Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_O06
(605 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q04671|P_HUMAN P protein (Melanocyte-specific transporte... 221 1e-57
sp|Q8MIQ9|P_PIG P protein (Melanocyte-specific transporter ... 219 4e-57
sp|Q62052|P_MOUSE P protein (Melanocyte-specific transporte... 215 8e-56
sp|P74635|Y753_SYNY3 Hypothetical protein slr0753 92 1e-18
sp|P46838|AG45_MYCLE 46 kDa membrane protein 86 6e-17
sp|P0A607|Y2703_MYCBO Hypothetical protein Mb2703 >gi|61250... 82 1e-15
sp|O07187|Y2685_MYCTU Hypothetical protein Rv2685/MT2759 74 4e-13
sp|Q57486|Y608_HAEIN Hypothetical protein HI0608 47 3e-05
sp|P72958|Y640_SYNY3 Hypothetical protein sll0640 45 1e-04
sp|Q21339|NAD3_CAEEL Sodium-dependent high-affinity dicarbo... 44 3e-04
>sp|Q04671|P_HUMAN P protein (Melanocyte-specific transporter protein) (Pink-eyed
dilution protein homolog)
Length = 838
Score = 221 bits (563), Expect = 1e-57
Identities = 102/185 (55%), Positives = 140/185 (75%), Gaps = 4/185 (2%)
Frame = +1
Query: 4 AFFGAIWIIVLSDFANFEVILDKVEWATXXXXXXXXXXMKEIEELHLITFIGKEISTLIL 183
A GAIW+++L+D +FE+IL +VEWAT M+ + LHLI ++G++ + LI
Sbjct: 654 AILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIK 713
Query: 184 MVPENHRLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDI----LPLVWALA 351
MVPE RL+ +I++V+W+SAL SS IDNIPFT MIP+++ L + ++ PL++ALA
Sbjct: 714 MVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALA 773
Query: 352 FGACLGGNGTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFIAMNYLLVCHV 531
FGACLGGNGTLIGASANVV AGIA+QHGY FSFM+FF++GFPMM+++ + M YLLV HV
Sbjct: 774 FGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHV 833
Query: 532 LIGWN 546
++GWN
Sbjct: 834 VVGWN 838
Score = 39.3 bits (90), Expect = 0.008
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Frame = +1
Query: 202 RLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDILP--LVWALAFGACLGGN 375
R+ II++ I+A++S+F+DN+ P+ I L +++ P ++ A +GG
Sbjct: 421 RVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGA 480
Query: 376 GTLIGASANVVVAGIAQQHGYSFSFMDF---FKIGFPMMLLTTFIAMNYL 516
T IG NV++ + F F IG ++LL F + L
Sbjct: 481 ATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLL 530
>sp|Q8MIQ9|P_PIG P protein (Melanocyte-specific transporter protein) (Pink-eyed
dilution protein homolog)
Length = 845
Score = 219 bits (558), Expect = 4e-57
Identities = 103/185 (55%), Positives = 138/185 (74%), Gaps = 4/185 (2%)
Frame = +1
Query: 4 AFFGAIWIIVLSDFANFEVILDKVEWATXXXXXXXXXXMKEIEELHLITFIGKEISTLIL 183
A GAIW+++L+D +FE+IL +VEWAT M+ + LHLI ++G++ + LI
Sbjct: 661 AILGAIWLLILADIHDFEIILHRVEWATLLFFAALFILMEALAHLHLIEYVGEQTALLIK 720
Query: 184 MVPENHRLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDIL----PLVWALA 351
MVPE+ RL +IIVV+W+SA+ SS IDNIPFT MIP+++ L +I PL++ALA
Sbjct: 721 MVPEDQRLAAAIIVVVWVSAIASSLIDNIPFTATMIPVLLNLSRDPEISLPAPPLMYALA 780
Query: 352 FGACLGGNGTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFIAMNYLLVCHV 531
