Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_P14
(602 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P20060|HEXB_MOUSE Beta-hexosaminidase beta chain precurs... 159 7e-39
sp|P06865|HEXA_HUMAN Beta-hexosaminidase alpha chain precur... 158 9e-39
sp|P07686|HEXB_HUMAN Beta-hexosaminidase beta chain precurs... 157 1e-38
sp|Q29548|HEXB_PIG Beta-hexosaminidase beta chain precursor... 154 2e-37
sp|P29416|HEXA_MOUSE Beta-hexosaminidase alpha chain precur... 147 3e-35
sp|Q22492|HEXA_CAEEL Probable beta-hexosaminidase A precurs... 146 3e-35
sp|P49614|HEXB_FELCA Beta-hexosaminidase beta chain precurs... 145 1e-34
sp|P13723|HEXA_DICDI Beta-hexosaminidase A precursor (N-ace... 80 5e-15
sp|P49009|HEXA_ENTHI Beta-hexosaminidase alpha chain precur... 72 8e-13
sp|Q86M34|HEXB_ENTHI Beta-hexosaminidase beta chain precurs... 72 8e-13
>sp|P20060|HEXB_MOUSE Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
Length = 536
Score = 159 bits (401), Expect = 7e-39
Identities = 78/166 (46%), Positives = 108/166 (65%), Gaps = 2/166 (1%)
Frame = +3
Query: 9 VQKLVQKRNIKTLVWQEVFDNKNEVDHNLSIINIWKGEDNWQQEMTAVTKSNYTAVLSSC 188
+ +++ ++VWQEVFD+K E+ +++ +WK E ++ E+ VT S + A+LS+
Sbjct: 370 ILEIISSLKKNSIVWQEVFDDKVELQPG-TVVEVWKSE-HYSYELKQVTGSGFPAILSAP 427
Query: 189 WYLNYISYGIDWKKYYRCDPQNYNGINKN--LVIGGEACMWGEYVDGTNVIPRTWPRASV 362
WYL+ ISYG DWK YY+ +P N+ G K LVIGGEAC+WGE+VD TN+ PR WPRAS
Sbjct: 428 WYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASA 487
Query: 363 VAERLWSNETVKDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYCN 500
V ERLWS +TV D + RL RCR+V G A+ + G YCN
Sbjct: 488 VGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAAQPLYTG--YCN 531
>sp|P06865|HEXA_HUMAN Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase A)
Length = 529
Score = 158 bits (400), Expect = 9e-39
Identities = 80/152 (52%), Positives = 103/152 (67%), Gaps = 5/152 (3%)
Frame = +3
Query: 45 LVWQEVFDNKNEVDHNLSIINIWKGED---NWQQEMTAVTKSNYTAVLSSCWYLNYISYG 215
+VWQEVFDNK ++ + +II +W+ ED N+ +E+ VTK+ + A+LS+ WYLN ISYG
Sbjct: 371 VVWQEVFDNKVKIQPD-TIIQVWR-EDIPVNYMKELELVTKAGFRALLSAPWYLNRISYG 428
Query: 216 IDWKKYYRCDPQNYNGI--NKNLVIGGEACMWGEYVDGTNVIPRTWPRASVVAERLWSNE 389
DWK +Y +P + G K LVIGGEACMWGEYVD TN++PR WPRA VAERLWSN+
Sbjct: 429 PDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNK 488
Query: 390 TVKDETDMSYRLHEFRCRLVVNGFNAETMNGG 485
D T RL FRC L+ G A+ +N G
Sbjct: 489 LTSDLTFAYERLSHFRCELLRRGVQAQPLNVG 520
>sp|P07686|HEXB_HUMAN Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
(Cervical cancer proto-oncogene 7) (HCC-7) [Contains:
Beta-hexosaminidase beta-B chain; Beta-hexosaminidase
beta-A chain]
Length = 556
Score = 157 bits (398), Expect = 1e-38
Identities = 77/166 (46%), Positives = 109/166 (65%), Gaps = 2/166 (1%)
Frame = +3
Query: 9 VQKLVQKRNIKTLVWQEVFDNKNEVDHNLSIINIWKGEDNWQQEMTAVTKSNYTAVLSSC 188
V ++ N ++VWQEVFD+K ++ +I+ +WK + + +E++ VT S + +LS+
Sbjct: 391 VLDIIATINKGSIVWQEVFDDKAKLAPG-TIVEVWK-DSAYPEELSRVTASGFPVILSAP 448
Query: 189 WYLNYISYGIDWKKYYRCDPQNYNGINKN--LVIGGEACMWGEYVDGTNVIPRTWPRASV 362
WYL+ ISYG DW+KYY+ +P ++ G K L IGGEAC+WGEYVD TN+ PR WPRAS
Sbjct: 449 WYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASA 508
Query: 363 VAERLWSNETVKDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYCN 500
