Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_K14
(903 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precur... 282 1e-75
sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precur... 279 9e-75
sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precur... 275 1e-73
sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precurso... 275 2e-73
sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ... 227 3e-59
sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precur... 219 8e-57
sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precur... 218 2e-56
sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precurso... 212 1e-54
sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase ... 208 1e-53
sp|P29828|PDI_MEDSA Protein disulfide-isomerase precursor (... 160 6e-39
>sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERP60) (58 kDa microsomal protein) (P58) (ERp57)
Length = 505
Score = 282 bits (721), Expect = 1e-75
Identities = 141/304 (46%), Positives = 199/304 (65%), Gaps = 5/304 (1%)
Frame = +3
Query: 6 NFEQSIKE---HSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETK 176
NFE I + ++LVEF+APWCGHCKKLAPEYE AAT LK +P+AKVDCTA T
Sbjct: 34 NFESRITDTGSSGLMLVEFFAPWCGHCKKLAPEYEAAATRLKGI---VPLAKVDCTANTN 90
Query: 177 TCEKHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIA 356
TC K+GVSGYPTLKIF++G+ + Y G R++DGI+ ++ ++GP+S +K+EE F+KFI+
Sbjct: 91 TCNKYGVSGYPTLKIFRDGEESGAYDGPRTADGIVSHLKKQAGPASVPLKSEEEFEKFIS 150
Query: 357 STDPVVVGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFE-NNIVIYHPQK 533
D VVGFF S+ + FL A L +++RFAH ESL K + + I ++ P
Sbjct: 151 DKDASVVGFFKDLFSEAHSEFLKAASNLRDNYRFAHTNVESLVNKYDDDGEGITLFRPSH 210
Query: 534 MANKFEESQIKY-KGDASEYQIRTWVEEKIMGMVGLRTSSNMKYFSSKPLLVALYSVDYE 710
+ NKFE+ + Y + + +I+ +++E I G+ T N K LL+A Y VDYE
Sbjct: 211 LTNKFEDKTVAYTEQKMTSGKIKRFIQENIFGICPHMTEDNKDLLQGKDLLIAYYDVDYE 270
Query: 711 KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESPDSNKVYIVARD 890
KN KG+NYWRNR+M VAKKF+D+G+ +HFA+++ + SHELS+FG+ES + R
Sbjct: 271 KNAKGSNYWRNRVMMVAKKFLDAGQKLHFAVASRKTFSHELSDFGLESTTGEIPVVAVRT 330
Query: 891 EKNQ 902
K +
Sbjct: 331 AKGE 334
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/117 (38%), Positives = 61/117 (52%), Gaps = 3/117 (2%)
Frame = +3
Query: 6 NFEQSIK-EHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTC 182
NF++ + E+ +L+EFYAPWCGHCK L P+Y+ L R+DP I IAK+D TA
Sbjct: 385 NFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKL-RKDPNIVIAKMDATA-NDVP 442
Query: 183 EKHGVSGYPTLKI--FKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKK 347
+ V G+PT+ Q Y G R I Y+ K ++ V EE KK
Sbjct: 443 SPYEVRGFPTIYFSPANKKQNPKKYEGGRELSDFISYL--KREATNPPVIQEEKPKK 497
>sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(58 kDa glucose regulated protein)
Length = 505
Score = 279 bits (713), Expect = 9e-75
Identities = 139/304 (45%), Positives = 198/304 (65%), Gaps = 5/304 (1%)
Frame = +3
Query: 6 NFEQSIKEHS---VILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETK 176
