Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_P21
(848 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 298 1e-80
sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 295 1e-79
sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 293 5e-79
sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 288 1e-77
sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 284 2e-76
sp|Q26563|CATC_SCHMA Cathepsin C precursor 243 5e-64
sp|P80884|ANAN_ANACO Ananain precursor 94 4e-19
sp|P00786|CATH_RAT Cathepsin H precursor (Cathepsin B3) (Ca... 93 8e-19
sp|P25326|CATS_BOVIN Cathepsin S 92 2e-18
sp|Q9R1T3|CATZ_RAT Cathepsin Z precursor (Cathepsin Y) 92 2e-18
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 298 bits (763), Expect = 1e-80
Identities = 140/272 (51%), Positives = 179/272 (65%), Gaps = 9/272 (3%)
Frame = +1
Query: 19 WFHDVLIRQWQCFKAQRTTTLKE---------KNNVLPHSNIFALTSLRYGSQKRIVDKI 171
W HDVL R W CF ++ T E KN+ +SN Y V I
Sbjct: 125 WVHDVLGRNWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRL------YKYDHNFVKAI 178
Query: 172 NLENNGWTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWR 351
N WTA Y E+ TL ++I +GG K+ RPKPAP+T I + +P S+DWR
Sbjct: 179 NAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWR 238
Query: 352 NVNGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGC 531
NV+G+N+VSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CS Y+QGC
Sbjct: 239 NVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGC 298
Query: 532 DGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEP 711
+GGFPYLIAGK+A+DFG+ +E+C PY G + C +DC RY+++ Y Y+GG+YG NE
Sbjct: 299 EGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEA 358
Query: 712 LMRMELVKNGPIAVGFEVYDDFMSYSGGVYHH 807
LM++ELV +GP+AV FEVYDDF+ Y G+YHH
Sbjct: 359 LMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH 390
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 295 bits (754), Expect = 1e-79
Identities = 140/270 (51%), Positives = 184/270 (68%), Gaps = 7/270 (2%)
Frame = +1
Query: 19 WFHDVLIRQWQCFKAQRTTTLKEKNNVLPHSNIFALTSLR-------YGSQKRIVDKINL 177
W HDVL R W CF ++ + EK N+ N L L+ Y V IN
Sbjct: 125 WVHDVLGRNWACFVGKKVESHIEKVNM----NAAHLGGLQERYSERLYTHNHNFVKAINT 180
Query: 178 ENNGWTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNV 357
WTA Y E+ + +L ++I +G S+ ++ RPKPAP+T I + +P+S+DWRNV
Sbjct: 181 VQKSWTATAYKEYEKMSLRDLIRRSGHSQ-RIPRPKPAPMTDEIQQQILNLPESWDWRNV 239
Query: 358 NGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDG 537
G+NYVSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY+QGCDG
Sbjct: 240 QGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDG 299
Query: 538 GFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLM 717
GFPYLIAGK+A+DFG+ +ESC PY + C ++C RY++++Y Y+GG+YG NE LM
Sbjct: 300 GFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKpreNCLRYYSSDYYYVGGFYGGCNEALM 359
Query: 718 RMELVKNGPIAVGFEVYDDFMSYSGGVYHH 807
