Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_E14
(903 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y561|LRP12_HUMAN Low-density lipoprotein receptor-rela... 119 2e-26
sp|Q8BUJ9|LRP12_MOUSE Low-density lipoprotein receptor-rela... 118 3e-26
sp|Q9BE74|LRP12_MACFA Low-density lipoprotein receptor-rela... 115 2e-25
sp|O88204|LRP3_RAT Low-density lipoprotein receptor-related... 107 6e-23
sp|O75074|LRP3_HUMAN Low-density lipoprotein receptor-relat... 105 1e-22
sp|Q7Z4F1|LRP10_HUMAN Low-density lipoprotein receptor-rela... 103 9e-22
sp|Q7TQH7|LRP10_MOUSE Low-density lipoprotein receptor-rela... 100 6e-21
sp|Q91VN0|LRP5_MOUSE Low-density lipoprotein receptor-relat... 66 1e-10
sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-rela... 66 1e-10
sp|O75197|LRP5_HUMAN Low-density lipoprotein receptor-relat... 65 3e-10
>sp|Q9Y561|LRP12_HUMAN Low-density lipoprotein receptor-related protein 12 precursor
(Suppressor of tumorigenicity protein 7)
Length = 859
Score = 119 bits (297), Expect = 2e-26
Identities = 71/229 (31%), Positives = 112/229 (48%), Gaps = 6/229 (2%)
Frame = +1
Query: 118 PSSHCAWILELGYYNVLEIRIESVNLAAR---DYIDIHDGPTINSPILMKL---YGTSRF 279
P S+C W+++ G + + +R L DY+ I+DG N L+++ + +
Sbjct: 281 PGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 340
Query: 280 RKISTSTGSALIHFQSQSFGKSSAFNITYQIKGVCIPGIQESCSEAELNCYDIRYEKCNS 459
+ +S+G +HF + + FN TYQ+ G C+P E CY ++C+
Sbjct: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW--EIPCGGNWGCYT-EQQRCDG 397
Query: 460 IWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLADEMY 639
W+CP +G+DE NCT+C+ ++ +PCS+ CY RC+ C + +DE
Sbjct: 398 YWHCP-NGRDETNCTMCQKEE-------FPCSRNGV--CYPRSDRCNYQNHCPNGSDEKN 447
Query: 640 CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNCDMILP 786
C Q G F C+ RC+ ES CD C DGSDE NC +I+P
Sbjct: 448 CFFCQPG----NFHCKN--NRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/114 (30%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Frame = +1
Query: 478 SGKDEE-NCTLCKSKQIKSNYRLYPCSQFP--TIECYSHKQRCDGYADCESLADEMYC-- 642
SGK EE NC C QF +C +C+ +C +DE C
Sbjct: 158 SGKSEEPNCA---------------CDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 202
Query: 643 --DPVQCGAHN----KTFLCQTFPTR---CIIESLRCDGTITCRDGSDEHNCDM 777
+P A F C + T+ C+ ESL+CDG I C D DE +CD+
Sbjct: 203 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 256
Score = 40.4 bits (93), Expect = 0.007
Identities = 26/84 (30%), Positives = 36/84 (42%), Gaps = 7/84 (8%)
Frame = +1
Query: 448 KCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIE-------CYSHKQRCDGY 606
KCN++ C S DEE C + + ++ +QF + C +CDG
Sbjct: 184 KCNNMDECGDSS-DEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGN 242
Query: 607 ADCESLADEMYCDPVQCGAHNKTF 678
DC L DE+ CD CG K F
Sbjct: 243 IDCLDLGDEIDCDVPTCGQWLKYF 266
>sp|Q8BUJ9|LRP12_MOUSE Low-density lipoprotein receptor-related protein 12 precursor
Length = 858
Score = 118 bits (295), Expect = 3e-26
Identities = 71/229 (31%), Positives = 112/229 (48%), Gaps = 6/229 (2%)
Frame = +1
Query: 118 PSSHCAWILELGYYNVLEIRIESVNLAAR---DYIDIHDGPTINSPILMKL---YGTSRF 279
P S+C W+++ G + + +R L DY+ I+DG N L+++ + +
Sbjct: 281 PGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPRKLLRVLTAFDSHAP 340
