39%), Positives = 20/38 (52%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEE 168
P C G + PVQC + C+CV+ G I G + I E
Sbjct: 685 PTCTSEGYFLPVQCFNSECYCVDAEGQVIPGTQSTIGE 722
Score = 33.9 bits (76), Expect = 0.13
Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 3/34 (8%)
Frame = +1
Query: 55 PFCEDT-GMYKPVQC--VGAACWCVEESGDEIEG 147
P CE G + PVQC +CWCV SG+E+ G
Sbjct: 1168 PVCEALDGGFSPVQCDLAQGSCWCVLASGEEVPG 1201
Score = 30.8 bits (68), Expect = 1.1
Identities = 13/37 (35%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Frame = +1
Query: 232 GRTF--RCDHLGNYEKVQCHGSICYCADLSGNKIPTS 336
GR F C G+YE +QC+ C+C + G ++ S
Sbjct: 613 GRFFVPSCTAEGSYEDIQCYAGECWCVNSQGKEVEGS 649
Score = 28.9 bits (63), Expect = 4.1
Identities = 12/29 (41%), Positives = 17/29 (58%), Gaps = 1/29 (3%)
Frame = +1
Query: 247 CDHLGNYEKVQCHGS-ICYCADLSGNKIP 330
C G+Y+ VQC +C+C D G +IP
Sbjct: 320 CHRDGHYQTVQCQMERMCWCVDAQGIEIP 348
Score = 28.9 bits (63), Expect = 4.1
Identities = 8/14 (57%), Positives = 13/14 (92%)
Frame = +1
Query: 106 ACWCVEESGDEIEG 147
+CWCV+E+G E++G
Sbjct: 898 SCWCVDEAGQELDG 911
>sp|O08710|THYG_MOUSE Thyroglobulin precursor
Length = 2766
Score = 56.6 bits (135), Expect = 2e-08
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE-YSQRKI 228
P C G Y+ +QC CWCV+ G E++G + G C + +++ + +
Sbjct: 618 PSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPTKCEKQRAQMQSLASAQP 677
Query: 229 VGRTF---RCDHLGNYEKVQCHGSICYCADLSGNKIP 330
G +F C G + VQC S CYC D G IP
Sbjct: 678 AGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIP 714
Score = 49.3 bits (116), Expect = 3e-06
Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 13/104 (12%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCV--GAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRKI 228
P C + G ++ VQC G +CWCV+ G E+ G G+ C + QR +
Sbjct: 51 PQCSEDGSFQTVQCQNDGQSCWCVDSDGREVPG-----SRQLGRPTVCLSFCQLHKQRIL 105
Query: 229 VGRTF---------RCDHLGNYEKVQC--HGSICYCADLSGNKI 327
+G +C GNY VQC C+C D G ++
Sbjct: 106 LGSYINSTDALYLPQCQDSGNYAPVQCDLQRVQCWCVDTEGMEV 149
Score = 40.4 bits (93), Expect = 0.001
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 6/82 (7%)
Frame = +1
Query: 55 PFCEDTGMYKPVQC--VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRKI 228
P C+D+G Y PVQC CWCV+ G E+ G G+ C + ++R +
Sbjct: 119 PQCQDSGNYAPVQCDLQRVQCWCVDTEGMEVYG-----TRQQGRPTRCPRSCEIRNRRLL 173
Query: 229 VGRTFR----CDHLGNYEKVQC 282
G R C G + VQC
Sbjct: 174 HGVGDRSPPQCTADGEFMPVQC 195
Score = 39.3 bits (90), Expect = 0.003
Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 4/103 (3%)
Frame = +1
Query: 34 GAVDVTFPFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEY 213
G D+ P C TG Y Q G WCV+ + E T C+ K +
Sbjct: 1100 GPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVNTNGSAQCPGLCDVLKSR-AL 1158
Query: 214 SQRKIVGRTFRCDHL-GNYEKVQC---HGSICYCADLSGNKIP 330
S++ +G + C+ L G + VQC GS C+C SG ++P
Sbjct: 1159 SRKVGLGYSPVCEALDGAFSPVQCDLAQGS-CWCVLGSGEEVP 1200
Score = 35.8 bits (81), Expect = 0.033
Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 16/94 (17%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTC-NCAKDKLEYSQRKIV 231
P C G + PVQC + C+CV+ G I G + + E+ K C + + + E + +V
