Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_K24
(909 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P20908|CA15_HUMAN Collagen alpha 1(V) chain precursor 90 8e-18
sp|Q61245|COBA1_MOUSE Collagen alpha 1(XI) chain precursor 87 8e-17
sp|P12107|CA1B_HUMAN Collagen alpha 1(XI) chain precursor 86 1e-16
sp|P25940|CO5A3_HUMAN Collagen alpha 3(V) chain precursor 79 1e-14
sp|P13942|COBA2_HUMAN Collagen alpha 2(XI) chain precursor 74 4e-13
sp|Q64739|CA2B_MOUSE Collagen alpha 2(XI) chain precursor 73 1e-12
sp|Q90827|NEL_CHICK NEL protein precursor (93 kDa protein) 57 5e-08
sp|Q99435|NELL2_HUMAN Protein kinase C-binding protein NELL... 57 9e-08
sp|Q62919|NELL1_RAT Protein kinase C-binding protein NELL1 ... 54 6e-07
sp|Q62918|NELL2_RAT Protein kinase C-binding protein NELL2 ... 54 6e-07
>sp|P20908|CA15_HUMAN Collagen alpha 1(V) chain precursor
Length = 1838
Score = 90.1 bits (222), Expect = 8e-18
Identities = 61/218 (27%), Positives = 101/218 (46%), Gaps = 10/218 (4%)
Frame = +2
Query: 233 DLLNSVQISDKNIGITAEEPFCANSKRK-----AFQYESGNSLMAKSDSLFKGK-LPKEF 394
DLL + + GIT FCA + A++ L A + L+ P++F
Sbjct: 41 DLLKVLDFHNLPDGITKTTGFCATRRSSKGPDVAYRVTKDAQLSAPTKQLYPASAFPEDF 100
Query: 395 SILITAKSESIESQDVFSIRNKDNNIVLSVTYGRQITLRYRD----PSSTTYMNLPFEVD 562
SIL T K++ + SI N+ + + GR Y D P Y L ++
Sbjct: 101 SILTTVKAKKGSQAFLVSIYNEQGIQQIGLELGRSPVFLYEDHTGKPGPEDYP-LFRGIN 159
Query: 563 LTDGQWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGDASFTG 742
L+DG+WHR+A S+ K +V+L++DC+ + L+R+ +P+ G + + F G
Sbjct: 160 LSDGKWHRIALSVHKKNVTLILDCKKKTTKFLDRSDHPMIDINGIIVFGTRILDEEVFEG 219
Query: 743 VLDSLLLIDGAREAFKQCQIYNPDCQNDISDVMMNQGP 856
+ LL + R A+ C+ Y+PDC + D +Q P
Sbjct: 220 DIQQLLFVSDHRAAYDYCEHYSPDCDTAVPDTPQSQDP 257
>sp|Q61245|COBA1_MOUSE Collagen alpha 1(XI) chain precursor
Length = 1804
Score = 86.7 bits (213), Expect = 8e-17
Identities = 60/210 (28%), Positives = 102/210 (48%), Gaps = 10/210 (4%)
Frame = +2
Query: 218 GDGVVDLLNSVQISDKNIGITAEEPFCANSKRK-----AFQYESGNSLMAKSDSLFKGKL 382
G VD+L ++ + +GI+ FC N K A++ + A + LF G +
Sbjct: 34 GAAPVDILKALDFHNSPVGISKTTGFCTNRKNSKDPDVAYRVTEEAQISAPTKQLFPGGI 93
Query: 383 -PKEFSILITAKSESIESQDVFSIRNKDNNIVLSVTYGRQITLRYRDPSST-TYMNLPF- 553
P++FSIL T K + + S+ N+ L V GR + D + T N P
Sbjct: 94 FPQDFSILFTIKPKKGTQAFLLSLYNEHGIQQLGVEVGRSPVFLFEDHTGKPTPENYPLF 153
Query: 554 -EVDLTDGQWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPL-DISGGFLYVLQNHKGD 727
V++ DG+WHRVA S+ K +V+++VDC+ + L+R+ + D +G ++ + + D
Sbjct: 154 STVNIADGKWHRVAISVEKKTVTMIVDCKKKITKPLDRSERSIVDTNGIMVFGTRILEAD 213
Query: 728 ASFTGVLDSLLLIDGAREAFKQCQIYNPDC 817
F G + L+ + A+ C Y+PDC
