Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_J22
(868 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07909|ROA1_DROME Heterogeneous nuclear ribonucleoprotei... 97 8e-20
sp|P21522|ROA1_SCHAM Heterogeneous nuclear ribonucleoprotei... 94 5e-19
sp|P51990|RO22_XENLA Heterogeneous nuclear ribonucleoprotei... 92 2e-18
sp|P17130|ROA1_XENLA Heterogeneous nuclear ribonucleoprotei... 91 3e-18
sp|P51989|RO21_XENLA Heterogeneous nuclear ribonucleoprotei... 90 9e-18
sp|P49312|ROA1_MOUSE Heterogeneous nuclear ribonucleoprotei... 89 1e-17
sp|P09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotei... 89 1e-17
sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoprotei... 89 2e-17
sp|O88569|ROA2_MOUSE Heterogeneous nuclear ribonucleoprotei... 89 2e-17
sp|P04256|ROA1_RAT Heterogeneous nuclear ribonucleoprotein ... 89 2e-17
>sp|P07909|ROA1_DROME Heterogeneous nuclear ribonucleoprotein A1 (hnRNP core protein
A1-A) (PEN repeat clone P9)
Length = 365
Score = 96.7 bits (239), Expect = 8e-20
Identities = 53/140 (37%), Positives = 80/140 (57%), Gaps = 16/140 (11%)
Frame = +2
Query: 2 AMPKEDT-SPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDA-VIINNSNGESRGF 175
A+P++D SP ATV +LFVG LK + +R YF +G IVD ++I+ G+ RGF
Sbjct: 106 AVPRQDIDSPNAGATVKKLFVGALKDDHDEQSIRDYFQHFGNIVDINIVIDKETGKKRGF 165
Query: 176 GFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDDNK--------------SNSKQSN 313
FV F+D D VDK+++ + HQL+G+ ++VKKALP+ +++ ++ +
Sbjct: 166 AFVEFDDYDPVDKVVLQKQHQLNGKMVDVKKALPKQNDQQGGGGGRGGPGGRAGGNRGNM 225
Query: 314 PVGNKSTPKGGYNNNTGSNN 373
GN GG N N G NN
Sbjct: 226 GGGNYGNQNGGGNWNNGGNN 245
Score = 70.5 bits (171), Expect = 6e-12
Identities = 33/90 (36%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Frame = +2
Query: 20 TSPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFED 196
T PE + +LF+G L ++L+ +F ++G IVD V++ + + SRGFGF+T+
Sbjct: 25 TEPEH---MRKLFIGGLDYRTTDENLKAHFEKWGNIVDVVVMKDPRTKRSRGFGFITYSH 81
Query: 197 TDSVDKIIVTRPHQLDGQSIEVKKALPRDD 286
+ +D+ +RPH++DG+ +E K+A+PR D
Sbjct: 82 SSMIDEAQKSRPHKIDGRVVEPKRAVPRQD 111
>sp|P21522|ROA1_SCHAM Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog
Length = 342
Score = 94.0 bits (232), Expect = 5e-19
Identities = 51/123 (41%), Positives = 73/123 (59%), Gaps = 2/123 (1%)
Frame = +2
Query: 2 AMPKEDTS-PEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDA-VIINNSNGESRGF 175
A+P+ + PE ATV +LFVG +K + +DLR YF +YGT+V A ++++ + RGF
Sbjct: 92 AVPRTEIGRPEAGATVKKLFVGGIKEEMEENDLRDYFKQYGTVVSAAIVVDKETRKKRGF 151
Query: 176 GFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDDNKSNSKQSNPVGNKSTPKGGYNN 355
FV F+D D VDKI ++R HQ+ G+ I+VKKALP+ D P G +GG
Sbjct: 152 AFVEFDDYDPVDKICLSRNHQIRGKHIDVKKALPKGD--------APGGRGGGGRGGVGG 203
Query: 356 NTG 364
G
Sbjct: 204 GAG 206
Score = 68.2 bits (165), Expect = 3e-11
Identities = 32/82 (39%), Positives = 52/82 (63%), Gaps = 1/82 (1%)
Frame = +2
Query: 44 VNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDTDSVDKII 220
V +LF+G L + L+Q+F ++G IVD V++ + + SRGFGF+T+ VD
Sbjct: 16 VRKLFIGGLDYRTTDESLKQHFEQWGEIVDVVVMKDPKTKRSRGFGFITYSRAHMVDDAQ 75
Query: 221 VTRPHQLDGQSIEVKKALPRDD 286
RPH++DG+ +E K+A+PR +
Sbjct: 76 NARPHKVDGRVVEPKRAVPRTE 97
>sp|P51990|RO22_XENLA Heterogeneous nuclear ribonucleoprotein A2 homolog 2 (hnRNP A2(B))
Length = 358
Score = 92.0 bits (227), Expect = 2e-18
