Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_N10
(731 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6PE01|WDR57_MOUSE WD-repeat protein 57 51 4e-06
sp|Q96DI7|WDR57_HUMAN WD-repeat protein 57 (Prp8-binding pr... 50 5e-06
sp|Q5RF51|WDR57_PONPY WD-repeat protein 57 50 5e-06
sp|Q7ZUV2|KTNB1_BRARE Katanin p80 WD40-containing subunit B... 43 8e-04
sp|P90917|RBA1_CAEEL Trp-Asp repeats containing protein RBA-1 43 0.001
sp|Q9EPV5|APAF_RAT Apoptotic protease-activating factor 1 (... 43 0.001
sp|Q58D20|NLE1_BOVIN Notchless homolog 1 43 0.001
sp|Q20168|COPB2_CAEEL Probable coatomer beta' subunit (Beta... 42 0.001
sp|Q8VEJ4|NLE1_MOUSE Notchless homolog 1 42 0.002
sp|P47025|YJL2_YEAST Hypothetical 80.0 kDa Trp-Asp repeats ... 42 0.002
>sp|Q6PE01|WDR57_MOUSE WD-repeat protein 57
Length = 358
Score = 50.8 bits (120), Expect = 4e-06
Identities = 40/161 (24%), Positives = 76/161 (47%), Gaps = 1/161 (0%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPE-IATASRDGMV 415
L + + T+A+WD E E+ + +KGH +N+ P+ + T S DG V
Sbjct: 125 LFSASTDKTVAVWDSETGER-VKRLKGHTSFVNSC------YPARRGPQLVCTGSDDGTV 177
Query: 416 KIWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAMK 595
K+WD R+K +T ++ + V + D+ + G DN D+K++DLR K
Sbjct: 178 KLWDIRKK---------AAVQTFQNTYQVLAVTFNDTSDQIISGGIDN-DIKVWDLRQNK 227
Query: 596 LRWQTNLKNGVCSVQFDRKDIDMNKMVATTLERRLHVFDMR 718
L + ++ SV + + +++ ++ + V+D+R
Sbjct: 228 LTY--TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 266
Score = 34.7 bits (78), Expect = 0.27
Identities = 34/162 (20%), Positives = 67/162 (41%), Gaps = 2/162 (1%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIATASRDGMVK 418
LA+ F+ + +W++ +KGH + + + +AS D V
Sbjct: 82 LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM------LFSASTDKTVA 135
Query: 419 IWDQRQKDDPVASMEPTEGET--VRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAM 592
+WD + ++ +G T V C+ G + VC G D+G VKL+D+R
Sbjct: 136 VWDSETGE----RVKRLKGHTSFVNSCYPARRG------PQLVCTGSDDGTVKLWDIRKK 185
Query: 593 KLRWQTNLKNGVCSVQFDRKDIDMNKMVATTLERRLHVFDMR 718
V +V F+ +++++ ++ + V+D+R
Sbjct: 186 AAVQTFQNTYQVLAVTFNDTS---DQIISGGIDNDIKVWDLR 224
>sp|Q96DI7|WDR57_HUMAN WD-repeat protein 57 (Prp8-binding protein) (hPRP8BP) (U5
snRNP-specific 40 kDa protein) (38 kDa splicing factor)
Length = 357
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/161 (24%), Positives = 76/161 (47%), Gaps = 1/161 (0%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPE-IATASRDGMV 415
L + + T+A+WD E E+ + +KGH +N+ P+ + T S DG V
Sbjct: 124 LFSASTDKTVAVWDSETGER-VKRLKGHTSFVNSC------YPARRGPQLVCTGSDDGTV 176
Query: 416 KIWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAMK 595
K+WD R+K +T ++ + V + D+ + G DN D+K++DLR K
Sbjct: 177 KLWDIRKK---------AAIQTFQNTYQVLAVTFNDTSDQIISGGIDN-DIKVWDLRQNK 226
Query: 596 LRWQTNLKNGVCSVQFDRKDIDMNKMVATTLERRLHVFDMR 718
L + ++ SV + + +++ ++ + V+D+R
Sbjct: 227 LTY--TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 34.7 bits (78), Expect = 0.27
Identities = 34/162 (20%), Positives = 67/162 (41%), Gaps = 2/162 (1%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIATASRDGMVK 418
LA+ F+ + +W++ +KGH + + + +AS D V
Sbjct: 81 LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM------LFSASTDKTVA 134
Query: 419 IWDQRQKDDPVASMEPTEGET--VRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAM 592
+WD + ++ +G T V C+ G + VC G D+G VKL+D+R
Sbjct: 135 VWDSETGE----RVKRLKGHTSFVNSCYPARRG------PQLVCTGSDDGTVKLWDIRKK 184
Query: 593 KLRWQTNLKNGVCSVQFDRKDIDMNKMVATTLERRLHVFDMR 718