Query: 280 RKISTSTGSALIHFQSQSFGKSSAFNITYQIKGVCIPGIQESCSEAELNCYDIRYEKCNS 459
+ +S+G +HF + + FN TYQ+ G C+P E CY ++C+
Sbjct: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW--EIPCGGNWGCYT-EQQRCDG 397
Query: 460 IWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLADEMY 639
W+CP +G+DE NCT+C+ ++ +PCS+ CY RC+ C + +DE
Sbjct: 398 YWHCP-NGRDEINCTMCQKEE-------FPCSRNGV--CYPRSDRCNYQNHCPNGSDEKN 447
Query: 640 CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNCDMILP 786
C Q G F C+ RC+ ES CD C DGSDE NC +I+P
Sbjct: 448 CFFCQPG----NFHCKN--NRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 14/90 (15%)
Frame = +1
Query: 550 CSQFP--TIECYSHKQRCDGYADCESLADEMYC---------DPVQCGAHNKTFLCQTFP 696
C QF +C +C+ +C +DE C Q A+N+ F C +
Sbjct: 168 CDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVCASDAHPPTTTAFQPCAYNQ-FQCLSRF 226
Query: 697 TR---CIIESLRCDGTITCRDGSDEHNCDM 777
T+ C+ ESL+CDG I C D DE +CDM
Sbjct: 227 TKVYTCLPESLKCDGNIDCLDLGDEIDCDM 256
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/205 (22%), Positives = 76/205 (37%), Gaps = 17/205 (8%)
Frame = +1
Query: 115 YPSS-HCAWILELGYYNVLEIRIESVNLAAR-----DYIDIHDGPTINSPILMKLYGTSR 276
YP+ +C+W++ ++ I + ++ D++ I I S + G++
Sbjct: 70 YPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTIETYKNIES---YRACGSTI 126
Query: 277 FRKISTSTGSALIHFQSQSFGKSSAFNITYQIKGVCIPGIQESCSEAELNCYDIRYE--- 447
+S I F S F + Y G Q C+ + C + +
Sbjct: 127 PPPYISSQDHVWIRFHSDDSVSRKGFRLAY-FSG---KSEQPDCACDQFRCGNGKCIPEA 182
Query: 448 -KCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIE-------CYSHKQRCDG 603
KCNS+ C S DEE C + ++ +QF + C +CDG
Sbjct: 183 WKCNSMDECGDSS-DEEVCASDAHPPTTTAFQPCAYNQFQCLSRFTKVYTCLPESLKCDG 241
Query: 604 YADCESLADEMYCDPVQCGAHNKTF 678
DC L DE+ CD CG K F
Sbjct: 242 NIDCLDLGDEIDCDMPTCGQWLKYF 266
>sp|Q9BE74|LRP12_MACFA Low-density lipoprotein receptor-related protein 12
Length = 701
Score = 115 bits (287), Expect = 2e-25
Identities = 70/229 (30%), Positives = 111/229 (48%), Gaps = 6/229 (2%)
Frame = +1
Query: 118 PSSHCAWILELGYYNVLEIRIESVNLAAR---DYIDIHDGPTINSPILMKL---YGTSRF 279
P S+C W+++ G + + + L DY+ I+DG N L+++ + +
Sbjct: 123 PGSNCTWLIDTGDHRKVILCFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 182
Query: 280 RKISTSTGSALIHFQSQSFGKSSAFNITYQIKGVCIPGIQESCSEAELNCYDIRYEKCNS 459
+ +S+G +HF + + FN TYQ+ G C+P E CY ++C+
Sbjct: 183 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW--EIPCGGNWGCYT-EQQRCDG 239
Query: 460 IWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLADEMY 639
W+CP +G+DE NCT+C+ ++ +PCS+ CY RC+ C + +DE
Sbjct: 240 YWHCP-NGRDEINCTMCQKEE-------FPCSRNGV--CYPRSDRCNYQNHCPNGSDEKN 289
Query: 640 CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNCDMILP 786
C Q G F C+ RC+ ES CD C DGSDE NC +I+P
Sbjct: 290 CFFCQPG----NFHCKN--NRCVFESWVCDSQDDCGDGSDEENCPVIVP 332
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 14/90 (15%)
Frame = +1
Query: 550 CSQFP--TIECYSHKQRCDGYADCESLADEMYC---------DPVQCGAHNKTFLCQTFP 696
C QF +C +C+ +C +DE C Q A+N+ F C +
Sbjct: 10 CDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTATAFQPCAYNQ-FQCLSRF 68
Query: 697 TR---CIIESLRCDGTITCRDGSDEHNCDM 777
T+ C+ ESL+CDG I C D DE +CD+
Sbjct: 69 TKVYTCLAESLKCDGNIDCLDLGDEIDCDV 98
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 7/84 (8%)
Frame = +1