Sbjct: 685 PTCTREGYFLPVQCFNSECYCVDTEGQVIPGTQSTVGEA--KQCPSVCQLQAEQAFLGVV 742
Query: 232 GRTF---------------RCDHLGNYEKVQCHG 288
G +C G + VQC G
Sbjct: 743 GVLLSNSSMVPSISNVYIPQCSASGQWRHVQCDG 776
Score = 35.4 bits (80), Expect = 0.044
Identities = 18/51 (35%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Frame = +1
Query: 55 PFCEDTGMYKPVQC-VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDK 204
P C G Y+ VQC CWCV+ G E+ G G+ +CA D+
Sbjct: 318 PRCHRDGHYQTVQCQTEGMCWCVDAQGREVPG-----TRQQGQPPSCAADQ 363
Score = 34.3 bits (77), Expect = 0.097
Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 3/34 (8%)
Frame = +1
Query: 55 PFCEDT-GMYKPVQC--VGAACWCVEESGDEIEG 147
P CE G + PVQC +CWCV SG+E+ G
Sbjct: 1168 PVCEALDGAFSPVQCDLAQGSCWCVLGSGEEVPG 1201
Score = 32.7 bits (73), Expect = 0.28
Identities = 28/110 (25%), Positives = 41/110 (37%), Gaps = 16/110 (14%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGK---TCNCAKDKLEYSQ 219
P C G ++PVQC CWCV+ G+ I G + + C ++ S
Sbjct: 1030 PQCNMIGGWEPVQCHAGTGQCWCVDGRGEFIPGSLMSRSSQMPQCPTNCELSRASGLISA 1089
Query: 220 RKIVGRTFR----------CDHLGNYEKVQCHGSICYCAD-LSGNKIPTS 336
K G C G Y + Q G+ +C D SG +P +
Sbjct: 1090 WKQAGPQRNPGPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVN 1139
Score = 32.0 bits (71), Expect = 0.48
Identities = 12/30 (40%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +1
Query: 244 RCDHLGNYEKVQCHGS-ICYCADLSGNKIP 330
RC G+Y+ VQC +C+C D G ++P
Sbjct: 319 RCHRDGHYQTVQCQTEGMCWCVDAQGREVP 348
Score = 31.2 bits (69), Expect = 0.82
Identities = 11/30 (36%), Positives = 17/30 (56%)
Frame = +1
Query: 247 CDHLGNYEKVQCHGSICYCADLSGNKIPTS 336
C G+YE +QC+ C+C D G ++ S
Sbjct: 620 CTAGGSYEDIQCYAGECWCVDSRGKELDGS 649
>sp|P31226|SAX_RANCA Saxiphilin precursor (SAX)
Length = 844
Score = 56.2 bits (134), Expect = 2e-08
Identities = 37/104 (35%), Positives = 52/104 (50%), Gaps = 13/104 (12%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGKTCN------CAKDKLE 210
P C++ G Y+P QC G+ CWCV G++I G T ++ TC C K++
Sbjct: 128 PQCDEKGNYQPQQCHGSTGHCWCVNAMGEKISGTNTPPGQTRA-TCERHELPKCLKERQV 186
Query: 211 Y--SQRKIVGRTF-RCDHLGNYEKVQCHGSICY--CADLSGNKI 327
K++GR +CD GNYE Q HGS Y C + G +I
Sbjct: 187 ALGGDEKVLGRFVPQCDEKGNYEPQQFHGSTGYSWCVNAIGEEI 230
Score = 42.7 bits (99), Expect = 3e-04
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Frame = +1
Query: 190 CAKDKLEYSQRKIVGRTF-RCDHLGNYEKVQCHGSI--CYCADLSGNKI 327
C K++ + +K++G +CD GNY+ QCHGS C+C + G KI
Sbjct: 110 CLKERQQALAKKMIGHYIPQCDEKGNYQPQQCHGSTGHCWCVNAMGEKI 158
Score = 31.2 bits (69), Expect = 0.82
Identities = 14/33 (42%), Positives = 19/33 (57%), Gaps = 2/33 (6%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 147
P C++ G Y+P Q G+ WCV G+EI G
Sbjct: 200 PQCDEKGNYEPQQFHGSTGYSWCVNAIGEEIAG 232
>sp|P01267|THYG_BOVIN Thyroglobulin precursor
Length = 2769
Score = 55.5 bits (132), Expect = 4e-08
Identities = 31/97 (31%), Positives = 41/97 (42%), Gaps = 5/97 (5%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE--YSQRK 225
P C G Y+ VQC CWCV+ G E+ G + G C + +++ +
Sbjct: 617 PACTAEGSYEEVQCFAGDCWCVDAQGRELAGSRVRGGRPRCPTECEKQRARMQSLLGSQP 676
Query: 226 IVGRTF--RCDHLGNYEKVQCHGSICYCADLSGNKIP 330
F C GN+ VQC S CYC D G IP
Sbjct: 677 AGSSLFVPACTSKGNFLPVQCFNSECYCVDTEGQPIP 713