Identities = 51/134 (38%), Positives = 73/134 (54%), Gaps = 6/134 (4%)
Frame = +2
Query: 11 KEDTSPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNS-NGESRGFGFVT 187
+E P H TV +LFVG +K + LR+YF EYG I II + +G+ RGFGFVT
Sbjct: 88 EESAKPGAHVTVKKLFVGGIKEDTEEHHLREYFEEYGKIESTEIITDKQSGKKRGFGFVT 147
Query: 188 FEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDD-----NKSNSKQSNPVGNKSTPKGGYN 352
F D D VDKI++ + H ++G + EV+KAL + + N N++ N S G +
Sbjct: 148 FNDHDPVDKIVLQKYHTINGHNAEVRKALSKQEMQDVQNTRNNRGGNFGFGDSRGGGNFG 207
Query: 353 NNTGSNNRYSQDDF 394
+ G N R D +
Sbjct: 208 SGPGGNFRGGSDGY 221
Score = 66.2 bits (160), Expect = 1e-10
Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 1/105 (0%)
Frame = +2
Query: 50 RLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVT 226
+LF+G L + LR ++ ++G + D V++ + ++ SRGFGFVTF + VD +
Sbjct: 10 KLFIGGLSFETTEESLRNFYEQWGQLTDCVVMRDPASKRSRGFGFVTFSCMNEVDAAMSA 69
Query: 227 RPHQLDGQSIEVKKALPRDDNKSNSKQSNPVGNKSTPKGGYNNNT 361
RPH +DG+ +E K+A+ R++ ++K V K GG +T
Sbjct: 70 RPHTIDGRVVEPKRAVAREE---SAKPGAHVTVKKLFVGGIKEDT 111
>sp|P17130|ROA1_XENLA Heterogeneous nuclear ribonucleoproteins A1 homolog (hnRNP A1)
(Helix-destabilizing protein) (Single-strand binding
protein) (hnRNP core protein A1)
Length = 365
Score = 91.3 bits (225), Expect = 3e-18
Identities = 51/133 (38%), Positives = 79/133 (59%), Gaps = 2/133 (1%)
Frame = +2
Query: 2 AMPKEDTS-PEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTI-VDAVIINNSNGESRGF 175
A+ +ED+S P H TV ++FVG +K + D LR+YF +YG I V ++ + +G+ RGF
Sbjct: 89 AVSREDSSRPGAHLTVKKIFVGGIKEDTEEDHLREYFEQYGKIEVIEIMTDRGSGKKRGF 148
Query: 176 GFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDDNKSNSKQSNPVGNKSTPKGGYNN 355
FVTFED DSVDKI++ + H ++ + +V+KAL + + S V +GG +
Sbjct: 149 AFVTFEDHDSVDKIVIQKYHTVNNHNSQVRKALSKQEMAS-------VSGSQRERGG-SG 200
Query: 356 NTGSNNRYSQDDF 394
N GS + D+F
Sbjct: 201 NYGSRGGFGNDNF 213
Score = 78.2 bits (191), Expect = 3e-14
Identities = 35/90 (38%), Positives = 59/90 (65%), Gaps = 1/90 (1%)
Frame = +2
Query: 23 SPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDT 199
+P + +LF+G L + LR++F ++GT+ D V++ + N + SRGFGFVT+ T
Sbjct: 6 APNEPEQLRKLFIGGLSFETTDESLREHFEQWGTLTDCVVMRDPNSKRSRGFGFVTYLST 65
Query: 200 DSVDKIIVTRPHQLDGQSIEVKKALPRDDN 289
D VD + RPH++DG+ +E K+A+ R+D+
Sbjct: 66 DEVDAAMTARPHKVDGRVVEPKRAVSREDS 95
>sp|P51989|RO21_XENLA Heterogeneous nuclear ribonucleoprotein A2 homolog 1 (hnRNP A2(A))
Length = 346
Score = 89.7 bits (221), Expect = 9e-18
Identities = 50/134 (37%), Positives = 73/134 (54%), Gaps = 6/134 (4%)
Frame = +2
Query: 11 KEDTSPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNS-NGESRGFGFVT 187
+E P H TV +LFVG +K + LR+YF EYG I II + +G+ RGF FVT
Sbjct: 88 EESAKPGAHVTVKKLFVGGIKEDTEEHHLREYFEEYGKIDSIEIITDKQSGKKRGFAFVT 147
Query: 188 FEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDD-----NKSNSKQSNPVGNKSTPKGGYN 352
F+D D VDKI++ + H ++G + EV+KAL + + N N++ N S G +
Sbjct: 148 FDDHDPVDKIVLQKYHTINGHNAEVRKALSKQEMQDVQNTRNNRGGNFGFGDSRGGGNFG 207
Query: 353 NNTGSNNRYSQDDF 394
+ G N R D +
Sbjct: 208 SGPGGNFRGGSDGY 221
Score = 72.8 bits (177), Expect = 1e-12
Identities = 38/105 (36%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Frame = +2
Query: 50 RLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVT 226
+LF+G L + LR Y+ ++GT+ D V++ + ++ SRGFGFVTF + VD + T