Query: 448 KCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIE-------CYSHKQRCDGY 606
KCN++ C S DEE C + + ++ +QF + C + +CDG
Sbjct: 26 KCNNMDECGDSS-DEEICAKEANPPTATAFQPCAYNQFQCLSRFTKVYTCLAESLKCDGN 84
Query: 607 ADCESLADEMYCDPVQCGAHNKTF 678
DC L DE+ CD CG K F
Sbjct: 85 IDCLDLGDEIDCDVPTCGQWLKYF 108
>sp|O88204|LRP3_RAT Low-density lipoprotein receptor-related protein 3 precursor
(rLRp105)
Length = 770
Score = 107 bits (266), Expect = 6e-23
Identities = 71/231 (30%), Positives = 107/231 (46%), Gaps = 11/231 (4%)
Frame = +1
Query: 127 HCAWILELGYYNVLEIRIESVNLAARDYIDIHDG-PTINSPILMKLYGTSRFRKIS--TS 297
HC W+++ + +++E + L DY+ +++G +L L S R +S +
Sbjct: 281 HCTWLVDTQDPRRVLLQLE-LRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAA 339
Query: 298 TGSALIHFQSQSFGKSSAFNITYQIKGVCIPGIQ--------ESCSEAELNCYDIRYEKC 453
G + + +++ FN TYQ+KG C+P Q + S E C+ ++C
Sbjct: 340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSEGDDGSTGEQGCFS-EPQRC 398
Query: 454 NSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLADE 633
+ W+C SG+DE+ C C Q YPC + CY+ RC+ C ADE
Sbjct: 399 DGWWHCA-SGRDEQGCPACPPDQ-------YPCEGGSGL-CYAPADRCNNQKSCPDGADE 449
Query: 634 MYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNCDMILP 786
C Q G TF C T CI E+ RCDG C+DGSDEH C +P
Sbjct: 450 KNCFSCQPG----TFHCGT--NLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 6/127 (4%)
Frame = +1
Query: 316 HFQSQSFGKSSAFNITYQIKGVCIPGIQESCSEAELNCYDIRYE----KCNSIWNCPISG 483
H + S G++ F ++Y I+G Q SC E C + + +CN + C G
Sbjct: 140 HSDASSSGQAQGFRLSY-IRGKLG---QASCQTDEFRCDNGKCLPGPWQCNMVDECG-DG 194
Query: 484 KDEENCTLCKSKQIKSNYR--LYPCSQFPTIECYSHKQRCDGYADCESLADEMYCDPVQC 657
DE NC+ S+ S +PCS + C ++RCDG DC +DE C + C
Sbjct: 195 SDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGTQDCGDGSDEAGCPDLAC 254
Query: 658 GAHNKTF 678
G +F
Sbjct: 255 GRRLGSF 261
>sp|O75074|LRP3_HUMAN Low-density lipoprotein receptor-related protein 3 precursor
(hLRp105)
Length = 770
Score = 105 bits (263), Expect = 1e-22
Identities = 70/231 (30%), Positives = 108/231 (46%), Gaps = 11/231 (4%)
Frame = +1
Query: 127 HCAWILELGYYNVLEIRIESVNLAARDYIDIHDG-PTINSPILMKLYGTSRFRKIS--TS 297
HC W+++ + +++E + L DY+ +++G +L L S R +S +
Sbjct: 281 HCTWLVDTQDSRRVLLQLE-LRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAA 339
Query: 298 TGSALIHFQSQSFGKSSAFNITYQIKGVCIPGIQESCSEAELN--------CYDIRYEKC 453
G + + +++ FN TYQ+KG C+P Q S ++ + C+ ++C
Sbjct: 340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFS-EPQRC 398
Query: 454 NSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLADE 633
+ W+C SG+DE+ C C Q YPC + CY+ RC+ C ADE
Sbjct: 399 DGWWHCA-SGRDEQGCPACPPDQ-------YPCEGGSGL-CYTPADRCNNQKSCPDGADE 449
Query: 634 MYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNCDMILP 786
C Q G TF C T CI E+ RCDG C+DGSDEH C +P
Sbjct: 450 KNCFSCQPG----TFHCGT--NLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/127 (29%), Positives = 58/127 (45%), Gaps = 6/127 (4%)
Frame = +1
Query: 316 HFQSQSFGKSSAFNITYQIKGVCIPGIQESCSEAELNCYDIRYE----KCNSIWNCPISG 483
H + S G++ F ++Y I+G Q SC E C + + +CN++ C G
Sbjct: 140 HSDASSSGQAQGFRLSY-IRGKLG---QASCQADEFRCDNGKCLPGPWQCNTVDECG-DG 194
Query: 484 KDEENCTLCKSKQIKSNYR--LYPCSQFPTIECYSHKQRCDGYADCESLADEMYCDPVQC 657
DE NC+ S+ S +PCS + C ++RCDG DC +DE C + C