NFE I + ++LVEF+APWCGHCK+LAPEYE AAT LK +P+AKVDCTA T
Sbjct: 34 NFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI---VPLAKVDCTANTN 90
Query: 177 TCEKHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIA 356
TC K+GVSGYPTLKIF++G+ A Y G R++DGI+ ++ ++GP+S ++TEE FKKFI+
Sbjct: 91 TCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFIS 150
Query: 357 STDPVVVGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFE-NNIVIYHPQK 533
D +VGFF S+ + FL A L +++RFAH ESL + + I+++ P
Sbjct: 151 DKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSH 210
Query: 534 MANKFEESQIKY-KGDASEYQIRTWVEEKIMGMVGLRTSSNMKYFSSKPLLVALYSVDYE 710
+ NKFE+ + Y + + +I+ +++E I G+ T N K LL+A Y VDYE
Sbjct: 211 LTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYE 270
Query: 711 KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESPDSNKVYIVARD 890
KN KG+NYWRNR+M VAKKF+D+G ++FA+++ + SHELS+FG+ES + R
Sbjct: 271 KNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRT 330
Query: 891 EKNQ 902
K +
Sbjct: 331 AKGE 334
Score = 64.7 bits (156), Expect = 3e-10
Identities = 43/124 (34%), Positives = 63/124 (50%), Gaps = 4/124 (3%)
Frame = +3
Query: 6 NFEQSIK-EHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTC 182
NF++ + E+ +L+EFYAPWCGHCK L P+Y+ L + DP I IAK+D TA
Sbjct: 385 NFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSK-DPNIVIAKMDATA-NDVP 442
Query: 183 EKHGVSGYPTLKIFKNGQFAFD---YSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFI 353
+ V G+PT+ F + Y G R I Y + + + ++ E+ KK
Sbjct: 443 SPYEVRGFPTI-YFSPANKKLNPKKYEGGRELSDFISY-LQREATNPPVIQEEKPKKKKK 500
Query: 354 ASTD 365
A D
Sbjct: 501 AQED 504
>sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
Length = 504
Score = 275 bits (704), Expect = 1e-73
Identities = 140/304 (46%), Positives = 195/304 (64%), Gaps = 5/304 (1%)
Frame = +3
Query: 6 NFEQSIKEHS---VILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETK 176
NFE + + ++LVEF+APWCGHCK+LAPEYE AAT LK +P+AKVDCTA T
Sbjct: 34 NFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKI----VPLAKVDCTANTN 89
Query: 177 TCEKHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIA 356
TC K+GVSGYPTLKIF+ G+ A Y G R++DGI+ ++ ++GP+S ++TEE FKKFI+
Sbjct: 90 TCNKYGVSGYPTLKIFRAGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFIS 149
Query: 357 STDPVVVGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFE-NNIVIYHPQK 533
D VVGFF SD + FL A L +++RFAH ESL + + I I+ P
Sbjct: 150 DKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLH 209
Query: 534 MANKFEESQIKY-KGDASEYQIRTWVEEKIMGMVGLRTSSNMKYFSSKPLLVALYSVDYE 710
+ANKFE+ + Y + + +I+ ++++ I G+ T N K LL A Y VDYE
Sbjct: 210 LANKFEDKTVAYTEKKMTSAKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYE 269
Query: 711 KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESPDSNKVYIVARD 890
KN KG+NYWRNR+M VAKKF+D+G ++FA+++ + SHELS+F +ES + R
Sbjct: 270 KNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFSLESTTGEVPVVAIRT 329
Query: 891 EKNQ 902
K +
Sbjct: 330 AKGE 333
