Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_L19
(809 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 297 3e-80
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 294 2e-79
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 292 6e-79
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 284 2e-76
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 276 5e-74
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 268 1e-71
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 250 3e-66
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 224 3e-58
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 205 1e-52
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 203 4e-52
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 297 bits (760), Expect = 3e-80
Identities = 141/242 (58%), Positives = 171/242 (70%), Gaps = 1/242 (0%)
Frame = +2
Query: 86 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLNRVRL 262
PLS +L+N+VN TTWKAG +S ++K+ G ++ P KLP+R V L
Sbjct: 25 PLSDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGP---KLPQRDAFAADVVL 80
Query: 263 PTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLT 442
P +FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSNG +SAED+LT
Sbjct: 81 PESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLT 140
Query: 443 CCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTG 622
CCG CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTG
Sbjct: 141 CCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTG 200
Query: 623 EFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFP 802
E TPKC K C+ GYS +Y EDK +G SSYSV +N++ IM EI NGPVE AFSVY+DF
Sbjct: 201 EGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFL 260
Query: 803 SY 808
Y
Sbjct: 261 LY 262
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 294 bits (752), Expect = 2e-79
Identities = 137/246 (55%), Positives = 171/246 (69%), Gaps = 1/246 (0%)
Frame = +2
Query: 74 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 250
P PLS D+INY+N TTW+AG IS ++K+ G V+ PN LP+R
Sbjct: 21 PSSHPLSDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPN---LPERVGFSE 76
Query: 251 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 430
+ LP +FDAR QW C +I +IRDQ +CGSCWAFGAVEA++DR CIH+NG +SAE
Sbjct: 77 DINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAE 136
Query: 431 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 610
DLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRP 196
Query: 611 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 790
CTGE TPKC K C+AGYS +Y EDK YG +SYSV +++ IM EI NGPVE AF+V+
Sbjct: 197 PCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVF 256
Query: 791 ADFPSY 808
+DF +Y
Sbjct: 257 SDFLTY 262
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 292 bits (748), Expect = 6e-79
Identities = 139/246 (56%), Positives = 171/246 (69%), Gaps = 1/246 (0%)
Frame = +2
Query: 74 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 250
P PLS DLINY+N TTW+AG IS ++K+ G V+ P KLP R
Sbjct: 21 PSFHPLSDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGP---KLPGRVAFGE 76
Query: 251 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 430
+ LP TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+NG +SAE
Sbjct: 77 DIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAE 136
Query: 431 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 610
DLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRP 196
Query: 611 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 790
CTGE TP+C K+C+AGYS +Y EDK +G +SYSV ++ + IM EI NGPVE AF+V+
Sbjct: 197 PCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVF 256
Query: 791 ADFPSY 808
+DF +Y
Sbjct: 257 SDFLTY 262
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 284 bits (727), Expect = 2e-76
Identities = 133/245 (54%), Positives = 169/245 (68%)
Frame = +2
Query: 74 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR 253
P PLS +L+NYVN TTW+AG +S ++++ G K P+R
Sbjct: 21 PSFHPLSDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFL--GGPKPPQRVMFTED 77
Query: 254 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 433
++LP +FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N + +SAED
Sbjct: 78 LKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAED 137
Query: 434 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 613
LLTCCG CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV G P
Sbjct: 138 LLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 614 CTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 793
CTGE TPKC K C+ GYS TY +DK YG +SYSV ++++ IM EI NGPVE AFSVY+
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYS 257
Query: 794 DFPSY 808
DF Y
Sbjct: 258 DFLLY 262
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 276 bits (706), Expect = 5e-74
Identities = 130/247 (52%), Positives = 163/247 (65%), Gaps = 1/247 (0%)
Frame = +2
Query: 71 IPIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLN 250
IP + PLS DL+N++N + TT +AG +S ++K+ G K P+R
Sbjct: 20 IPYYPPLSSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFL--GGPKAPERVDFAE 76
Query: 251 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 430
+ LP TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N + +SAE
Sbjct: 77 DMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAE 136
Query: 431 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 610
DLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV G P
