Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_E02
(540 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q94261|CSN7_CAEEL Probable COP9 signalosome complex subu... 84 2e-16
sp|Q9H9Q2|CSN7B_HUMAN COP9 signalosome complex subunit 7b (... 48 1e-05
sp|Q8BV13|CSN7B_MOUSE COP9 signalosome complex subunit 7b (... 48 2e-05
sp|Q9UBW8|CSN7A_HUMAN COP9 signalosome complex subunit 7a (... 48 2e-05
sp|Q94JU3|CSN7_ARATH COP9 signalosome complex subunit 7 (CS... 46 7e-05
sp|Q9CZ04|CSN7A_MOUSE COP9 signalosome complex subunit 7a (... 45 1e-04
sp|Q04062|RPN9_YEAST 26S proteasome regulatory subunit RPN9... 43 4e-04
sp|Q6IQT4|CSN2_BRARE COP9 signalosome complex subunit 2 (Si... 35 0.12
sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 (Si... 34 0.20
sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Si... 34 0.20
>sp|Q94261|CSN7_CAEEL Probable COP9 signalosome complex subunit 7 (Signalosome subunit 7)
Length = 390
Score = 84.3 bits (207), Expect = 2e-16
Identities = 50/153 (32%), Positives = 90/153 (58%), Gaps = 4/153 (2%)
Frame = +3
Query: 3 PNALTMDQILELKPVQCL--AGEAIHDLLSIFVSGTINDYRKFLDDHPDFM-EKYELDKE 173
P + + D + L V+ L + + L +F+SGT+ DY++F+ +P F+ E ++D+
Sbjct: 223 PKSFSFDHLERLSAVKALKTSDPLMFTALELFISGTLKDYKEFVAKNPKFVTEHLKVDET 282
Query: 174 ACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERAE-LEAFVIEAVRQQAVTCKLDQQN 350
L KIR+L+LM+LA + E+S D + K+L + E LE FVI+A++ A++ K+++
Sbjct: 283 ILLKKIRLLTLMSLAE-EKNEISLDELAKQLDILADETLEEFVIDAIQVNAISGKINEMA 341
Query: 351 EKVLISGAVPRSFGPDQWTKLYRDLQMWQNNFK 449
+++S R FG +QW L + L++ N K
Sbjct: 342 RTLIVSSYQHRRFGTEQWVLLEKRLKVLIANLK 374
>sp|Q9H9Q2|CSN7B_HUMAN COP9 signalosome complex subunit 7b (Signalosome subunit 7b)
(SGN7b) (JAB1-containing signalosome subunit 7b)
Length = 264
Score = 48.1 bits (113), Expect = 1e-05
Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 4/148 (2%)
Frame = +3
Query: 3 PNALTMDQILELKPVQCLA---GEAIHDLLSIFVSGTINDYRKFLDDHPDFMEKYELDKE 173
P ++LEL VQ LA A LL++F GT DY + P+ +
Sbjct: 38 PGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSTAQQ---- 93
Query: 174 ACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVTCKLDQQN 350
K++ L++++LA+ + Y + K+L++ ELE +IEAV + KLDQ+N
Sbjct: 94 ---NKLKHLTIVSLASRMKC-IPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRN 149
Query: 351 EKVLISGAVPRSFGPDQWTKLYRDLQMW 434
+ + + + R + + L W
Sbjct: 150 QLLEVDFCIGRDIRKKDINNIVKTLHEW 177
>sp|Q8BV13|CSN7B_MOUSE COP9 signalosome complex subunit 7b (Signalosome subunit 7b)
(SGN7b) (JAB1-containing signalosome subunit 7b)
Length = 264
Score = 47.8 bits (112), Expect = 2e-05
Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 4/148 (2%)
Frame = +3
Query: 3 PNALTMDQILELKPVQCLA---GEAIHDLLSIFVSGTINDYRKFLDDHPDFMEKYELDKE 173
P ++LEL VQ LA A LL++F GT DY + P+ +
Sbjct: 38 PGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSVAQQ---- 93
Query: 174 ACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVTCKLDQQN 350
K++ L++++LA+ + Y + K+L++ ELE +IEAV + KLDQ+N
