Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_K17
(676 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P58003|SESN1_XENLA Sestrin-1 (p53-regulated protein PA26... 99 8e-21
sp|Q9W1K5|SEST_DROME Putative sestrin 98 2e-20
sp|Q9Y6P5|SESN1_HUMAN Sestrin-1 (p53-regulated protein PA26) 96 1e-19
sp|P58006|SESN1_MOUSE Sestrin-1 (p53-regulated protein PA26) 96 1e-19
sp|P58005|SESN3_HUMAN Sestrin-3 91 4e-18
sp|P58004|SESN2_HUMAN Sestrin-2 (Hi95) 90 5e-18
sp|P58043|SESN2_MOUSE Sestrin-2 89 8e-18
sp|Q9CYP7|SESN3_MOUSE Sestrin-3 88 2e-17
sp|Q9N4D6|SEST_CAEEL Putative sestrin 69 1e-11
sp|Q9WUS1|RNAS1_MYOGL Ribonuclease pancreatic precursor (RN... 30 4.4
>sp|P58003|SESN1_XENLA Sestrin-1 (p53-regulated protein PA26) (XPA26)
Length = 481
Score = 99.4 bits (246), Expect = 8e-21
Identities = 48/138 (34%), Positives = 77/138 (55%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R+Q+YSW D L +R Y D+G+ L++KF+ R +VW YV
Sbjct: 339 RVQDYSWEDHGYSLVNRLYPDVGQLLDEKFHIAYNLTYNTMAMHKDVDTSTLRRAVWNYV 398
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
H ++GIR+DD++Y +++ LL K ++K + P + K F+ +FK SEKVH+ L
Sbjct: 399 HCMFGIRYDDYDYGEINQLLDRSFKVYIKNVVCSPEKTSKRMYDGFWRQFKHSEKVHVNL 458
Query: 396 MAADARQQACLLHILKAM 449
+ +AR Q LL+ L+A+
Sbjct: 459 LLMEARMQGELLYALRAI 476
>sp|Q9W1K5|SEST_DROME Putative sestrin
Length = 497
Score = 98.2 bits (243), Expect = 2e-20
Identities = 51/136 (37%), Positives = 70/136 (51%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R+Q+YSW D L D Y D+G L+ KF FR ++W Y+
Sbjct: 355 RIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTMGGIKNVDTSKFRRAIWNYI 414
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
+YGIRHDD++Y +++ LL PLK F+K A P D E + SEKVH+ L
Sbjct: 415 QCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVNL 474
Query: 396 MAADARQQACLLHILK 443
M +AR QA LL+ L+
Sbjct: 475 MIMEARNQAELLYALR 490
>sp|Q9Y6P5|SESN1_HUMAN Sestrin-1 (p53-regulated protein PA26)
Length = 492
Score = 95.5 bits (236), Expect = 1e-19
Identities = 45/138 (32%), Positives = 76/138 (55%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R+Q+Y W D L +R Y D+G+ +++KF+ R ++W Y+
Sbjct: 350 RVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYI 409
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
H ++GIR+DD++Y +++ LL K ++K + P K F+ +FK SEKVH+ L
Sbjct: 410 HCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNL 469
Query: 396 MAADARQQACLLHILKAM 449
+ +AR QA LL+ L+A+
Sbjct: 470 LLIEARMQAELLYALRAI 487
>sp|P58006|SESN1_MOUSE Sestrin-1 (p53-regulated protein PA26)
Length = 492
Score = 95.5 bits (236), Expect = 1e-19
Identities = 45/138 (32%), Positives = 76/138 (55%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R+Q+Y W D L +R Y D+G+ +++KF+ R ++W Y+
Sbjct: 350 RVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIPYNLTYNTMAMHKDVDTSMLRRAIWNYI 409
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
H ++GIR+DD++Y +++ LL K ++K + P K F+ +FK SEKVH+ L
Sbjct: 410 HCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNL 469
Query: 396 MAADARQQACLLHILKAM 449
+ +AR QA LL+ L+A+
Sbjct: 470 LLIEARMQAELLYALRAI 487
>sp|P58005|SESN3_HUMAN Sestrin-3
Length = 492
Score = 90.5 bits (223), Expect = 4e-18
Identities = 46/138 (33%), Positives = 76/138 (55%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R Q+Y+W + L +R Y+DIG L++KF R +++ YV
Sbjct: 350 RAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYV 409