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 8/99 (8%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCV--GAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKL---EYS 216
P C + G ++ VQC GA+CWCV+ G E+ G G + C K ++ Y
Sbjct: 50 PQCAEDGSFQTVQCGKDGASCWCVDADGREVPGSRQPGRPAACLSFCQLQKQQILLSSYI 109
Query: 217 QRKIVGRTFRCDHLGNYEKVQC--HGSICYCADLSGNKI 327
+C G+Y VQC C+C D G ++
Sbjct: 110 NSTATSYLPQCQDSGDYSPVQCDLRRRQCWCVDAEGMEV 148
Score = 40.8 bits (94), Expect = 0.001
Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 10/102 (9%)
Frame = +1
Query: 7 LDARRLIKSGAVDVT----FPFCEDTGMYKPVQCV--GAACWCVEESGDEIEGYITGIEE 168
L ++++ S ++ T P C+D+G Y PVQC CWCV+ G E+ G
Sbjct: 98 LQKQQILLSSYINSTATSYLPQCQDSGDYSPVQCDLRRRQCWCVDAEGMEVYG-----TR 152
Query: 169 SYGKTCNCAKDKLEYSQRKIVGRTFR----CDHLGNYEKVQC 282
G+ C + ++R + G R C G + VQC
Sbjct: 153 QQGRPARCPRSCEIRNRRLLHGVGDRSPPQCSPDGAFRPVQC 194
Score = 40.0 bits (92), Expect = 0.002
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 1/58 (1%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCV-GAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 225
P C G Y+ QC G CWCV+ G EI G G+ +CA+D+ S+R+
Sbjct: 317 PSCHPDGEYQAAQCQQGGPCWCVDSRGQEIPG-----TRQRGEPPSCAEDQSCPSERR 369
Score = 37.4 bits (85), Expect = 0.011
Identities = 25/96 (26%), Positives = 36/96 (37%), Gaps = 18/96 (18%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRKIVG 234
P C G + PVQC + C+CV+ G I G + G+ C ++R +G
Sbjct: 684 PACTSKGNFLPVQCFNSECYCVDTEGQP----IPGTRSALGEPKKCPSPCQLQAERAFLG 739
Query: 235 --RTF----------------RCDHLGNYEKVQCHG 288
RT +C G + VQC G
Sbjct: 740 TVRTLVSNPSTLPALSSIYIPQCSASGQWSPVQCDG 775
Score = 37.0 bits (84), Expect = 0.015
Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 2/33 (6%)
Frame = +1
Query: 244 RCDHLGNYEKVQCHGSI--CYCADLSGNKIPTS 336
+CD G +E VQCH + C+C D G +PTS
Sbjct: 1030 QCDAFGGWEPVQCHAATGHCWCVDGKGEYVPTS 1062
Score = 35.4 bits (80), Expect = 0.044
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Frame = +1
Query: 55 PFCE-DTGMYKPVQCVGA--ACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 225
P C + G + PVQC A +CWCV SG+E+ G T + S C + L +S
Sbjct: 1167 PACRAEDGGFSPVQCDPAQGSCWCVLGSGEEVPG--TRVAGSQ-PACESPQCPLPFSVAD 1223
Query: 226 IVGRTFRCD 252
+ G C+
Sbjct: 1224 VAGGAILCE 1232
Score = 34.3 bits (77), Expect = 0.097
Identities = 28/100 (28%), Positives = 42/100 (42%), Gaps = 4/100 (4%)
Frame = +1
Query: 43 DVTFPFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQR 222
D+ P C +TG + +Q A WCV+ + E T C + + S+R
Sbjct: 1102 DLFIPTCLETGEFARLQASEAGTWCVDPASGEGVPPGTNSSAQCPSLCEVLQSGVP-SRR 1160
Query: 223 KIVGRTFRC-DHLGNYEKVQC---HGSICYCADLSGNKIP 330
G + C G + VQC GS C+C SG ++P
Sbjct: 1161 TSPGYSPACRAEDGGFSPVQCDPAQGS-CWCVLGSGEEVP 1199
Score = 33.1 bits (74), Expect = 0.22
Identities = 14/36 (38%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYIT 156
P C+ G ++PVQC A CWCV+ G+ + +T
Sbjct: 1029 PQCDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLT 1064
Score = 32.3 bits (72), Expect = 0.37
Identities = 12/30 (40%), Positives = 17/30 (56%)
Frame = +1
Query: 247 CDHLGNYEKVQCHGSICYCADLSGNKIPTS 336
C G+YE+VQC C+C D G ++ S
Sbjct: 619 CTAEGSYEEVQCFAGDCWCVDAQGRELAGS 648
