Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_H01
(804 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxid... 170 5e-42
sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxid... 169 8e-42
sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxid... 165 2e-40
sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide ... 163 4e-40
sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 ... 150 3e-36
sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 ... 148 2e-35
sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Ju... 125 1e-28
sp|Q06816|HYEP_STIAU Epoxide hydrolase (Epoxide hydratase) 70 5e-12
sp|P44248|Y1543_HAEIN Hypothetical protein HI1543 32 2.0
>sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 170 bits (430), Expect = 5e-42
Identities = 89/185 (48%), Positives = 126/185 (68%), Gaps = 5/185 (2%)
Frame = +1
Query: 76 LTQRELDMVYPWSDKI-NTILSSMGYFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWS 252
LT+R+++++YP +K+ +++ GY +Q T+P T+G AL+DSP GLAAYILEKF W+
Sbjct: 274 LTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWT 333
Query: 253 NNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEMLNE----QNHKLF 420
N +L +GGLE K + D++LTNVM+Y+ T TI SS R YKE L + Q H+
Sbjct: 334 NTEFRYLE--DGGLER-KFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERM 390
Query: 421 KTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEPELLANDIRSF 600
K V VPT + FP E++ P+ +V FKY + ++YM RGGHFAA EEPELLA DIR F
Sbjct: 391 K--VYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKF 448
Query: 601 INLME 615
++++E
Sbjct: 449 LSVLE 453
>sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 169 bits (428), Expect = 8e-42
Identities = 90/200 (45%), Positives = 131/200 (65%), Gaps = 3/200 (1%)
Frame = +1
Query: 25 YLTQVFIGSMLPAKLHFLTQRELDMVYPWSDKI-NTILSSMGYFGLQSTRPSTIGIALSD 201
Y + +G + L + T+R+++++YP+ +K+ +++ GY +++T+P T+G AL+D
Sbjct: 258 YTLTLLLGRRIGGLLGY-TERDMELLYPFKEKVFYSLMRESGYMHIRATKPDTVGCALND 316
Query: 202 SPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRL 381
SP GLAAYILEKF W+N+ L +GGLE K + ++LTN+MIY+ T +I SS R
Sbjct: 317 SPVGLAAYILEKFSTWTNSEFRDLE--DGGLER-KFSLQDLLTNIMIYWTTGSIVSSQRY 373
Query: 382 YKEMLNE--QNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFA 555
YKE L + HK + V VPT A FP EI+ VP+ +V KY + ++YMPRGGHFA
Sbjct: 374 YKENLGQGFMAHKHERLKVHVPTGFAAFPCEIMHVPEKWVRTKYPQLISYSYMPRGGHFA 433
Query: 556 ALEEPELLANDIRSFINLME 615
A EEPELLA DI F+ L+E
Sbjct: 434 AFEEPELLARDICKFVGLVE 453
>sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 165 bits (417), Expect = 2e-40
Identities = 86/182 (47%), Positives = 122/182 (67%), Gaps = 3/182 (1%)
Frame = +1
Query: 79 TQRELDMVYPWSDKI-NTILSSMGYFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSN 255
T+++L+++YP+ +K+ I+ GY +Q+T+P T+G AL+DSP GLAAYILEKF W+
Sbjct: 275 TEKDLELLYPFKEKVFYNIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTK 334
Query: 256 NNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTP 429
+ L +GGLE K + +++LTN+MIY+ T TI SS R YKE L + H+
Sbjct: 335 SEYRELE--DGGLER-KFSLEDLLTNIMIYWTTGTIVSSQRFYKENLGQGVMVHRHEGMK 391
Query: 430 VRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEPELLANDIRSFINL 609
V VPT + FP+EI+ PK +V KY + ++YM RGGHFAA EEP+LLA DIR F++L
Sbjct: 392 VFVPTGYSAFPSEILHAPKKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSL 451
Query: 610 ME 615
E
Sbjct: 452 AE 453
>sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 163 bits (413), Expect = 4e-40
Identities = 84/182 (46%), Positives = 122/182 (67%), Gaps = 3/182 (1%)
Frame = +1
Query: 79 TQRELDMVYPWSDKI-NTILSSMGYFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSN 255
T+++++++YP+ +K+ +I+ GY +Q+T+P T+G AL+DSP GLAAYILEKF W+
Sbjct: 275 TEKDIELLYPYKEKVFYSIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTK 334
Query: 256 NNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTP 429
+ L +GGLE K + D++L N+MIY+ T TI SS R YKE L + HK
Sbjct: 335 SEYRELE--DGGLER-KFSLDDLLVNIMIYWTTGTIVSSQRYYKENLGQGIMVHKHEGMK 391
Query: 430 VRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEPELLANDIRSFINL 609
V VPT + FP+E++ P+ +V KY + ++YM RGGHFAA EEP+LLA DIR F++L
Sbjct: 392 VFVPTGFSAFPSELLHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSL 451
