Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_C08
(816 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5RBI3|PSD12_PONPY 26S proteasome non-ATPase regulatory ... 249 8e-66
sp|O00232|PSD12_HUMAN 26S proteasome non-ATPase regulatory ... 249 8e-66
sp|Q9D8W5|PSD12_MOUSE 26S proteasome non-ATPase regulatory ... 242 1e-63
sp|Q12250|RPN5_YEAST 26S proteasome regulatory subunit RPN5... 174 3e-43
sp|Q9UTM3|RPN5_SCHPO 26S proteasome regulatory subunit rpn5 169 1e-41
sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4 (Si... 44 4e-04
sp|Q9V345|CSN4_DROME COP9 signalosome complex subunit 4 (Si... 43 0.001
sp|Q97FK1|SBCC_CLOAB Nuclease sbcCD subunit C 37 0.065
sp|O01422|CSN2_CAEEL COP9 signalosome complex subunit 2 (Si... 37 0.065
sp|Q9HFR0|CSN2_SCHPO COP9 signalosome complex subunit 2 (CS... 35 0.32
>sp|Q5RBI3|PSD12_PONPY 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome
regulatory subunit p55)
Length = 456
Score = 249 bits (635), Expect = 8e-66
Identities = 129/268 (48%), Positives = 179/268 (66%), Gaps = 8/268 (2%)
Frame = +1
Query: 1 MRLCLAKKDAIRTQXXXXXXXXXXFVDESFEPLKLKFYKLMIDLDLSENNYLNISKHYFE 180
MRLCLA KD IRTQ F +E+ E LKLK+Y LMI LD E +YL+I KHY
Sbjct: 190 MRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRA 249
Query: 181 IYQSKSIHAVEENRLLNLKNVMVFLLLARFDHEQNDLLYRHKSACEKDIEKLPMIKEIIT 360
IY + I A E LK+V+++++LA FD+EQ+DL+ H+ + +K +E++P K+++
Sbjct: 250 IYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLV--HRISGDKKLEEIPKYKDLLK 307
Query: 361 LFCTKEVMLWRVFCEKYESELKK--------DLIFNGEQGDKRWEQLHNRIVEHNIRIMA 516
LF T E+M W E Y EL+K D+ + E+G+KRW+ L NR+VEHNIRIMA
Sbjct: 308 LFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMA 367
Query: 517 EYYTQIRVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGITHFTKTKDATEIVND 696
+YYT+I + +MA +LD+ E FLS+LVVNKTI AK+DRL GI +F + KD ++ND
Sbjct: 368 KYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLND 427
Query: 697 WSYNINQLLSLIKKTNHLINKEKMIHHV 780
WS +N L+SL+ KT HLI KE+MIH++
Sbjct: 428 WSQKLNSLMSLVNKTTHLIAKEEMIHNL 455
>sp|O00232|PSD12_HUMAN 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome
regulatory subunit p55)
Length = 456
Score = 249 bits (635), Expect = 8e-66
Identities = 129/268 (48%), Positives = 179/268 (66%), Gaps = 8/268 (2%)
Frame = +1
Query: 1 MRLCLAKKDAIRTQXXXXXXXXXXFVDESFEPLKLKFYKLMIDLDLSENNYLNISKHYFE 180
MRLCLA KD IRTQ F +E+ E LKLK+Y LMI LD E +YL+I KHY
Sbjct: 190 MRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRA 249
Query: 181 IYQSKSIHAVEENRLLNLKNVMVFLLLARFDHEQNDLLYRHKSACEKDIEKLPMIKEIIT 360
IY + I A E LK+V+++++LA FD+EQ+DL+ H+ + +K +E++P K+++
Sbjct: 250 IYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLV--HRISGDKKLEEIPKYKDLLK 307