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
H ++GIR+DD++Y +++ LL LK ++K P + K ++ +FK SEKVH+ L
Sbjct: 410 HCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNL 469
Query: 396 MAADARQQACLLHILKAM 449
+ +AR QA LL+ L+A+
Sbjct: 470 LLMEARMQAELLYALRAI 487
>sp|P58004|SESN2_HUMAN Sestrin-2 (Hi95)
Length = 480
Score = 90.1 bits (222), Expect = 5e-18
Identities = 44/138 (31%), Positives = 73/138 (52%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R Q+Y+W D L R Y + G+ L++KF R ++W Y+
Sbjct: 338 RAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYI 397
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
H ++GIR+DD++Y +++ LL LK ++K P + + F+ F+ SEKVH+ L
Sbjct: 398 HCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNL 457
Query: 396 MAADARQQACLLHILKAM 449
+ +AR QA LL+ L+A+
Sbjct: 458 LLLEARMQAALLYALRAI 475
>sp|P58043|SESN2_MOUSE Sestrin-2
Length = 480
Score = 89.4 bits (220), Expect = 8e-18
Identities = 44/138 (31%), Positives = 73/138 (52%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R Q+Y+W D L R Y + G+ L++KF R ++W Y+
Sbjct: 338 RAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQVACSLTYNTIAMHSGVDTSMLRRAIWNYI 397
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
H ++GIR+DD++Y +++ LL LK ++K P + + F+ F+ SEKVH+ L
Sbjct: 398 HCVFGIRYDDYDYGEVNQLLERNLKIYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNL 457
Query: 396 MAADARQQACLLHILKAM 449
+ +AR QA LL+ L+A+
Sbjct: 458 LLLEARMQAALLYALRAI 475
>sp|Q9CYP7|SESN3_MOUSE Sestrin-3
Length = 492
Score = 88.2 bits (217), Expect = 2e-17
Identities = 45/138 (32%), Positives = 75/138 (54%)
Frame = +3
Query: 36 RMQEYSWSDEACCLADRFYTDIGKALEDKFNCXXXXXXXXXXXXXXXXXXXFRLSVWIYV 215
R Q+Y+W + L +R Y+DIG L++KF R +++ YV
Sbjct: 350 RAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTTLRRALFNYV 409
Query: 216 HSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIAL 395
H ++GIR+DD++Y +++ LL LK ++K P + K ++ +F SEKVH+ L
Sbjct: 410 HCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFTHSEKVHVNL 469
Query: 396 MAADARQQACLLHILKAM 449
+ +AR QA LL+ L+A+
Sbjct: 470 LLMEARMQAELLYALRAI 487
>sp|Q9N4D6|SEST_CAEEL Putative sestrin
Length = 517
Score = 68.9 bits (167), Expect = 1e-11
Identities = 34/87 (39%), Positives = 53/87 (60%)
Frame = +3
Query: 189 FRLSVWIYVHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFK 368
FR ++W Y LYG+R DD++Y++++ +L KTF+K A P ++ R P FK
Sbjct: 414 FREAIWNYTQGLYGVRVDDYDYSKINRVLDKGTKTFIKLAACYP-HKLTTEFTRALPGFK 472
Query: 369 ISEKVHIALMAADARQQACLLHILKAM 449
SEK+H+ +M A AR QA + H +A+
Sbjct: 473 DSEKIHVVMMVAMARFQASMFHYTRAV 499
>sp|Q9WUS1|RNAS1_MYOGL Ribonuclease pancreatic precursor (RNase 1) (RNase A)
Length = 156
Score = 30.4 bits (67), Expect = 4.4
Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Frame = -1
Query: 640 KYIKNFLNEILSVNDQTQFKYEYISFKQGKINCMNLGSSLHVDSTIT----DYIRCYVRT 473
K + F++E L+ F+ E ++ K G+ NC GSS+HV T Y C RT
Sbjct: 69 KPVNTFVHEPLADVQAVCFQ-ENVTCKNGQTNCYRSGSSMHVTDCRTTGSSKYPNCAYRT 127
Query: 472 NNQL 461
++
Sbjct: 128 TQKV 131
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,410,334
Number of Sequences: 369166
Number of extensions: 1459176
Number of successful extensions: 3231
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3155
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3222
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5684835195
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)