++ELVK+GP+AV FEV+DDF+ Y G+YHH
Sbjct: 360 KLELVKHGPMAVAFEVHDDFLHYHSGIYHH 389
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 293 bits (749), Expect = 5e-79
Identities = 137/272 (50%), Positives = 176/272 (64%), Gaps = 9/272 (3%)
Frame = +1
Query: 19 WFHDVLIRQWQCFKAQRTTTLKE---------KNNVLPHSNIFALTSLRYGSQKRIVDKI 171
W HDVL R W CF ++ T E KN+ +SN Y V I
Sbjct: 125 WVHDVLGRNWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRL------YKYDHNFVKAI 178
Query: 172 NLENNGWTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWR 351
N WTA Y E+ TL ++I +GG K+ RPKP P+T I + +P S+DWR
Sbjct: 179 NAIQKSWTATTYMEYETLTLGDMIKRSGGHSRKIPRPKPTPLTAEIQQKILHLPTSWDWR 238
Query: 352 NVNGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGC 531
NV+G+N+VSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILS Q+VV CS Y+QGC
Sbjct: 239 NVHGINFVSPVRNQASCGSCYSFASVGMLEARIRILTNNSQTPILSSQEVVSCSQYAQGC 298
Query: 532 DGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEP 711
+GGFPYL AGK+A+DFG+ +E+C PY G + C +DC RY+++ Y Y+GG+YG NE
Sbjct: 299 EGGFPYLTAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEA 358
Query: 712 LMRMELVKNGPIAVGFEVYDDFMSYSGGVYHH 807
LM++ELV +GP+AV FEVYDDF+ Y G+YHH
Sbjct: 359 LMKLELVYHGPLAVAFEVYDDFLHYQNGIYHH 390
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 288 bits (737), Expect = 1e-77
Identities = 136/270 (50%), Positives = 179/270 (66%), Gaps = 7/270 (2%)
Frame = +1
Query: 19 WFHDVLIRQWQCFKAQRTTTLKEKNNVLPHSNIFALTSLR-------YGSQKRIVDKINL 177
W HD L R W CF ++ EK V N+ L L+ Y V IN
Sbjct: 125 WVHDYLGRNWACFVGKKMANHSEKVYV----NVAHLGGLQEKYSERLYSHHHNFVKAINS 180
Query: 178 ENNGWTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNV 357
WTA Y + + ++ ++I +G S ++ RPKPAPIT I + +P+S+DWRNV
Sbjct: 181 VQKSWTATTYRRYEKLSIRDLIRRSGHS-GRILRPKPAPITDEIQQQILSLPESWDWRNV 239
Query: 358 NGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDG 537
G+N+VSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY+QGCDG
Sbjct: 240 RGINFVSPVRNQESCGSCYSFASIGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDG 299
Query: 538 GFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLM 717
GFPYLIAGK+A+DFG+ +E+C PY + C ++C RY+++ Y Y+GG+YG NE LM
Sbjct: 300 GFPYLIAGKYAQDFGVVEENCFPYTATDAPCKPKENCLRYYSSEYYYVGGFYGGCNEALM 359
Query: 718 RMELVKNGPIAVGFEVYDDFMSYSGGVYHH 807
++ELVK+GP+AV FEV+DDF+ Y G+YHH
Sbjct: 360 KLELVKHGPMAVAFEVHDDFLHYHSGIYHH 389
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain 1;
Dipeptidyl-peptidase I heavy chain 2;
Dipeptidyl-peptidase I heavy chain 3;
Dipeptidyl-peptidase I heavy chain 4;
Dipeptidyl-peptidase I light chain]
Length = 435
Score = 284 bits (727), Expect = 2e-76
Identities = 137/270 (50%), Positives = 174/270 (64%), Gaps = 7/270 (2%)
Frame = +1
Query: 19 WFHDVLIRQWQCFKAQRTTTLKEKNNV-------LPHSNIFALTSLRYGSQKRIVDKINL 177
W HDVL R W CF + T EK V L +N L Y V IN
Sbjct: 100 WVHDVLGRNWACFTGTKMGTTSEKAKVNTKHIERLQENNSNRLYKYNY----EFVKAINT 155
