Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_D14
(972 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP) 424 e-118
sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha) 397 e-110
sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resista... 395 e-110
sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100) 394 e-109
sp|Q62667|MVP_RAT Major vault protein (MVP) 388 e-107
sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP) 385 e-106
sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta) 333 6e-91
sp|P31976|EZRI_BOVIN Ezrin (p81) (Cytovillin) (Villin-2) 37 0.064
sp|Q8M867|NU1M_MURSU NADH-ubiquinone oxidoreductase chain 1... 37 0.064
sp|Q9UL16|CCDCJ_HUMAN Coiled-coil domain-containing protein... 35 0.32
>sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP)
Length = 871
Score = 424 bits (1091), Expect = e-118
Identities = 216/317 (68%), Positives = 250/317 (78%)
Frame = +1
Query: 4 VRSVTGHTYMLTENEELWEKILPDTVEDLLSSCVDPLADRSERNEKPXXXXXXXXXXXXX 183
VR+V GHTYMLT +EELWEK LP VE LLS+ DPLADRSE N+
Sbjct: 426 VRAVIGHTYMLTHDEELWEKELPPNVEKLLSTVRDPLADRSEHNQNAVAEPRDKTMVVS- 484
Query: 184 YRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLG 363
YRVPHNAAVQ+YDY+EK AR+ +GPDLVMLGPDE FT LSLSG KPK+ N+IK++CLLLG
Sbjct: 485 YRVPHNAAVQVYDYREKKARVVFGPDLVMLGPDEQFTVLSLSGEKPKRANVIKAICLLLG 544
Query: 364 PDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRI 543
PDFCTDII +ET+DHARL LQ++YNWHF+ + LFSVPDFVGDACKA+ASRI
Sbjct: 545 PDFCTDIITIETADHARLQLQLAYNWHFEVKNHSDPAQAAALFSVPDFVGDACKAIASRI 604
Query: 544 RGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVDQR 723
RG VA+V+FDDFHKNS RII S+VFG D VR F QN L I+S+DIQSVEPVDQR
Sbjct: 605 RGAVASVQFDDFHKNSIRIICSAVFGFDEKLAVRSSLRFNQNGLVISSVDIQSVEPVDQR 664
Query: 724 TRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQL 903
TR++LQKSVQLAIEITT SQEA+ARHEA+R+EQ+A+G+LERQ ITDQAEAER R ELL+L
Sbjct: 665 TRDALQKSVQLAIEITTNSQEATARHEAERLEQEARGKLERQKITDQAEAERARKELLEL 724
Query: 904 RAASAAVESTGQAKGRS 954
A SAAVESTG AK +
Sbjct: 725 EALSAAVESTGAAKAEA 741
>sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha)
Length = 843
Score = 397 bits (1020), Expect = e-110
Identities = 201/313 (64%), Positives = 244/313 (77%)
Frame = +1
Query: 4 VRSVTGHTYMLTENEELWEKILPDTVEDLLSSCVDPLADRSERNEKPXXXXXXXXXXXXX 183
V S+ G +YML NEELWEK+LP TVE++L+ + + P
Sbjct: 395 VASIKGQSYMLKANEELWEKVLPRTVEEVLA----------KESLNPEFTDNRDSTRVVT 444
Query: 184 YRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLG 363
YR PHN+AVQIYDYKEK +R+ +GPDLVMLGPDEHFT LSLSG KPK+P+ IK++ L LG
Sbjct: 445 YRAPHNSAVQIYDYKEKKSRVVFGPDLVMLGPDEHFTVLSLSGDKPKRPHQIKAIALFLG 504
Query: 364 PDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRI 543
PDF TD+++VETSDHARLSL++SYNW FK + K ++ K+F VPDFVGD+CKA+ASR+
Sbjct: 505 PDFMTDVVIVETSDHARLSLKLSYNWEFKVDRSKIEDA-QKIFQVPDFVGDSCKAIASRV 563
Query: 544 RGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVDQR 723
RG VAAV FDDFHK SA +IR SVFG+D + +VR+ F F NNL IT+IDIQSVEPVDQR
