Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_L22
(925 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9QZ05|E2AK4_MOUSE Eukaryotic translation initiation fac... 134 4e-31
sp|P15442|GCN2_YEAST Serine/threonine-protein kinase GCN2 130 4e-30
sp|Q9HGN1|GCN2_SCHPO Serine/threonine-protein kinase gcn2 130 7e-30
sp|Q9P2K8|E2AK4_HUMAN Eukaryotic translation initiation fac... 126 8e-29
sp|P33279|E2AK1_RABIT Eukaryotic translation initiation fac... 115 2e-25
sp|Q9NZJ5|E2AK3_HUMAN Eukaryotic translation initiation fac... 111 3e-24
sp|Q9Z1Z1|E2AK3_RAT Eukaryotic translation initiation facto... 111 3e-24
sp|Q9Z2B5|E2AK3_MOUSE Eukaryotic translation initiation fac... 109 1e-23
sp|Q9Z2R9|E2AK1_MOUSE Eukaryotic translation initiation fac... 108 3e-23
sp|Q63185|E2AK1_RAT Eukaryotic translation initiation facto... 107 5e-23
>sp|Q9QZ05|E2AK4_MOUSE Eukaryotic translation initiation factor 2-alpha kinase 4 (GCN2-like
protein) (mGCN2)
Length = 1648
Score = 134 bits (337), Expect = 4e-31
Identities = 105/351 (29%), Positives = 158/351 (45%), Gaps = 47/351 (13%)
Frame = +1
Query: 4 DYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARAKLLQEVQAFAHLEHPGI 183
++E ++ LGKGAFG V + ++++D YAVKR+ + + + ++ EV + L H I
Sbjct: 588 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENI 647
Query: 184 VRYYQAWFEL----------PPEGWQDKKD------------KEMGLENLYDDDMVMSTD 297
VRYY AW E PP+ +D +E+G ++S+
Sbjct: 648 VRYYNAWIERHERPAVPGTPPPDCTPQAQDSPATCGKTSGDTEELGSVEAAAPPPILSSS 707
Query: 298 VQESQQMSDGDSTRCTTTSDWSRNSLLANDAQDSLIIFDRSALPSGDG-----------N 444
V+ S STR T S + D +D +F +S LP+ D N
Sbjct: 708 VEWSTSAERSTSTRFPVTGQDSSSDEEDEDERDG--VFSQSFLPASDSDSDIIFDNEDEN 765
Query: 445 VITRXXXXXXXXXXXXXXXXXHI------YLYISMHLYSSRSLKDWLHEQQG---STSRP 597
++ + YLYI M +L+D + QG TSR
Sbjct: 766 SKSQNQDEDCNQKDGSHEIEPSVTAEAVHYLYIQMEYCEKSTLRDTI--DQGLFRDTSR- 822
Query: 598 QNRSLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSLVRSKPSS 777
L +F +I+D +AY+H G++HRDLKP NI D+ +H++I DFGLAT +
Sbjct: 823 ----LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTAEG 878
Query: 778 CPDGRASN---NENEYSSLTSNVGTELYMSPEQQEGTH--YDQKLMCFLLG 915
D +A + + LT VGT LY+SPE Q T Y+QK+ F LG
Sbjct: 879 KQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLG 929
>sp|P15442|GCN2_YEAST Serine/threonine-protein kinase GCN2
Length = 1590
Score = 130 bits (328), Expect = 4e-30
Identities = 90/323 (27%), Positives = 160/323 (49%), Gaps = 18/323 (5%)
Frame = +1
Query: 1 TDYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARAKLLQEVQAFAHLEHPG 180
+D+E I LG+GAFG V +AR+ +D YA+K++R ++++ + +L EV A L H
Sbjct: 528 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR--HTEEKLSTILSEVMLLASLNHQY 585
Query: 181 IVRYYQAWFELPP------EGWQDKKDKEMGLENLYDDDMVMSTDVQESQQMSDGDSTRC 342
+VRYY AW E E ++ D + ++D++ + + +++ D D++
Sbjct: 586 VVRYYAAWLEEDSMDENVFESTDEESDLSESSSDFEENDLLDQSSIFKNRTNHDLDNSNW 645
Query: 343 TTTSDWSRNSLL----ANDAQDSLIIFDRSALPSGDGNVIT-------RXXXXXXXXXXX 489
S ++ + D ++ + D S+ S + T +
Sbjct: 646 DFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQNVPRRRNFVKP 705