Query: 178 ENNGWTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNV 357
WTA Y E+ TL +++ GG K+ RPKP P+T I + + +P S+DWRNV
Sbjct: 156 IQKSWTATRYIEYETLTLRDMMTRVGGR--KIPRPKPTPLTAEIHEEISRLPTSWDWRNV 213
Query: 358 NGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDG 537
G N+VSPVRNQ CGSCY+FAS MLEAR RI +NNT PILSPQ++V CS Y+QGC+G
Sbjct: 214 RGTNFVSPVRNQASCGSCYAFASTAMLEARIRILTNNTQTPILSPQEIVSCSQYAQGCEG 273
Query: 538 GFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLM 717
GFPYLIAGK+A+DFG+ +E+C PY G + C DC RY+++ Y Y+GG+YGA NE LM
Sbjct: 274 GFPYLIAGKYAQDFGLVEEACFPYAGSDSPCK-PNDCFRYYSSEYYYVGGFYGACNEALM 332
Query: 718 RMELVKNGPIAVGFEVYDDFMSYSGGVYHH 807
++ELV++GP+AV FEVYDDF Y G+Y+H
Sbjct: 333 KLELVRHGPMAVAFEVYDDFFHYQKGIYYH 362
>sp|Q26563|CATC_SCHMA Cathepsin C precursor
Length = 454
Score = 243 bits (620), Expect = 5e-64
Identities = 128/272 (47%), Positives = 166/272 (61%), Gaps = 7/272 (2%)
Frame = +1
Query: 13 PSWFHDVLIRQWQCFKAQRTTTLKEKNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGW 192
P W HD LI + K N L S F T Y V KIN W
Sbjct: 112 PMWTHDTLIDSGSVCSGKIGVHDKFHINKLFGSKSFGRTL--YHINPSFVGKINAHQKSW 169
Query: 193 TAKDYPEFHEKTLYEVINMAGGSRSKLERP----KPAPITKSILDSVKLIPKSFDWRNV- 357
+ YPE + T+ E+ N AGG +S + RP + P +K ++ +P FDW +
Sbjct: 170 RGEIYPELSKYTIDELRNRAGGVKSMVTRPSVLNRKTP-SKELISLTGNLPLEFDWTSPP 228
Query: 358 -NGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCD 534
+ V+P+RNQG CGSCY+ SA LEAR R+ SN + +PILSPQ VV+CSPYS+GC+
Sbjct: 229 DGSRSPVTPIRNQGICGSCYASPSAAALEARIRLVSNFSEQPILSPQTVVDCSPYSEGCN 288
Query: 535 GGFPYLIAGKFAEDFGMAQESCNPYKGMN-GKCSTTKDCKRYFATNYKYIGGYYGATNEP 711
GGFP+LIAGK+ EDFG+ Q+ PY G + GKC+ +K+C RY+ T+Y YIGGYYGATNE
Sbjct: 289 GGFPFLIAGKYGEDFGLPQKIVIPYTGEDTGKCTVSKNCTRYYTTDYSYIGGYYGATNEK 348
Query: 712 LMRMELVKNGPIAVGFEVYDDFMSYSGGVYHH 807
LM++EL+ NGP VGFEVY+DF Y G+YHH
Sbjct: 349 LMQLELISNGPFPVGFEVYEDFQFYKEGIYHH 380
>sp|P80884|ANAN_ANACO Ananain precursor
Length = 345
Score = 94.4 bits (233), Expect = 4e-19
Identities = 71/265 (26%), Positives = 115/265 (43%)
Frame = +1
Query: 28 DVLIRQWQCFKAQRTTTLKEKNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGWTAKDY 207
D +++Q++ + A+ K+ + + IF + ++ N N
Sbjct: 31 DPMMKQFEEWMAEYGRVYKDNDEKMLRFQIFK-------NNVNHIETFNNRNGNSYTLGI 83
Query: 208 PEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGLNYVSPVR 387
+F + T E + G L + ++ +D + +P+S DWR+ V+ V+
Sbjct: 84 NQFTDMTNNEFVAQYTGLSLPLNIKREPVVSFDDVD-ISSVPQSIDWRDSGA---VTSVK 139
Query: 388 NQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKF 567
NQG CGSC++FAS +E+ Y+I+ N V LS Q V++C+ S GC GG+
Sbjct: 140 NQGRCGSCWAFASIATVESIYKIKRGNLVS--LSEQQVLDCA-VSYGCKGGWINKAYSFI 196
Query: 568 AEDFGMAQESCNPYKGMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPI 747
+ G+A + PYK G C T + T Y Y+ N M V N PI
Sbjct: 197 ISNKGVASAAIYPYKAAKGTCKTNGVPNSAYITRYTYV-----QRNNERNMMYAVSNQPI 251
Query: 748 AVGFEVYDDFMSYSGGVYHHNFGTR 822