Sbjct: 195 SDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
Query: 658 GAHNKTF 678
G +F
Sbjct: 255 GRRLGSF 261
>sp|Q7Z4F1|LRP10_HUMAN Low-density lipoprotein receptor-related protein 10 precursor
Length = 713
Score = 103 bits (256), Expect = 9e-22
Identities = 71/251 (28%), Positives = 111/251 (44%), Gaps = 18/251 (7%)
Frame = +1
Query: 88 GVIHFSKIIYPSSHCAWILELGYYNVLEIRIESVNLAARDYIDIHDGP--TINSPILMKL 261
G H + + +P S C W+L+ L +R +++L D + ++DGP +S +L L
Sbjct: 207 GYTHLASVSHPQS-CHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSL 265
Query: 262 --YGTSRFRKISTSTGSALIHFQSQSFGKSSAFNITYQIKGVCIP-----------GIQE 402
+ + + T +G A++ + + ++ FN TY ++G C+P G E
Sbjct: 266 THFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGE 325
Query: 403 SCSEAELNCYDIRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPT---IE 573
E CY ++C+ W+C G DEE+C C +PC T
Sbjct: 326 GLGE---RCYS-EAQRCDGSWDCA-DGTDEEDCPGCPPGH-------FPCGAAGTSGATA 373
Query: 574 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 753
CY RC+ C ADE C Q G F C+ +C+ E+ CDG C DG
Sbjct: 374 CYLPADRCNYQTFCADGADERRCRHCQPG----NFRCRD--EKCVYETWVCDGQPDCADG 427
Query: 754 SDEHNCDMILP 786
SDE +C +LP
Sbjct: 428 SDEWDCSYVLP 438
Score = 33.1 bits (74), Expect = 1.1
Identities = 13/24 (54%), Positives = 14/24 (58%)
Frame = +1
Query: 700 RCIIESLRCDGTITCRDGSDEHNC 771
RC+ RCDG C DGSDE C
Sbjct: 151 RCVSAVQRCDGVDACGDGSDEAGC 174
>sp|Q7TQH7|LRP10_MOUSE Low-density lipoprotein receptor-related protein 10 precursor
Length = 713
Score = 100 bits (249), Expect = 6e-21
Identities = 70/251 (27%), Positives = 109/251 (43%), Gaps = 18/251 (7%)
Frame = +1
Query: 88 GVIHFSKIIYPSSHCAWILELGYYNVLEIRIESVNLAARDYIDIHDG--PTINSPILMKL 261
G H + + +P S C W+L+ L +R +++L+ D + ++DG P +L L
Sbjct: 208 GYSHLASVSHPQS-CLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGAGPPETPRLLRSL 266
Query: 262 --YGTSRFRKISTSTGSALIHFQSQSFGKSSAFNITYQIKGVCIP-----------GIQE 402
+ + + T +G A++ + + ++ FN TY ++G C+P G E
Sbjct: 267 THFSNGKAVTVETLSGQAVVSYHTVAWSSGRGFNATYHVRGYCLPWDRPCGLGSGLGASE 326
Query: 403 SCSEAELNCYDIRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPT---IE 573
+ E CY ++C+ W+C G DEE C C +PC T
Sbjct: 327 NLGE---RCYS-EAQRCDGSWDCA-DGTDEEGCPGCPPGH-------FPCGAAGTPGATA 374
Query: 574 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 753
CY RC+ C ADE C Q G F C+ +C+ E+ CDG C DG
Sbjct: 375 CYLPADRCNYQTFCADGADERRCRHCQPG----NFRCRD--EKCVYETWVCDGQPDCTDG 428
Query: 754 SDEHNCDMILP 786
SDE +C LP
Sbjct: 429 SDEWDCSYALP 439
Score = 33.9 bits (76), Expect = 0.64
Identities = 14/24 (58%), Positives = 15/24 (62%)
Frame = +1
Query: 700 RCIIESLRCDGTITCRDGSDEHNC 771
RCI + RCDG C DGSDE C
Sbjct: 152 RCIPAAQRCDGIDACGDGSDEAGC 175
>sp|Q91VN0|LRP5_MOUSE Low-density lipoprotein receptor-related protein 5 precursor (LRP7)
(Lr3)
Length = 1614
Score = 66.2 bits (160), Expect = 1e-10
Identities = 42/135 (31%), Positives = 65/135 (48%)
Frame = +1
Query: 382 CIPGIQESCSEAELNCYDIRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQF 561
C P Q +C+ E++C + +C+ C DEE C +C + Q +PC++
Sbjct: 1258 CSPD-QFACTTGEIDCIPGAW-RCDGFPECA-DQSDEEGCPVCSASQ-------FPCARG 1307
Query: 562 PTIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTIT 741
+C + RCDG ADC+ +DE CD V F C + +C++ +CD
Sbjct: 1308 ---QCVDLRLRCDGEADCQDRSDEANCDAV---CLPNQFRCTS--GQCVLIKQQCDSFPD 1359