Score = 64.3 bits (155), Expect = 4e-10
Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Frame = +3
Query: 6 NFEQSIKEHSV-ILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTC 182
NF+ + E +L+EFYAPWCGHCK L P+Y+ L + DP I IAK+D TA
Sbjct: 384 NFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSK-DPNIVIAKMDATA-NDVP 441
Query: 183 EKHGVSGYPTLKIFKNGQ--FAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIA 356
+ V G+PT+ + Y G R + I Y + + + ++ E+ KK A
Sbjct: 442 SPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISY-LQREATNPPIIQEEKPKKKKKA 500
Query: 357 STD 365
D
Sbjct: 501 QED 503
>sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(HIP-70) (Q-2)
Length = 505
Score = 275 bits (702), Expect = 2e-73
Identities = 140/304 (46%), Positives = 196/304 (64%), Gaps = 5/304 (1%)
Frame = +3
Query: 6 NFEQSIKEHS---VILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETK 176
NFE + + ++LVEF+APWCGHCK+LAPEYE AAT LK +P+AKVDCTA T
Sbjct: 34 NFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI---VPLAKVDCTANTN 90
Query: 177 TCEKHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIA 356
TC K+GVSGYPTLKIF++G+ A Y G R++DGI+ ++ ++GP+S ++TE+ FKKFI+
Sbjct: 91 TCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEDEFKKFIS 150
Query: 357 STDPVVVGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFE-NNIVIYHPQK 533
D VVGFF SD + FL A L +++RFAH ESL + + I I+ P
Sbjct: 151 DKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITIFRPLH 210
Query: 534 MANKFEESQIKY-KGDASEYQIRTWVEEKIMGMVGLRTSSNMKYFSSKPLLVALYSVDYE 710
+ANKFE+ + Y + + +I+ +++E I G+ T N K LL A Y VDYE
Sbjct: 211 LANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYE 270
Query: 711 KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESPDSNKVYIVARD 890
KN KG+NYWRNR+M VAK F+D+G ++FA+++ + SHELS+FG+ES + R
Sbjct: 271 KNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEIPVVAIRT 330
Query: 891 EKNQ 902
K +
Sbjct: 331 AKGE 334
Score = 62.4 bits (150), Expect = 2e-09
Identities = 40/115 (34%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Frame = +3
Query: 27 EHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCEKHGVSGY 206
E +L+EFYAPWCGHCK L P+Y+ L + DP I IAK+D TA + V G+
Sbjct: 393 EDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSK-DPNIVIAKMDATA-NDVPSPYEVKGF 450
Query: 207 PTLKIFKNGQ--FAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIASTD 365
PT+ + Y G R + I Y + + + ++ E+ KK A D
Sbjct: 451 PTIYFSPANKKLTPKKYEGGRELNDFISY-LQREATNPPIIQEEKPKKKKKAQED 504
>sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ER-60 precursor (ERP60)
Length = 484
Score = 227 bits (579), Expect = 3e-59
Identities = 113/297 (38%), Positives = 172/297 (57%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF +K V LV+FYAPWCGHCKKLAPE+ AA + + + + KVDCT + C
Sbjct: 26 NFHSELKSIPVALVKFYAPWCGHCKKLAPEFTSAAQIISGKTNDVKLVKVDCTTQESICS 85
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIASTD 365
+ GVSGYPTLKIF+NG +Y+G R+++GI YMIS++GP SKEV T + + ++
Sbjct: 86 EFGVSGYPTLKIFRNGDLDGEYNGPRNANGIANYMISRAGPVSKEVSTVSDVENVLSDDK 145