Sbjct: 137 DLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRP 196
Query: 611 NCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSV 787
CTGE TP+C + C+ GYS +Y EDK YG +SY V +++ IM EI NGPVE AF V
Sbjct: 197 PCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIV 256
Query: 788 YADFPSY 808
Y DF Y
Sbjct: 257 YEDFLMY 263
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 268 bits (685), Expect = 1e-71
Identities = 126/246 (51%), Positives = 162/246 (65%), Gaps = 5/246 (2%)
Frame = +2
Query: 86 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 253
PLS ++I+++N WKA + RF S+ D R ++G K+ K R+P ++
Sbjct: 29 PLSDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKR-NRRPTVDHHDLN 87
Query: 254 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 433
V +P+ FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 434 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 613
L++CC CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH G YP
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 614 C-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 790
C T + TP+CK+ CQ GY Y +DK YG SY+V +N++ I ++I+ GPVEAAF VY
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVY 266
Query: 791 ADFPSY 808
DF +Y
Sbjct: 267 EDFLNY 272
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 250 bits (639), Expect = 3e-66
Identities = 119/246 (48%), Positives = 159/246 (64%), Gaps = 5/246 (2%)
Frame = +2
Query: 86 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 253
PLS D+I+Y+N W+A + RF S+ D R +G ++ + + KR+P ++
Sbjct: 28 PLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRR-KRRPTVDHNDWN 86
Query: 254 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 433
V +P+ FD+R +WP CKSI IRDQS CGSCW+FGAVEA++DR CI S G Q +SA D
Sbjct: 87 VEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVD 146
Query: 434 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 613
LLTCC CG GC GG AW YWV +G+VT H GC+ Y FPKC HH G YP
Sbjct: 147 LLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPP 205
Query: 614 CTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 790
C + + TP+CK+ CQ Y Y +DK GKSSY+V ++++AI +EI+ GPVEA+F+VY
Sbjct: 206 CGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVY 265
Query: 791 ADFPSY 808
DF +Y
Sbjct: 266 EDFLNY 271
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 224 bits (570), Expect = 3e-58
Identities = 120/249 (48%), Positives = 158/249 (63%), Gaps = 12/249 (4%)
Frame = +2
Query: 98 DLINYVNYIAQTTWKAGPTTRFQSI-SDIRKVLGVMKDPNNFKLP-KRKPLLNRVR---- 259
DLI+YVN Q W A RF S+ + K + N+ +L K K L++ +
Sbjct: 45 DLIDYVNE-NQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDL 103
Query: 260 -LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDL 436
+P +FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DL
Sbjct: 104 DIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDL 163
Query: 437 LTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV----IGP 604
L+CC CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH P
Sbjct: 164 LSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDP 222
Query: 605 YPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAF 781
P+ +PTPKC+K C + Y+ KTY+EDK +G S+Y V + +AI +E++T+GP+E AF
Sbjct: 223 CPH--DLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAF 280
Query: 782 SVYADFPSY 808
VY DF +Y
Sbjct: 281 EVYEDFLNY 289
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 205 bits (521), Expect = 1e-52
Identities = 110/245 (44%), Positives = 141/245 (57%), Gaps = 9/245 (3%)
Frame = +2
Query: 101 LINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNRV---RLPTT 271
LI+YVN AQ W AG + K+ + D K + ++ +P
Sbjct: 32 LIDYVNS-AQKLWTAG-----HQVIPKEKITKKLMDVKYLVPHKDEDIVATEVSDAIPDH 85
Query: 272 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 451
FDAR QWP C SI IRDQS+CGSCWAF A EAI+DR CI SNG +S+EDLL+CC
Sbjct: 86 FDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVNTLLSSEDLLSCCT 145
Query: 452 --FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTG 622
F CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C V G +P C
Sbjct: 146 GMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPE 205
Query: 623 EF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 793
+ PTPKC +C + Y+ Y +DK +G ++Y+V + I EILTNGP+E AF+VY
Sbjct: 206 DTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAFTVYE 265
Query: 794 DFPSY 808
DF Y
Sbjct: 266 DFYQY 270
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 203 bits (517), Expect = 4e-52
Identities = 97/183 (53%), Positives = 120/183 (65%)
Frame = +2
Query: 260 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 439
+P TFD+R QW +CKSI IRDQ+ CGSCWAFGA E I+DR CI + G Q P IS +DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 440 TCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCT 619
+CCG CG+GC GG+P A +W + G+VTGG+Y GC+ Y C+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197
Query: 620 GEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADF 799
E TP C +CQ+GYS YA+DK +G S+Y+V N +I EI NGPVEAAFSVY DF
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDF 256
Query: 800 PSY 808
Y
Sbjct: 257 YKY 259
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,139,068
Number of Sequences: 369166
Number of extensions: 2191464
Number of successful extensions: 6898
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6391
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6737
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)