Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_E10
(870 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31939|PUR9_HUMAN Bifunctional purine biosynthesis prote... 155 1e-37
sp|Q9CWJ9|PUR9_MOUSE Bifunctional purine biosynthesis prote... 155 2e-37
sp|P31335|PUR9_CHICK Bifunctional purine biosynthesis prote... 152 2e-36
sp|P54113|PUR91_YEAST Bifunctional purine biosynthesis prot... 135 1e-31
sp|P38009|PUR92_YEAST Bifunctional purine biosynthesis prot... 132 1e-30
sp|O74928|PUR9_SCHPO Bifunctional purine biosynthesis prote... 122 1e-27
sp|Q8REV6|PUR9_FUSNN Bifunctional purine biosynthesis prote... 69 1e-11
sp|Q8XMK2|PUR9_CLOPE Bifunctional purine biosynthesis prote... 68 3e-11
sp|Q9CFG0|PUR9_LACLA Bifunctional purine biosynthesis prote... 68 4e-11
sp|P57143|PUR9_BUCAI Bifunctional purine biosynthesis prote... 67 5e-11
>sp|P31939|PUR9_HUMAN Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 592
Score = 155 bits (393), Expect = 1e-37
Identities = 75/127 (59%), Positives = 96/127 (75%), Gaps = 2/127 (1%)
Frame = +1
Query: 439 WLRHHTKVLNLKFKSGLKRADINNLIDLYVSGE--SKNDLENFEKGFEVVPEPLTDGERE 612
WLRHH +VL++KFK+G+KRA+I+N ID YV+G DL ++ FE VPE LT+ E++
Sbjct: 466 WLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKK 525
Query: 613 DWIKKLTNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIHT 792
+W++KLT V +SSDAFFPFRDN+DRA +SGV YIAAPSGS D +IEAC E + L HT
Sbjct: 526 EWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHT 585
Query: 793 TKRLFHH 813
RLFHH
Sbjct: 586 NLRLFHH 592
>sp|Q9CWJ9|PUR9_MOUSE Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 592
Score = 155 bits (391), Expect = 2e-37
Identities = 75/127 (59%), Positives = 95/127 (74%), Gaps = 2/127 (1%)
Frame = +1
Query: 439 WLRHHTKVLNLKFKSGLKRADINNLIDLYVSGE--SKNDLENFEKGFEVVPEPLTDGERE 612
WLRHH +VL++KFK+G+KRA+I+N ID YV+G DL +E FE VPE LT+ E++
Sbjct: 466 WLRHHPRVLSMKFKAGVKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKK 525
Query: 613 DWIKKLTNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIHT 792
+W+ KL+ V +SSDAFFPFRDN+DRA +SGV YI APSGST D +IEAC E + L HT
Sbjct: 526 EWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHT 585
Query: 793 TKRLFHH 813
RLFHH
Sbjct: 586 DLRLFHH 592
>sp|P31335|PUR9_CHICK Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 593
Score = 152 bits (383), Expect = 2e-36
Identities = 73/127 (57%), Positives = 93/127 (73%), Gaps = 2/127 (1%)
Frame = +1
Query: 439 WLRHHTKVLNLKFKSGLKRADINNLIDLYVSGE--SKNDLENFEKGFEVVPEPLTDGERE 612
WLRHH +VL++KFK+G+KRA+++N ID YV+G DL ++ FE VP LT+ E++
Sbjct: 467 WLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKK 526
Query: 613 DWIKKLTNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIHT 792
WI KLT V LSSDAFFPFRDN+DRA + GV++I APSGS D +IEAC E + LIHT
Sbjct: 527 QWIAKLTAVSLSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHT 586
Query: 793 TKRLFHH 813
RLFHH
Sbjct: 587 NLRLFHH 593
>sp|P54113|PUR91_YEAST Bifunctional purine biosynthesis protein ADE16 [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 591
Score = 135 bits (340), Expect = 1e-31
Identities = 67/127 (52%), Positives = 86/127 (67%), Gaps = 2/127 (1%)
Frame = +1
Query: 439 WLRHHTKVLNLKFKSGLKRADINNLIDLYVSGESKNDLE--NFEKGFEVVPEPLTDGERE 612
WLR H KVLN+K+ G+KRAD +N IDL+V+G+ E ++E FE VPEP T ER
Sbjct: 465 WLRQHPKVLNMKWAKGIKRADKSNAIDLFVTGQRIEGPEKVDYESKFEEVPEPFTKEERL 524
Query: 613 DWIKKLTNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIHT 792
+W+ KL NV LSSDAFFPF DN+ RAV+SGVK+I APSGS D + +A ++ +
Sbjct: 525 EWLSKLNNVSLSSDAFFPFPDNVYRAVQSGVKFITAPSGSVMDKVVFQAADSFDIVYVEN 584
Query: 793 TKRLFHH 813
RLFHH
Sbjct: 585 PIRLFHH 591
Score = 31.6 bits (70), Expect = 3.0
Identities = 12/18 (66%), Positives = 16/18 (88%)
Frame = +3
Query: 3 IHCTRLAGNKADNCYVQQ 56
