Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_018_A15
(735 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54939|TLN1_CHICK Talin-1 164 2e-40
sp|P26039|TLN1_MOUSE Talin-1 164 2e-40
sp|Q9Y490|TLN1_HUMAN Talin-1 163 5e-40
sp|Q9Y4G6|TLN2_HUMAN Talin-2 154 2e-37
sp|Q71LX4|TLN2_MOUSE Talin-2 129 1e-29
sp|Q9P6L5|SLA2_SCHPO Endocytosis protein end4 (SLA2 protein... 91 4e-18
sp|Q02328|SLAP2_CAEEL Protein SLA2 homolog 89 9e-18
sp|O00291|HIP1_HUMAN Huntingtin interacting protein 1 (HIP-I) 88 2e-17
sp|Q9JKY5|HIP1R_MOUSE Huntingtin interacting protein 1 rela... 75 1e-13
sp|O75146|HIP1R_HUMAN Huntingtin-interacting protein 1-rela... 74 5e-13
>sp|P54939|TLN1_CHICK Talin-1
Length = 2541
Score = 164 bits (416), Expect = 2e-40
Identities = 105/228 (46%), Positives = 140/228 (61%), Gaps = 2/228 (0%)
Frame = +3
Query: 3 AKKLALLKPRKSIKKETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMK- 179
AKKL LKPR K+ E F+ QI+ A SI +ATS LVK AS +Q+ELVA G++
Sbjct: 2319 AKKLEQLKPRAK-PKQADESLDFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGV 2377
Query: 180 -PSENVSSQHETQWTHGLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGT 356
P+ V + QW+ GLISAAR+VAAAT NL ++A A VQG + ++LIS++KQVAA T
Sbjct: 2378 IPANAVD---DGQWSQGLISAARMVAAATNNLCEAANAAVQGHASEEKLISSAKQVAAST 2434
Query: 357 AHLLLACQVKSDPDSITNQRLQTAGAAVKKATEALVKEATEHRDVQDGSVPYTYDGTNKS 536
A LL+AC+VK+D DS +RLQ AG AVK+A++ LVK A + QD +
Sbjct: 2435 AQLLVACKVKADHDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFQDHDETVV---VKEK 2491
Query: 537 MVSSMRNVIQAQADIVAKERELEMLRNKYQSIRQGHINTHPELFTDKD 680
MV + +I AQ +++ KERELE R K IRQ P D++
Sbjct: 2492 MVGGIAQIIAAQEEMLRKERELEEARKKLAMIRQQQYKFLPTELRDEE 2539
>sp|P26039|TLN1_MOUSE Talin-1
Length = 2541
Score = 164 bits (416), Expect = 2e-40
Identities = 103/225 (45%), Positives = 138/225 (61%)
Frame = +3
Query: 3 AKKLALLKPRKSIKKETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKP 182
AKKL LKPR KE E F+ QI+ A SI +ATS LVK AS +Q+ELVA G++
Sbjct: 2320 AKKLEQLKPRAK-PKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGA 2378
Query: 183 SENVSSQHETQWTHGLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAH 362
++ + QW+ GLISAAR+VAAAT NL ++A A VQG + ++LIS++KQVAA TA
Sbjct: 2379 IP-ANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQ 2437
Query: 363 LLLACQVKSDPDSITNQRLQTAGAAVKKATEALVKEATEHRDVQDGSVPYTYDGTNKSMV 542
LL+AC+VK+D DS +RLQ AG AVK+A++ LVK A + +D + MV
Sbjct: 2438 LLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEDQENETVV--VKEKMV 2495
Query: 543 SSMRNVIQAQADIVAKERELEMLRNKYQSIRQGHINTHPELFTDK 677
+ +I AQ +++ KERELE R K IRQ P D+
Sbjct: 2496 GGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDE 2540
>sp|Q9Y490|TLN1_HUMAN Talin-1
Length = 2541
Score = 163 bits (412), Expect = 5e-40
Identities = 102/225 (45%), Positives = 138/225 (61%)
Frame = +3
Query: 3 AKKLALLKPRKSIKKETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKP 182
AKKL LKPR KE E F+ QI+ A SI +ATS LVK AS +Q+ELVA G++
Sbjct: 2320 AKKLEQLKPRAK-PKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGA 2378
Query: 183 SENVSSQHETQWTHGLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAH 362
++ + QW+ GLISAAR+VAAAT NL ++A A VQG + ++LIS++KQVAA TA
Sbjct: 2379 IP-ANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQ 2437
Query: 363 LLLACQVKSDPDSITNQRLQTAGAAVKKATEALVKEATEHRDVQDGSVPYTYDGTNKSMV 542
LL+AC+VK+D DS +RLQ AG AVK+A++ LVK A + ++ + MV