Query: 361 LFCTKEVMLWRVFCEKYESELKK--------DLIFNGEQGDKRWEQLHNRIVEHNIRIMA 516
LF T E+M W E Y EL+K D+ + E+G+KRW+ L NR+VEHNIRIMA
Sbjct: 308 LFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMA 367
Query: 517 EYYTQIRVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGITHFTKTKDATEIVND 696
+YYT+I + +MA +LD+ E FLS+LVVNKTI AK+DRL GI +F + KD ++ND
Sbjct: 368 KYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLND 427
Query: 697 WSYNINQLLSLIKKTNHLINKEKMIHHV 780
WS +N L+SL+ KT HLI KE+MIH++
Sbjct: 428 WSQKLNSLMSLVNKTTHLIAKEEMIHNL 455
>sp|Q9D8W5|PSD12_MOUSE 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome
regulatory subunit p55)
Length = 456
Score = 242 bits (617), Expect = 1e-63
Identities = 125/268 (46%), Positives = 178/268 (66%), Gaps = 8/268 (2%)
Frame = +1
Query: 1 MRLCLAKKDAIRTQXXXXXXXXXXFVDESFEPLKLKFYKLMIDLDLSENNYLNISKHYFE 180
MRLCLA KD IRTQ +E+ E +KLK+Y LMI LD E +YL+I KHY
Sbjct: 190 MRLCLAVKDYIRTQIISKKINTKFSQEENTENMKLKYYNLMIQLDQHEGSYLSICKHYRA 249
Query: 181 IYQSKSIHAVEENRLLNLKNVMVFLLLARFDHEQNDLLYRHKSACEKDIEKLPMIKEIIT 360
IY + I A + LK+V+++++LA FD+EQ+DL++R S +K +E++P K+++
Sbjct: 250 IYDTPCIQAESDKWQQALKSVVLYVILAPFDNEQSDLVHRISS--DKKLEEIPKYKDLLK 307
Query: 361 LFCTKEVMLWRVFCEKYESELKK--------DLIFNGEQGDKRWEQLHNRIVEHNIRIMA 516
LF T E+M W E Y EL+K D+ + E+G+KRW+ L +R+VEHNIRIMA
Sbjct: 308 LFTTMELMRWSTLVEDYGVELRKGSSETPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMA 367
Query: 517 EYYTQIRVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGITHFTKTKDATEIVND 696
+YYT+I + +MA +LD+ E FLS+LVVNKTI AK+DRL G+ +F + KD ++ND
Sbjct: 368 KYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPNNLLND 427
Query: 697 WSYNINQLLSLIKKTNHLINKEKMIHHV 780
WS +N L+SL+ KT HLI KE+MIH++
Sbjct: 428 WSQKLNSLMSLVNKTTHLIAKEEMIHNL 455
>sp|Q12250|RPN5_YEAST 26S proteasome regulatory subunit RPN5 (Proteasome non-ATPase
subunit 5)
Length = 445
Score = 174 bits (440), Expect = 3e-43
Identities = 87/259 (33%), Positives = 156/259 (60%), Gaps = 1/259 (0%)
Frame = +1
Query: 1 MRLCLAKKDAIRTQXXXXXXXXXXFVDESFEPLKLKFYKLMIDLDLSENNYLNISKHYFE 180
M L + K D + F + +E LKL++Y L++ + L + YL ++++ E
Sbjct: 184 MELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQYLQE 243
Query: 181 IYQSKSIHAVEENRLLNLKNVMVFLLLARFDHEQNDLLYRHKSACEKDIEKLPMIKEIIT 360
IYQ+ +I + E L +++ FL+L+ + + QNDL+ HK + +++KL + ++
Sbjct: 244 IYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLI--HKIQNDNNLKKLESQESLVK 301
Query: 361 LFCTKEVMLWRVFCEKYESELKKD-LIFNGEQGDKRWEQLHNRIVEHNIRIMAEYYTQIR 537
LF T E+M W + + YE L +D L F GE WE L R++EHN+R+++EYY++I
Sbjct: 302 LFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRIT 361
