Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_A22
(454 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I ... 158 6e-39
sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I ... 157 8e-39
sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II... 155 3e-38
sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (... 155 4e-38
sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II... 155 4e-38
sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase II... 152 4e-37
sp|P38063|KPR4_YEAST Probable ribose-phosphate pyrophosphok... 133 2e-31
sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (... 133 2e-31
sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (... 127 1e-29
sp|P38620|KPR2_YEAST Ribose-phosphate pyrophosphokinase 2 (... 126 2e-29
>sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I) (PPRibP)
sp|P60892|PRPS1_RAT Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 158 bits (399), Expect = 6e-39
Identities = 77/152 (50%), Positives = 110/152 (72%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PI+AKLVA++L +AGA+HIITMDLHASQIQGFF++PVDNL +E + WI++NI
Sbjct: 100 KDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENI 159
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
S+W TI S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 160 SEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + +L GA VY I THG
Sbjct: 220 DDMADTCGTICHAADKLLSAGATRVYAILTHG 251
>sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 157 bits (398), Expect = 8e-39
Identities = 77/152 (50%), Positives = 109/152 (71%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PI+AKLVA++L +AGA+HIITMDLHASQIQGFF++PVDNL +E + WI++NI
Sbjct: 100 KDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENI 159
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
S+W TI S + A+RV ++A L V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 160 SEWRNCTIVSPDAGGAKRVTSIAERLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + +L GA VY I THG
Sbjct: 220 DDMADTCGTICHAADKLLSAGATRVYAILTHG 251
>sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
sp|P11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II) (PPRibP)
Length = 318
Score = 155 bits (393), Expect = 3e-38
Identities = 75/152 (49%), Positives = 110/152 (72%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PI+AKLVA++L +AGA+HIITMDLHASQIQGFF++PVDNL +E + WI++NI
Sbjct: 100 KDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENI 159
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
++W+ I S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 160 AEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + +L GA VY I THG
Sbjct: 220 DDMADTCGTICHAADKLLSAGATKVYAILTHG 251
>sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 155 bits (392), Expect = 4e-38
Identities = 75/152 (49%), Positives = 109/152 (71%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PI+AKLVA++L +AGA+HIITMDLHASQIQGFF++PVDNL +E + WI++NI
Sbjct: 100 KDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENI 159
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
++W I S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 160 TEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + +L GA VY I THG
Sbjct: 220 DDMADTCGTICHAADKLLSAGATKVYAILTHG 251
>sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 155 bits (392), Expect = 4e-38
Identities = 75/152 (49%), Positives = 109/152 (71%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PI+AKLVA++L +AGA+HIITMDLHASQIQGFF++PVDNL +E + WI++NI
Sbjct: 100 KDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENI 159
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
++W I S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 160 TEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + +L GA VY I THG
Sbjct: 220 DDMADTCGTICHAADKLLSAGATKVYAILTHG 251
>sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase III (Phosphoribosyl
pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl
pyrophosphate synthetase 1-like 1)
Length = 318
Score = 152 bits (383), Expect = 4e-37
Identities = 77/152 (50%), Positives = 108/152 (71%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PI+AKLVA++L IAGA+HIITMDLHASQIQGFF++PVDNL +E + WI++NI
Sbjct: 100 KDKSRSPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENI 159
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQ--IILVGDVVSRIAVIL 356
+W+ I S + A+RV ++A+ L V F LI+ E+K+A+E I+LVGDV R+A+++
Sbjct: 160 PEWKNCIIVSPDAGGAKRVTSIADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILV 219
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + +L GA VY I THG
Sbjct: 220 DDMADTCVTICLAADKLLSAGATRVYAILTHG 251
>sp|P38063|KPR4_YEAST Probable ribose-phosphate pyrophosphokinase 4 (Phosphoribosyl
pyrophosphate synthetase 4)
Length = 355
Score = 133 bits (335), Expect = 2e-31
Identities = 68/152 (44%), Positives = 105/152 (69%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PITAKLVA+LL AGA+H+ITMDLHASQIQGFF++PVDNL +E +++I+
Sbjct: 140 KDKSRAPITAKLVANLLQTAGADHVITMDLHASQIQGFFHIPVDNLYAEPSVLNYIRARK 199
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
+ ++ + S + A+RVA +A+ L + F LI+ E+++A+E +++LVGDV ++ +++
Sbjct: 200 TDFDNAILVSPDAGGAKRVAALADKLDLNFALIHKERQKANEVSKMVLVGDVTNKSCLLV 259
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C ++ + L E GA V I THG
Sbjct: 260 DDMADTCGTLVKACDTLMEHGAKEVIAIVTHG 291
>sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (Phosphoribosyl pyrophosphate
synthetase 3)
Length = 320
Score = 133 bits (334), Expect = 2e-31
Identities = 71/152 (46%), Positives = 102/152 (67%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PITAKL+AD+L AG +H+ITMDLHASQIQGFF+VPVDNL +E + +IK+N+
Sbjct: 103 KDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKENV 162
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
+ + I I S + A+R A +A+ L + F LI+ E+ A+E +++LVGDV +I +I+
Sbjct: 163 NYMDSI-IISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICIIV 221
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + + L E A V I THG
Sbjct: 222 DDMADTCGTLAKAAEILLENRAKSVIAIVTHG 253
>sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (Phosphoribosyl pyrophosphate
synthetase 1)
Length = 321
Score = 127 bits (319), Expect = 1e-29
Identities = 70/152 (46%), Positives = 99/152 (65%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PITAKL+AD+L AG +H+ITMDLHASQIQGFF+VPVDNL +E + +IK+ I
Sbjct: 103 KDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKETI 162
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
+ E I S + A+R A +A+ L + F LI+ E+ A+E +++LV DV +I VI+
Sbjct: 163 D-YSEAIIISSDAGGAKRAAGLADRLDLNFELIHKERARANEVSRMVLVVDVTDKICVIV 221
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C + + + L + A V I THG
Sbjct: 222 DDMADTCGTLAKAAEVLLDNNAKDVIAIVTHG 253
>sp|P38620|KPR2_YEAST Ribose-phosphate pyrophosphokinase 2 (Phosphoribosyl pyrophosphate
synthetase 2)
Length = 318
Score = 126 bits (317), Expect = 2e-29
Identities = 65/152 (42%), Positives = 102/152 (67%), Gaps = 2/152 (1%)
Frame = +3
Query: 3 KDNNRVPITAKLVADLLHIAGANHIITMDLHASQIQGFFNVPVDNLLSESCHISWIKKNI 182
KD +R PITAKL+A+LL AG +H+ITMDLHASQIQGFF++PVDNL E +++I+
Sbjct: 104 KDKSRAPITAKLIANLLETAGCDHVITMDLHASQIQGFFHIPVDNLYGEPSVLNYIRTK- 162
Query: 183 SKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 356
+ + + S + A+RVA++A+ L + F LI+ E+++A+E +++LVGDV + +++
Sbjct: 163 TDFNNAILVSPDAGGAKRVASLADKLDMNFALIHKERQKANEVSRMLLVGDVAGKSCLLI 222
Query: 357 LDIIDNCDLVISSVKRLKEVGAAGVYVIATHG 452
D+ D C ++ + L + GA V I THG
Sbjct: 223 DDMADTCGTLVKACDTLMDHGAKEVIAIVTHG 254
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,239,776
Number of Sequences: 369166
Number of extensions: 1014439
Number of successful extensions: 3129
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2873
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3039
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2435140505
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)