Sbjct: 2438 LLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVV--VKEKMV 2495
Query: 543 SSMRNVIQAQADIVAKERELEMLRNKYQSIRQGHINTHPELFTDK 677
+ +I AQ +++ KERELE R K IRQ P D+
Sbjct: 2496 GGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDE 2540
>sp|Q9Y4G6|TLN2_HUMAN Talin-2
Length = 2542
Score = 154 bits (390), Expect = 2e-37
Identities = 98/212 (46%), Positives = 133/212 (62%)
Frame = +3
Query: 3 AKKLALLKPRKSIKKETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKP 182
AKKL LKPR K+ E F+ QI+ A SI +ATS LVK AS +Q+ELVA G++
Sbjct: 2321 AKKLEQLKPRAK-PKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVG- 2378
Query: 183 SENVSSQHETQWTHGLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAH 362
S ++ + QW+ GLISAAR+VAAAT +L ++A A VQG + ++LIS++KQVAA TA
Sbjct: 2379 SIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAASTAQ 2438
Query: 363 LLLACQVKSDPDSITNQRLQTAGAAVKKATEALVKEATEHRDVQDGSVPYTYDGTNKSMV 542
LL+AC+VK+D DS +RLQ AG AVK+A++ LV+ A + G V
Sbjct: 2439 LLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAA---QKAAFGKADDDDVVVKTKFV 2495
Query: 543 SSMRNVIQAQADIVAKERELEMLRNKYQSIRQ 638
+ +I AQ +++ KERELE R K IRQ
Sbjct: 2496 GGIAQIIAAQEEMLKKERELEEARKKLAQIRQ 2527
>sp|Q71LX4|TLN2_MOUSE Talin-2
Length = 2375
Score = 129 bits (323), Expect = 1e-29
Identities = 77/146 (52%), Positives = 102/146 (69%)
Frame = +3
Query: 3 AKKLALLKPRKSIKKETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKP 182
AKKL LKPR K+ E F+ QI+ A SI +ATS LVK AS +Q+ELVA G++
Sbjct: 2232 AKKLEQLKPRAK-PKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVG- 2289
Query: 183 SENVSSQHETQWTHGLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAH 362
S ++ + QW+ GLISAAR+VAAAT +L ++A A VQG + ++LIS++KQVAA TA
Sbjct: 2290 SIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAASTAQ 2349
Query: 363 LLLACQVKSDPDSITNQRLQTAGAAV 440
LL+AC+VK+D DS +RLQ AG AV
Sbjct: 2350 LLVACKVKADQDSEAMKRLQAAGNAV 2375
>sp|Q9P6L5|SLA2_SCHPO Endocytosis protein end4 (SLA2 protein homolog)
Length = 1092
Score = 90.5 bits (223), Expect = 4e-18
Identities = 65/188 (34%), Positives = 103/188 (54%), Gaps = 7/188 (3%)
Frame = +3
Query: 81 IIVACGSIVSATSHLVKMASLSQQELVALGRMKPSENVSSQHETQWTHGLISAARLVAAA 260
++ A +I A + L+K A+ SQ E+VA GR S + +WT GLISAA+ VA A
Sbjct: 901 LLSASIAITEAIARLIKAATASQAEIVAQGRGSSSRGAFYKKHNRWTEGLISAAKAVARA 960
Query: 261 TENLSDSAKAVVQGKSGTDRLISASKQVAAGTAHLLLACQVKSDPDSITNQRLQTAGAAV 440
T L ++A VV G S + LI A V+A TA L+ A +VK++ S L+ A AV
Sbjct: 961 TTTLIETADGVVNGTSSFEHLIVACNGVSAATAQLVAASRVKANFASKVQDHLEDAAKAV 1020
Query: 441 KKATEALVKE----ATEHRDVQ--DGSVPYTYDGTNKSMVSSMRNVIQAQADIVAKEREL 602
+A +ALV++ A + ++VQ D S ++ K + ++ +++ + D+VA R L
Sbjct: 1021 TEACKALVRQVESVALKAKEVQHEDFSSLGVHEYRRKEIEQQVQ-ILKLENDLVAARRRL 1079
Query: 603 -EMLRNKY 623
+M + Y
Sbjct: 1080 FDMRKTSY 1087
>sp|Q02328|SLAP2_CAEEL Protein SLA2 homolog
Length = 927
Score = 89.4 bits (220), Expect = 9e-18
Identities = 60/207 (28%), Positives = 104/207 (50%), Gaps = 2/207 (0%)
Frame = +3
Query: 30 RKSIKKETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKPSENVSSQHE 209
R++ + G + I+ C +++S LV + Q E+VA G+ S +
Sbjct: 708 RRARESSDGIRLEVNESILANCQALMSVIMQLVIASRELQTEIVAAGKAGGSPAEFYKRN 767
Query: 210 TQWTHGLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAHLLLACQVKS 389
QWT GL+SAA+ V A L +SA VV GK + LI A++++AA TA L ++ +VK+
Sbjct: 768 HQWTEGLLSAAKAVGVAARVLVESADGVVTGKGKFEHLIVAAQEIAASTAQLFVSSRVKA 827