V +V F+ +++++ ++ + V+D+R
Sbjct: 185 AAIQTFQNTYQVLAVTFNDTS---DQIISGGIDNDIKVWDLR 223
>sp|Q5RF51|WDR57_PONPY WD-repeat protein 57
Length = 357
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/161 (24%), Positives = 76/161 (47%), Gaps = 1/161 (0%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPE-IATASRDGMV 415
L + + T+A+WD E E+ + +KGH +N+ P+ + T S DG V
Sbjct: 124 LFSASTDKTVAVWDSETGER-VKRLKGHTSFVNSC------YPARRGPQLVCTGSDDGTV 176
Query: 416 KIWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAMK 595
K+WD R+K +T ++ + V + D+ + G DN D+K++DLR K
Sbjct: 177 KLWDIRKK---------AAIQTFQNTYQVLAVTFNDTSDQIISGGIDN-DIKVWDLRQNK 226
Query: 596 LRWQTNLKNGVCSVQFDRKDIDMNKMVATTLERRLHVFDMR 718
L + ++ SV + + +++ ++ + V+D+R
Sbjct: 227 LTY--TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 32.0 bits (71), Expect = 1.7
Identities = 33/162 (20%), Positives = 67/162 (41%), Gaps = 2/162 (1%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIATASRDGMVK 418
LA+ F+ + +W++ +KG+ + + + +AS D V
Sbjct: 81 LASAGFDRLILLWNVYGDCGNYATLKGYSGAVMELHYNTDGSM------LFSASTDKTVA 134
Query: 419 IWDQRQKDDPVASMEPTEGET--VRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAM 592
+WD + ++ +G T V C+ G + VC G D+G VKL+D+R
Sbjct: 135 VWDSETGE----RVKRLKGHTSFVNSCYPARRG------PQLVCTGSDDGTVKLWDIRKK 184
Query: 593 KLRWQTNLKNGVCSVQFDRKDIDMNKMVATTLERRLHVFDMR 718
V +V F+ +++++ ++ + V+D+R
Sbjct: 185 AAIQTFQNTYQVLAVTFNDTS---DQIISGGIDNDIKVWDLR 223
>sp|Q7ZUV2|KTNB1_BRARE Katanin p80 WD40-containing subunit B1 homolog
Length = 694
Score = 43.1 bits (100), Expect = 8e-04
Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 1/142 (0%)
Frame = +2
Query: 221 NLKDRNLATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIATAS 400
N + + G G++ +WDLE + K + + GHK I+++D +A+ S
Sbjct: 72 NSSEERVVAGSLSGSLRLWDLE-AAKILRTLMGHKASISSLD------FHPMGEYLASGS 124
Query: 401 RDGMVKIWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFD 580
D +K+WD R+K T+ A++ + + + D+ VKL+D
Sbjct: 125 VDSNIKLWDVRRKGCVFRYKGHTQAVRCL---------AFSPDGKWLASASDDSTVKLWD 175
Query: 581 LRAMKLRWQ-TNLKNGVCSVQF 643
L A K+ + T+ + V VQF
Sbjct: 176 LIAGKMITEFTSHTSAVNVVQF 197
>sp|P90917|RBA1_CAEEL Trp-Asp repeats containing protein RBA-1
Length = 412
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/98 (25%), Positives = 42/98 (42%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIATASRDGMVK 418
LATG + T+A+WD+ K +Y +K H + I + +A++ D V
Sbjct: 280 LATGSVDKTVALWDMRNMRKKMYTLKHHNDEIFQVSFSPHYETV-----LASSGSDDRVI 334
Query: 419 IWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHD 532
+WD + DP +S + + + GH V D
Sbjct: 335 VWDISKIQDPSSSSAASSDSVPPEVIFIHAGHTGKVAD 372
>sp|Q9EPV5|APAF_RAT Apoptotic protease-activating factor 1 (Apaf-1)
Length = 1249
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/186 (22%), Positives = 74/186 (39%), Gaps = 7/186 (3%)
Frame = +2
Query: 128 LQIYEIEKSDIKLIKELEKPKSFKCGTFGASNLKDRNLATGDFEGTMAIWDLERSEKPIY 307
LQ+++ E + KL+ C F + D +AT + + IWD + K ++
Sbjct: 639 LQVFKAETGE-KLLDIKAHEDEVLCCAFSSD---DSYIATCSVDKKVKIWD-SGTGKLVH 693
Query: 308 NVKGHKEIINAIDXXXXXXXXXXAPEIATASRDGMVKIWDQRQKDDPVASMEPTEGETVR 487
+ H E +N +AT S D +K+WD QK
Sbjct: 694 TYEEHSEQVNCCHFTNKSNHLL----LATGSNDSFLKLWDLNQK---------------- 733
Query: 488 DCWTVAFGHAYNV-------HDRCVCAGYDNGDVKLFDLRAMKLRWQTNLKNGVCSVQFD 646
+C FGH +V D + + +G +KL+D+R+ + N+K S +
Sbjct: 734 ECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSINVKRFFLSSEDP 793
Query: 647 RKDIDM 664
+D+++
Sbjct: 794 PEDVEV 799