Sbjct: 564 RGAVAAVSFDDFHKRSAEVIRQSVFGLDESGEVRKNFSFNSNNLVITNIDIQSVEPVDQR 623
Query: 724 TRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQL 903
TR+SLQKSVQLAIEITTKSQEA+ARHEA+R+EQ A+GRLERQ I D+A+AE R +LLQL
Sbjct: 624 TRDSLQKSVQLAIEITTKSQEAAARHEAERLEQGARGRLERQKIHDEAQAELARKDLLQL 683
Query: 904 RAASAAVESTGQA 942
+A SAAVESTGQA
Sbjct: 684 QAQSAAVESTGQA 696
>sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resistance-related protein)
Length = 893
Score = 395 bits (1015), Expect = e-110
Identities = 199/329 (60%), Positives = 250/329 (75%), Gaps = 12/329 (3%)
Frame = +1
Query: 4 VRSVTGHTYMLTENEELWEKILPDTVEDLLSSCVDPLADRSERN--EKPXXXXXXXXXXX 177
VR+V G TYMLT++E LWEK LP VE+LL+ DPLADR E++ +
Sbjct: 398 VRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRV 457
Query: 178 XXYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 357
YRVPHNAAVQ+YDY+EK AR+ +GP+LV LGP+E FT LSLS G+PK+P+ ++LCLL
Sbjct: 458 VSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLL 517
Query: 358 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 537
LGPDF TD+I +ET+DHARL LQ++YNWHF+ K KLFSVPDFVGDACKA+AS
Sbjct: 518 LGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIAS 577
Query: 538 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITS 687
R+RG VA+V FDDFHKNSARIIR++VFG + + + R++ VFPQN L ++S
Sbjct: 578 RVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSS 637
Query: 688 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 867
+D+QSVEPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+
Sbjct: 638 VDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQS 697
Query: 868 EAERTRTELLQLRAASAAVESTGQAKGRS 954
EAE+ R ELL+L A S AVESTG AK +
Sbjct: 698 EAEKARKELLELEALSMAVESTGTAKAEA 726
>sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100)
Length = 852
Score = 394 bits (1013), Expect = e-109
Identities = 197/321 (61%), Positives = 248/321 (77%), Gaps = 4/321 (1%)
Frame = +1
Query: 4 VRSVTGHTYMLTENEELWEKILPDTVEDLLSSCVDPLADR----SERNEKPXXXXXXXXX 171
VR+V G +YML+++EELWEK LP VE LL+ DP+ +R SE +
Sbjct: 396 VRAVIGESYMLSQDEELWEKTLPPNVEALLTPDKDPVLNRNVHQSEAGHQEEGVKKRDPT 455
Query: 172 XXXXYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLC 351
+RVPHNAAVQ+YDY +K+AR+ +GP+LVML DE T LSLSGG+PK+P +I+SLC
Sbjct: 456 RVVTFRVPHNAAVQVYDYSQKSARVVFGPELVMLETDEQLTVLSLSGGRPKRPGVIRSLC 515
Query: 352 LLLGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKAL 531
LLLGPDF TD+IV+ET+DHARL LQ++YNWHF+ + K+FSV DFVGDACKA+
Sbjct: 516 LLLGPDFFTDVIVIETADHARLQLQLAYNWHFEVKDRSDPMESAKVFSVLDFVGDACKAI 575
Query: 532 ASRIRGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEP 711
ASRIRG VA+V+FDDFHKNS+RI+R++VFG+D +VRE +FPQN+LC+TS+D+ SVEP
Sbjct: 576 ASRIRGAVASVQFDDFHKNSSRILRAAVFGLDPELRVRERLLFPQNSLCVTSVDVHSVEP 635
Query: 712 VDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTE 891
VDQRTR++LQ+SVQLAIEITTKSQEA+AR EA R+EQ+AKGRLERQ I DQAE+ER R E
Sbjct: 636 VDQRTRDALQRSVQLAIEITTKSQEAAARQEAARLEQEAKGRLERQRILDQAESERARRE 695
Query: 892 LLQLRAASAAVESTGQAKGRS 954
LL L A S AVES G A+ +
