Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_D02
(787 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 187 3e-47
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 183 4e-46
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 182 7e-46
sp|O35186|CATK_RAT Cathepsin K precursor 176 5e-44
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 176 6e-44
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 176 8e-44
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 175 1e-43
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 175 1e-43
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 174 2e-43
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 174 2e-43
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 187 bits (475), Expect = 3e-47
Identities = 93/200 (46%), Positives = 127/200 (63%), Gaps = 5/200 (2%)
Frame = +3
Query: 33 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 212
P + LP S DWR+KG V+PV NQ+ +AF+A GALEGQ F T L LS+Q ++D
Sbjct: 109 PLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVD 168
Query: 213 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYV 389
CS GN GC GG +++A+ Y+ + G + +E YP+V + CKY + GF V
Sbjct: 169 CSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVV 228
Query: 390 SRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEES 569
+ GKE LM AV +GPIS A+DA +SF+ YK+GIY + CSS N++H VLV+GYG E
Sbjct: 229 APGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEG 288
Query: 570 GQS----FWIIKNSWGSKWG 617
S +W++KNSWG +WG
Sbjct: 289 ANSNNSKYWLVKNSWGPEWG 308
Score = 35.4 bits (80), Expect = 0.18
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVP 690
G GY+K+++D NN CGIA+ AS P
Sbjct: 308 GSNGYVKIAKDKNNHCGIATAASYP 332
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 183 bits (465), Expect = 4e-46
Identities = 82/198 (41%), Positives = 129/198 (65%), Gaps = 2/198 (1%)
Frame = +3
Query: 30 TPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQII 209
+P ++ LP S DWR KGAV+ V +Q + +AF++ GALEGQ+F + L LS+Q ++
Sbjct: 118 SPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLV 177
Query: 210 DCSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKY 386
DCS YGN+GC GG++ A+ Y+ D G + ++ YP+ + +C ++K GF
Sbjct: 178 DCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTD 237
Query: 387 VSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYG-E 563
+ +G E + AV +GP+S AIDAS SF+ Y G+Y++ C + N++H VLV+G+G +
Sbjct: 238 IPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTD 297
Query: 564 ESGQSFWIIKNSWGSKWG 617
ESG+ +W++KNSWG+ WG
Sbjct: 298 ESGEDYWLVKNSWGTTWG 315
Score = 33.1 bits (74), Expect = 0.89
Identities = 14/27 (51%), Positives = 20/27 (74%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVPLL 696
G KG++K+ R+ N CGIAS +S PL+
Sbjct: 315 GDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 182 bits (463), Expect = 7e-46
Identities = 83/197 (42%), Positives = 126/197 (63%), Gaps = 2/197 (1%)
Frame = +3
Query: 33 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 212
P ++ +P S DWRE GAV+ V +Q + +AF++ GALEGQ+F L LS+Q ++D
Sbjct: 117 PAHVTVPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVD 176
Query: 213 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYV 389
CS YGN+GC GG++ A+ Y+ D G + ++ YP+ G + +C ++K+ GF +
Sbjct: 177 CSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDI 236
Query: 390 SRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYG-EE 566
G E + AV +GP+S AIDAS SF+ Y G+Y++ C N++H VLV+GYG +E
Sbjct: 237 PEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDE 296
Query: 567 SGQSFWIIKNSWGSKWG 617
SG +W++KNSWG+ WG
Sbjct: 297 SGMDYWLVKNSWGTTWG 313
Score = 33.9 bits (76), Expect = 0.52
Identities = 13/25 (52%), Positives = 20/25 (80%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVP 690
G +GY+K++R+ NN CGIA+ +S P
Sbjct: 313 GEQGYIKMARNQNNQCGIATASSYP 337
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 176 bits (447), Expect = 5e-44