Query: 366 PVVVGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFENNIVIYHPQKMANK 545
P V F S S L K F+++A+ + +D F H + +N + +Y P+++ K
Sbjct: 146 PTVFAFVKSSSDPLIKTFMALAKSMVDDAVFCHSHNNLFVTP--SDNELRVYLPKRLRTK 203
Query: 546 FEESQIKYKGDASEYQIRTWVEEKIMGMVGLRTSSNMKYFSSKPLLVALYSVDYEKNPKG 725
FE+ YKG+ I+ W+ + G+VG R+ SN YF + L+V + + P G
Sbjct: 204 FEDDFAVYKGELESNNIKDWIRKHGQGLVGYRSPSNTFYFENSDLVVLYNNQSIDSYPSG 263
Query: 726 TNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESPDSNKVYIVARDEK 896
Y RNR++K K K++ FA S + + S+E+S++GIE+ V I ++D+K
Sbjct: 264 VKYLRNRVLKTLKDNPQKFKNLVFAYSFADDFSYEISDYGIEADKLPAVVIQSKDKK 320
Score = 65.1 bits (157), Expect = 3e-10
Identities = 36/98 (36%), Positives = 57/98 (58%), Gaps = 3/98 (3%)
Frame = +3
Query: 6 NFEQSIK-EHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTC 182
NF++ + E ++V F+A WCGHCK L P+YE AA+ +K +P + +A +D TA
Sbjct: 367 NFDEIVNNEEKDVMVVFHAGWCGHCKNLMPKYEEAASKVK-NEPNLVLAAMDATA-NDVP 424
Query: 183 EKHGVSGYPTLKIFKNGQFA--FDYSGERSSDGIIKYM 290
+ V G+PT+ G+ + Y G R ++ IIKY+
Sbjct: 425 SPYQVRGFPTIYFVPKGKKSSPVSYEGGRDTNDIIKYL 462
>sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 645
Score = 219 bits (558), Expect = 8e-57
Identities = 114/287 (39%), Positives = 178/287 (62%), Gaps = 6/287 (2%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF++ + + +ILVEFYAPWCGHCKKLAPEYE AA L ++ PPIP+AKVD TAET +
Sbjct: 186 NFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAK 245
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIASTD 365
+ VSGYPTLKIF+ G+ +DY+G R GI+ YMI +SGP SKE+ T + ++F+ D
Sbjct: 246 RFDVSGYPTLKIFRKGR-PYDYNGpreKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGD 304
Query: 366 PV-VVGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNF-ENNIVIYHPQKMA 539
V ++G F ES Y+ + A L ED++F H F + L + +V+ P+K
Sbjct: 305 DVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQ 364
Query: 540 NKFE--ESQIKYKGDASEYQIRTWVEEKIMGMVGLRTSSN-MKYFSSKPLLVALYSVDYE 710
+K+E + +G + I+ +V + + +VG R SN K ++ +PL+V YSVD+
Sbjct: 365 SKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFS 424
Query: 711 KNPK-GTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGI 848
+ + T +WR+++++VAK F + FAI++ ++ + E+ + G+
Sbjct: 425 FDYRAATQFWRSKVLEVAKDFPE----YTFAIADEEDYAGEVKDLGL 467
Score = 120 bits (302), Expect = 4e-27
Identities = 59/135 (43%), Positives = 83/135 (61%), Gaps = 6/135 (4%)
Frame = +3
Query: 3 SNFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTC 182
+NF+ + + +L+EFYAPWCGHCK+ APEYE A LK +DPPIP+AK+D T+ +
Sbjct: 70 ANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLA 129
Query: 183 EKHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKE------VKTEENFK 344
+ VSGYPT+KI K GQ A DY G R+ + I+ + S P V T+ENF
Sbjct: 130 SRFDVSGYPTIKILKKGQ-AVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFD 188
Query: 345 KFIASTDPVVVGFFA 389
+ + D ++V F+A
Sbjct: 189 EVVNDADIILVEFYA 203
Score = 62.8 bits (151), Expect = 1e-09
Identities = 29/65 (44%), Positives = 40/65 (61%)