Sbjct: 214 V-FQGDIQQFLITGDPKAAYDYCDHYSPDC 242
>sp|P12107|CA1B_HUMAN Collagen alpha 1(XI) chain precursor
Length = 1806
Score = 86.3 bits (212), Expect = 1e-16
Identities = 61/223 (27%), Positives = 99/223 (44%), Gaps = 10/223 (4%)
Frame = +2
Query: 218 GDGVVDLLNSVQISDKNIGITAEEPFCANSKRK-----AFQYESGNSLMAKSDSLFKG-K 379
G VD+L ++ + GI+ FC N K A++ L A + LF G
Sbjct: 35 GAAPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGT 94
Query: 380 LPKEFSILITAKSESIESQDVFSIRNKDNNIVLSVTYGRQITLRYRD----PSSTTYMNL 547
P++FSIL T K + + SI N+ + V GR + D P+ Y L
Sbjct: 95 FPEDFSILFTVKPKKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYP-L 153
Query: 548 PFEVDLTDGQWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGD 727
V++ DG+WHRVA S+ K +V+++VDC+ + L+R+ + + G +
Sbjct: 154 FRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSERAIVDTNGITVFGTRILDE 213
Query: 728 ASFTGVLDSLLLIDGAREAFKQCQIYNPDCQNDISDVMMNQGP 856
F G + L+ + A+ C+ Y+PDC + Q P
Sbjct: 214 EVFEGDIQQFLITGDPKAAYDYCEHYSPDCDSSAPKAAQAQEP 256
>sp|P25940|CO5A3_HUMAN Collagen alpha 3(V) chain precursor
Length = 1745
Score = 79.3 bits (194), Expect = 1e-14
Identities = 60/202 (29%), Positives = 99/202 (49%), Gaps = 4/202 (1%)
Frame = +2
Query: 230 VDLLNSVQISDKNIGITAEEPFCANSKR---KAFQYESGNSLMAKSDSLF-KGKLPKEFS 397
VD+L ++ + G+ FC +AF+ ++L + LF +G P+ FS
Sbjct: 32 VDVLKALGVQGGQAGVPEGPGFCPQRTPEGDRAFRIGQASTLGIPTWELFPEGHFPENFS 91
Query: 398 ILITAKSESIESQDVFSIRNKDNNIVLSVTYGRQITLRYRDPSSTTYMNLPFEVDLTDGQ 577
+LIT + + + SI ++ L + G + L DP + LP +V+LTDG+
Sbjct: 92 LLITLRGQPANQSVLLSIYDERGARQLGLALGPALGL-LGDP----FRPLPQQVNLTDGR 146
Query: 578 WHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGDASFTGVLDSL 757
WHRVA SI V+L+ DC+ + L + I+G + Q+ G+ +F G + L
Sbjct: 147 WHRVAVSIDGEMVTLVADCEAQPPV-LGHGPRFISIAGLTVLGTQD-LGEKTFEGDIQEL 204
Query: 758 LLIDGAREAFKQCQIYNPDCQN 823
L+ + AF+ C+ Y PDC N
Sbjct: 205 LISPDPQAAFQACERYLPDCDN 226
>sp|P13942|COBA2_HUMAN Collagen alpha 2(XI) chain precursor
Length = 1736
Score = 74.3 bits (181), Expect = 4e-13
Identities = 53/222 (23%), Positives = 97/222 (43%), Gaps = 7/222 (3%)
Frame = +2
Query: 212 YSGDGVVDLLNSVQISDKNIGITAEEPFCANSKRKAFQYESGNSLMAKSDSLFKGKLPKE 391
++G VD+L +++ G+ + C A++ L A + LF G PK+
Sbjct: 26 WAGAPPVDVLRALRFPSLPDGVRRAKGICPADV--AYRVARPAQLSAPTRQLFPGGFPKD 83
Query: 392 FSILITAKSESIESQDVFSIRNKDNNIVLSVTYGRQITLRYRD-------PSSTTYMNLP 550
FS+L ++ + ++ + L + GR + Y D PS + L
Sbjct: 84 FSLLTVVRTRPGLQAPLLTLYSAQGVRQLGLELGRPVRFLYEDQTGRPQPPSQPVFRGL- 142
Query: 551 FEVDLTDGQWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGDA 730
L DG+WHRVA ++ SV+L+VDC+ + L R+ P+ + G + +