GACLGGNGTLIGASANVV AGIA+QHGY FSFM+FF++GFPMM+++ + M YLLV HV
Sbjct: 781 LGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCMVGMCYLLVAHV 840
Query: 532 LIGWN 546
++GWN
Sbjct: 841 VMGWN 845
Score = 37.0 bits (84), Expect = 0.039
Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Frame = +1
Query: 202 RLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDILP--LVWALAFGACLGGN 375
R+ II++ I+A++S+F+DN+ P+ I L +++ P ++ A +GG
Sbjct: 428 RVWAMIIMLCLIAAVLSAFLDNVTTALLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGA 487
Query: 376 GTLIGASANVVVAGIAQQHGYSFSFMDF 459
T IG NV++ + F F
Sbjct: 488 ATAIGDPPNVIIVSNQELRKMGLDFAGF 515
>sp|Q62052|P_MOUSE P protein (Melanocyte-specific transporter protein) (Pink-eyed
dilution protein)
Length = 833
Score = 215 bits (547), Expect = 8e-56
Identities = 97/185 (52%), Positives = 137/185 (74%), Gaps = 4/185 (2%)
Frame = +1
Query: 4 AFFGAIWIIVLSDFANFEVILDKVEWATXXXXXXXXXXMKEIEELHLITFIGKEISTLIL 183
A GAIW+++L+D +FE+IL +VEWAT M+ + LHL+ ++G++ + LI
Sbjct: 649 AILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALTHLHLVEYVGEQTALLIK 708
Query: 184 MVPENHRLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDI----LPLVWALA 351
MVPE+ R +I++++W+SAL SS IDNIPFT MIP+++ L +I LPL++ALA
Sbjct: 709 MVPEDQRFAAAIVLIVWVSALASSLIDNIPFTATMIPVLLNLSQDPEISLPALPLMYALA 768
Query: 352 FGACLGGNGTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFIAMNYLLVCHV 531
GACLGGNGTLIGAS NVV AGIA++HGY FSFM+FF++GFP+ML++ I M YLL+ H+
Sbjct: 769 LGACLGGNGTLIGASTNVVCAGIAEKHGYGFSFMEFFRLGFPVMLMSCTIGMCYLLIAHI 828
Query: 532 LIGWN 546
++GWN
Sbjct: 829 VVGWN 833
Score = 37.0 bits (84), Expect = 0.039
Identities = 26/110 (23%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Frame = +1
Query: 202 RLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDILP--LVWALAFGACLGGN 375
R+ I ++ ++A++S+F+DN+ P+ I L +++ P ++ A +GG
Sbjct: 416 RVWAMIFMLCLMAAILSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGA 475
Query: 376 GTLIGASANVVVAGIAQQHGYSFSFMDF---FKIGFPMMLLTTFIAMNYL 516
T IG NV++ + F F +G ++LL +F + L
Sbjct: 476 ATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFLGICLVLLVSFPLLRLL 525
>sp|P74635|Y753_SYNY3 Hypothetical protein slr0753
Length = 449
Score = 92.0 bits (227), Expect = 1e-18
Identities = 58/188 (30%), Positives = 95/188 (50%), Gaps = 21/188 (11%)
Frame = +1
Query: 4 AFFGAIWIIVLSDFANFEV---ILDKVEWATXXXXXXXXXXMKEIEELHLITFIGKEIST 174
A GA ++L+ + + IL V+W+T + +E+ + + +
Sbjct: 254 ALMGACLALLLASQSKIDTVHNILRDVDWSTLIFFMSIFVIIGSLEKTGVTASLAQ---- 309
Query: 175 LILMVPENHRLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIE------------LGNH 318
+L V + IV+++ L+SS + NIP AM+P++ + LG +
Sbjct: 310 -LLAVVVGQNIAFGAIVLVFTVGLLSSVVPNIPLVVAMVPLLKQYVVNIGFAGPEILGAN 368
Query: 319 MD------ILPLVWALAFGACLGGNGTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPM 480
D +LPL +A+ FGA LGGNGTL+GAS+N+V AGI++QHG SF F + G P+
Sbjct: 369 FDGQLPAEVLPLFYAMMFGATLGGNGTLVGASSNIVAAGISEQHGRPISFHRFLRYGLPV 428
Query: 481 MLLTTFIA 504
M + +A
Sbjct: 429 MAVQLVVA 436
