Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_C18
(785 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 389 e-108
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 387 e-107
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 378 e-105
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 378 e-104
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 366 e-101
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 347 3e-95
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 335 8e-92
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 315 9e-86
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 311 2e-84
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 305 9e-83
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 389 bits (999), Expect = e-108
Identities = 170/248 (68%), Positives = 197/248 (79%)
Frame = +2
Query: 2 TFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCC 181
+FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSNG +SAED+LTCC
Sbjct: 83 SFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCC 142
Query: 182 GFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF 361
G CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTGE
Sbjct: 143 GGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 362 PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNY 541
TPKC K C+ GYS +Y EDK +G SSYSV +N++ IM EI NGPVE AFSVY+DF Y
Sbjct: 203 DTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLY 262
Query: 542 KSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIE 721
KSGVYQHV+G ++GGHAI+ILGWGVEN TPYWLV NSWN WGDNG+FKILRG D CGIE
Sbjct: 263 KSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIE 322
Query: 722 DEVVAGIP 745
E+VAG+P
Sbjct: 323 SEIVAGMP 330
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 387 bits (993), Expect = e-107
Identities = 170/249 (68%), Positives = 199/249 (79%)
Frame = +2
Query: 2 TFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCC 181
+FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N + +SAEDLLTCC
Sbjct: 83 SFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCC 142
Query: 182 GFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF 361
G CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTGE
Sbjct: 143 GSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 362 PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNY 541
TPKC K C+ GYS TY +DK YG +SYSV ++++ IM EI NGPVE AFSVY+DF Y
Sbjct: 203 DTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLY 262
Query: 542 KSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIE 721
KSGVYQHVTG M+GGHAI+ILGWGVEN TPYWLVANSWN WGDNG+FKILRG D CGIE
Sbjct: 263 KSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIE 322
Query: 722 DEVVAGIPK 748
EVVAGIP+
Sbjct: 323 SEVVAGIPR 331
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 378 bits (971), Expect = e-105
Identities = 163/249 (65%), Positives = 194/249 (77%)
Frame = +2
Query: 2 TFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCC 181
TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+NG +SAEDLLTCC
Sbjct: 83 TFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCC 142
Query: 182 GFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF 361
G +CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV G P CTGE
Sbjct: 143 GIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEG 202
Query: 362 PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNY 541
TP+C K+C+AGYS +Y EDK +G +SYSV ++ + IM EI NGPVE AF+V++DF Y
Sbjct: 203 DTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTY 262
Query: 542 KSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIE 721
KSGVY+H G M+GGHAI+ILGWGVEN PYWL ANSWN WGDNG+FKILRG + CGIE
Sbjct: 263 KSGVYKHEAGDMMGGHAIRILGWGVENGVPYWLAANSWNLDWGDNGFFKILRGENHCGIE 322
Query: 722 DEVVAGIPK 748
E+VAGIP+
Sbjct: 323 SEIVAGIPR 331
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 378 bits (970), Expect = e-104
Identities = 161/249 (64%), Positives = 194/249 (77%)
Frame = +2
Query: 2 TFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCC 181
+FDAR QW C +I +IRDQ +CGSCWAFGAVEA++DR CIH+NG +SAEDLLTCC
Sbjct: 83 SFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCC 142
Query: 182 GFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF 361
G +CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV G P CTGE
Sbjct: 143 GIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEG 202
Query: 362 PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNY 541
TPKC K C+AGYS +Y EDK YG +SYSV +++ IM EI NGPVE AF+V++DF Y
Sbjct: 203 DTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTY 262
Query: 542 KSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIE 721
KSGVY+H G ++GGHAI+ILGWG+EN PYWLVANSWN WGDNG+FKILRG + CGIE
Sbjct: 263 KSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIE 322
Query: 722 DEVVAGIPK 748
E+VAGIP+
Sbjct: 323 SEIVAGIPR 331
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 366 bits (939), Expect = e-101
Identities = 160/251 (63%), Positives = 189/251 (75%), Gaps = 1/251 (0%)
Frame = +2
Query: 2 TFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCC 181
TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N + +SAEDLL+CC
Sbjct: 83 TFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCC 142
Query: 182 GFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF 361
GF CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV G P CTGE
Sbjct: 143 GFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEG 202
Query: 362 -PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPN 538
TP+C + C+ GYS +Y EDK YG +SY V +++ IM EI NGPVE AF VY DF
Sbjct: 203 GETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLM 262
Query: 539 YKSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGI 718
YKSGVYQHV+G +GGHAI+ILGWGVEN TPYWL ANSWN WG G+FKILRG D CGI