Query: 490 XXXXXXHIYLYISMHLYSSRSLKDWLHEQQGSTSRPQNRSLLHIFAQIVDAVAYLHSNGL 669
L+I M +R+L D +H + + R + +F QI++A++Y+HS G+
Sbjct: 706 MTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDE---YWRLFRQILEALSYIHSQGI 762
Query: 670 MHRDLKPSNILFDNQNHIRIVDFGLATSLVRSKPSSCPDGRASNNENEYSSLTSNVGTEL 849
+HRDLKP NI D +++I DFGLA ++ RS D + N +LTS +GT +
Sbjct: 763 IHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLD--SQNLPGSSDNLTSAIGTAM 820
Query: 850 YMSPEQQEGT-HYDQKLMCFLLG 915
Y++ E +GT HY++K+ + LG
Sbjct: 821 YVATEVLDGTGHYNEKIDMYSLG 843
>sp|Q9HGN1|GCN2_SCHPO Serine/threonine-protein kinase gcn2
Length = 1576
Score = 130 bits (326), Expect = 7e-30
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 7/312 (2%)
Frame = +1
Query: 1 TDYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARAKLLQEVQAFAHLEHPG 180
TD+E + LG+G FG V + ++R+D YAVK++ + D+ +++L+EV + L H
Sbjct: 554 TDFEELEFLGRGGFGEVVKVKNRIDGRFYAVKKLVLLSDDKENSRILREVMTLSRLHHEH 613
Query: 181 IVRYYQAWFELPPEGWQDK---KDKEMGLENLYDDDMVMSTDVQESQQM-SDGDSTRCTT 348
+VRYY AW E + D E ++L M+ D ++S + +D S+
Sbjct: 614 VVRYYTAWVETEANDTVTEIISSDSESLSQSLN-----MAVDFRQSSSLPADKLSSLDIH 668
Query: 349 TSDWSRNSLLANDAQDSLIIFDRSALPSGDGNVITRXXXXXXXXXXXXXXXXXHIYLYIS 528
D +S D + S I F S +G+ + + LYI
Sbjct: 669 FEDDYNSSADEEDPEASDISFQYSNTSDKEGSS-DKDSSIEEASSVKTQENGLNATLYIQ 727
Query: 529 MHLYSSRSLKDWLHEQQGSTSRPQNRSLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFD 708
M SL+D + ++ + +F QI++A+AY+HS G+MHRDLKP NI D
Sbjct: 728 MEYCEKLSLQDIIRDKIPVDE------MWRLFRQILEALAYIHSRGMMHRDLKPGNIFLD 781
Query: 709 NQNHIRIVDFGLATSLVRSKPSSCPDGRASNNENEYSSLTSNVGTELYMSPE---QQEGT 879
++++ DFGLAT + + + + N ++ LT+ VGT LY++PE ++ G
Sbjct: 782 ENRNVKLGDFGLATENENYQDN---NDKWKNRQSADEDLTTGVGTALYVAPELLSRRNGV 838
Query: 880 HYDQKLMCFLLG 915
YD K+ + LG
Sbjct: 839 RYDAKVDMYSLG 850
>sp|Q9P2K8|E2AK4_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 4 (GCN2-like
protein)
Length = 1649
Score = 126 bits (317), Expect = 8e-29
Identities = 103/346 (29%), Positives = 150/346 (43%), Gaps = 42/346 (12%)
Frame = +1
Query: 4 DYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARAKLLQEVQAFAHLEHPGI 183
++E ++ LGKGAFG V + ++++D YAVKR+ + + + ++ EV + L H I
Sbjct: 589 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENI 648
Query: 184 VRYYQAWFEL-----------PPEGWQDKKDKEMGLENLYDDD-----------MVMSTD 297
VRYY AW E P G K D+ + D D ++S+
Sbjct: 649 VRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSS 708
Query: 298 VQESQQMSDGDSTRCTTTSDWSRN---------------SLLANDAQDSLIIFDRSALPS 432
V+ S S R T S + S L +S IIFD S
Sbjct: 709 VEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENS 768
Query: 433 GDGNVITRXXXXXXXXXXXXXXXXXHI-YLYISMHLYSSRSLKDWLHEQQGSTSRPQNRS 609
N + YLYI M +L+D + + R R
Sbjct: 769 KSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ---GLYRDTVR- 824
Query: 610 LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSLVRSKPSSCPDG 789
L +F +I+D +AY+H G++HRDLKP NI D+ +H++I DFGLAT + S D
Sbjct: 825 LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDD 884
Query: 790 RASN--NENEYSSLTSNVGTELYMSPEQQEGTH--YDQKLMCFLLG 915