Frame = +3
Query: 39 ILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCEKHGVSGYPTLK 218
+L+EFYAPWCGHCK+L P Y A K Q + IAK+D TA +++ V G+PT+
Sbjct: 546 VLIEFYAPWCGHCKQLEPVYNSLAKKYKGQ-KGLVIAKMDATANDVPSDRYKVEGFPTIY 604
Query: 219 IFKNG 233
+G
Sbjct: 605 FAPSG 609
>sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 638
Score = 218 bits (555), Expect = 2e-56
Identities = 115/287 (40%), Positives = 174/287 (60%), Gaps = 6/287 (2%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF+ + +ILVEFYAPWCGHCKKLAPEYE AA L ++ PPIP+AKVD T +T +
Sbjct: 179 NFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLAK 238
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIASTD 365
+ VSGYPTLKIF+ G+ FDY+G R GI+ YMI +SGP SKE+ T + ++F+ D
Sbjct: 239 RFDVSGYPTLKIFRKGR-PFDYNGpreKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGD 297
Query: 366 PVV-VGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFE-NNIVIYHPQKMA 539
VV +G F + Y + A L ED++F H F + L +V+ HP+K
Sbjct: 298 DVVIIGLFQGDGDPAYLQYQDAANNLREDYKFHHTFSPEIAKFLKVSLGKLVLTHPEKFQ 357
Query: 540 NKFEE--SQIKYKGDASEYQIRTWVEEKIMGMVGLR-TSSNMKYFSSKPLLVALYSVDYE 710
+K+E + +G I+ +V + + +VG R TS++ K +S +PL+V YSVD+
Sbjct: 358 SKYEPRFHVMDVQGSTEASAIKDYVVKHALPLVGHRKTSNDAKRYSKRPLVVVYYSVDFS 417
Query: 711 KNPK-GTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGI 848
+ + T +WRN++++VAK F + FAI++ ++ + E+ + G+
Sbjct: 418 FDYRAATQFWRNKVLEVAKDFPE----YTFAIADEEDYATEVKDLGL 460
Score = 119 bits (297), Expect = 2e-26
Identities = 60/134 (44%), Positives = 83/134 (61%), Gaps = 6/134 (4%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF+ + + +L+EFYAPWCGHCK+ APEYE A+TLK DPPI +AK+D T+ +
Sbjct: 64 NFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLAS 123
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPS---SKEVK---TEENFKK 347
K VSGYPT+KI K GQ A DY G R+ + I+ + S P EV T++NF
Sbjct: 124 KFDVSGYPTIKILKKGQ-AVDYDGSRTQEEIVAKVREVSQPDWTPPPEVTLSLTKDNFDD 182
Query: 348 FIASTDPVVVGFFA 389
+ + D ++V F+A
Sbjct: 183 VVNNADIILVEFYA 196
Score = 61.6 bits (148), Expect = 3e-09
Identities = 29/65 (44%), Positives = 40/65 (61%)
Frame = +3
Query: 39 ILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCEKHGVSGYPTLK 218
+L+EFYAPWCGHCK+L P Y K Q + IAK+D TA T +++ V G+PT+
Sbjct: 539 VLIEFYAPWCGHCKQLEPIYTSLGKKYKGQ-KDLVIAKMDATANDITNDQYKVEGFPTIY 597
Query: 219 IFKNG 233
+G
Sbjct: 598 FAPSG 602
>sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
(Calcium-binding protein 2) (CaBP2)
Length = 643
Score = 212 bits (540), Expect = 1e-54
Identities = 113/287 (39%), Positives = 172/287 (59%), Gaps = 6/287 (2%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF+ + +ILVEFYAPWCGHCKKLAPEYE AA L ++ PPIP+AKVD T +T +
Sbjct: 184 NFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLAK 243
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIASTD 365
+ VSGYPTLKIF+ G+ FDY+G R GI+ YM+ +SGP SKE+ T + ++F+ D
Sbjct: 244 RFDVSGYPTLKIFRKGR-PFDYNGpreKYGIVDYMVEQSGPPSKEILTLKQVQEFLKDGD 302