V ERLWS++ V+D D RL RCR+V G A+ + G YCN
Sbjct: 509 VGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAG--YCN 552
>sp|Q29548|HEXB_PIG Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B) (65 kDa
epididymal boar protein)
Length = 531
Score = 154 bits (389), Expect = 2e-37
Identities = 75/167 (44%), Positives = 107/167 (64%), Gaps = 3/167 (1%)
Frame = +3
Query: 9 VQKLVQKRNIKTLVWQEVFDNKNEVDHNLSIINIWKGED-NWQQEMTAVTKSNYTAVLSS 185
+ ++ + +VWQE FD +++ +++ +WK ED W+Q + +TK+ + +LS+
Sbjct: 365 ISNMISAMKKRPIVWQEAFDGRDKFMPG-TVVQVWKIEDYKWEQSL--ITKAGFPVILSA 421
Query: 186 CWYLNYISYGIDWKKYYRCDPQNYNGINKNL--VIGGEACMWGEYVDGTNVIPRTWPRAS 359
WYL+ ISYG DWK YY +PQ++ G +K V+GGEAC+WGEYVD TN+ PR WPRAS
Sbjct: 422 PWYLDLISYGQDWKNYYEVEPQDFPGSDKERKRVLGGEACLWGEYVDATNLTPRLWPRAS 481
Query: 360 VVAERLWSNETVKDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYCN 500
V ERLWS++ V+D D RL RCR+V G AE + G YCN
Sbjct: 482 AVGERLWSHKDVRDIHDAYSRLTIHRCRMVRRGIAAEPLFTG--YCN 526
>sp|P29416|HEXA_MOUSE Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase A)
Length = 528
Score = 147 bits (370), Expect = 3e-35
Identities = 75/155 (48%), Positives = 100/155 (64%), Gaps = 4/155 (2%)
Frame = +3
Query: 45 LVWQEVFDNKNEVDHNLSIINIWKGED--NWQQEMTAVTKSNYTAVLSSCWYLNYISYGI 218
+VWQEVFDNK +V + +II +W+ E + EM +T++ + A+LS+ WYLN + YG
Sbjct: 370 VVWQEVFDNKVKVRPD-TIIQVWREEMPVEYMLEMQDITRAGFRALLSAPWYLNRVKYGP 428
Query: 219 DWKKYYRCDPQNYNGI--NKNLVIGGEACMWGEYVDGTNVIPRTWPRASVVAERLWSNET 392
DWK Y+ +P ++G K LVIGGEACMWGEYVD TN++PR WPRA VAERLWS+
Sbjct: 429 DWKDMYKVEPLAFHGTPEQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAVAERLWSSNL 488
Query: 393 VKDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYC 497
+ RL FRC LV G A+ ++ G YC
Sbjct: 489 TTNIDFAFKRLSHFRCELVRRGIQAQPISVG--YC 521
>sp|Q22492|HEXA_CAEEL Probable beta-hexosaminidase A precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase)
Length = 555
Score = 146 bits (369), Expect = 3e-35
Identities = 81/180 (45%), Positives = 107/180 (59%), Gaps = 16/180 (8%)
Frame = +3
Query: 6 LVQKLVQKRNIKTLVWQEVFDNKNEVDHNLSIINIWKGEDNWQ--QEMTAVTKSNYTAVL 179
+V+ L KR K + WQEVFDN N D N ++I+IWKG + + +++ +T N+ ++
Sbjct: 367 IVENLKLKR--KPIFWQEVFDN-NIPDPN-AVIHIWKGNTHEEIYEQVKNITSQNFPVIV 422
Query: 180 SSCWYLNYISYGIDWK-----------KYYRCDPQNYNGI--NKNLVIGGEACMWGEYVD 320
S+CWYLNYI YG DW+ +YY CDP N+NG K LV GG A +WGE VD
Sbjct: 423 SACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVD 482
Query: 321 GTNVIPRTWPRASVVAERLWS-NETVKDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYC 497
TN+ R WPRAS AERLWS E + D R+HE RCRLV G+ + N +YC
Sbjct: 483 NTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQP-NNNPDYC 541
>sp|P49614|HEXB_FELCA Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
Length = 499
Score = 145 bits (365), Expect = 1e-34
Identities = 71/155 (45%), Positives = 103/155 (66%), Gaps = 2/155 (1%)
Frame = +3
Query: 42 TLVWQEVFDNKNEVDHNLSIINIWKGEDNWQQEMTAVTKSNYTAVLSSCWYLNYISYGID 221
++VWQEVFD+ ++ +I+ +WK + + +E+ VT + + +LS+ WYL++ISYG D
Sbjct: 344 SIVWQEVFDDHVKLLPG-TIVQVWKNQV-YTEELREVTAAGFPVILSAPWYLDWISYGQD 401
Query: 222 WKKYYRCDPQNYNGIN--KNLVIGGEACMWGEYVDGTNVIPRTWPRASVVAERLWSNETV 395
W+ YY+ DP +++G K LVIGGEAC+WGE+VD TN+ PR WPRAS V ERLWS E +
