Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_B09
(475 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 133 2e-31
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 129 3e-30
sp|Q63088|CATJ_RAT Cathepsin J precursor (Cathepsin L-relat... 121 9e-28
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 120 2e-27
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 120 2e-27
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 118 6e-27
sp|O35186|CATK_RAT Cathepsin K precursor 118 6e-27
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 118 6e-27
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 118 6e-27
sp|P55097|CATK_MOUSE Cathepsin K precursor 115 4e-26
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 133 bits (335), Expect = 2e-31
Identities = 58/107 (54%), Positives = 81/107 (75%), Gaps = 1/107 (0%)
Frame = +3
Query: 27 FIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGY 206
F D+ + +E ++A AV+ GP++ IDAS SFQFY EG+YN+P C + +H VL+VG+
Sbjct: 235 FTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGF 294
Query: 207 GESE-GEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 344
G E GEDYW+VKNSWG WGD G+IKM+R+ NQCGIAS++S+P++
Sbjct: 295 GTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 129 bits (324), Expect = 3e-30
Identities = 56/105 (53%), Positives = 77/105 (73%), Gaps = 1/105 (0%)
Frame = +3
Query: 27 FIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGY 206
F+D+ +E ++ AV+ GP++ IDAS SFQ Y EG+YN+P C + + +H VL+VGY
Sbjct: 233 FVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGY 292
Query: 207 GESE-GEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
G E G DYW+VKNSWG WG+ GYIKM R+ NNQCGIA+++S+P
Sbjct: 293 GTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYP 337
>sp|Q63088|CATJ_RAT Cathepsin J precursor (Cathepsin L-related protein)
Length = 236
Score = 121 bits (303), Expect = 9e-28
Identities = 55/113 (48%), Positives = 81/113 (71%), Gaps = 4/113 (3%)
Frame = +3
Query: 12 AHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAV 191
A++ F+++ N E+ + AV++ GP++A IDAS SF+FY G+Y++P CS NHAV
Sbjct: 122 ANITGFVNLPPN-ELYLWVAVASIGPVSAAIDASHDSFRFYSGGVYHEPNCSSYVVNHAV 180
Query: 192 LIVGYG----ESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
L+VGYG E++G +YW++KNSWG WG +G++K+ +D NN CGIAS SFP
Sbjct: 181 LVVGYGFEGNETDGNNYWLIKNSWGEEWGINGFMKIAKDRNNHCGIASQASFP 233
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 120 bits (301), Expect = 2e-27
Identities = 55/114 (48%), Positives = 75/114 (65%)
Frame = +3
Query: 3 SVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPN 182
SV A ++A +E + AV GP++ IDA+ SFQFY G+Y +P+CS + +
Sbjct: 210 SVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLD 269
Query: 183 HAVLIVGYGESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 344
HAVL VGYG G+D+W+VKNSW WGD GYIKM R+ NN CGIA+ S+P++
Sbjct: 270 HAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 120 bits (300), Expect = 2e-27
Identities = 54/102 (52%), Positives = 69/102 (67%)
Frame = +3
Query: 33 DVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGE 212
++ NE + AV+ GP++ IDASL SFQFY +G+Y D CS + NHAVL VGYG
Sbjct: 226 EIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGI 285
Query: 213 SEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
+G +WI+KNSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 286 QKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFP 327
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 118 bits (296), Expect = 6e-27
Identities = 53/102 (51%), Positives = 70/102 (68%)
Frame = +3
Query: 33 DVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGE 212
++ NE + AV+ GP++ IDASL SFQFY +G+Y D +C+ + NHAVL VGYG
Sbjct: 226 EIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGI 285
Query: 213 SEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
+G +WI+KNSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 286 QKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 118 bits (296), Expect = 6e-27
Identities = 51/102 (50%), Positives = 68/102 (66%)
Frame = +3
Query: 33 DVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGE 212
++ NE + AV+ GP++ IDASL SFQFY G+Y D C + + NHAVL+VGYG
Sbjct: 226 EIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGT 285
Query: 213 SEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
+G YWI+KNSWG WG+ GY+ + R+ NN CGI + SFP
Sbjct: 286 QKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFP 327
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 118 bits (296), Expect = 6e-27
Identities = 53/102 (51%), Positives = 70/102 (68%)
Frame = +3
Query: 33 DVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGE 212
++ NE + AV+ GP++ IDASL SFQFY +G+Y D +C+ + NHAVL VGYG
Sbjct: 226 EIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGI 285
Query: 213 SEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
+G +WI+KNSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 286 QKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 118 bits (296), Expect = 6e-27
Identities = 53/102 (51%), Positives = 70/102 (68%)
Frame = +3
Query: 33 DVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGE 212
++ NE + AV+ GP++ IDASL SFQFY +G+Y D C+ + NHAVL VGYG
Sbjct: 227 EIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGI 286
Query: 213 SEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
+G+ +WI+KNSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 287 QKGKKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 328
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 115 bits (289), Expect = 4e-26
Identities = 50/102 (49%), Positives = 67/102 (65%)
Frame = +3
Query: 33 DVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGE 212
++ NE + AV+ GP++ IDASL SFQFY G+Y D C + + NHAVL+VGYG
Sbjct: 226 EIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGT 285
Query: 213 SEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 338
+G +WI+KNSWG WG+ GY + R+ NN CGI + SFP
Sbjct: 286 QKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFP 327
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,273,939
Number of Sequences: 369166
Number of extensions: 666234
Number of successful extensions: 2114
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1958
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1980
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2783017720
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)