>sp|P46838|AG45_MYCLE 46 kDa membrane protein
Length = 429
Score = 86.3 bits (212), Expect = 6e-17
Identities = 61/181 (33%), Positives = 96/181 (53%), Gaps = 6/181 (3%)
Frame = +1
Query: 13 GAIWIIVLSDFANFEVILDKVEWATXXXXXXXXXXMKEIEELHLITFIGKEISTLILMVP 192
GA +IV+S + L V+W T + + + ++ + + +TL
Sbjct: 256 GAGILIVISKLERSDY-LSSVKWETLLFFAGLFIMVGALVKTDVVNQLARATTTLT---- 310
Query: 193 ENHRLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIEL------GNHMDILPLVWALAF 354
H LL ++++ L +S LVSS IDNIP+ M PI+ EL +H DIL WALA
Sbjct: 311 GGHELL-TVVLTLGVSTLVSSIIDNIPYVATMTPIVSELVASMPDQSHTDIL--WWALAL 367
Query: 355 GACLGGNGTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFIAMNYLLVCHVL 534
GA GGN T +GASANVV+ IA+ G SF +F + G + +++ +A YL + +++
Sbjct: 368 GADFGGNLTAVGASANVVMLEIAKSAGTPISFWEFTRKGIAVTVISIALAGIYLWLRYLV 427
Query: 535 I 537
+
Sbjct: 428 M 428
Score = 44.3 bits (103), Expect = 2e-04
Identities = 28/102 (27%), Positives = 54/102 (52%), Gaps = 2/102 (1%)
Frame = +1
Query: 202 RLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDI--LPLVWALAFGACLGGN 375
R+L+ +++V+ AL S+ +DN+ + P+ + + + I P + A F + +GG
Sbjct: 94 RILLLLVLVM---ALGSALLDNVTTVLLIAPVTLLVCERLTINAAPFLMAEVFASNIGGA 150
Query: 376 GTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFI 501
TL+G N+++A A FSF DF P++++ T +
Sbjct: 151 ATLVGDPPNIIIASRA-----GFSFNDFLIHLTPIVIIVTVV 187
>sp|P0A607|Y2703_MYCBO Hypothetical protein Mb2703
sp|P0A606|Y2684_MYCTU Hypothetical protein Rv2684/MT2758
Length = 429
Score = 81.6 bits (200), Expect = 1e-15
Identities = 57/175 (32%), Positives = 86/175 (49%), Gaps = 4/175 (2%)
Frame = +1
Query: 4 AFFGAIWIIVLSDFANFEVILDKVEWATXXXXXXXXXXMKEIEELHLITFIGKEISTLIL 183
A GA +IV+S E L VEW T + + + ++ + + + L
Sbjct: 252 ALLGAGMLIVVSGLTRSEY-LSSVEWDTLLFFAGLFIMVGALVKTGVVNDLARAATQLT- 309
Query: 184 MVPENHRLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDILPLV----WALA 351
++ + ++L +SA +S IDNIP+ M P++ EL M P WALA
Sbjct: 310 ----GGNIVATAFLILGVSAPISGIIDNIPYVATMTPLVAELVAVMGGQPSTDTPWWALA 365
Query: 352 FGACLGGNGTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFIAMNYL 516
GA GGN T IGASANVV+ GIA++ G SF +F + G + ++ +A YL
Sbjct: 366 LGADFGGNLTAIGASANVVMLGIARRAGAPISFWEFTRKGAVVTAVSIALAAIYL 420
Score = 40.4 bits (93), Expect = 0.004
Identities = 27/97 (27%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Frame = +1
Query: 205 LLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDI--LPLVWALAFGACLGGNG 378
L + I++VL +SAL S+ +DN+ + P+ + + + ++I + A F + +GG
Sbjct: 93 LRIMILLVL-VSALASALLDNVTTVLLIAPVTLLVCDRLNINTTSFLMAEVFASNIGGAA 151
Query: 379 TLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLL 489
TL+G N++VA A +F DF P++++
Sbjct: 152 TLVGDPPNIIVASRA-----GLTFNDFMLHLTPLVVI 183
>sp|O07187|Y2685_MYCTU Hypothetical protein Rv2685/MT2759
Length = 428
Score = 73.6 bits (179), Expect = 4e-13
Identities = 44/115 (38%), Positives = 65/115 (56%), Gaps = 4/115 (3%)
Frame = +1
Query: 208 LVSIIVVLWISALVSSFIDNIPFTTAMIPIIIEL----GNHMDILPLVWALAFGACLGGN 375