Sbjct: 94 ---NKLKHLTIVSLASRMKC-IPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRN 149
Query: 351 EKVLISGAVPRSFGPDQWTKLYRDLQMW 434
+ + + + R + + L W
Sbjct: 150 QLLEVDFCIGRDIRKKDINNIVKTLHEW 177
>sp|Q9UBW8|CSN7A_HUMAN COP9 signalosome complex subunit 7a (Signalosome subunit 7a)
(SGN7a) (JAB1-containing signalosome subunit 7a) (Dermal
papilla derived protein 10)
sp|Q5R762|CSN7A_PONPY COP9 signalosome complex subunit 7a (Signalosome subunit 7a)
(SGN7a) (JAB1-containing signalosome subunit 7a)
Length = 275
Score = 47.8 bits (112), Expect = 2e-05
Identities = 43/166 (25%), Positives = 75/166 (45%), Gaps = 4/166 (2%)
Frame = +3
Query: 3 PNALTMDQILELKPVQCLAGE---AIHDLLSIFVSGTINDYRKFLDDHPDFMEKYELDKE 173
P ++L++ V+ LA + LL++F GT DY + P E +
Sbjct: 38 PGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQK---- 93
Query: 174 ACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVTCKLDQQN 350
K+R LS++TLAA + Y + + L L +LE VIEAV + LDQ+N
Sbjct: 94 ---NKLRHLSVVTLAA-KVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRN 149
Query: 351 EKVLISGAVPRSFGPDQWTKLYRDLQMWQNNFKIITEDLRKLRSDA 488
+++ + ++ R + + R LQ W +++ + + S A
Sbjct: 150 QRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRA 195
>sp|Q94JU3|CSN7_ARATH COP9 signalosome complex subunit 7 (CSN complex subunit 7) (FUSCA
protein 5) (FUSCA5)
Length = 260
Score = 45.8 bits (107), Expect = 7e-05
Identities = 45/151 (29%), Positives = 66/151 (43%), Gaps = 5/151 (3%)
Frame = +3
Query: 3 PNALTMDQILELKPVQCLAG--EAIH-DLLSIFVSGTINDYRKFLDDHPDFMEKYELDKE 173
P+ +IL L V L G ++++ DLL +F GT DY+ P
Sbjct: 37 PSLFAFSEILALPNVAQLEGTTDSVYLDLLRLFAHGTWGDYKCNATRLPHLSPDQ----- 91
Query: 174 ACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVI-EAVRQQAVTCKLDQQ 347
+ K++ L+++TLA + L YDT+ EL + ELE F+I E + V KLDQ
Sbjct: 92 --ILKLKQLTVLTLAESNKV-LPYDTLMVELDVSNVRELEDFLINECMYAGIVRGKLDQL 148
Query: 348 NEKVLISGAVPRSFGPDQWTKLYRDLQMWQN 440
+ A R P Q + L W N
Sbjct: 149 KRCFEVPFAAGRDLRPGQLGNMLHTLSNWLN 179
>sp|Q9CZ04|CSN7A_MOUSE COP9 signalosome complex subunit 7a (Signalosome subunit 7a)
(SGN7a) (JAB1-containing signalosome subunit 7a)
Length = 275
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/166 (24%), Positives = 75/166 (45%), Gaps = 4/166 (2%)
Frame = +3
Query: 3 PNALTMDQILELKPVQCLAGE---AIHDLLSIFVSGTINDYRKFLDDHPDFMEKYELDKE 173
P ++L++ V+ LA + LL++F GT DY + P + +
Sbjct: 38 PGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTDAQK---- 93
Query: 174 ACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVTCKLDQQN 350
K+R LS++TLAA + Y + + L L +LE VIEAV + LDQ+N
Sbjct: 94 ---NKLRHLSVVTLAA-KVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRN 149
Query: 351 EKVLISGAVPRSFGPDQWTKLYRDLQMWQNNFKIITEDLRKLRSDA 488
+++ + ++ R + + + LQ W +++ + + S A
Sbjct: 150 QRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRA 195
>sp|Q04062|RPN9_YEAST 26S proteasome regulatory subunit RPN9 (Proteasome non-ATPase
subunit 7)
Length = 393
Score = 43.1 bits (100), Expect = 4e-04
Identities = 38/149 (25%), Positives = 69/149 (46%), Gaps = 10/149 (6%)