+ + + LT VGT LY+SPE Q T Y+QK+ F LG
Sbjct: 885 QTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLG 930
Score = 41.2 bits (95), Expect = 0.004
Identities = 16/44 (36%), Positives = 29/44 (65%)
Frame = +1
Query: 625 AQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSL 756
AQ++ + YLHSN ++H+ L SN+L D + ++I D+ ++ L
Sbjct: 407 AQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRL 450
>sp|P33279|E2AK1_RABIT Eukaryotic translation initiation factor 2-alpha kinase 1
(Heme-regulated eukaryotic initiation factor eIF-2-alpha
kinase) (Heme-regulated inhibitor) (Heme-controlled
repressor) (HCR) (Hemin-sensitive initiation factor
2-alpha kinase)
Length = 626
Score = 115 bits (287), Expect = 2e-25
Identities = 97/354 (27%), Positives = 157/354 (44%), Gaps = 50/354 (14%)
Frame = +1
Query: 4 DYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARA-KLLQEVQAFAHLEHPG 180
++E + LGKG +G V++ R+++D YA+K++ ++ + + K+L+EV+ A L+HP
Sbjct: 169 EFEELSILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTDCMKVLREVKVLAGLQHPN 228
Query: 181 IVRYYQAWFE-----------------LPPEGWQDKKDKEMGLENLYDDDMVMSTDVQES 309
IV Y+ AW E L Q++ + G++N D S E
Sbjct: 229 IVGYHTAWIEHVHVHVQADRVPIQLPSLEVLSDQEEDRDQYGVKN--DASSSSSIIFAEF 286
Query: 310 QQMSDGDSTRCTTTSDWSRNSLLANDAQDSLII----FDRSALPSGDGNVITRXXXXXXX 477
+ S C S +N+ L N + ++ F+ S +G+++ R
Sbjct: 287 SPEKEKSSDECAVES---QNNKLVNYTTNLVVRDTGEFESSTERQENGSIVERQLLFGHN 343
Query: 478 XXXXXXXXXX------------------HIYLYISMHLYSSRSLKDWLHEQQGSTSRPQN 603
H+ L+I M L SL DW+ E+ + +
Sbjct: 344 SDVEEDFTSAEESSEEDLSALRHTEVQYHLMLHIQMQL-CELSLWDWIAERNRRSRECVD 402
Query: 604 RSLL---------HIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLATS 753
S IF ++V+ V Y+H+ G++HRDLKP NI L ++I DFGLA +
Sbjct: 403 ESACPYVMVSVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACA 462
Query: 754 LVRSKPSSCPDGRASNNENEYSSLTSNVGTELYMSPEQQEGTHYDQKLMCFLLG 915
+ K ++ R S N + TS VGT LY SPEQ EG+ YD K + +G
Sbjct: 463 DIIQKNAA----RTSRNGERAPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSVG 512
>sp|Q9NZJ5|E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 precursor
(PRKR-like endoplasmic reticulum kinase) (Pancreatic
eIF2-alpha kinase) (HsPEK)
Length = 1115
Score = 111 bits (278), Expect = 3e-24
Identities = 48/82 (58%), Positives = 66/82 (80%)
Frame = +1
Query: 1 TDYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARAKLLQEVQAFAHLEHPG 180
TD+E I+CLG+G FGVVFEA+++VD +YA+KR+R+ + AR K+++EV+A A LEHPG
Sbjct: 590 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 649
Query: 181 IVRYYQAWFELPPEGWQDKKDK 246
IVRY+ AW E PPE WQ+K D+
Sbjct: 650 IVRYFNAWLEAPPEKWQEKMDE 671
Score = 106 bits (265), Expect = 8e-23
Identities = 60/136 (44%), Positives = 81/136 (59%), Gaps = 1/136 (0%)
Frame = +1
Query: 511 IYLYISMHLYSSRSLKDWLHEQQGSTSRPQNRSL-LHIFAQIVDAVAYLHSNGLMHRDLK 687
+YLYI M L +LKDW++ + T + RS+ LHIF QI +AV +LHS GLMHRDLK
Sbjct: 881 VYLYIQMQLCRKENLKDWMNGR--CTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLK 938
Query: 688 PSNILFDNQNHIRIVDFGLATSLVRSKPSSCPDGRASNNENEYSSLTSNVGTELYMSPEQ 867
PSNI F + +++ DFGL T++ + + + Y+ T VGT+LYMSPEQ