Query: 390 DPDSITNQRLQTAGAAVKKATEALVKEATEHRDV--QDGSVPYTYDGTNKSMVSSMRNVI 563
D DS L A AV + T +V + +GS+ ++Y S+ ++ + +
Sbjct: 828 DKDSSKLDALSVAAKAVNQNTAQVVAAVKNGQTTLNDEGSLDFSY----LSLHAAKKEEM 883
Query: 564 QAQADIVAKERELEMLRNKYQSIRQGH 644
++Q ++ E+ L R K ++R+ H
Sbjct: 884 ESQVKMLELEQSLNQERAKLAALRKQH 910
>sp|O00291|HIP1_HUMAN Huntingtin interacting protein 1 (HIP-I)
Length = 1030
Score = 88.2 bits (217), Expect = 2e-17
Identities = 59/204 (28%), Positives = 101/204 (49%)
Frame = +3
Query: 33 KSIKKETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKPSENVSSQHET 212
KS +TG + + +I+ C S++ A L+ + Q+E+V GR S +
Sbjct: 800 KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS 859
Query: 213 QWTHGLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAHLLLACQVKSD 392
+WT GLISA++ V + D+A VVQG+ + L+ S ++AA TA L+ A +VK+D
Sbjct: 860 RWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKAD 919
Query: 393 PDSITNQRLQTAGAAVKKATEALVKEATEHRDVQDGSVPYTYDGTNKSMVSSMRNVIQAQ 572
DS +LQ A V +AT +V + + + D ++ ++ R + +Q
Sbjct: 920 KDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEET--DNMDFSSMTLTQIKRQEMDSQ 977
Query: 573 ADIVAKERELEMLRNKYQSIRQGH 644
++ E EL+ R K +R+ H
Sbjct: 978 VRVLELENELQKERQKLGELRKKH 1001
>sp|Q9JKY5|HIP1R_MOUSE Huntingtin interacting protein 1 related (Hip1-related)
Length = 1068
Score = 75.5 bits (184), Expect = 1e-13
Identities = 52/201 (25%), Positives = 98/201 (48%), Gaps = 1/201 (0%)
Frame = +3
Query: 45 KETGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKPSENVSSQHETQWTH 224
+ +G + + +I+ +C ++ A LV ++ Q+E+V GR ++ ++WT
Sbjct: 811 ESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAATQQEFYAKNSRWTE 870
Query: 225 GLISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAHLLLACQVKSDPDSI 404
GLISA++ V L +SA VV + LI S ++AA TA L+ A +VK++ +S
Sbjct: 871 GLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEIAASTAQLVAASKVKANKNSP 930
Query: 405 TNQRLQTAGAAV-KKATEALVKEATEHRDVQDGSVPYTYDGTNKSMVSSMRNVIQAQADI 581
RLQ V ++A + + ++D T D + S++ + ++ Q +
Sbjct: 931 HLSRLQECSRTVNERAANVVASTKSGQEQIEDRD---TMDFSGLSLIKLKKQEMETQVRV 987
Query: 582 VAKERELEMLRNKYQSIRQGH 644
+ E+ LE R + +R+ H
Sbjct: 988 LELEKTLEAERVRLGELRKQH 1008
>sp|O75146|HIP1R_HUMAN Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip
12)
Length = 1068
Score = 73.6 bits (179), Expect = 5e-13
Identities = 51/199 (25%), Positives = 96/199 (48%), Gaps = 1/199 (0%)
Frame = +3
Query: 51 TGEEYTFDGQIIVACGSIVSATSHLVKMASLSQQELVALGRMKPSENVSSQHETQWTHGL 230
+G + + +I+ +C ++ A LV ++ Q+E+V GR ++ ++WT GL
Sbjct: 813 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
Query: 231 ISAARLVAAATENLSDSAKAVVQGKSGTDRLISASKQVAAGTAHLLLACQVKSDPDSITN 410
ISA++ V L ++A VV + LI S ++AA TA L+ A +VK++ S
Sbjct: 873 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
Query: 411 QRLQTAGAAV-KKATEALVKEATEHRDVQDGSVPYTYDGTNKSMVSSMRNVIQAQADIVA 587
RLQ V ++A + + ++D T D + S++ + ++ Q ++
Sbjct: 933 SRLQECSRTVNERAANVVASTKSGQEQIEDRD---TMDFSGLSLIKLKKQEMETQVRVLE 989
Query: 588 KERELEMLRNKYQSIRQGH 644
E+ LE R + +R+ H
Sbjct: 990 LEKTLEAERMRLGELRKQH 1008
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,345,749
Number of Sequences: 369166
Number of extensions: 1329961
Number of successful extensions: 3933
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3827
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3910
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6582889600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)