Query: 742 CRDGSDEHNCDMILP 786
C DGSDE C++ P
Sbjct: 1360 CADGSDELMCEINKP 1374
>sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/108 (34%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Frame = +1
Query: 451 CNSIWNCPISGKDEENC-TLCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLA 627
C+ ++C G DE NC T C Q + CS +C K +CDG+ DC+
Sbjct: 3534 CDGDFDCA-DGSDERNCETSCSKDQFR-------CSNG---QCIPAKWKCDGHEDCKYGE 3582
Query: 628 DEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNC 771
DE C+P ++ ++C + CI SL+C+G C DGSDE +C
Sbjct: 3583 DEKSCEPASPTCSSREYICAS--DGCISASLKCNGEYDCADGSDEMDC 3628
Score = 57.0 bits (136), Expect = 7e-08
Identities = 45/141 (31%), Positives = 63/141 (44%), Gaps = 10/141 (7%)
Frame = +1
Query: 391 GIQESCSEAELNCYDIR----YEKCNSIWNC-PISGKDEENCTLCKSKQIKS----NYRL 543
G SC + + C R + C+ +C S + + NCT ++I S N
Sbjct: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCT---KEEIHSPAGCNGNE 1057
Query: 544 YPCSQFPTIECYSHKQRCDGYADCESLADEMYCD-PVQCGAHNKTFLCQTFPTRCIIESL 720
+ C P C RCDG DCE +DE C+ ++ H F C + RCI ++
Sbjct: 1058 FQCH--PDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWS-TGRCINKAW 1114
Query: 721 RCDGTITCRDGSDEHNCDMIL 783
CDG I C D SDE +CD L
Sbjct: 1115 VCDGDIDCEDQSDEDDCDSFL 1135
Score = 55.5 bits (132), Expect = 2e-07
Identities = 37/123 (30%), Positives = 52/123 (42%)
Frame = +1
Query: 406 CSEAELNCYDIRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIECYSH 585
C E Y + C+ I +C K +E C+++ + ++ PC C H
Sbjct: 2518 CGNGECIDYQLT---CDGIPHC--KDKSDEKLLYCENRSCRRGFK--PCYNR---RCIPH 2567
Query: 586 KQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEH 765
+ CDG DC +DE+ C C F C CI S RC+ I C D SDE
Sbjct: 2568 GKLCDGENDCGDNSDELDCKVSTCA--TVEFRCA--DGTCIPRSARCNQNIDCADASDEK 2623
Query: 766 NCD 774
NC+
Sbjct: 2624 NCN 2626
Score = 55.5 bits (132), Expect = 2e-07
Identities = 41/132 (31%), Positives = 50/132 (37%), Gaps = 6/132 (4%)
Frame = +1
Query: 397 QESCSEAELNCYDIRYEKCNS-IWNCP-----ISGKDEENCTLCKSKQIKSNYRLYPCSQ 558
+ SCS C ++ C S +W C DE NC K+ + Q
Sbjct: 3433 ENSCSPDYFQCKTTKH--CISKLWVCDEDPDCADASDEANC----DKKTCGPHEF----Q 3482
Query: 559 FPTIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTI 738
C RCD DC +DE C P C K FLC C+ CDG
Sbjct: 3483 CKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTL--KDFLCANGD--CVSSRFWCDGDF 3538
Query: 739 TCRDGSDEHNCD 774
C DGSDE NC+
Sbjct: 3539 DCADGSDERNCE 3550
Score = 52.4 bits (124), Expect = 2e-06
Identities = 43/137 (31%), Positives = 57/137 (41%), Gaps = 13/137 (9%)
Frame = +1
Query: 403 SCSEAELNCYD----IRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRL-------YP 549
+C+ E C D R +CN +C DE+NC + Y+L
Sbjct: 2590 TCATVEFRCADGTCIPRSARCNQNIDCA-DASDEKNCN---NTDCTHFYKLGVKTTGFIR 2645
Query: 550 CSQFPTIECYSHKQRCDGYADCESLADEMYCDPVQCG--AHNKTFLCQTFPTRCIIESLR 723
C+ T C CDG DC +DE+ C PVQ F C + RCI+ +
Sbjct: 2646 CNS--TSLCVLPTWICDGSNDCGDYSDELKC-PVQNKHKCEENYFSCPS--GRCILNTWI 2700
Query: 724 CDGTITCRDGSDEHNCD 774
CDG C DG DE +CD
Sbjct: 2701 CDGQKDCEDGRDEFHCD 2717
Score = 51.2 bits (121), Expect = 4e-06
Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 8/134 (5%)
Frame = +1
Query: 397 QESCSEAELNCYDIRYE----KCNSIWNCPISGKDEENCT----LCKSKQIKSNYRLYPC 552
+ SCS+ + C + + KC+ +C G+DE++C C S++ Y C