Identities = 92/203 (45%), Positives = 125/203 (61%), Gaps = 2/203 (0%)
Frame = +3
Query: 15 NDFITTPN-NIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEIL 191
ND + TP ++PDS D+R+KG V+PV NQ +AF++AGALEGQ T L L
Sbjct: 103 NDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLAL 162
Query: 192 SKQQIIDCSIYYGNSGCYGGILSKAYAYLADYGSELDED-YPFVGCNSNCKYDKSLATVK 368
S Q ++DC N GC GG ++ A+ Y+ G ED YP+VG + +C Y+ + K
Sbjct: 163 SPQNLVDC--VSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAK 220
Query: 369 PYGFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 548
G++ + G E L AV +GP+S +IDAS TSF+ Y G+Y D +C +NVNHAVLV
Sbjct: 221 CRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLV 280
Query: 549 IGYGEESGQSFWIIKNSWGSKWG 617
+GYG + G +WIIKNSWG WG
Sbjct: 281 VGYGTQKGNKYWIIKNSWGESWG 303
Score = 34.7 bits (78), Expect = 0.30
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVP 690
G KGY+ L+R+ NN CGI ++AS P
Sbjct: 303 GNKGYVLLARNKNNACGITNLASFP 327
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 176 bits (446), Expect = 6e-44
Identities = 92/196 (46%), Positives = 123/196 (62%), Gaps = 5/196 (2%)
Frame = +3
Query: 45 KLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIY 224
++P S DWREKG V+PV NQ +AF+A GALEGQ F T L LS+Q ++DCS
Sbjct: 113 EIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRA 172
Query: 225 YGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNS-NCKYDKSLATVKPYGFKYVSRG 398
GN GC GG++ A+ Y+ D G + +E YP++G ++ C Y + GF + +
Sbjct: 173 QGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ- 231
Query: 399 KEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEE---S 569
+E LM AV +GPIS AIDA SF+ YK+GIY D CSS +++H VLV+GYG E S
Sbjct: 232 REKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDS 291
Query: 570 GQSFWIIKNSWGSKWG 617
FWI+KNSWG +WG
Sbjct: 292 NNKFWIVKNSWGPEWG 307
Score = 35.4 bits (80), Expect = 0.18
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVP 690
G GY+K+++D NN CGIA+ AS P
Sbjct: 307 GWNGYVKMAKDQNNHCGIATAASYP 331
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 176 bits (445), Expect = 8e-44
Identities = 92/198 (46%), Positives = 124/198 (62%), Gaps = 6/198 (3%)
Frame = +3
Query: 42 IKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSI 221
+++P S DWREKG V+ V NQ +AF+A GALEGQ F T L LS+Q ++DCS
Sbjct: 112 LEVPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSR 171
Query: 222 YYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSN-CKYDKSLATVKPYGFKYVSR 395
GN GC GG++ A+ Y+ D G + +E YP++G +N C Y + GF + +
Sbjct: 172 PQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ 231
Query: 396 GKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESGQ 575
+E LM AV +GPIS AIDA +SF+ YK+GIY D CSS +++H VLV+GYG E
Sbjct: 232 -REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTD 290
Query: 576 S----FWIIKNSWGSKWG 617
S FWI+KNSWG +WG
Sbjct: 291 SNSSKFWIVKNSWGPEWG 308
Score = 34.3 bits (77), Expect = 0.40
Identities = 13/25 (52%), Positives = 19/25 (76%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVP 690
G GY+K+++D NN CGI++ AS P
Sbjct: 308 GWNGYVKMAKDQNNHCGISTAASYP 332
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 175 bits (444), Expect = 1e-43
Identities = 89/200 (44%), Positives = 126/200 (63%), Gaps = 5/200 (2%)
Frame = +3
Query: 33 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 212
P +K+P S DWREKG V+PV NQ +AF+A+G LEGQ F T L LS+Q ++D
Sbjct: 109 PLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVD 168
Query: 213 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYV 389
CS GN GC GG++ A+ Y+ + G + +E YP+ + +CKY A GF +
Sbjct: 169 CSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDI 228
Query: 390 SRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEES 569
+ ++A LM AV +GPIS A+DAS S + Y +GIY + +CSS N++H VL++GYG E
Sbjct: 229 PQQEKA-LMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEG 287