L+++ ++L ISA VS IDNIP+ M PI+ EL H+ WALA A GGN
Sbjct: 314 LLTVGLILGISAPVSGIIDNIPYVATMTPIVTELVAAMPGHVHPDTFWWALALSADFGGN 373
Query: 376 GTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFIAMNYLLVCHVLIG 540
T + ASANVV+ GIA++ G SF F + G + ++ ++ YL + + + G
Sbjct: 374 LTAVAASANVVMLGIARRSGTPISFWKFTRKGAVVTAVSLVLSAVYLWLRYFVFG 428
Score = 38.9 bits (89), Expect = 0.010
Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 2/107 (1%)
Frame = +1
Query: 205 LLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMDI--LPLVWALAFGACLGGNG 378
L + I++VL ++AL S+ +DN+ + P+ + + + + + P + A F + +GG
Sbjct: 93 LRIMILLVL-VTALGSALLDNVTTVLLIAPVTLLVCDRLGVNSTPFLVAEVFASNVGGAA 151
Query: 379 TLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMMLLTTFIAMNYLL 519
TL+G N+++A A +F DF I +L IA+ LL
Sbjct: 152 TLVGDPPNIIIASRA-----GLTFNDFL-IHMAPAVLVVMIALIGLL 192
>sp|Q57486|Y608_HAEIN Hypothetical protein HI0608
Length = 461
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/122 (24%), Positives = 61/122 (50%), Gaps = 9/122 (7%)
Frame = +1
Query: 181 LMVPENHRLLVSIIVVLWISALVSSFIDNIPFTTAMIPIIIELGNHMD-------ILPLV 339
+M L +++I + I+A +S ++ N M+P+ + + + +D + ++
Sbjct: 114 IMALARGNLFIAVIYLFLITAFLSMWMSNTATAAMMLPLAMGILSQLDREKDHNTYVFVL 173
Query: 340 WALAFGACLGGNGTLIGASANVVVAGIAQQHGYSFSFMDFFKIGFPMM--LLTTFIAMNY 513
+A+ A +GG GTL+G+ N +VA + +F D+ G P+M LL I + Y
Sbjct: 174 LGIAYSASIGGMGTLVGSPPNAIVAS-----NLNLTFSDWLWYGLPIMIILLPLMIGILY 228
Query: 514 LL 519
++
Sbjct: 229 II 230
>sp|P72958|Y640_SYNY3 Hypothetical protein sll0640
Length = 612
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 3/94 (3%)
Frame = +1
Query: 250 SSFIDNIPFTTAMIPIIIELGNH--MDILPLVWALAFGACLGGNGTLIGASANVVVAGIA 423
S+F++N +PII E + + L+ L++ LGG TL+G S N++ +G+A
Sbjct: 114 SAFLNNTAIVAIFLPIIEEWARQRQISVSKLLIPLSYATILGGMITLLGTSTNILASGLA 173
Query: 424 QQ-HGYSFSFMDFFKIGFPMMLLTTFIAMNYLLV 522
++ G FS F +G LLT + + Y+++
Sbjct: 174 EKLTGQGFSIFQFTPLG----LLTFSVGLIYIVL 203
>sp|Q21339|NAD3_CAEEL Sodium-dependent high-affinity dicarboxylate transporter 3
(Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (ceNaDC3)
Length = 566
Score = 43.9 bits (102), Expect = 3e-04
Identities = 32/114 (28%), Positives = 54/114 (47%), Gaps = 24/114 (21%)
Frame = +1
Query: 235 ISALVSSFIDNIPFTTAMIPI---IIE-----------------LGNHMDILPLVWALAF 354
++AL+SSFI N T M+PI +++ LG LV ++ F
Sbjct: 170 VTALLSSFISNTATTAMMVPIGQSVVQQLISSFQHHPTNGERGRLGCKKMATGLVLSICF 229
Query: 355 GACLGGNGTLIGASANVVVAG----IAQQHGYSFSFMDFFKIGFPMMLLTTFIA 504
A +GG GT G +N+V+ G + + S +++ + +P+MLL F+A
Sbjct: 230 AANIGGTGTATGTPSNLVMLGQLSALFPKVDGSLNYVTWIFFAYPLMLLCLFVA 283
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,585,431
Number of Sequences: 369166
Number of extensions: 1412108
Number of successful extensions: 3774
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3657
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3761
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4699949280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)