Sbjct: 3550 ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKY-GEDEKSCEPASPTCSSRE-------YIC 3601
Query: 553 SQFPTIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDG 732
+ + C S +C+G DC +DEM C +C F C+ CI CDG
Sbjct: 3602 A---SDGCISASLKCNGEYDCADGSDEMDC-VTEC--KEDQFRCKN-KAHCIPIRWLCDG 3654
Query: 733 TITCRDGSDEHNCD 774
C DGSDE NC+
Sbjct: 3655 IHDCVDGSDEENCE 3668
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/133 (32%), Positives = 56/133 (42%), Gaps = 11/133 (8%)
Frame = +1
Query: 424 NCYDIRYEKCNSIWNCPISGKDEENC----TLCKSKQIKSNYRLYPCSQFPTIECYSHKQ 591
+C IR+ C+ I +C + G DEENC +C++ + N L C H
Sbjct: 3644 HCIPIRW-LCDGIHDC-VDGSDEENCERGGNICRADEFLCNNSL----------CKLHFW 3691
Query: 592 RCDGYADCESLADEMYCDPVQCGAHNKTFLC-QTFPTRC------IIESLRCDGTITCRD 750
CDG DC +DE P C FLC T P RC + C+G C D
Sbjct: 3692 VCDGEDDCGDNSDEA---PDMC----VKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGD 3744
Query: 751 GSDEHNCDMILPY 789
SDE +C L Y
Sbjct: 3745 NSDEDHCGGKLTY 3757
Score = 48.9 bits (115), Expect = 2e-05
Identities = 36/127 (28%), Positives = 52/127 (40%), Gaps = 5/127 (3%)
Frame = +1
Query: 406 CSEAELNCYDIRYEKCNSIWNCPISGKD---EENCTLCKSKQIKSNYRLYPCSQFPTIEC 576
C+ C+D+ N NC G E+N + K+ + Y + C EC
Sbjct: 2468 CALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNA-YSEFECGNG---EC 2523
Query: 577 YSHKQRCDGYADCESLADE--MYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 750
++ CDG C+ +DE +YC+ C K + RCI CDG C D
Sbjct: 2524 IDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKP----CYNRRCIPHGKLCDGENDCGD 2579
Query: 751 GSDEHNC 771
SDE +C
Sbjct: 2580 NSDELDC 2586
Score = 48.5 bits (114), Expect = 3e-05
Identities = 47/169 (27%), Positives = 59/169 (34%), Gaps = 36/169 (21%)
Frame = +1
Query: 376 GVCIPG---------IQESCSEAELNCYDIRYEK---CNS--------------IWNCP- 474
G CIPG + EA++NC CN +W C
Sbjct: 1016 GRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDG 1075
Query: 475 ----ISGKDEENCT----LCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLAD 630
G DE+ C LC K S + T C + CDG DCE +D
Sbjct: 1076 EKDCEDGSDEKGCNGTIRLCDHKT--------KFSCWSTGRCINKAWVCDGDIDCEDQSD 1127
Query: 631 EMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDE-HNCD 774
E CD CG C + C+ C+G C DGSDE + CD
Sbjct: 1128 EDDCDSFLCGPPKHP--CANDTSVCLQPEKLCNGKKDCPDGSDEGYLCD 1174
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/134 (26%), Positives = 56/134 (41%), Gaps = 4/134 (2%)
Frame = +1
Query: 397 QESCSEAELNCYDIR----YEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFP 564
+++C E C + + +C+S +C DEENC K + + C+
Sbjct: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCS-DNSDEENC-----KPQTCTLKDFLCANG- 3525
Query: 565 TIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 744
+C S + CDG DC +DE C+ F C +CI +CDG C
Sbjct: 3526 --DCVSSRFWCDGDFDCADGSDERNCET---SCSKDQFRCSN--GQCIPAKWKCDGHEDC 3578
Query: 745 RDGSDEHNCDMILP 786
+ G DE +C+ P
Sbjct: 3579 KYGEDEKSCEPASP 3592
Score = 45.8 bits (107), Expect = 2e-04
Identities = 35/128 (27%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Frame = +1
Query: 403 SCSEAELNCYDIR----YEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCS-QFPT 567
+C+ ++ C + + KC+++ +C + ++C +R P Q T
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCP---------EFRCQPGRFQCGT 3366
