Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_N13
(651 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P05091|ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial... 297 2e-80
sp|P81178|ALDH2_MESAU Aldehyde dehydrogenase, mitochondrial... 296 3e-80
sp|P11884|ALDH2_RAT Aldehyde dehydrogenase, mitochondrial p... 296 4e-80
sp|P47738|ALDH2_MOUSE Aldehyde dehydrogenase, mitochondrial... 294 1e-79
sp|P12762|ALDH2_HORSE Aldehyde dehydrogenase, mitochondrial... 291 8e-79
sp|P20000|ALDH2_BOVIN Aldehyde dehydrogenase, mitochondrial... 289 5e-78
sp|Q63639|AL1A2_RAT Retinal dehydrogenase 2 (RalDH2) (RALDH... 283 4e-76
sp|P27463|AL1A1_CHICK Retinal dehydrogenase 1 (RalDH1) (RAL... 283 4e-76
sp|Q62148|AL1A2_MOUSE Retinal dehydrogenase 2 (RalDH2) (RAL... 282 5e-76
sp|O93344|AL1A2_CHICK Retinal dehydrogenase 2 (RalDH2) (RAL... 282 5e-76
>sp|P05091|ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial precursor (ALDH class 2)
(ALDHI) (ALDH-E2)
Length = 517
Score = 297 bits (760), Expect = 2e-80
Identities = 138/211 (65%), Positives = 171/211 (81%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDD-VDQGPQVDKDQ 179
+HFALFFN GQCCCAGSR +V+E IYD+FVE VA AK+++VGNPFD +QGPQVD+ Q
Sbjct: 307 AHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQ 366
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
KI+ IN+GK EGA+L GG D+GYF++PT+F V D M IAKEEIFGPVMQI+K
Sbjct: 367 FKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILK 426
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK I+EV+ RANN+ YGLAA+VFTKD++K+ ++ Q+L+AGTVW+NCYD F A +PFGGYK
Sbjct: 427 FKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYK 486
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRELGEYGL Y+EVK VT+KVP K+S
Sbjct: 487 MSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 517
>sp|P81178|ALDH2_MESAU Aldehyde dehydrogenase, mitochondrial (ALDH class 2) (ALDH1)
(ALDH-E2)
Length = 500
Score = 296 bits (758), Expect = 3e-80
Identities = 138/211 (65%), Positives = 171/211 (81%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDD-VDQGPQVDKDQ 179
+HFALFFN GQCCCAGSR +V+E +YD+FVE VA AK+++VGNPFD +QGPQVD+ Q
Sbjct: 290 AHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQ 349
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
KI+ I SG+ EGA+L GG D+GYF++PT+F V D M IAKEEIFGPVMQI+K
Sbjct: 350 FKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILK 409
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK I+EV+ RANN++YGLAA+VFTKD++K+ ++ Q+L+AGTVWINCYD F A +PFGGYK
Sbjct: 410 FKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYK 469
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRELGEYGL Y+EVK VTIKVP K+S
Sbjct: 470 MSGSGRELGEYGLQAYTEVKTVTIKVPQKNS 500
>sp|P11884|ALDH2_RAT Aldehyde dehydrogenase, mitochondrial precursor (ALDH class 2)
(ALDH1) (ALDH-E2)
Length = 519
Score = 296 bits (757), Expect = 4e-80
Identities = 137/211 (64%), Positives = 171/211 (81%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDD-VDQGPQVDKDQ 179
+HFALFFN GQCCCAGSR +V+E +YD+FVE VA AK+++VGNPFD +QGPQVD+ Q
Sbjct: 309 AHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQ 368
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
KI+ I SG+ EGA+L GG D+GYF++PT+F V D M IAKEEIFGPVMQI+K
Sbjct: 369 FKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILK 428
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK I+EV+ RANN++YGLAA+VFTKD++K+ ++ Q+L+AGTVWINCYD F A +PFGGYK
Sbjct: 429 FKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYK 488
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRELGEYGL Y+EVK VT+KVP K+S
Sbjct: 489 MSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 519