Sbjct: 402 WRNYYKVDPLHFDGSQEQKKLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPEDI 461
Query: 396 KDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYCN 500
+ RL RCR+V G +AE + G YC+
Sbjct: 462 TSVGNAYNRLTVHRCRMVRRGISAEPLFTG--YCD 494
>sp|P13723|HEXA_DICDI Beta-hexosaminidase A precursor (N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase)
Length = 532
Score = 79.7 bits (195), Expect = 5e-15
Identities = 47/169 (27%), Positives = 78/169 (46%), Gaps = 8/169 (4%)
Frame = +3
Query: 33 NIKTLVWQEVFDNKNEVDHNLSIINIWKGEDNWQQEMTAVTKSNYTAVLSSCWYLN---- 200
N + W + D +++ +++ +W + Q + S Y A++S WYL+
Sbjct: 350 NRTKITWNDPIDYGVQLNPE-TLVQVWSSGSDLQ----GIVNSGYKALVSFAWYLDKQNP 404
Query: 201 ----YISYGIDWKKYYRCDPQNYNGINKNLVIGGEACMWGEYVDGTNVIPRTWPRASVVA 368
+ + W+ +Y DP N N +IGGEA MW E ++ N R WPRA +A
Sbjct: 405 DNNIHYEWQDTWQDFYAADPTNNISTNAENIIGGEATMWAEQINQVNWDVRVWPRAIGIA 464
Query: 369 ERLWSNETVKDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYCNIPGDV 515
ERLWS ++V + R+ F C L G + + +YC + D+
Sbjct: 465 ERLWSAQSVNSVSLALPRIGHFTCDLSRRGIQSGPL--FPDYCPMQDDL 511
>sp|P49009|HEXA_ENTHI Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase) (Beta-GlcNAcase)
(Beta-N-acetylhexosaminidase)
Length = 564
Score = 72.4 bits (176), Expect = 8e-13
Identities = 56/176 (31%), Positives = 80/176 (45%), Gaps = 22/176 (12%)
Frame = +3
Query: 45 LVWQEVFDNKNEVDHNLSIINIWKGEDNWQQEMTAVTKSNYTAVLSSCWYLNY------- 203
+VW+EVF K D N +II +W QQ V S Y A+ S+ +YL+
Sbjct: 393 VVWEEVF-KKGNADKN-TIIQVWDDIRLLQQ----VVNSGYKAIFSAGFYLDKQMPLCNS 446
Query: 204 ------ISYGIDW----KKYYRCDP-QNYNGINKNLVIGGEACMWGEYVDGTNVIPRTWP 350
++ W + Y DP ++ + K V+GGE C WGE D N R +
Sbjct: 447 YDSSTCVNTHSMWVWTNRDMYDNDPVKSLSSSEKENVLGGEGCSWGESTDEQNFFDRVFQ 506
Query: 351 RASVVAERLWSNETVKDETDMSYRLHEFRCRLVVNGFNAETMNGGG----NYCNIP 506
R S +AERLWS E+V D+ R + RC V + M G G ++C +P
Sbjct: 507 RYSAIAERLWSKESVVDKESHEVRANYLRCLDV----RRDIMKGTGPLYHSFCQLP 558
>sp|Q86M34|HEXB_ENTHI Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase) (Beta-GlcNAcase)
(Beta-N-acetylhexosaminidase)
Length = 565
Score = 72.4 bits (176), Expect = 8e-13
Identities = 56/186 (30%), Positives = 82/186 (44%), Gaps = 18/186 (9%)
Frame = +3
Query: 12 QKLVQKRNIKTLVWQEVFDNKNEVDHNLSIINIWKGEDNWQQEMTAVTKSNYTAVLSSCW 191
Q+ + K + W+EV+ K D +II +W + ++ TA Y +LS+ +
Sbjct: 386 QEQIIKNGKTPVCWEEVYQ-KGSADKK-TIIQVWNNVNLLKEAATA----GYKVILSAGY 439
Query: 192 YLNY-----ISYGID----------W--KKYYRCDP-QNYNGINKNLVIGGEACMWGEYV 317
YL+ Y D W + YR DP + + K V+GGEAC W E V
Sbjct: 440 YLDMQMPLCSDYVADSCTNPNHMWVWTNRDMYRNDPIKELDYATKQNVLGGEACSWDESV 499
Query: 318 DGTNVIPRTWPRASVVAERLWSNETVKDETDMSYRLHEFRCRLVVNGFNAETMNGGGNYC 497
D N R + R S VAER WS+E + D R + RC + F T +YC
Sbjct: 500 DEQNFFDRVFQRFSAVAERFWSSEDITDPESHEVRANYVRCLGLRRNFLKGTGPLYHSYC 559
Query: 498 NIPGDV 515
+P D+
Sbjct: 560 QLPEDI 565
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,283,771
Number of Sequences: 369166
Number of extensions: 1413848
Number of successful extensions: 3603
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3501
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3583
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4650991475
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)