Sbjct: 143 ---SLADGKWHRVAVAVKGQSVTLIVDCKKRVTRPLPRSARPVLDTHGVIIFGARILDEE 199
Query: 731 SFTGVLDSLLLIDGAREAFKQCQIYNPDCQNDISDVMMNQGP 856
F G + L ++ G + A++ C+ +C+ + NQ P
Sbjct: 200 VFEGDVQELAIVPGVQAAYESCEQKELECEGGQRERPQNQQP 241
>sp|Q64739|CA2B_MOUSE Collagen alpha 2(XI) chain precursor
Length = 1736
Score = 72.8 bits (177), Expect = 1e-12
Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 3/218 (1%)
Frame = +2
Query: 212 YSGDGVVDLLNSVQISDKNIGITAEEPFCANSKRKAFQYESGNSLMAKSDSLFKGKLPKE 391
++G VD+L +++ G+ + C A++ L A + LF G PK+
Sbjct: 26 WAGAPSVDVLRALRFPSLPDGVRRSKGVCPGDV--AYRVARPAQLSAPTRQLFPGGFPKD 83
Query: 392 FSILITAKSESIESQDVFSIRNKDNNIVLSVTYGRQITLRYRDPSSTTYMNLP---FEVD 562
FS+L ++ + ++ + L + GR + Y D + +
Sbjct: 84 FSLLTVVRTRPGLQAPLLTLYSAQGVQQLGLELGRPVRFLYEDQRGRPQASAQPIFRGLS 143
Query: 563 LTDGQWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGDASFTG 742
L DG+WH VA ++ SV+L+VDC+ + L R+ +P+ + G + + D F G
Sbjct: 144 LADGKWHHVAVAVKGQSVTLIVDCKKRVTRPLPRSVHPVLDTHGVVIFGAHILDDEVFEG 203
Query: 743 VLDSLLLIDGAREAFKQCQIYNPDCQNDISDVMMNQGP 856
+ LL++ G + A++ C + +C+ + D Q P
Sbjct: 204 DVQELLVVPGVQAAYQSCGQKDLECEREQRDGPQTQKP 241
>sp|Q90827|NEL_CHICK NEL protein precursor (93 kDa protein)
Length = 816
Score = 57.4 bits (137), Expect = 5e-08
Identities = 50/202 (24%), Positives = 93/202 (46%), Gaps = 6/202 (2%)
Frame = +2
Query: 230 VDLLNSVQISDKNIGITAEEPFCANSKRKAFQYESGNSLMAKSDS--LFKGKLPK--EFS 397
+D+L+ + + G+ + P N + ++ S+ A ++ +F KL EF+
Sbjct: 30 IDVLSELGLPGYAAGVR-QVPGLHNGSKAFLFPDTSRSVKASPETAEIFFQKLRNKYEFT 88
Query: 398 ILITAKSESIESQDVFSIRNKDNNIVLSVTYGR--QITLRYRDPSSTTYMNLPFEVDLTD 571
IL+T K + S +FSI + D+ + + G +I L YR S ++ + F L D
Sbjct: 89 ILVTLKQAHLNSGVIFSIHHLDHRYLELESSGHRNEIRLHYRTGSHRSHTEV-FPYILAD 147
Query: 572 GQWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGDASFTGVLD 751
+WHR++ +I+ S + L VDC I + + L + G ++ Q + F G++
Sbjct: 148 DKWHRLSLAISASHLILHVDCNKIYERVVEKPFMDLPV-GTTFWLGQRNNAHGYFKGIMQ 206
Query: 752 SLLLIDGAREAFKQCQIYNPDC 817
+ L+ + QC N C
Sbjct: 207 DVQLLVMPQGFISQCPDLNRTC 228
>sp|Q99435|NELL2_HUMAN Protein kinase C-binding protein NELL2 precursor (NEL-like protein
2) (Nel-related protein 2)
Length = 816
Score = 56.6 bits (135), Expect = 9e-08
Identities = 46/201 (22%), Positives = 90/201 (44%), Gaps = 5/201 (2%)
Frame = +2
Query: 230 VDLLNSVQISDKNIGITAEEPFCANSKRKAFQY--ESGNSLMAKSDSLFKGKLPK-EFSI 400
+D+L +++ + G+ +K FQ S + A ++ F+ K EF+I
Sbjct: 30 IDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQFFQKLRNKHEFTI 89
Query: 401 LITAKSESIESQDVFSIRNKDNNIVLSVTYGR--QITLRYRDPSSTTYMNLPFEVDLTDG 574
L+T K + S + SI + D+ + + G ++ L YR S + + F L D
Sbjct: 90 LVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPHTEV-FPYILADD 148