Sbjct: 10 KLFIGGLSFETTEESLRNYYEQWGTLTDCVVMRDPASKRSRGFGFVTFSCMNEVDAAMAT 69
Query: 227 RPHQLDGQSIEVKKALPRDDNKSNSKQSNPVGNKSTPKGGYNNNT 361
RPH +DG+ +E K+A+ R++ ++K V K GG +T
Sbjct: 70 RPHTIDGRVVEPKRAVAREE---SAKPGAHVTVKKLFVGGIKEDT 111
>sp|P49312|ROA1_MOUSE Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing
protein) (Single-strand binding protein) (hnRNP core
protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed)
Length = 320
Score = 89.4 bits (220), Expect = 1e-17
Identities = 47/130 (36%), Positives = 73/130 (56%), Gaps = 2/130 (1%)
Frame = +2
Query: 2 AMPKEDTS-PEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTI-VDAVIINNSNGESRGF 175
A+ +ED+ P H TV ++FVG +K + LR YF +YG I V ++ + +G+ RGF
Sbjct: 89 AVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGF 148
Query: 176 GFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDDNKSNSKQSNPVGNKSTPKGGYNN 355
FVTF+D DSVDKI++ + H ++G + EV+KAL + + S S GG
Sbjct: 149 AFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGG 208
Query: 356 NTGSNNRYSQ 385
G N+ + +
Sbjct: 209 GFGGNDNFGR 218
Score = 74.3 bits (181), Expect = 4e-13
Identities = 34/91 (37%), Positives = 59/91 (64%), Gaps = 1/91 (1%)
Frame = +2
Query: 23 SPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDT 199
SP+ + +LF+G L + LR +F ++GT+ D V++ + N + SRGFGFVT+
Sbjct: 6 SPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATV 65
Query: 200 DSVDKIIVTRPHQLDGQSIEVKKALPRDDNK 292
+ VD + RPH++DG+ +E K+A+ R+D++
Sbjct: 66 EEVDAAMNARPHKVDGRVVEPKRAVSREDSQ 96
>sp|P09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing
protein) (Single-strand binding protein) (hnRNP core
protein A1)
Length = 372
Score = 89.4 bits (220), Expect = 1e-17
Identities = 47/130 (36%), Positives = 73/130 (56%), Gaps = 2/130 (1%)
Frame = +2
Query: 2 AMPKEDTS-PEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTI-VDAVIINNSNGESRGF 175
A+ +ED+ P H TV ++FVG +K + LR YF +YG I V ++ + +G+ RGF
Sbjct: 89 AVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGF 148
Query: 176 GFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDDNKSNSKQSNPVGNKSTPKGGYNN 355
FVTF+D DSVDKI++ + H ++G + EV+KAL + + S S GG
Sbjct: 149 AFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGG 208
Query: 356 NTGSNNRYSQ 385
G N+ + +
Sbjct: 209 GFGGNDNFGR 218
Score = 74.3 bits (181), Expect = 4e-13
Identities = 34/91 (37%), Positives = 59/91 (64%), Gaps = 1/91 (1%)
Frame = +2
Query: 23 SPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDT 199
SP+ + +LF+G L + LR +F ++GT+ D V++ + N + SRGFGFVT+
Sbjct: 6 SPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATV 65
Query: 200 DSVDKIIVTRPHQLDGQSIEVKKALPRDDNK 292
+ VD + RPH++DG+ +E K+A+ R+D++
Sbjct: 66 EEVDAAMNARPHKVDGRVVEPKRAVSREDSQ 96
>sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2 / hnRNP
B1)
Length = 353
Score = 89.0 bits (219), Expect = 2e-17
Identities = 54/135 (40%), Positives = 75/135 (55%), Gaps = 7/135 (5%)
Frame = +2
Query: 11 KEDTSPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTI-VDAVIINNSNGESRGFGFVT 187
+E P H TV +LFVG +K + LR YF EYG I +I + +G+ RGFGFVT
Sbjct: 100 EESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVT 159
Query: 188 FEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDD-NKSNSKQSNPVGN--KSTPKGGYNN- 355
F+D D VDKI++ + H ++G + EV+KAL R + + S +S GN +GG N