>sp|P47738|ALDH2_MOUSE Aldehyde dehydrogenase, mitochondrial precursor (ALDH class 2)
(AHD-M1) (ALDHI) (ALDH-E2)
Length = 519
Score = 294 bits (753), Expect = 1e-79
Identities = 136/211 (64%), Positives = 171/211 (81%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDD-VDQGPQVDKDQ 179
+HFALFFN GQCCCAGSR +V+E +YD+FVE VA AK+++VGNPFD +QGPQVD+ Q
Sbjct: 309 AHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQ 368
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
KI+ I SG+ EGA+L GG D+GYF++PT+F V D M IAKEEIFGPVMQI+K
Sbjct: 369 FKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILK 428
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK I+EV+ RAN+++YGLAA+VFTKD++K+ ++ Q+L+AGTVWINCYD F A +PFGGYK
Sbjct: 429 FKTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYK 488
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRELGEYGL Y+EVK VT+KVP K+S
Sbjct: 489 MSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 519
>sp|P12762|ALDH2_HORSE Aldehyde dehydrogenase, mitochondrial (ALDH class 2) (ALDHI)
(ALDH-E2)
Length = 500
Score = 291 bits (746), Expect = 8e-79
Identities = 137/211 (64%), Positives = 170/211 (80%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDD-VDQGPQVDKDQ 179
+HFALFFN GQCC AGSR +V+E +Y +FVE VA AK+++VGNPFD +QGPQVD+ Q
Sbjct: 290 AHFALFFNQGQCCGAGSRTFVQEDVYAEFVERSVARAKSRVVGNPFDSQTEQGPQVDETQ 349
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
NK++ I SGK EGA+L GG D+GYF++PT+F V D M IAKEEIFGPVMQI+K
Sbjct: 350 FNKVLGYIKSGKEEGAKLLCGGGAAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILK 409
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK I+EV+ RANN++YGLAA+VFTKD++K+ ++ Q+L+AGTVWINCYD F A +PFGGYK
Sbjct: 410 FKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYK 469
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRELGEYGL Y+EVK VTIKVP K+S
Sbjct: 470 MSGNGRELGEYGLQAYTEVKTVTIKVPQKNS 500
>sp|P20000|ALDH2_BOVIN Aldehyde dehydrogenase, mitochondrial precursor (ALDH class 2)
(ALDHI) (ALDH-E2)
Length = 520
Score = 289 bits (739), Expect = 5e-78
Identities = 132/211 (62%), Positives = 170/211 (80%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDD-VDQGPQVDKDQ 179
+HFALFFN GQCCCAGSR +V+E IY +FVE VA AK+++VGNPFD +QGPQVD+ Q
Sbjct: 310 AHFALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQ 369
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
K++ I SGK EG +L GG D+GYF++PT+F + D M IAKEEIFGPVMQI+K
Sbjct: 370 FKKVLGYIKSGKEEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILK 429
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK+++EV+ RANN++YGLAA+VFTKD++K+ ++ Q+L+AGTVW+NCYD F A +PFGGYK
Sbjct: 430 FKSMEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYK 489
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRELGEYGL Y+EVK VT++VP K+S
Sbjct: 490 LSGSGRELGEYGLQAYTEVKTVTVRVPQKNS 520
>sp|Q63639|AL1A2_RAT Retinal dehydrogenase 2 (RalDH2) (RALDH 2) (RALDH(II))
(Retinaldehyde-specific dehydrogenase type 2) (Aldehyde
dehydrogenase family 1 member A2)
Length = 499
Score = 283 bits (723), Expect = 4e-76
Identities = 131/211 (62%), Positives = 172/211 (81%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDDV-DQGPQVDKDQ 179
+H +FFN GQCC AGSRI+VEE IY++FV+ V AK +IVG+PFD +QGPQ+DK Q
Sbjct: 289 AHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQ 348
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
NKI++LI SG +EGA+L GGK LG KG+F+EPT+FS V D+MRIAKEEIFGPV +I++
Sbjct: 349 YNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILR 408
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK +DEVIERANN+++GL A+VFT DI K++ + +++AGTVWINCY+A +A +PFGG+K