Query: 538 VSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGITHFTKTKDATEIVNDWSYNINQ 717
+ ++ +LD+ E E ++SDLV I AK++R I +F K K++++++N+WS+N+++
Sbjct: 362 LLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVDE 421
Query: 718 LLSLIKKTNHLINKEKMIH 774
LL I+ HLI KE+++H
Sbjct: 422 LLEHIETIGHLITKEEIMH 440
>sp|Q9UTM3|RPN5_SCHPO 26S proteasome regulatory subunit rpn5
Length = 443
Score = 169 bits (427), Expect = 1e-41
Identities = 88/262 (33%), Positives = 147/262 (56%), Gaps = 2/262 (0%)
Frame = +1
Query: 1 MRLCLAKKDAIRTQXXXXXXXXXXFVDESFEPLKLKFYKLMIDLDLSENNYLNISKHYFE 180
+RL L + D F E + LKLK+Y+ I + L ++ YL++ K+Y
Sbjct: 178 VRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRA 237
Query: 181 IYQSKSIHAVEENRLLNLKNVMVFLLLARFDHEQNDLLYRHKSACEKDIEKLPMIKEIIT 360
+Y + + E L+NV+ F LL +D+EQ DLL H+ + + LP++++++
Sbjct: 238 VYDTAVVQEDPEKWKEILENVVCFALLTPYDNEQADLL--HRINADHKLNSLPLLQQLVK 295
Query: 361 LFCTKEVMLWRVFCEKYESELKKDLIF--NGEQGDKRWEQLHNRIVEHNIRIMAEYYTQI 534
F E+M W E Y S L+ + +F N E+G+KRW +L R++EHNIR++A YY++I
Sbjct: 296 CFIVNELMRWPKIAEIYGSALRSNPVFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRI 355
Query: 535 RVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGITHFTKTKDATEIVNDWSYNIN 714
S++ +LD+ E+FL DL+ AKIDR + F K+++ E +N+W NI
Sbjct: 356 HCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNIT 415
Query: 715 QLLSLIKKTNHLINKEKMIHHV 780
+LL ++K LI KE+M++ +
Sbjct: 416 ELLGKLEKVRQLIIKEEMMNSI 437
>sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4 (Signalosome subunit 4)
(Constitutive photomorphogenesis protein 8) (FUSCA
protein 4) (FUSCA4) (AtS4)
Length = 397
Score = 44.3 bits (103), Expect = 4e-04
Identities = 22/82 (26%), Positives = 41/82 (50%)
Frame = +1
Query: 475 LHNRIVEHNIRIMAEYYTQIRVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGIT 654
L ++EHN+ ++ YT IR ++ +L ID + EK ++++ + ID+ +
Sbjct: 299 LDRAMIEHNLLSASKLYTNIRFDELGTLLAIDPRKAEKIAANMIGQDRMRGSIDQEEAVI 358
Query: 655 HFTKTKDATEIVNDWSYNINQL 720
HF +D E + W I+ L
Sbjct: 359 HF---EDDVEELQQWDQQISGL 377
>sp|Q9V345|CSN4_DROME COP9 signalosome complex subunit 4 (Signalosome subunit 4) (Dch4)
Length = 407
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/95 (26%), Positives = 43/95 (45%)
Frame = +1
Query: 475 LHNRIVEHNIRIMAEYYTQIRVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGIT 654
L + EHN+ ++ Y I ++ +LDI EK S ++ + ID++ I
Sbjct: 307 LDRAVFEHNLLSASKLYNNITFEELGALLDIPAVKAEKIASQMITEGRMNGHIDQISAIV 366
Query: 655 HFTKTKDATEIVNDWSYNINQLLSLIKKTNHLINK 759
HF + E++ W Q+ SL + N +I K
Sbjct: 367 HF----ENRELLPQWD---RQIQSLCYQVNSIIEK 394
>sp|Q97FK1|SBCC_CLOAB Nuclease sbcCD subunit C
Length = 1163