>sp|Q58D20|NLE1_BOVIN Notchless homolog 1
Length = 485
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/120 (25%), Positives = 57/120 (47%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIATASRDGMVK 418
L +G + T+ +W +KP+ + GH+ +IN + + IA+AS D +K
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQV------VFSPDSRVIASASFDKSIK 397
Query: 419 IWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAMKL 598
+WD R +AS+ R + A++ R + +G + +K++D++A KL
Sbjct: 398 LWDGR-TGKYLASL--------RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448
Score = 32.7 bits (73), Expect = 1.0
Identities = 19/68 (27%), Positives = 34/68 (50%), Gaps = 3/68 (4%)
Frame = +2
Query: 233 RNLATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPE---IATASR 403
+ LA+G G + +WD ++ + GH + I A+ PE +A++S+
Sbjct: 169 KKLASGCKNGQILLWDPSTGKQVGRALTGHSKWITALSWEPLHAN----PECRYVASSSK 224
Query: 404 DGMVKIWD 427
DG V++WD
Sbjct: 225 DGSVRVWD 232
>sp|Q20168|COPB2_CAEEL Probable coatomer beta' subunit (Beta'-coat protein) (Beta'-COP)
Length = 1000
Score = 42.4 bits (98), Expect = 0.001
Identities = 34/129 (26%), Positives = 53/129 (41%), Gaps = 8/129 (6%)
Frame = +2
Query: 215 ASNLKDRN-LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIA 391
A N KD N AT + T+ +W S P + ++GH++ +N +D P I
Sbjct: 149 AINPKDNNTFATASLDKTVKVWQFG-SNVPNFTLEGHEKGVNCVDYYHGGEK----PYII 203
Query: 392 TASRDGMVKIWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHDRC-------VCAG 550
+ + D +VKIWD + K C GHA NV C + G
Sbjct: 204 SGADDHLVKIWDYQNK----------------TCVQTLDGHAQNVSSVCFHPELPLIITG 247
Query: 551 YDNGDVKLF 577
++ V+L+
Sbjct: 248 SEDSTVRLW 256
>sp|Q8VEJ4|NLE1_MOUSE Notchless homolog 1
Length = 485
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/120 (24%), Positives = 57/120 (47%)
Frame = +2
Query: 239 LATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPEIATASRDGMVK 418
L +G + T+ +W +KP+ + GH+ +IN + + +A+AS D +K
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQV------LFSPDSRIVASASFDKSIK 397
Query: 419 IWDQRQKDDPVASMEPTEGETVRDCWTVAFGHAYNVHDRCVCAGYDNGDVKLFDLRAMKL 598
+WD R +AS+ R + A++ R + +G + +K++D++A KL
Sbjct: 398 LWDGR-TGKYLASL--------RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448
Score = 30.4 bits (67), Expect = 5.1
Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 3/68 (4%)
Frame = +2
Query: 233 RNLATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPE---IATASR 403
+ LA+G G + +WD + + GH + I + PE +A++S+
Sbjct: 169 KKLASGCKNGQILLWDPSTGLQVGRTLTGHSKWITGLSWEPLHMN----PECRYVASSSK 224
Query: 404 DGMVKIWD 427
DG V++WD
Sbjct: 225 DGSVRVWD 232
>sp|P47025|YJL2_YEAST Hypothetical 80.0 kDa Trp-Asp repeats containing protein in
ASF1-CCT7 intergenic region
Length = 714
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/76 (35%), Positives = 37/76 (48%)
Frame = +2
Query: 206 TFGASNLKDRNLATGDFEGTMAIWDLERSEKPIYNVKGHKEIINAIDXXXXXXXXXXAPE 385
+ GA D LATG +G + +WDL RS K I +KGH + I ++
Sbjct: 568 SIGALQSFDAALATGTKDGVVRLWDL-RSGKVIRTLKGHTDAITSLKFDSAC-------- 618
Query: 386 IATASRDGMVKIWDQR 433
+ T S D V+IWD R
Sbjct: 619 LVTGSYDRTVRIWDLR 634
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,297,509
Number of Sequences: 369166
Number of extensions: 1716187
Number of successful extensions: 5250
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4594
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5114
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6534486000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)