Query: 366 PVVV-GFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFE-NNIVIYHPQKMA 539
VV+ G F Y + A L ED++F H F + L +V+ P+K
Sbjct: 303 DVVILGVFQGVGDPGYLQYQDAANTLREDYKFHHTFSTEIAKFLKVSLGKLVLMQPEKFQ 362
Query: 540 NKFEESQ--IKYKGDASEYQIRTWVEEKIMGMVGLR-TSSNMKYFSSKPLLVALYSVDYE 710
+K+E + +G I+ +V + + +VG R TS++ K +S +PL+V YSVD+
Sbjct: 363 SKYEPRMHVMDVQGSTEASAIKDYVVKHALPLVGHRKTSNDAKRYSKRPLVVVYYSVDFS 422
Query: 711 KNPK-GTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGI 848
+ + T +WRN++++VAK F + FAI++ ++ + E+ + G+
Sbjct: 423 FDYRTATQFWRNKVLEVAKDFPE----YTFAIADEEDYATEVKDLGL 465
Score = 120 bits (300), Expect = 7e-27
Identities = 61/134 (45%), Positives = 83/134 (61%), Gaps = 6/134 (4%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF+ + + +L+EFYAPWCGHCK+ APEYE A+TLK DPPI +AK+D T+ +
Sbjct: 69 NFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLAS 128
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPS---SKEVK---TEENFKK 347
K VSGYPT+KI K GQ A DY G R+ + I+ + S P EV T+ENF
Sbjct: 129 KFDVSGYPTIKILKKGQ-AVDYDGSRTQEEIVAKVREVSQPDWTPPPEVTLTLTKENFDD 187
Query: 348 FIASTDPVVVGFFA 389
+ + D ++V F+A
Sbjct: 188 VVNNADIILVEFYA 201
Score = 62.4 bits (150), Expect = 2e-09
Identities = 29/65 (44%), Positives = 40/65 (61%)
Frame = +3
Query: 39 ILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCEKHGVSGYPTLK 218
+L+EFYAPWCGHCK+L P Y K Q + IAK+D TA T +++ V G+PT+
Sbjct: 544 VLIEFYAPWCGHCKQLEPVYTSLGKKYKGQ-KDLVIAKMDATANDITNDRYKVEGFPTIY 602
Query: 219 IFKNG 233
+G
Sbjct: 603 FAPSG 607
>sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase A4 precursor (ERp-72 homolog)
Length = 618
Score = 208 bits (530), Expect = 1e-53
Identities = 115/303 (37%), Positives = 181/303 (59%), Gaps = 6/303 (1%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF+ I + ++LVEFYAPWCGHCKKLAPEYE AA LK Q + + KVD T E
Sbjct: 156 NFDDFISNNELVLVEFYAPWCGHCKKLAPEYEKAAQKLKAQGSKVKLGKVDATIEKDLGT 215
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFIASTD 365
K+GVSGYPT+KI +NG+ FDY+G R + GIIKYM +S P++K++ ++ ++F++ D
Sbjct: 216 KYGVSGYPTMKIIRNGR-RFDYNGpreAAGIIKYMTDQSKPAAKKLPKLKDVERFMSKDD 274
Query: 366 PVVVGFFASESSDLYKAFLSVAEKLNEDFR-FAHVFDESLKAKLNFE-NNIVIYHPQKMA 539
++GFFA+E S ++AF AE L E+F+ H D + K + + N+I+I++P
Sbjct: 275 VTIIGFFATEDSTAFEAFSDSAEMLREEFKTMGHTSDPAAFKKWDAKPNDIIIFYPSLFH 334
Query: 540 NKFEESQIKY-KGDASEYQIRTWVEEKIMGMVGLRTSSN-MKYFSSKPLLVALYSVDYE- 710
+KFE Y K A+ + + E +VG T N ++ KPL+V Y+ D+
Sbjct: 335 SKFEPKSRTYNKAAATSEDLLAFFREHSAPLVGKMTKKNAATRYTKKPLVVVYYNADFSV 394
Query: 711 KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGI-ESPDSNKVYIVAR 887
+ +G+ YWR++++ +A+K+ FA+++ +E + EL E G+ +S + V +
Sbjct: 395 QYREGSEYWRSKVLNIAQKY--QKDKYKFAVADEEEFAKELEELGLGDSGLEHNVVVFGY 452
Query: 888 DEK 896
D K
Sbjct: 453 DGK 455
Score = 114 bits (285), Expect = 4e-25
Identities = 58/134 (43%), Positives = 86/134 (64%), Gaps = 6/134 (4%)
Frame = +3
Query: 6 NFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCE 185
NF+ +K++ +LV+FYAPWCGHCK LAPEYE A++ + IP+AKVD T ET+ +