Query: 568 IECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCR 747
C CDG DC +DE+ CD C + F C T +CI +LRC+G C
Sbjct: 3367 GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQ--FKC-TKNQKCIPVNLRCNGQDDCG 3423
Query: 748 DGSDEHNC 771
D DE +C
Sbjct: 3424 DEEDERDC 3431
Score = 45.8 bits (107), Expect = 2e-04
Identities = 38/134 (28%), Positives = 49/134 (36%), Gaps = 3/134 (2%)
Frame = +1
Query: 382 CIPGIQESCSEAELNCYDIRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQF 561
C G E E C R++ + P D EN S ++ + + QF
Sbjct: 3342 CGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQF 3401
Query: 562 PTIE---CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDG 732
+ C RC+G DC DE C C F C+T CI + CD
Sbjct: 3402 KCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSP--DYFQCKT-TKHCISKLWVCDE 3458
Query: 733 TITCRDGSDEHNCD 774
C D SDE NCD
Sbjct: 3459 DPDCADASDEANCD 3472
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/101 (28%), Positives = 44/101 (43%), Gaps = 7/101 (6%)
Frame = +1
Query: 490 EENCTLCKSKQIKSNYRLYPCSQFPTIE--CYSHKQ-RCDGYADCESLADEM----YCDP 648
+++C + + YR +F + C + Q +CDG DC +DE C
Sbjct: 2827 DDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKS 2886
Query: 649 VQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNC 771
+ ++ F+C+ RCI CD C DGSDE NC
Sbjct: 2887 AEQSCNSSFFMCKN--GRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 41.2 bits (95), Expect = 0.004
Identities = 33/106 (31%), Positives = 43/106 (40%), Gaps = 2/106 (1%)
Frame = +1
Query: 451 CNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTIECYSHKQRCDGYADCESLAD 630
C+ +C G+DE +C ++ + CS +C S CDG DC D
Sbjct: 2701 CDGQKDCE-DGRDEFHC------DSSCSWNQFACS---AQKCISKHWICDGEDDCGDGLD 2750
Query: 631 EM--YCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDE 762
E C + C A F CQ C+ CDG C DGSDE
Sbjct: 2751 ESDSICGAITCAAD--MFSCQG-SRACVPRHWLCDGERDCPDGSDE 2793
Score = 40.4 bits (93), Expect = 0.007
Identities = 30/98 (30%), Positives = 40/98 (40%), Gaps = 5/98 (5%)
Frame = +1
Query: 490 EENCTLCKSKQIKSNYRLYPCSQF--PTIECYSHKQRCDGYADCESLADEMYCDPVQCGA 663
+EN T C ++ + +F C + +CDG DC +DE D V C
Sbjct: 827 DENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDE---DSVNCFN 883
Query: 664 H---NKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHN 768
H + F CQ RCI + CDG C DE N
Sbjct: 884 HSCPDDQFKCQN--NRCIPKRWLCDGANDCGSNEDESN 919
Score = 40.4 bits (93), Expect = 0.007
Identities = 37/128 (28%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Frame = +1
Query: 403 SCSEAELNCYDIRYEK----CNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTI 570
SC + + C + R C+ +C S +DE N T C ++ + + + C
Sbjct: 885 SCPDDQFKCQNNRCIPKRWLCDGANDCG-SNEDESNQT-CTARTCQVDQ--FSCGNG--- 937
Query: 571 ECYSHKQRCDGYADCESLADEMY-CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCR 747
C CD DC DEM C+ C + F+C++ RCI CD C
Sbjct: 938 RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQ-FVCKS--GRCISSKWHCDSDDDCG 994
Query: 748 DGSDEHNC 771
DGSDE C
Sbjct: 995 DGSDEVGC 1002
Score = 38.1 bits (87), Expect = 0.034
Identities = 28/77 (36%), Positives = 34/77 (44%), Gaps = 3/77 (3%)
Frame = +1
Query: 553 SQF--PTIECYSHKQRCDGYADCESLADEMY-CDPVQCGAHNKTFLCQTFPTRCIIESLR 723
SQF T +C +CD DC +DE C +C F C T C + +