Score = 37.0 bits (84), Expect = 0.065
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 9/149 (6%)
Frame = +1
Query: 271 DHEQNDLLYRHKSACEKDIEKLPMIKEIITLFCTKEVMLWRVFCEKYESELKK------- 429
D + ND+ +K E+ E + KE KE+ L + EKY++EL K
Sbjct: 871 DRKVNDIDKLNKILMEEKFENIEKAKE--NYLNDKEINLLKSDVEKYKNELSKVNGAVEV 928
Query: 430 --DLIFNGEQGDKRWEQLHNRIVEHNIRIMAEYYTQIRVSKMANMLDIDEKTLEKFLSDL 603
+ N + +++W ++ N VE + A I++ + ++I K L K L
Sbjct: 929 LSKKLKNRKLTEEKWIEIQNNRVEKASKAKALQERSIKLEEEVKNIEIKLKELGKLLK-- 986
Query: 604 VVNKTIEAKIDRLLGITHFTKTKDATEIV 690
+ +E K+ L + K K E V
Sbjct: 987 -TKQELEHKLSLLDDLEKLFKGKKFVEFV 1014
>sp|O01422|CSN2_CAEEL COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 495
Score = 37.0 bits (84), Expect = 0.065
Identities = 31/181 (17%), Positives = 78/181 (43%)
Frame = +1
Query: 130 LDLSENNYLNISKHYFEIYQSKSIHAVEENRLLNLKNVMVFLLLARFDHEQNDLLYRHKS 309
+ L + +L+ +FE +++ + R LK +++ +L + D D ++
Sbjct: 244 MHLRDGRFLDAHTDFFEAFKNYD-ESGSPRRTTCLKYLVLANMLIKSDINPFD---SQEA 299
Query: 310 ACEKDIEKLPMIKEIITLFCTKEVMLWRVFCEKYESELKKDLIFNGEQGDKRWEQLHNRI 489
K+ ++ + +++ + ++ + ++ + D + E+L N I
Sbjct: 300 KPFKNEPEIVAMTQMVQAYQDNDIQAFEQIMAAHQDSIMADPFIR-----EHTEELMNNI 354
Query: 490 VEHNIRIMAEYYTQIRVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGITHFTKT 669
+ + YT +R+S ++ L + +K + L D +++ +EAKI+ G+ K
Sbjct: 355 RTQVLLRLIRPYTNVRISYLSQKLKVSQKEVIHLLVDAILDDGLEAKINEESGMIEMPKN 414
Query: 670 K 672
K
Sbjct: 415 K 415
>sp|Q9HFR0|CSN2_SCHPO COP9 signalosome complex subunit 2 (CSN complex subunit 2) (SGN2)
Length = 437
Score = 34.7 bits (78), Expect = 0.32
Identities = 35/203 (17%), Positives = 93/203 (45%)
Frame = +1
Query: 130 LDLSENNYLNISKHYFEIYQSKSIHAVEENRLLNLKNVMVFLLLARFDHEQNDLLYRHKS 309
+ + EN + ++FE ++S A +R+ LK +++ +L+ + D ++
Sbjct: 246 MHMQENQWSEAQTNFFESFKSYD-EAGSSDRIRVLKYLVLANMLSESEINPFD---SPET 301
Query: 310 ACEKDIEKLPMIKEIITLFCTKEVMLWRVFCEKYESELKKDLIFNGEQGDKRWEQLHNRI 489
KD + + +++ + +++ + Y+ ++ D F + DK + +++
Sbjct: 302 QPYKDNPHIIAMTKLVEAYQIRDITAVERILQTYQHDILDD-DFIRQYVDKILYSIRSQV 360
Query: 490 VEHNIRIMAEYYTQIRVSKMANMLDIDEKTLEKFLSDLVVNKTIEAKIDRLLGITHFTKT 669
+ + + YT +++S +A L + +E+ L L++++ + KID + + FT +
Sbjct: 361 LIE----LVKPYTSVKLSLLAKKLGVSISIIEQALVGLIIDERVNGKIDMVNEV--FTIS 414
Query: 670 KDATEIVNDWSYNINQLLSLIKK 738
+ I N ++ +L + K
Sbjct: 415 QPKNTIHNQLVEDVQKLWNTATK 437
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,272,385
Number of Sequences: 369166
Number of extensions: 1750320
Number of successful extensions: 5400
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5176
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5383
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)