Score = 28.5 bits (62), Expect = 5.3
Identities = 12/29 (41%), Positives = 15/29 (51%), Gaps = 1/29 (3%)
Frame = +1
Query: 247 CDHLGNYEKVQCH-GSICYCADLSGNKIP 330
C G Y+ QC G C+C D G +IP
Sbjct: 319 CHPDGEYQAAQCQQGGPCWCVDSRGQEIP 347
Score = 28.5 bits (62), Expect = 5.3
Identities = 8/14 (57%), Positives = 13/14 (92%)
Frame = +1
Query: 106 ACWCVEESGDEIEG 147
+CWCV+E+G ++EG
Sbjct: 897 SCWCVDEAGQKLEG 910
>sp|P01266|THYG_HUMAN Thyroglobulin precursor
Length = 2768
Score = 55.1 bits (131), Expect = 5e-08
Identities = 31/97 (31%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE-YSQRKI 228
P C G Y+ VQC CWCV G E+ G + G + C + +++ +
Sbjct: 618 PSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQP 677
Query: 229 VGRTF---RCDHLGNYEKVQCHGSICYCADLSGNKIP 330
G T C G++ VQC S CYC D G IP
Sbjct: 678 AGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIP 714
Score = 43.1 bits (100), Expect = 2e-04
Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Frame = +1
Query: 55 PFCE-DTGMYKPVQCVGA--ACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLEYSQR 222
P C + G + PVQC A +CWCV +SG+E+ G +TG + + C + L ++
Sbjct: 1167 PACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPA----CESPRCPLPFNAS 1222
Query: 223 KIVGRTFRCDHLGNYEKVQCHGSICYCADLSGNKIPTSPYV 345
++VG T C+ + C S + P P +
Sbjct: 1223 EVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPGPLI 1263
Score = 42.0 bits (97), Expect = 5e-04
Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 10/102 (9%)
Frame = +1
Query: 7 LDARRLIKSGAVDVT----FPFCEDTGMYKPVQC--VGAACWCVEESGDEIEGYITGIEE 168
L ++++ SG ++ T P C+D+G Y PVQC CWCV+ G E+ G
Sbjct: 98 LQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYG-----TR 152
Query: 169 SYGKTCNCAKDKLEYSQRKIVG----RTFRCDHLGNYEKVQC 282
G+ C + ++R + G +C G + VQC
Sbjct: 153 QLGRPKRCPRSCEIRNRRLLHGVGDKSPPQCSAEGEFMPVQC 194
Score = 40.8 bits (94), Expect = 0.001
Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Frame = +1
Query: 43 DVTFPFCEDTGMYKPVQCVGAACWCVE-ESGDEIEGYITGIEESYGKTCNCAKDKLEYSQ 219
D+ P C +TG Y +Q GA WCV+ SG+E+ + + CN K + S+
Sbjct: 1102 DLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSSSSAQC-PSLCNVLKSGV-LSR 1159
Query: 220 RKIVGRTFRC-DHLGNYEKVQC---HGSICYCADLSGNKIP 330
R G C G + VQC GS C+C SG ++P
Sbjct: 1160 RVSPGYVPACRAEDGGFSPVQCDQAQGS-CWCVMDSGEEVP 1199
Score = 39.7 bits (91), Expect = 0.002
Identities = 32/114 (28%), Positives = 47/114 (41%), Gaps = 15/114 (13%)
Frame = +1
Query: 13 ARRLIKSGAVDVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGK-- 180
A L++SG P C+ G ++PVQC CWCV+E G I G +T +
Sbjct: 1018 ASALLRSGPY---MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCP 1074
Query: 181 -TCNCAKD-------KLEYSQRKIVGRTF---RCDHLGNYEKVQCHGSICYCAD 309
TC ++ K SQ + C G Y ++Q G+ +C D
Sbjct: 1075 TTCEKSRTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVD 1128
Score = 36.2 bits (82), Expect = 0.026
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 16/94 (17%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGI--------------EESYGKTCNC 192
P C G + PVQC + C+CV+ G I G + I E+++ +T
Sbjct: 685 PACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAIGKPKKCPTPCQLQSEQAFLRTVQA 744
Query: 193 AKDKLEYSQRKIVGRTF--RCDHLGNYEKVQCHG 288