Query: 610 ME 615
E
Sbjct: 452 AE 453
>sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 (Juvenile hormone epoxide
hydrolase II) (Juvenile hormone-specific epoxide
hydrolase II) (JHEH II) (CfEH2)
Length = 465
Score = 150 bits (380), Expect = 3e-36
Identities = 87/190 (45%), Positives = 119/190 (62%), Gaps = 2/190 (1%)
Frame = +1
Query: 40 FIGSMLPAKLHFLTQRELDMVYPWSDKINTILSSMGYFGLQSTRPSTIGIALSDSPAGLA 219
F+GS+ P F ++ + +YP S+ T+L GYF +Q+T+P T+G+AL DSPAGLA
Sbjct: 261 FVGSLFPE--WFAGKQNVHKIYPLSEHFFTLLEESGYFHIQATKPDTVGVALRDSPAGLA 318
Query: 220 AYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEMLN 399
AYILEKF + N S+ +G L+ K T E+L NVMIYY+T +I++S+R+Y E +
Sbjct: 319 AYILEKFS--TGTNKAWRSAKDGNLQS-KFTFTELLDNVMIYYVTGSITTSMRIYAESYS 375
Query: 400 EQNHKL--FKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEPE 573
+ L + P VPTA A FP+EI + KY+ + Q MPRGGHFAALEEP
Sbjct: 376 WDHLSLNMDRVPTIVPTACAKFPHEIAYKTDFQLAEKYKTLLQSTIMPRGGHFAALEEPL 435
Query: 574 LLANDIRSFI 603
LLA DI S +
Sbjct: 436 LLAEDIFSAV 445
>sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 (Juvenile hormone epoxide
hydrolase I) (Juvenile hormone-specific epoxide
hydrolase I) (JHEH I) (CfEH1)
Length = 464
Score = 148 bits (373), Expect = 2e-35
Identities = 87/188 (46%), Positives = 111/188 (59%), Gaps = 2/188 (1%)
Frame = +1
Query: 34 QVFIGSMLPAKLHFLTQRELDMVYPWSDKINTILSSMGYFGLQSTRPSTIGIALSDSPAG 213
+ IGS P F +YP S+ T+L MGY LQ+T+P T+G+AL DSPAG
Sbjct: 259 KAIIGSFFPES--FAGTGNAHKMYPMSEHFFTLLEEMGYLHLQATKPDTVGVALRDSPAG 316
Query: 214 LAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEM 393
LAAYILEKF W+N + S G +K E+L NVMIYY+T++I++S+RLY E
Sbjct: 317 LAAYILEKFSTWTNRS---WRSVKDGNLLLKYNIPELLDNVMIYYVTDSITTSMRLYAES 373
Query: 394 LNEQNHKLFKTPVR--VPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEE 567
+ + L VR VP A A FPNE+ V + KY+ + Q N MP GGHFAA EE
Sbjct: 374 FTKAHLALNLDRVRNHVPAACAKFPNELAYVTDCQLAEKYKTLLQSNDMPSGGHFAAFEE 433
Query: 568 PELLANDI 591
P LLA DI
Sbjct: 434 PGLLAEDI 441
>sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Juvenile hormone-specific
epoxide hydrolase) (JHEH)
Length = 462
Score = 125 bits (315), Expect = 1e-28
Identities = 72/187 (38%), Positives = 114/187 (60%), Gaps = 1/187 (0%)
Frame = +1
Query: 34 QVFIGSMLPAKLHFLTQRELDMVYPWSDKINTILSSMGYFGLQSTRPSTIGIALSDSPAG 213
++FIG++ P+ + + + +D +YP + + IL GYF +Q+T+P TIG+AL+DSPAG
Sbjct: 262 KLFIGALFPSLI--VDAKYMDRIYPLKNLFSYILRETGYFHIQATKPDTIGVALTDSPAG 319
Query: 214 LAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEM 393
LA Y++EK SN + L +P+GGLE++ + D++L V I +I N I +S RLY E
Sbjct: 320 LAGYLIEKMAICSNRD--QLDTPHGGLENLNL--DDVLDTVTINWINNCIVTSTRLYAEG 375
Query: 394 LN-EQNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEP 570
+ + + + P VPTA F E++ P + K+ N+ + + GGHFAAL P
Sbjct: 376 FSWPEVLIVHRIPSMVPTAGINFKYEVLYQPDWILRDKFPNLVRSTVLDFGGHFAALHTP 435
Query: 571 ELLANDI 591
+ LA+DI
Sbjct: 436 QALADDI 442
>sp|Q06816|HYEP_STIAU Epoxide hydrolase (Epoxide hydratase)
Length = 232
Score = 70.5 bits (171), Expect = 5e-12
Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 2/98 (2%)
Frame = +1
Query: 307 ITKDEMLTNVMIYYITNTISSSVRLYKEML--NEQNHKLFKTPVRVPTAIAMFPNEIIQV 480
+++DEML N+ +Y++T+T +SS R+Y E N KL +P +++FP E+ +
Sbjct: 131 LSQDEMLDNISLYWLTDTAASSARIYWENAGSNFSGGKL-----DLPVGVSVFpreLFRA 185
Query: 481 PKPFVHFKYRNVRQFNYMPRGGHFAALEEPELLANDIR 594
PK + Y + +N RGGHFAA E+P L A+++R
Sbjct: 186 PKRWAEQTYSKLIYWNEPDRGGHFAAFEQPALFAHELR 223
>sp|P44248|Y1543_HAEIN Hypothetical protein HI1543
Length = 184
Score = 32.0 bits (71), Expect = 2.0
Identities = 23/66 (34%), Positives = 35/66 (53%)
Frame = +1
Query: 364 SSSVRLYKEMLNEQNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRG 543
S V++ +LNE+ KLF T +V TAI+ + ++ + FV+F R VR +
Sbjct: 59 SLQVKIDLNLLNEEYQKLFATNGKVMTAISAYGIDV----EEFVNF--RLVRNMPEVESA 112
Query: 544 GHFAAL 561
HFA L
Sbjct: 113 DHFALL 118
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,933,467
Number of Sequences: 369166
Number of extensions: 1840137
Number of successful extensions: 4244
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 4108
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4226
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)