Sbjct: 939 PSNIFFTMDDVVKVGDFGLVTAMDQDE----EEQTVLTPMPAYARHTGQVGTKLYMSPEQ 994
Query: 868 QEGTHYDQKLMCFLLG 915
G Y K+ F LG
Sbjct: 995 IHGNSYSHKVDIFSLG 1010
>sp|Q9Z1Z1|E2AK3_RAT Eukaryotic translation initiation factor 2-alpha kinase 3 precursor
(PRKR-like endoplasmic reticulum kinase) (Pancreatic
eIF2-alpha kinase)
Length = 1108
Score = 111 bits (277), Expect = 3e-24
Identities = 59/135 (43%), Positives = 82/135 (60%)
Frame = +1
Query: 511 IYLYISMHLYSSRSLKDWLHEQQGSTSRPQNRSLLHIFAQIVDAVAYLHSNGLMHRDLKP 690
+YLYI M L +LKDW++ + R ++R LHIF QI +AV +LHS GLMHRDLKP
Sbjct: 874 VYLYIQMQLCRKENLKDWMNRRCSMEDR-EHRVCLHIFLQIAEAVQFLHSKGLMHRDLKP 932
Query: 691 SNILFDNQNHIRIVDFGLATSLVRSKPSSCPDGRASNNENEYSSLTSNVGTELYMSPEQQ 870
SNI F + +++ DFGL T++ + + + Y++ T VGT+LYMSPEQ
Sbjct: 933 SNIFFTMDDVVKVGDFGLVTAMDQDE----EEQTVLTPMPAYATHTGQVGTKLYMSPEQI 988
Query: 871 EGTHYDQKLMCFLLG 915
G +Y K+ F LG
Sbjct: 989 HGNNYSHKVDIFSLG 1003
Score = 109 bits (272), Expect = 1e-23
Identities = 46/82 (56%), Positives = 66/82 (80%)
Frame = +1
Query: 1 TDYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARAKLLQEVQAFAHLEHPG 180
TD+E I+C+G+G FGVVFEA+++VD +YA+KR+R+ + AR K+++EV+A A LEHPG
Sbjct: 583 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 642
Query: 181 IVRYYQAWFELPPEGWQDKKDK 246
IVRY+ AW E PPE WQ++ D+
Sbjct: 643 IVRYFNAWLETPPEKWQEEMDE 664
>sp|Q9Z2B5|E2AK3_MOUSE Eukaryotic translation initiation factor 2-alpha kinase 3 precursor
(PRKR-like endoplasmic reticulum kinase) (Pancreatic
eIF2-alpha kinase)
Length = 1114
Score = 109 bits (272), Expect = 1e-23
Identities = 46/82 (56%), Positives = 66/82 (80%)
Frame = +1
Query: 1 TDYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARAKLLQEVQAFAHLEHPG 180
TD+E I+C+G+G FGVVFEA+++VD +YA+KR+R+ + AR K+++EV+A A LEHPG
Sbjct: 587 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 646
Query: 181 IVRYYQAWFELPPEGWQDKKDK 246
IVRY+ AW E PPE WQ++ D+
Sbjct: 647 IVRYFNAWLETPPEKWQEEMDE 668
Score = 108 bits (269), Expect = 3e-23
Identities = 58/135 (42%), Positives = 81/135 (60%)
Frame = +1
Query: 511 IYLYISMHLYSSRSLKDWLHEQQGSTSRPQNRSLLHIFAQIVDAVAYLHSNGLMHRDLKP 690
+YLYI M L +LKDW++ + R ++ LHIF QI +AV +LHS GLMHRDLKP
Sbjct: 880 VYLYIQMQLCRKENLKDWMNRRCSLEDR-EHGVCLHIFLQIAEAVEFLHSKGLMHRDLKP 938
Query: 691 SNILFDNQNHIRIVDFGLATSLVRSKPSSCPDGRASNNENEYSSLTSNVGTELYMSPEQQ 870
SNI F + +++ DFGL T++ + + + Y++ T VGT+LYMSPEQ
Sbjct: 939 SNIFFTMDDVVKVGDFGLVTAMDQDE----EEQTVLTPMPAYATHTGQVGTKLYMSPEQI 994
Query: 871 EGTHYDQKLMCFLLG 915
G +Y K+ F LG
Sbjct: 995 HGNNYSHKVDIFSLG 1009
>sp|Q9Z2R9|E2AK1_MOUSE Eukaryotic translation initiation factor 2-alpha kinase 1
(Heme-regulated eukaryotic initiation factor eIF-2-alpha
kinase) (Heme-regulated inhibitor) (Heme-controlled
repressor) (HCR) (Hemin-sensitive initiation factor
2-alpha kinase)
Length = 619
Score = 108 bits (269), Expect = 3e-23
Identities = 100/356 (28%), Positives = 162/356 (45%), Gaps = 52/356 (14%)
Frame = +1
Query: 4 DYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARA-KLLQEVQAFAHLEHPG 180
++E + LGKG +G V++ R+++D YA+K++ ++ + + K+L+EV+ A L+HP