Sbjct: 696 LLLLEADSTAVESRGAARAEA 716
>sp|Q62667|MVP_RAT Major vault protein (MVP)
Length = 861
Score = 388 bits (996), Expect = e-107
Identities = 198/329 (60%), Positives = 247/329 (75%), Gaps = 12/329 (3%)
Frame = +1
Query: 4 VRSVTGHTYMLTENEELWEKILPDTVEDLLSSCVDPLADRSERNE-KPXXXXXXXXXXXX 180
VR+V G TYMLT++E LWEK LP VE+LL+ DPLADR ++ KP
Sbjct: 398 VRAVIGSTYMLTQDEVLWEKELPSGVEELLNLGHDPLADRGQKGTAKPLQPSAPRNKTRV 457
Query: 181 X-YRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 357
YRVPHNAAVQ+YDY+ K AR+ +GP+LV L P+E FT LSLS G+PK+P+ ++LCLL
Sbjct: 458 VSYRVPHNAAVQVYDYRAKRARVVFGPELVTLDPEEQFTVLSLSAGRPKRPHARRALCLL 517
Query: 358 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 537
LGPDF TD+I +ET+DHARL LQ++YNWHF+ + KLFSVPDFVGDACKA+AS
Sbjct: 518 LGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPAEAAKLFSVPDFVGDACKAIAS 577
Query: 538 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITS 687
R+RG VA+V FDDFHKNSARIIR +VFG + + K R++ VFPQN L ++S
Sbjct: 578 RVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDTGPDGTLLPKARDQAVFPQNGLVVSS 637
Query: 688 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 867
+D+QSVEPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+
Sbjct: 638 VDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQS 697
Query: 868 EAERTRTELLQLRAASAAVESTGQAKGRS 954
EAE+ R ELL+L A S AVESTG AK +
Sbjct: 698 EAEKARKELLELEAMSMAVESTGNAKAEA 726
>sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP)
Length = 861
Score = 385 bits (988), Expect = e-106
Identities = 195/329 (59%), Positives = 244/329 (74%), Gaps = 12/329 (3%)
Frame = +1
Query: 4 VRSVTGHTYMLTENEELWEKILPDTVEDLLSSCVDPLADRSERNEKPXXXXXXXXXXXXX 183
VR+V G TYMLT++E LWEK LP VE+LL+ DPLADR ++
Sbjct: 398 VRAVIGSTYMLTQDEVLWEKELPSGVEELLNLGHDPLADRGQKGTAKVLQPSAARNKTRV 457
Query: 184 --YRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 357
YRVPHNAAVQ+YDY+ K AR+ +GP+LV L P+E FT LSLS G+PK+P+ ++LCLL
Sbjct: 458 VSYRVPHNAAVQVYDYRAKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLL 517
Query: 358 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 537
LGPDF TD+I +ET+DHARL LQ++YNWHF+ + KLFSVPDFVGDACKA+AS
Sbjct: 518 LGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPEETAKLFSVPDFVGDACKAIAS 577
Query: 538 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITS 687
R+RG VA+V FDDFHKNSARIIR +VFG + + + R+ VFPQN L ++S
Sbjct: 578 RVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDAGPDGALLPRARDRAVFPQNGLVVSS 637
Query: 688 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 867
+D+QSVEPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+
Sbjct: 638 VDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQS 697
Query: 868 EAERTRTELLQLRAASAAVESTGQAKGRS 954
EAE+ R ELL+L A S AVESTG AK +
Sbjct: 698 EAEKARKELLELEAMSMAVESTGNAKAEA 726
>sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta)
Length = 846
Score = 333 bits (853), Expect = 6e-91
Identities = 181/313 (57%), Positives = 224/313 (71%)
Frame = +1
Query: 4 VRSVTGHTYMLTENEELWEKILPDTVEDLLSSCVDPLADRSERNEKPXXXXXXXXXXXXX 183