Sbjct: 3320 SQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGR--FQCGT--GLCALPAFI 3375
Query: 724 CDGTITCRDGSDEHNCD 774
CDG C D SDE NCD
Sbjct: 3376 CDGENDCGDNSDELNCD 3392
Score = 34.7 bits (78), Expect = 0.38
Identities = 22/67 (32%), Positives = 27/67 (40%), Gaps = 4/67 (5%)
Frame = +1
Query: 574 CYSHKQRCDGYADCESLADEMYCDPVQCGAHN----KTFLCQTFPTRCIIESLRCDGTIT 741
C CDG DC +DE+ C +N F+C CI + CD
Sbjct: 2774 CVPRHWLCDGERDCPDGSDEL--STAGCAPNNTCDENAFMCHN--KVCIPKQFVCDHDDD 2829
Query: 742 CRDGSDE 762
C DGSDE
Sbjct: 2830 CGDGSDE 2836
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/45 (40%), Positives = 22/45 (48%)
Frame = +1
Query: 628 DEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDE 762
D+ CDP + FLC T C+ +S CDG C D SDE
Sbjct: 28 DQQLCDPGE-------FLCHDHVT-CVSQSWLCDGDPDCPDDSDE 64
Score = 32.7 bits (73), Expect = 1.4
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Frame = +1
Query: 568 IECYSHKQRCDGYADCESLADEMY--CDP---VQCGAHNKTFLCQTFPTRCIIESLRCDG 732
+ C S CDG DC +DE C ++C ++ L +C+ S C+G
Sbjct: 43 VTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTN---KCVHLSQLCNG 99
Query: 733 TITCRDGSDE 762
+ C DG DE
Sbjct: 100 VLDCPDGYDE 109
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/89 (24%), Positives = 32/89 (35%), Gaps = 5/89 (5%)
Frame = +1
Query: 406 CSEAELNCYDIR-----YEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQFPTI 570
C E +C D R +C+ ++CP + CKS + N + C
Sbjct: 2845 CGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNG--- 2901
Query: 571 ECYSHKQRCDGYADCESLADEMYCDPVQC 657
C CD DC +DE C +C
Sbjct: 2902 RCIPSGGLCDNKDDCGDGSDERNCHINEC 2930
Score = 31.6 bits (70), Expect = 3.2
Identities = 37/138 (26%), Positives = 51/138 (36%), Gaps = 13/138 (9%)
Frame = +1
Query: 397 QESCSEAELNCYD-----IRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQF 561
Q+ C E C+D + C+ +CP DE T + +IK C
Sbjct: 29 QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCP-DDSDESLDTCPEEVEIKCPLNHIAC--L 85
Query: 562 PTIECYSHKQRCDGYADCESLADE-MYCDPV--QCGAHNKTFLCQTF--PTRCIIESLRC 726
T +C Q C+G DC DE ++C + C N + C TRC E
Sbjct: 86 GTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCE---- 141
Query: 727 DGTITCRDG---SDEHNC 771
DG DG D+ C
Sbjct: 142 DGFEITEDGRSCKDQDEC 159
>sp|O75197|LRP5_HUMAN Low-density lipoprotein receptor-related protein 5 precursor
Length = 1615
Score = 65.1 bits (157), Expect = 3e-10
Identities = 41/135 (30%), Positives = 65/135 (48%)
Frame = +1
Query: 382 CIPGIQESCSEAELNCYDIRYEKCNSIWNCPISGKDEENCTLCKSKQIKSNYRLYPCSQF 561
C P Q +C+ E++C + +C+ C DEE C +C + Q +PC++
Sbjct: 1259 CSPD-QFACATGEIDCIPGAW-RCDGFPECD-DQSDEEGCPVCSAAQ-------FPCARG 1308
Query: 562 PTIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTIT 741
+C + RCDG ADC+ +DE CD + F C + +C++ +CD
Sbjct: 1309 ---QCVDLRLRCDGEADCQDRSDEADCDAI---CLPNQFRCAS--GQCVLIKQQCDSFPD 1360
Query: 742 CRDGSDEHNCDMILP 786
C DGSDE C++ P
Sbjct: 1361 CIDGSDELMCEITKP 1375
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,635,179
Number of Sequences: 369166
Number of extensions: 2147471
Number of successful extensions: 6295
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4771
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5581
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9126484700
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)