Sbjct: 166 EFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPN 225
Query: 181 IVRYYQAWFE--------------LPP-------EGWQDK---KDKEMGLENLYDD-DMV 285
IV Y+ AW E LP EG +D+ KD E ++ +
Sbjct: 226 IVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQGGVKDNESSSSIVFAELTPE 285
Query: 286 MSTDVQESQQMSDGDSTRCTTTSDWSRNSLLANDA----QDSLIIFD-----RSALPSG- 435
ES+ ++ ++ T + RNS + + +D L R LP G
Sbjct: 286 KEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVRPVVRHQLPLGH 345
Query: 436 ----DGNVI-TRXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLHEQQGSTSRPQ 600
+GN T H+ L+I M L SL DW+ E+ +
Sbjct: 346 SSELEGNFTSTDESSEGNLNLLGQTDVRYHLMLHIQMQL-CELSLWDWITERNKRSREYV 404
Query: 601 NRSLL---------HIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLA- 747
+ + IF ++V+ V Y+H+ G++HRDLKP NI L ++I DFGLA
Sbjct: 405 DEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLAC 464
Query: 748 TSLVRSKPSSCPDGRASNNENEYSSLTSNVGTELYMSPEQQEGTHYDQKLMCFLLG 915
++++ + +G+ + TS VGT LY SPEQ EG+ YD K + LG
Sbjct: 465 ADIIQNADWTNRNGKGTRTH------TSRVGTCLYASPEQLEGSQYDAKSDMYSLG 514
>sp|Q63185|E2AK1_RAT Eukaryotic translation initiation factor 2-alpha kinase 1
(Heme-regulated eukaryotic initiation factor eIF-2-alpha
kinase) (Heme-regulated inhibitor) (Heme-controlled
repressor) (HCR) (Hemin-sensitive initiation factor
2-alpha kinase)
Length = 620
Score = 107 bits (267), Expect = 5e-23
Identities = 99/355 (27%), Positives = 164/355 (46%), Gaps = 51/355 (14%)
Frame = +1
Query: 4 DYEHIRCLGKGAFGVVFEARHRVDQYSYAVKRVRVRYSDQARA-KLLQEVQAFAHLEHPG 180
++E + LGKG +G V++ R+++D YA+K++ ++ + + K+L+EV+ A L+HP
Sbjct: 166 EFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPN 225
Query: 181 IVRYYQAWF--------------ELPP-------EGWQDK---KDKEMGLENLY------ 270
IV Y+ AW +LP EG +++ KD E ++
Sbjct: 226 IVGYHTAWIEHVHVLQPQDRVPIQLPSLEVLSEHEGDRNQGGVKDNESSSSIIFAELTPE 285
Query: 271 DDDMVMSTDVQ-ESQQMSDGDSTRCTTTSDWSRNSL-LANDA--QDSLIIFDRSALPSG- 435
++ + +DV+ E+ + + +S S +S+ L D + L + LP G
Sbjct: 286 KENPLAESDVKNENNNLVSYRANLVIRSSSESESSIELQEDGLNESPLRPVVKHQLPLGH 345
Query: 436 ----DGNVI-TRXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLHEQQGSTSRPQ 600
+GN T H+ L+I M L SL DW+ E+ + +
Sbjct: 346 SSDVEGNFTSTDESSEDNLNLLGQTEARYHLMLHIQMQL-CELSLWDWIAERNKRSRKCV 404
Query: 601 NRSLL---------HIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLAT 750
+ + IF ++V+ V Y+H+ G++HRDLKP NI L ++I DFGLA
Sbjct: 405 DEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLAC 464
Query: 751 SLVRSKPSSCPDGRASNNENEYSSLTSNVGTELYMSPEQQEGTHYDQKLMCFLLG 915
+ + K + + N + TS VGT LY SPEQ EG+ YD K + LG
Sbjct: 465 ADIIQKSADW----TNRNGKGTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLG 515
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109,321,111
Number of Sequences: 369166
Number of extensions: 2289226
Number of successful extensions: 10769
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8600
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 10324
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9462723610
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)