Sbjct: 160 FDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNF 219
Query: 356 --NTGSNNRYSQDDF 394
GSN R D +
Sbjct: 220 GPGPGSNFRGGSDGY 234
Score = 68.6 bits (166), Expect = 2e-11
Identities = 30/81 (37%), Positives = 51/81 (62%), Gaps = 1/81 (1%)
Frame = +2
Query: 50 RLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVT 226
+LF+G L + LR Y+ ++G + D V++ + ++ SRGFGFVTF VD +
Sbjct: 22 KLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAA 81
Query: 227 RPHQLDGQSIEVKKALPRDDN 289
RPH +DG+ +E K+A+ R+++
Sbjct: 82 RPHSIDGRVVEPKRAVAREES 102
>sp|O88569|ROA2_MOUSE Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2 / hnRNP
B1)
Length = 341
Score = 89.0 bits (219), Expect = 2e-17
Identities = 54/135 (40%), Positives = 75/135 (55%), Gaps = 7/135 (5%)
Frame = +2
Query: 11 KEDTSPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTI-VDAVIINNSNGESRGFGFVT 187
+E P H TV +LFVG +K + LR YF EYG I +I + +G+ RGFGFVT
Sbjct: 88 EESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVT 147
Query: 188 FEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDD-NKSNSKQSNPVGN--KSTPKGGYNN- 355
F+D D VDKI++ + H ++G + EV+KAL R + + S +S GN +GG N
Sbjct: 148 FDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNF 207
Query: 356 --NTGSNNRYSQDDF 394
GSN R D +
Sbjct: 208 GPGPGSNFRGGSDGY 222
Score = 68.6 bits (166), Expect = 2e-11
Identities = 30/81 (37%), Positives = 51/81 (62%), Gaps = 1/81 (1%)
Frame = +2
Query: 50 RLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINN-SNGESRGFGFVTFEDTDSVDKIIVT 226
+LF+G L + LR Y+ ++G + D V++ + ++ SRGFGFVTF VD +
Sbjct: 10 KLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAA 69
Query: 227 RPHQLDGQSIEVKKALPRDDN 289
RPH +DG+ +E K+A+ R+++
Sbjct: 70 RPHSIDGRVVEPKRAVAREES 90
>sp|P04256|ROA1_RAT Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing
protein) (Single-strand binding protein) (hnRNP core
protein A1) (HDP)
Length = 320
Score = 88.6 bits (218), Expect = 2e-17
Identities = 47/130 (36%), Positives = 73/130 (56%), Gaps = 2/130 (1%)
Frame = +2
Query: 2 AMPKEDTS-PEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTI-VDAVIINNSNGESRGF 175
A+ +ED+ P H TV ++FVG +K + LR YF +YG I V ++ + +G+ RGF
Sbjct: 89 AVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGF 148
Query: 176 GFVTFEDTDSVDKIIVTRPHQLDGQSIEVKKALPRDDNKSNSKQSNPVGNKSTPKGGYNN 355
FVTF+D DSVDKI++ + H ++G + EV+KAL + + S S GG
Sbjct: 149 AFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALCKQEMASASSSQRGRSGSGNFGGGRGG 208
Query: 356 NTGSNNRYSQ 385
G N+ + +
Sbjct: 209 GFGGNDNFGR 218
Score = 74.3 bits (181), Expect = 4e-13
Identities = 34/91 (37%), Positives = 59/91 (64%), Gaps = 1/91 (1%)
Frame = +2
Query: 23 SPEFHATVNRLFVGRLKRNVVADDLRQYFGEYGTIVDAVIINNSNGE-SRGFGFVTFEDT 199
SP+ + +LF+G L + LR +F ++GT+ D V++ + N + SRGFGFVT+
Sbjct: 6 SPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATV 65
Query: 200 DSVDKIIVTRPHQLDGQSIEVKKALPRDDNK 292
+ VD + RPH++DG+ +E K+A+ R+D++
Sbjct: 66 EEVDAAMNARPHKVDGRVVEPKRAVSREDSQ 96
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,505,235
Number of Sequences: 369166
Number of extensions: 1373295
Number of successful extensions: 5134
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3869
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4645
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8550075140
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)