Sbjct: 45 NFDAFLKKNPSVLVKFYAPWCGHCKHLAPEYEKASSKVS-----IPLAKVDATVETELGK 99
Query: 186 KHGVSGYPTLKIFKNGQFAFDYSGERSSDGIIKYMISKSGPSSKE------VKTEENFKK 347
+ + GYPTLK +K+G+ DY G R GI++++ S+ P+ K T ENF
Sbjct: 100 RFEIQGYPTLKFWKDGKGPNDYDGGRDEAGIVEWVESRVDPNYKPPPEEVVTLTTENFDD 159
Query: 348 FIASTDPVVVGFFA 389
FI++ + V+V F+A
Sbjct: 160 FISNNELVLVEFYA 173
Score = 72.4 bits (176), Expect = 2e-12
Identities = 41/113 (36%), Positives = 62/113 (54%), Gaps = 3/113 (2%)
Frame = +3
Query: 3 SNFEQSIKEHSV-ILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKT 179
SNF++ + + S +L+EFYAPWCGHCK +Y A LK+ P + +AK+D T
Sbjct: 507 SNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPNVVLAKMDATINDAP 566
Query: 180 CEKHGVSGYPTLKIFKNGQFA--FDYSGERSSDGIIKYMISKSGPSSKEVKTE 332
+ V G+PT+ G+ + YSG R + + K+M +K G S + K E
Sbjct: 567 -SQFAVEGFPTIYFAPAGKKSEPIKYSGNRDLEDLKKFM-TKHGVKSFQKKDE 617
>sp|P29828|PDI_MEDSA Protein disulfide-isomerase precursor (PDI)
Length = 512
Score = 160 bits (404), Expect = 6e-39
Identities = 100/308 (32%), Positives = 169/308 (54%), Gaps = 10/308 (3%)
Frame = +3
Query: 3 SNFEQSIKEHSVILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAE--TK 176
+NF ++K+H I+VEFYAPWCGHCKKLAPEYE AA+ L +PP+ +AKVD E
Sbjct: 41 TNFHDTVKKHDFIVVEFYAPWCGHCKKLAPEYEKAASILSTHEPPVVLAKVDANEEHNKD 100
Query: 177 TCEKHGVSGYPTLKIFKN-GQFAFDYSGERSSDGIIKYMISKSGPSSKEVKTEENFKKFI 353
++ V G+PT+KIF+N G+ +Y G R ++GI++Y+ +SGP+S E+K+ ++ F+
Sbjct: 101 LASENDVKGFPTIKIFRNGGKNIQEYKGpreAEGIVEYLKKQSGPASTEIKSADDATAFV 160
Query: 354 ASTDPVVVGFFASESSDLYKAFLSVAEKLNEDFRFAHVFDESLKAKLNFENNIVIYHP-Q 530
V+VG F S + Y F+++AEKL D+ FAH +L AK + + + P
Sbjct: 161 GDNKVVIVGVFPKFSGEEYDNFIALAEKLRSDYDFAH----TLNAKHLPKGDSSVSGPVV 216
Query: 531 KMANKFEESQIKYKGDASEYQIRTWVEEKIMGMVGL--RTSSN----MKYFSSKPLLVAL 692
++ F+E + K D + + ++EE +V + SN +K+F+S P A+
Sbjct: 217 RLFKPFDELFVDSK-DFNVEALEKFIEESSTPIVTVFNNEPSNHPFVVKFFNS-PNAKAM 274
Query: 693 YSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESPDSNKV 872
+++ +G ++ + +VA+++ G V F + + + FG++ +
Sbjct: 275 LFINF--TTEGAESFKTKYHEVAEQYKQQG--VSFLVGDVESSQGAFQYFGLKEEQVPLI 330
Query: 873 YIVARDEK 896
I D K
Sbjct: 331 IIQHNDGK 338
Score = 71.2 bits (173), Expect = 4e-12
Identities = 38/99 (38%), Positives = 56/99 (56%), Gaps = 3/99 (3%)
Frame = +3
Query: 39 ILVEFYAPWCGHCKKLAPEYEIAATTLKRQDPPIPIAKVDCTAETKTCEKHGVSGYPTLK 218
+L+EFYAPWCGHCK+LAP + A + + D + IAK+D TA + V GYPTL
Sbjct: 398 VLIEFYAPWCGHCKQLAPILDEVAVSF-QSDADVVIAKLDATANDIPTDTFDVQGYPTLY 456
Query: 219 IFKNGQFAFDYSGERSSDGIIKYM---ISKSGPSSKEVK 326
Y G R+ + II+++ K+G + +EV+
Sbjct: 457 FRSASGKLSQYDGGRTKEDIIEFIEKNKDKTGAAHQEVE 495
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,740,828
Number of Sequences: 369166
Number of extensions: 1905014
Number of successful extensions: 5868
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5324
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5605
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9126484700
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)