A + +F Y GV+ GTR
Sbjct: 252 AAALDASGNFQHYKRGVFTGPCGTR 276
>sp|P00786|CATH_RAT Cathepsin H precursor (Cathepsin B3) (Cathepsin BA) [Contains:
Cathepsin H mini chain; Cathepsin H heavy chain;
Cathepsin H light chain]
Length = 333
Score = 93.2 bits (230), Expect = 8e-19
Identities = 62/180 (34%), Positives = 84/180 (46%), Gaps = 3/180 (1%)
Frame = +1
Query: 280 PKPAPITKS-ILDSVKLIPKSFDWRNVNGLNYVSPVRNQGGCGSCYSFASAGMLEARYRI 456
P+ TKS L P S DWR N VSPV+NQG CGSC++F++ G LE+ I
Sbjct: 97 PQNCSATKSNYLRGTGPYPSSMDWRKKG--NVVSPVKNQGACGSCWTFSTTGALESAVAI 154
Query: 457 RSNNTVRPILSPQDVVECSP--YSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKC 630
S + L+ Q +V+C+ + GC GG P + G+ E PY G NG+C
Sbjct: 155 ASGKMM--TLAEQQLVDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQC 212
Query: 631 STTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGGVYHHN 810
+ F N I +E M + P++ FEV +DFM Y GVY N
Sbjct: 213 KFNPEKAVAFVKNVVNI----TLNDEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSN 268
>sp|P25326|CATS_BOVIN Cathepsin S
Length = 217
Score = 91.7 bits (226), Expect = 2e-18
Identities = 56/163 (34%), Positives = 90/163 (55%), Gaps = 4/163 (2%)
Frame = +1
Query: 328 IPKSFDWRNVNGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVE 507
+P S DWR V+ V+ QG CGSC++F++ G LEA+ ++++ V LS Q++V+
Sbjct: 1 LPDSMDWREKG---CVTEVKYQGACGSCWAFSAVGALEAQVKLKTGKLVS--LSAQNLVD 55
Query: 508 CSPY---SQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRYFATNYKY 678
CS ++GC+GGF ++ G+ E+ PYK M+GKC D K AT +Y
Sbjct: 56 CSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMDGKCQ--YDVKNRAATCSRY 113
Query: 679 IGGYYGATNEPLMRMELVKNGPIAVGFEV-YDDFMSYSGGVYH 804
I +G +E ++ + GP++VG + + F Y GVY+
Sbjct: 114 IELPFG--SEEALKEAVANKGPVSVGIDASHSSFFLYKTGVYY 154
>sp|Q9R1T3|CATZ_RAT Cathepsin Z precursor (Cathepsin Y)
Length = 306
Score = 91.7 bits (226), Expect = 2e-18
Identities = 56/171 (32%), Positives = 84/171 (49%), Gaps = 13/171 (7%)
Frame = +1
Query: 328 IPKSFDWRNVNGLNYVSPVRNQ---GGCGSCYSFASAGMLEARYRI-RSNNTVRPILSPQ 495
+PK++DWRNVNG+NY S RNQ CGSC++ S L R I R +LS Q
Sbjct: 64 LPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSALADRINIKRKGAWPSTLLSVQ 123
Query: 496 DVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMN---------GKCSTTKDC 648
+V++C + C+GG L ++A G+ E+CN Y+ + G C+ K+C
Sbjct: 124 NVIDCG-NAGSCEGGND-LPVWEYAHKHGIPDETCNNYQAKDQECDKFNQCGTCTEFKEC 181
Query: 649 KRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGGVY 801
+G Y + M E+ NGPI+ G + +Y+GG+Y
Sbjct: 182 HTIQNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERMSNYTGGIY 232
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,326,290
Number of Sequences: 369166
Number of extensions: 2229711
Number of successful extensions: 6158
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5611
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5896
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)