Frame = +3
Query: 24 QILELKPVQCLAGEAIHD-LLSIFVSGTINDYRKFLDDHPDFMEKYELDKEACLT----- 185
++L ++ + ++ +D L + + T+ D+ KF D + K ++ K L
Sbjct: 232 ELLHHPIMETIVNDSNYDWLFQLLNALTVGDFDKF-----DSLIKVQISKIPILAQHESF 286
Query: 186 ---KIRILSLM-TLAAGDTTELSYDTIQKELQLERAELEAFVIEAVRQQAVTCKLDQQNE 353
KI +++L+ T+ + LS++ I K L + +E V+ A+ + +DQ NE
Sbjct: 287 LRQKICLMTLIETVFVKNIRMLSFEDISKATHLPKDNVEHLVMRAISLGLLKGSIDQVNE 346
Query: 354 KVLISGAVPRSFGPDQWTKLYRDLQMWQN 440
V IS PR DQ TK+ L W +
Sbjct: 347 LVTISWVQPRIISGDQITKMKDRLVEWND 375
>sp|Q6IQT4|CSN2_BRARE COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 443
Score = 35.0 bits (79), Expect = 0.12
Identities = 31/128 (24%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Frame = +3
Query: 66 AIHDLLSIFVSGTINDYRKFLD-DHPDFMEKYELDK--EACLTKIRILSLMTLAAGDTTE 236
A+ +L+S + + I ++ K L +H + M+ + + E L IR L+ L T
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIK-PYTR 368
Query: 237 LSYDTIQKELQLERAELEAFVIEAVRQQAVTCKLDQQNEKVLI-----SGAVPRSFGPDQ 401
+ I KEL ++ A++E+ +++ + + ++DQ N+ + + GA R D+
Sbjct: 369 IHIPFISKELNIDVADVESLLVQCILDNTINGRIDQVNQLLELDHQKRGGA--RYTALDK 426
Query: 402 WTKLYRDL 425
WT L
Sbjct: 427 WTNQLNSL 434
>sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
sp|P61203|CSN2_RAT COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
sp|P61202|CSN2_MOUSE COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
Length = 443
Score = 34.3 bits (77), Expect = 0.20
Identities = 31/128 (24%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Frame = +3
Query: 66 AIHDLLSIFVSGTINDYRKFLD-DHPDFMEKYELDK--EACLTKIRILSLMTLAAGDTTE 236
A+ +L+S + + I ++ K L +H + M+ + + E L IR L+ L T
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIK-PYTR 368
Query: 237 LSYDTIQKELQLERAELEAFVIEAVRQQAVTCKLDQQNEKVLI-----SGAVPRSFGPDQ 401
+ I KEL ++ A++E+ +++ + + ++DQ N+ + + GA R D+
Sbjct: 369 IHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGA--RYTALDK 426
Query: 402 WTKLYRDL 425
WT L
Sbjct: 427 WTNQLNSL 434
>sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 441
Score = 34.3 bits (77), Expect = 0.20
Identities = 31/128 (24%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Frame = +3
Query: 66 AIHDLLSIFVSGTINDYRKFLD-DHPDFMEKYELDK--EACLTKIRILSLMTLAAGDTTE 236
A+ +L+S + + I ++ K L +H + M+ + + E L IR L+ L T
Sbjct: 308 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIK-PYTR 366
Query: 237 LSYDTIQKELQLERAELEAFVIEAVRQQAVTCKLDQQNEKVLI-----SGAVPRSFGPDQ 401
+ I KEL ++ A++E+ +++ + + ++DQ N+ + + GA R D+
Sbjct: 367 IHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGA--RYTALDK 424
Query: 402 WTKLYRDL 425
WT L
Sbjct: 425 WTNQLNSL 432
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,222,574
Number of Sequences: 369166
Number of extensions: 964146
Number of successful extensions: 2615
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2549
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2613
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3685690500
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)