IHCTRLAG+K DN +++Q
Sbjct: 451 IHCTRLAGDKTDNWWLRQ 468
>sp|P38009|PUR92_YEAST Bifunctional purine biosynthesis protein ADE17 [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 592
Score = 132 bits (332), Expect = 1e-30
Identities = 63/128 (49%), Positives = 86/128 (67%), Gaps = 3/128 (2%)
Frame = +1
Query: 439 WLRHHTKVLNLKFKSGLKRADINNLIDLYVSGE---SKNDLENFEKGFEVVPEPLTDGER 609
W R H +VL +K+ G+KR + +N IDL+V+G+ + +L ++ FE +P+P T ER
Sbjct: 465 WFRQHPRVLEIKWAKGVKRPEKSNAIDLFVTGQIPTEEPELSEYQSKFEEIPKPFTPEER 524
Query: 610 EDWIKKLTNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIH 789
++W+ KLTNV LSSDAFFPF DN+ RAVKSGVKYIAAPSGS D + A ++ +
Sbjct: 525 KEWLSKLTNVSLSSDAFFPFPDNVYRAVKSGVKYIAAPSGSVMDKVVFSAADSFDLVYVE 584
Query: 790 TTKRLFHH 813
RLFHH
Sbjct: 585 NPIRLFHH 592
Score = 32.3 bits (72), Expect = 1.8
Identities = 13/18 (72%), Positives = 16/18 (88%)
Frame = +3
Query: 3 IHCTRLAGNKADNCYVQQ 56
IHCTRLAG+KADN + +Q
Sbjct: 451 IHCTRLAGDKADNWWFRQ 468
>sp|O74928|PUR9_SCHPO Bifunctional purine biosynthesis protein ade10 [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 585
Score = 122 bits (306), Expect = 1e-27
Identities = 61/128 (47%), Positives = 80/128 (62%), Gaps = 3/128 (2%)
Frame = +1
Query: 439 WLRHHTKVLNLKFKSGLKRADINNLIDLYVSGE---SKNDLENFEKGFEVVPEPLTDGER 609
WLRHH KVL ++FK KR + +N IDLYV ++ E +E FE +PEPLT ER
Sbjct: 458 WLRHHPKVLGMQFKKSAKRPEKSNAIDLYVLDAVPAEGSEREQWESAFETIPEPLTKKER 517
Query: 610 EDWIKKLTNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIH 789
E+++ +VV +SDAFFPF DNI R +SGVKY+AAP GS D ++ + E N+
Sbjct: 518 EEFLATCKDVVCASDAFFPFPDNIYRLAQSGVKYVAAPGGSVMDQAVRDTANEFNMVFSE 577
Query: 790 TTKRLFHH 813
RLFHH
Sbjct: 578 IPLRLFHH 585
>sp|Q8REV6|PUR9_FUSNN Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 504
Score = 69.3 bits (168), Expect = 1e-11
Identities = 34/61 (55%), Positives = 42/61 (68%)
Frame = +1
Query: 631 TNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIHTTKRLFH 810
T+VVLSSDAFFPF+D I+ A K+GVK I PSGS ND IE C +N+ +I + R F
Sbjct: 444 TDVVLSSDAFFPFKDVIELAAKNGVKAIIQPSGSVNDKDSIEECDRNNISMIFSKLRHFK 503
Query: 811 H 813
H
Sbjct: 504 H 504
>sp|Q8XMK2|PUR9_CLOPE Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 501
Score = 68.2 bits (165), Expect = 3e-11
Identities = 31/58 (53%), Positives = 38/58 (65%)
Frame = +1
Query: 640 VLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIHTTKRLFHH 813
VL+SDAFFPFRD +D A K+G+K I P GS D IEAC EH + ++ T R F H
Sbjct: 444 VLASDAFFPFRDCVDEAAKNGIKAIIQPGGSIRDEESIEACNEHGISMVFTGVRHFKH 501
>sp|Q9CFG0|PUR9_LACLA Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 518
Score = 67.8 bits (164), Expect = 4e-11
Identities = 29/60 (48%), Positives = 38/60 (63%)
Frame = +1
Query: 634 NVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIHTTKRLFHH 813
N VL SDAFFPF DNID K+G+K I P GS D +I+AC ++ + ++ T R F H
Sbjct: 459 NAVLGSDAFFPFADNIDEIAKAGIKAIVQPGGSVRDQEVIDACDKYGIAMVFTGLRHFRH 518
>sp|P57143|PUR9_BUCAI Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase); IMP
cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]
Length = 525
Score = 67.4 bits (163), Expect = 5e-11
Identities = 32/68 (47%), Positives = 39/68 (57%)
Frame = +1
Query: 610 EDWIKKLTNVVLSSDAFFPFRDNIDRAVKSGVKYIAAPSGSTNDASIIEACKEHNVCLIH 789
+D K + ++SDAFFPFRD ID A G+ I P GS D II A EHN+ +I
Sbjct: 458 KDQGKNIIGATMASDAFFPFRDGIDEAASVGISSIIQPGGSIRDEEIIRAADEHNITMIF 517
Query: 790 TTKRLFHH 813
T KR F H
Sbjct: 518 TKKRHFKH 525
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,786,708
Number of Sequences: 369166
Number of extensions: 2108150
Number of successful extensions: 5899
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5686
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5890
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)