Query: 575 QWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGDASFTGVLDS 754
+WH+++ +I+ S + L +DC I + + + L + G ++ Q + F G++
Sbjct: 149 KWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPL-GTTFWLGQRNNAHGYFKGIMQD 207
Query: 755 LLLIDGAREAFKQCQIYNPDC 817
+ L+ + QC N C
Sbjct: 208 VQLLVMPQGFIAQCPDLNRTC 228
>sp|Q62919|NELL1_RAT Protein kinase C-binding protein NELL1 precursor (NEL-like protein
1)
Length = 810
Score = 53.9 bits (128), Expect = 6e-07
Identities = 50/216 (23%), Positives = 89/216 (41%), Gaps = 8/216 (3%)
Frame = +2
Query: 230 VDLLNSVQISDKNIGITAEEPFCANSKRKAFQ-----YESGNSLMAKSDSLFKGKLPKEF 394
+D+++ + + + +G+T SK FQ S + K LF+ K EF
Sbjct: 30 LDIISELDLVNTTLGVTQVAGLHNASKAFLFQDVQREIHSAPHVSEKLIQLFRNK--SEF 87
Query: 395 SILITAKSESIESQDVFSIRNKDNNIVLSVTYGRQITLRYRDPSSTTYMNLPFEVDLTDG 574
+ L T + + S + SIR +++ + G + +RY + DG
Sbjct: 88 TFLATVQQKPSTSGVILSIRELEHSYFELESSGpreEIRYHYIHGGKPRTEALPYRMADG 147
Query: 575 QWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDIS---GGFLYVLQNHKGDASFTGV 745
QWH+VA S++ S + L +DC I R +P + + G L++ Q ++ F G+
Sbjct: 148 QWHKVALSVSASHLLLHIDCNRI----YERVIDPPETNLPPGSNLWLGQRNQKHGFFKGI 203
Query: 746 LDSLLLIDGAREAFKQCQIYNPDCQNDISDVMMNQG 853
+ +I QC N C + + QG
Sbjct: 204 IQDGKIIFMPNGFITQCPNLNRTCPTCSDFLSLVQG 239
>sp|Q62918|NELL2_RAT Protein kinase C-binding protein NELL2 precursor (NEL-like protein
2)
Length = 816
Score = 53.9 bits (128), Expect = 6e-07
Identities = 46/202 (22%), Positives = 92/202 (45%), Gaps = 6/202 (2%)
Frame = +2
Query: 230 VDLLNSVQISDKNIGITAEEPFCANSKRKAFQYESGNSL---MAKSDSLFKGKLPK-EFS 397
+D+L+ +++ + G+ +K FQ +S S+ +A ++ F+ K EF+
Sbjct: 30 IDVLSELELGESTAGVRQVPGLHNGTKAFLFQ-DSPRSIKAPIATAERFFQKLRNKHEFT 88
Query: 398 ILITAKSESIESQDVFSIRNKDNNIVLSVTYGR--QITLRYRDPSSTTYMNLPFEVDLTD 571
IL+T K + S + SI + D+ + + G +I L YR + + + F L D
Sbjct: 89 ILVTLKQIHLNSGVILSIHHLDHRYLELESSGHRNEIRLHYRSGTHRPHTEV-FPYILAD 147
Query: 572 GQWHRVAFSITKSSVSLLVDCQFIGSLKLNRTTNPLDISGGFLYVLQNHKGDASFTGVLD 751
+WH+++ + + S + L +DC I + + L + G ++ Q + F G++
Sbjct: 148 AKWHKLSLAFSASHLILHIDCNKIYERVVEMPSTDLPL-GTTFWLGQRNNAHGYFKGIMQ 206
Query: 752 SLLLIDGAREAFKQCQIYNPDC 817
+ L+ + QC N C
Sbjct: 207 DVQLLVMPQGFIAQCPDLNRTC 228
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,827,176
Number of Sequences: 369166
Number of extensions: 1751989
Number of successful extensions: 4119
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3912
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4108
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9222552960
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)