Sbjct: 409 FKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFK 468
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRE+GE+GL YSEVK VT+K+P K+S
Sbjct: 469 MSGNGREMGEFGLREYSEVKTVTVKIPQKNS 499
>sp|P27463|AL1A1_CHICK Retinal dehydrogenase 1 (RalDH1) (RALDH 1) (Aldehyde dehydrogenase
family 1 member A1) (Aldehyde dehydrogenase, cytosolic)
(ALHDII) (ALDH-E1)
Length = 509
Score = 283 bits (723), Expect = 4e-76
Identities = 135/211 (63%), Positives = 164/211 (77%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPF-DDVDQGPQVDKDQ 179
+H LF++ GQCC AGSRI+VEE IYD+FV + AK +G+P V QGPQ+DK+Q
Sbjct: 299 AHIGLFYHQGQCCIAGSRIFVEEPIYDEFVRRSIERAKKYTLGDPLLPGVQQGPQIDKEQ 358
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
KI+DLI SGK EGA+L GG G+KGYF++PT+FS V D+MRIAKEEIFGPV QIMK
Sbjct: 359 FQKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMK 418
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK IDEVI+RANN YGLAA+VFTKDI+K++ +L+AGTVW+NCY AF A PFGG+K
Sbjct: 419 FKTIDEVIKRANNTTYGLAAAVFTKDIDKALTFASALQAGTVWVNCYSAFSAQCPFGGFK 478
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRELGEYGL Y+EVK VTIK+P K+S
Sbjct: 479 MSGNGRELGEYGLQEYTEVKTVTIKIPQKNS 509
>sp|Q62148|AL1A2_MOUSE Retinal dehydrogenase 2 (RalDH2) (RALDH 2) (RALDH(II))
(Retinaldehyde-specific dehydrogenase type 2) (Aldehyde
dehydrogenase family 1 member A2)
Length = 499
Score = 282 bits (722), Expect = 5e-76
Identities = 130/211 (61%), Positives = 172/211 (81%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDDV-DQGPQVDKDQ 179
+H +FFN GQCC AGSRI+VEE IY++FV+ V AK +IVG+PFD +QGPQ+DK Q
Sbjct: 289 AHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQ 348
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
NK+++LI SG +EGA+L GGK LG KG+F+EPT+FS V D+MRIAKEEIFGPV +I++
Sbjct: 349 YNKVLELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILR 408
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK +DEVIERANN+++GL A+VFT DI K++ + +++AGTVWINCY+A +A +PFGG+K
Sbjct: 409 FKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFK 468
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRE+GE+GL YSEVK VT+K+P K+S
Sbjct: 469 MSGNGREMGEFGLREYSEVKTVTVKIPQKNS 499
>sp|O93344|AL1A2_CHICK Retinal dehydrogenase 2 (RalDH2) (RALDH 2) (RALDH(II))
(Retinaldehyde-specific dehydrogenase type 2) (Aldehyde
dehydrogenase family 1 member A2)
Length = 499
Score = 282 bits (722), Expect = 5e-76
Identities = 132/211 (62%), Positives = 170/211 (80%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 SHFALFFNMGQCCCAGSRIYVEEKIYDKFVEAMVAEAKTKIVGNPFDDV-DQGPQVDKDQ 179
+H +FFN GQCC AGSRIYVEE IY++FV V AK ++VG+PFD +QGPQ+DK Q
Sbjct: 289 AHQGVFFNQGQCCTAGSRIYVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQ 348
Query: 180 LNKIIDLINSGKSEGAQLCTGGKQLGDKGYFVEPTIFSKVNDNMRIAKEEIFGPVMQIMK 359
NKI++LI SG +EGA+L GGK LG KG+F+EPT+FS V D+MRIAKEEIFGPV +I++
Sbjct: 349 YNKILELIQSGITEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILR 408
Query: 360 FKNIDEVIERANNNEYGLAASVFTKDIEKSMHIMQSLRAGTVWINCYDAFDAAAPFGGYK 539
FK +DEVIERANN+++GL A+VFT DI K++ + +++AGTVWINCY+A +A +PFGG+K
Sbjct: 409 FKTVDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFK 468
Query: 540 ASGVGRELGEYGLNNYSEVKMVTIKVPSKSS 632
SG GRE+GE GL YSEVK VTIK+P K+S
Sbjct: 469 MSGNGREMGESGLREYSEVKTVTIKIPQKNS 499
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,155,665
Number of Sequences: 369166
Number of extensions: 1369868
Number of successful extensions: 4516
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4163
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4241
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5365037700
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)