S + T+ +C G + +VQC+G
Sbjct: 745 LLS--NSSMLPTLSDTYIPQCSTDGQWRQVQCNG 776
Score = 35.4 bits (80), Expect = 0.044
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Frame = +1
Query: 55 PFCEDTGMYKPVQC-VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 225
P C G Y+ VQC CWCV+ G E+ G G+ +CA+ + S+R+
Sbjct: 317 PSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHG-----TRQQGEPPSCAEGQSCASERQ 369
Score = 34.7 bits (78), Expect = 0.074
Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 2/33 (6%)
Frame = +1
Query: 244 RCDHLGNYEKVQCHGSI--CYCADLSGNKIPTS 336
+CD G++E VQCH C+C D G IP S
Sbjct: 1030 QCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGS 1062
Score = 31.6 bits (70), Expect = 0.63
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Frame = +1
Query: 109 CWCVEESGDEIEGYITGIEESYGKTC--NCAKDKLEYSQ 219
CWCV+E+G E+EG + E S TC +C + KL Q
Sbjct: 898 CWCVDEAGQELEGMRS--EPSKLPTCPGSCEEAKLRVLQ 934
Score = 31.2 bits (69), Expect = 0.82
Identities = 12/30 (40%), Positives = 17/30 (56%)
Frame = +1
Query: 247 CDHLGNYEKVQCHGSICYCADLSGNKIPTS 336
C G+YE VQC C+C + G ++P S
Sbjct: 620 CTTEGSYEDVQCFSGECWCVNSWGKELPGS 649
>sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2)
Length = 1403
Score = 52.4 bits (124), Expect = 3e-07
Identities = 33/114 (28%), Positives = 51/114 (44%), Gaps = 20/114 (17%)
Frame = +1
Query: 46 VTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYIT---------GIEESYGKTCNC 192
+ P C+D G + P+QC G+ CWCV+ +G E+ G T G +
Sbjct: 986 IHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVPGTQTPPGSTPPHCGPPPEPTQRPRT 1045
Query: 193 AKDKLEYSQRKIVGRTFR-------CDHLGNYEKVQCHG--SICYCADLSGNKI 327
++ S + G T R CD LG++ +QCHG C+C D G ++
Sbjct: 1046 VCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREL 1099
Score = 40.0 bits (92), Expect = 0.002
Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +1
Query: 43 DVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 147
D P C+D G + P+QC G + CWCV++ G E++G
Sbjct: 1065 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGRELQG 1101
Score = 38.5 bits (88), Expect = 0.005
Identities = 14/31 (45%), Positives = 22/31 (70%), Gaps = 2/31 (6%)
Frame = +1
Query: 244 RCDHLGNYEKVQCHGS--ICYCADLSGNKIP 330
+CD GN+ +QCHGS C+C D +G+++P
Sbjct: 990 QCDDQGNFVPLQCHGSTGFCWCVDRNGHEVP 1020
>sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonidogen)
Length = 1375
Score = 49.3 bits (116), Expect = 3e-06
Identities = 35/115 (30%), Positives = 50/115 (43%), Gaps = 24/115 (20%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQR-- 222
P C++ G + P+QC G+ CWCV+ G E+ G T G T E +QR
Sbjct: 961 PQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQT----PPGSTPPHCGPSPEPTQRPP 1016
Query: 223 -----------KIVGRTFR-------CDHLGNYEKVQCHG--SICYCADLSGNKI 327
+ G T R CD LG++ +QCHG C+C D G ++
Sbjct: 1017 TICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREV 1071
Score = 40.4 bits (93), Expect = 0.001
Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +1
Query: 43 DVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 147
D P C+D G + P+QC G + CWCV++ G E++G
Sbjct: 1037 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQG 1073
Score = 37.7 bits (86), Expect = 0.009