VRSV G +YML NEE W K L VE+LL D++E + +
Sbjct: 407 VRSVHGSSYMLLPNEERWAKPLAPIVEELLKKSAS--RDQNEEHNESDRDSTKVIT---- 460
Query: 184 YRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLG 363
YRVPHNAAVQI+DY++K AR+ +GP+LVML PDE FT LSLSG PK+PN I+SL L LG
Sbjct: 461 YRVPHNAAVQIFDYRKKEARVVFGPELVMLEPDEEFTVLSLSGKIPKRPNHIRSLALFLG 520
Query: 364 PDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRI 543
PDF TD+I VET+DHARLSL++SYNWHFK E Q+ +KLF+ DF GD CKA S +
Sbjct: 521 PDFMTDLITVETADHARLSLKLSYNWHFKVE----QDNPSKLFATSDFTGDLCKATGSLV 576
Query: 544 RGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVDQR 723
R VAA FD+FHK+S+ II+ +VFG + + F N L IT+ID+QSVEPVDQR
Sbjct: 577 RAAVAASTFDNFHKHSSDIIQQAVFG-STDGSSNDCLYFETNGLVITNIDVQSVEPVDQR 635
Query: 724 TRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQL 903
T +SLQKSVQLAIEITTKSQEA+AR EA+R+EQ A+G LERQ I D+A+ E +R++L+QL
Sbjct: 636 TLDSLQKSVQLAIEITTKSQEATARQEAERLEQMARGELERQKIIDEAKNEESRSKLVQL 695
Query: 904 RAASAAVESTGQA 942
+A SAAVESTGQA
Sbjct: 696 QAQSAAVESTGQA 708
>sp|P31976|EZRI_BOVIN Ezrin (p81) (Cytovillin) (Villin-2)
Length = 581
Score = 37.4 bits (85), Expect = 0.064
Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 4/88 (4%)
Frame = +1
Query: 694 IQSVEPVDQRTRESLQKSVQLAIEITT---KSQEASARHEADRIEQ-QAKGRLERQMITD 861
+Q E ++ + L +Q A+++ ++QE + R EADR+ +AK LERQ
Sbjct: 351 LQDYEEKTRKAEKELSDQIQRALKLEEERKRAQEEAGRLEADRLAALRAKEELERQAADQ 410
Query: 862 QAEAERTRTELLQLRAASAAVESTGQAK 945
E+ TEL + A A +E + K
Sbjct: 411 IKSQEQLATELAEYTAKIALLEEARRRK 438
>sp|Q8M867|NU1M_MURSU NADH-ubiquinone oxidoreductase chain 1 (NADH dehydrogenase subunit
1)
Length = 318
Score = 37.4 bits (85), Expect = 0.064
Identities = 24/83 (28%), Positives = 40/83 (48%)
Frame = -1
Query: 285 LIWTKHYQIGTIMNTSSLFFIIVYLHSSVVGNSICYNFSFVTLLFISRFLISFTSICQWI 106
L + Y +MN ++ + H+S+V NF+ TLLF + FL S ++
Sbjct: 222 LFFLAEYANIIMMNALTIILFLGAYHNSMVPELYTINFTIKTLLFTAFFLWIRASYPRFR 281
Query: 105 NT*TKQIFNGIWKNFLP*FFILC 37
Q+ + +WKNFLP ++C
Sbjct: 282 ---YDQLMHLLWKNFLPLTLVMC 301
>sp|Q9UL16|CCDCJ_HUMAN Coiled-coil domain-containing protein 19 (Nasopharyngeal
epithelium-specific protein 1)
Length = 386
Score = 35.0 bits (79), Expect = 0.32
Identities = 18/56 (32%), Positives = 28/56 (50%)
Frame = +1
Query: 712 VDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAER 879
+DQ QKS+Q E+ K +E R +EQ K + ER ++ +Q E E+
Sbjct: 90 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEK 145
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.131 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,867,400
Number of Sequences: 369166
Number of extensions: 2025804
Number of successful extensions: 6154
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5979
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6131
length of database: 68,354,980
effective HSP length: 111
effective length of database: 47,849,395
effective search space used: 10144071740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)