Query: 570 GQS----FWIIKNSWGSKWG 617
S +W++KNSWGS+WG
Sbjct: 288 TDSNKNKYWLVKNSWGSEWG 307
Score = 36.2 bits (82), Expect = 0.10
Identities = 13/27 (48%), Positives = 23/27 (85%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVPLL 696
GM+GY+K+++D +N CG+A+ AS P++
Sbjct: 307 GMEGYIKIAKDRDNHCGLATAASYPVV 333
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 175 bits (443), Expect = 1e-43
Identities = 81/194 (41%), Positives = 113/194 (58%)
Frame = +3
Query: 36 NNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDC 215
NN +PD DWRE G V+ V +Q N +AF+ G +EGQ +T S+QQ++DC
Sbjct: 104 NNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDC 163
Query: 216 SIYYGNSGCYGGILSKAYAYLADYGSELDEDYPFVGCNSNCKYDKSLATVKPYGFKYVSR 395
S +GN+GC GG++ AY YL +G E + YP+ C+Y+K L K G+ V
Sbjct: 164 SGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHS 223
Query: 396 GKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESGQ 575
G E +L N V P + A+D + F Y++GIY +CS VNHAVL +GYG + G
Sbjct: 224 GSEVELKNLVGARRPAAVAVDVE-SDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGT 282
Query: 576 SFWIIKNSWGSKWG 617
+WI+KNSWG+ WG
Sbjct: 283 DYWIVKNSWGTYWG 296
Score = 38.1 bits (87), Expect = 0.028
Identities = 13/29 (44%), Positives = 25/29 (86%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVPLLKK 702
G +GY++++R+ N+CGIAS+AS+P++ +
Sbjct: 296 GERGYIRMARNRGNMCGIASLASLPMVAR 324
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 174 bits (442), Expect = 2e-43
Identities = 90/194 (46%), Positives = 121/194 (62%), Gaps = 5/194 (2%)
Frame = +3
Query: 51 PDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYG 230
P S DWREKG V+PV NQ +AF+A GALEGQ F T L LS+Q ++DCS G
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 231 NSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYVSRGKEA 407
N GC GG++ A+ Y+ D G + +E YP+ +CKY+ + GF + + ++A
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA 234
Query: 408 DLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESGQS--- 578
LM AV +GPIS AIDA SF YK GIY + CSS +++H VLV+GYG ES +S
Sbjct: 235 -LMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 579 -FWIIKNSWGSKWG 617
+W++KNSWG +WG
Sbjct: 294 KYWLVKNSWGEEWG 307
Score = 35.8 bits (81), Expect = 0.14
Identities = 15/25 (60%), Positives = 19/25 (76%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVP 690
GM GY+K+++D N CGIAS AS P
Sbjct: 307 GMGGYVKMAKDRRNHCGIASAASYP 331
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 174 bits (441), Expect = 2e-43
Identities = 91/201 (45%), Positives = 123/201 (61%), Gaps = 6/201 (2%)
Frame = +3
Query: 33 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 212
P + +P S DW +KG V+PV NQ +AF+A GALEGQ F T L LS+Q ++D
Sbjct: 109 PLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVD 168
Query: 213 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSN-CKYDKSLATVKPYGFKY 386
CS GN GC GG++ A+ Y+ D G + +E YP++ ++N C Y + GF
Sbjct: 169 CSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVD 228
Query: 387 VSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEE 566
+ + +E LM AV +GPIS AIDA TSF+ YK+GIY D CS +++H VLV+GYG E
Sbjct: 229 IPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFE 287
Query: 567 SGQS----FWIIKNSWGSKWG 617
S FWI+KNSWG +WG
Sbjct: 288 GTDSNNNKFWIVKNSWGPEWG 308
Score = 35.4 bits (80), Expect = 0.18
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +1
Query: 616 GMKGYMKLSRDTNNLCGIASMASVP 690
G GY+K+++D NN CGIA+ AS P
Sbjct: 308 GWNGYVKMAKDQNNHCGIATAASYP 332
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,302,542
Number of Sequences: 369166
Number of extensions: 1666366
Number of successful extensions: 5272
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4648
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4864
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7405750800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)