Identities = 14/31 (45%), Positives = 21/31 (67%), Gaps = 2/31 (6%)
Frame = +1
Query: 244 RCDHLGNYEKVQCHGS--ICYCADLSGNKIP 330
+CD GN+ +QCHGS C+C D G+++P
Sbjct: 962 QCDEQGNFLPLQCHGSTGFCWCVDPDGHEVP 992
>sp|P81439|EQST_ACTEQ Equistatin
Length = 199
Score = 49.3 bits (116), Expect = 3e-06
Identities = 38/111 (34%), Positives = 53/111 (47%), Gaps = 12/111 (10%)
Frame = +1
Query: 31 SGAVDVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGKTCNCAKDK 204
SG + P C++TG ++ QC G+ CWCV+E G EI G T I S C+ K
Sbjct: 14 SGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILG--TKIRGS--PDCSRRKAA 69
Query: 205 L---EYSQRKIVG-----RTFRCDHLGNYEKVQCHGS--ICYCADLSGNKI 327
L + Q IV C G++++VQC S CYC D G ++
Sbjct: 70 LTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKEL 120
Score = 45.8 bits (107), Expect = 3e-05
Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 7/101 (6%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGA--ACWCVEESGDEIEGYITGIEESYGKTCN-CAKDKLEYSQRK 225
P C+ G + VQC + C+CV++ G E+EG S + + C + +L+
Sbjct: 90 PSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQKGRPSCERHLSPCEEARLQAHSNS 149
Query: 226 IVGRTF--RCDHLGNYEKVQCHGS--ICYCADLSGNKIPTS 336
+ F +C G+Y VQC S C+C D G K+P S
Sbjct: 150 LRVGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPGS 190
Score = 37.0 bits (84), Expect = 0.015
Identities = 16/38 (42%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Frame = +1
Query: 40 VDVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 147
V + P C + G Y PVQC + CWCV+E G ++ G
Sbjct: 152 VGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPG 189
>sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 43.1 bits (100), Expect = 2e-04
Identities = 16/33 (48%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 147
P C++ G YKP QC G+ CWCV+ G+E+ G
Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMG 371
Score = 37.0 bits (84), Expect = 0.015
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Frame = +1
Query: 220 RKIVGRTFR-CDHLGNYEKVQCHGSI--CYCADLSGNKIPTSPYVDIAN 357
+K++G+ CD G Y+ QCHGS+ C+C D GN++ S +A+
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVAD 379
>sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 43.1 bits (100), Expect = 2e-04
Identities = 16/33 (48%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +1
Query: 55 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 147
P C++ G YKP QC G+ CWCV+ G+E+ G
Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVG 371
Score = 37.0 bits (84), Expect = 0.015
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Frame = +1
Query: 220 RKIVGRTFR-CDHLGNYEKVQCHGSI--CYCADLSGNKIPTSPYVDIAN 357
+K++G+ CD G Y+ QCHGS+ C+C D GN++ S +A+
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVAD 379
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,350,534
Number of Sequences: 369166
Number of extensions: 997664
Number of successful extensions: 2848
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2633
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2791
length of database: 68,354,980
effective HSP length: 98
effective length of database: 50,250,950
effective search space used: 1809034200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)