Sbjct: 263 YKSGVYQHVSGEQVGGHAIRILGWGVENGTPYWLAANSWNTDWGITGFFKILRGEDHCGI 322
Query: 719 EDEVVAGIPKL 751
E E+VAG+P++
Sbjct: 323 ESEIVAGVPRM 333
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 347 bits (889), Expect = 3e-95
Identities = 152/249 (61%), Positives = 185/249 (74%), Gaps = 1/249 (0%)
Frame = +2
Query: 5 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 184
FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA DL++CC
Sbjct: 94 FDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALDLISCCK 153
Query: 185 FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNC-TGEF 361
CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH G YP C T +
Sbjct: 154 -DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGTKIY 212
Query: 362 PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNY 541
TP+CK+ CQ GY Y +DK YG SY+V +N++ I ++I+ GPVEAAF VY DF NY
Sbjct: 213 KTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVYEDFLNY 272
Query: 542 KSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIE 721
KSG+Y+HVTG ++GGHAI+I+GWGVE TPYWL+ANSWN WG+ G F+++RG DEC IE
Sbjct: 273 KSGIYRHVTGSIVGGHAIRIIGWGVEKRTPYWLIANSWNEDWGEKGLFRMVRGRDECSIE 332
Query: 722 DEVVAGIPK 748
+VVAG+ K
Sbjct: 333 SDVVAGLIK 341
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 335 bits (859), Expect = 8e-92
Identities = 148/246 (60%), Positives = 181/246 (73%), Gaps = 1/246 (0%)
Frame = +2
Query: 5 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 184
FD+R +WP CKSI IRDQS CGSCW+FGAVEA++DR CI S G Q +SA DLLTCC
Sbjct: 93 FDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCE 152
Query: 185 FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGE-F 361
CG GC GG AW YWV +G+VT H GC+ Y FPKC HH G YP C + +
Sbjct: 153 -SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIY 211
Query: 362 PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNY 541
TP+CK+ CQ Y Y +DK GKSSY+V ++++AI +EI+ GPVEA+F+VY DF NY
Sbjct: 212 NTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNY 271
Query: 542 KSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIE 721
KSG+Y+H+TG LGGHAI+I+GWGVEN TPYWL+ANSWN WG+NGYF+I+RG DEC IE
Sbjct: 272 KSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIE 331
Query: 722 DEVVAG 739
EV+AG
Sbjct: 332 SEVIAG 337
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 315 bits (807), Expect = 9e-86
Identities = 145/255 (56%), Positives = 183/255 (71%), Gaps = 5/255 (1%)
Frame = +2
Query: 2 TFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCC 181
+FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DLL+CC
Sbjct: 108 SFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDLLSCC 167
Query: 182 GFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV----IGPYPNC 349
CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH P P+
Sbjct: 168 K-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHD 226
Query: 350 TGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 526
+PTPKC+K C + Y+ KTY+EDK +G S+Y V + +AI +E++T+GP+E AF VY
Sbjct: 227 L--YPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYE 284
Query: 527 DFPNYKSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSD 706
DF NY GVY H G + GGHA+K++GWG+++ PYW VANSWN WG++G+F+ILRG D
Sbjct: 285 DFLNYDGGVYVHTGGKLGGGHAVKLIGWGIDDGIPYWTVANSWNTDWGEDGFFRILRGVD 344
Query: 707 ECGIEDEVVAGIPKL 751
ECGIE VV GIPKL
Sbjct: 345 ECGIESGVVGGIPKL 359
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 311 bits (796), Expect = 2e-84
Identities = 144/255 (56%), Positives = 174/255 (68%), Gaps = 6/255 (2%)
Frame = +2
Query: 5 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 184
FDAR QWP C SI IRDQS+CGSCWAF A EAI+DR CI SNG +S+EDLL+CC
Sbjct: 86 FDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVNTLLSSEDLLSCCT 145
Query: 185 --FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTG 355
F CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C V G +P C
Sbjct: 146 GMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPE 205
Query: 356 EF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 526
+ PTPKC +C + Y+ Y +DK +G ++Y+V + I EILTNGP+E AF+VY
Sbjct: 206 DTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAFTVYE 265
Query: 527 DFPNYKSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSD 706
DF Y +GVY H G LGGHA+KILGWGV+N TPYWLVANSWN WG+ GYF+I+RG +
Sbjct: 266 DFYQYTTGVYVHTAGASLGGHAVKILGWGVDNGTPYWLVANSWNVAWGEKGYFRIIRGLN 325
Query: 707 ECGIEDEVVAGIPKL 751
ECGIE VAGIP L
Sbjct: 326 ECGIEHSAVAGIPDL 340
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 305 bits (781), Expect = 9e-83
Identities = 142/250 (56%), Positives = 173/250 (69%)
Frame = +2
Query: 2 TFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCC 181
TFD+R QW +CKSI IRDQ+ CGSCWAFGA E I+DR CI + G Q P IS +DLL+CC
Sbjct: 88 TFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLLSCC 147
Query: 182 GFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF 361
G CG+GC GG+P A +W + G+VTGG+Y GC+ Y C+ NC E
Sbjct: 148 GSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTSG------NCP-ES 199
Query: 362 PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNY 541
TP C +CQ+GYS YA+DK +G S+Y+V N +I EI NGPVEAAFSVY DF Y
Sbjct: 200 KTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDFYKY 259
Query: 542 KSGVYQHVTGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIE 721
KSGVY+H G LGGHAIKI+GWG E+ +PYWLVANSW WG++G+FKI RG D+CGIE
Sbjct: 260 KSGVYKHTAGKYLGGHAIKIIGWGTESGSPYWLVANSWGVNWGESGFFKIYRGDDQCGIE 319
Query: 722 DEVVAGIPKL 751
VVAG K+
Sbjct: 320 SAVVAGKAKV 329
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,890,011
Number of Sequences: 369166
Number of extensions: 2245521
Number of successful extensions: 6792
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6088
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6549
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7405750800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)