Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_M13
(772 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q91XV4|DCXR_MESAU L-xylulose reductase (XR) (Dicarbonyl/... 193 4e-49
sp|Q920P0|DCXR_RAT L-xylulose reductase (XR) (Dicarbonyl/L-... 192 8e-49
sp|Q7Z4W1|DCXR_HUMAN L-xylulose reductase (XR) (Dicarbonyl/... 191 1e-48
sp|Q91X52|DCXR_MOUSE L-xylulose reductase (XR) (Dicarbonyl/... 191 1e-48
sp|Q8JIS3|DER_CHICK D-erythrulose reductase 189 5e-48
sp|Q920N9|DCXR_CAVPO L-xylulose reductase (XR) (Dicarbonyl/... 183 5e-46
sp|P08074|CBR2_MOUSE Lung carbonyl reductase [NADPH] (NADPH... 175 1e-43
sp|Q29529|CBR2_PIG Lung carbonyl reductase [NADPH] (NADPH-d... 169 8e-42
sp|Q21929|CBR2_CAEEL Probable carbonyl reductase [NADPH] (N... 169 8e-42
sp|Q8CPI3|FABG_STAES 3-oxoacyl-[acyl-carrier-protein] reduc... 111 2e-24
>sp|Q91XV4|DCXR_MESAU L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase) (Sperm
antigen P26h)
Length = 244
Score = 193 bits (491), Expect = 4e-49
Identities = 101/234 (43%), Positives = 145/234 (61%)
Frame = +3
Query: 69 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 248
++ G+ LVTG KGIG+ V L +GA V+++SR+ S+ SE +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAHVVAVSRTQADLDSLVSEC-PGVETVCV 59
Query: 249 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 428
D++ W+ + S+ PVD LVNNAA+ L F E+ + D FN N++A+I +SQ+VA
Sbjct: 60 DLADWEATEQALSSVGPVDLLVNNAAVALLQPFLEVTKEAFDMSFNVNLRAVIQVSQIVA 119
Query: 429 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 608
R G IVNVSSQASQRA+ + YC+ K A+D +T+ MALELGP IRVN+VNP
Sbjct: 120 RGMIARGAPGAIVNVSSQASQRALANHSVYCSTKGALDMLTKMMALELGPHKIRVNAVNP 179
Query: 609 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL++ + TG+
Sbjct: 180 TVVMTSMGRTNWSDPHKAKVMLDRIPLGKFAEVENVVDAILFLLSHRSNMTTGS 233
>sp|Q920P0|DCXR_RAT L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase)
Length = 244
Score = 192 bits (488), Expect = 8e-49
Identities = 99/234 (42%), Positives = 146/234 (62%)
Frame = +3
Query: 69 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 248
++ G+ LVTG KGIG+ V L +GA+V+++SR+ S+ E +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAQVVAVSRTREDLDSLVREC-PGVEPVCV 59
Query: 249 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 428
D++ W+ + ++ PVD LVNNAA+ L F E+ + D FN N +A++ +SQ+VA
Sbjct: 60 DLADWEATEQALSNVGPVDLLVNNAAVATLQPFLEVTKEACDTSFNVNFRAVVQVSQIVA 119
Query: 429 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 608
R + G IVNVSSQASQRA+ + YC+ K A+D +T+ MALELGP IRVN+VNP
Sbjct: 120 RGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179
Query: 609 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL+N ++ TG+
Sbjct: 180 TVVMTPMGRANWSDPHKAKVMLDRIPLGKFAEVENVVDTILFLLSNRSSMTTGS 233
>sp|Q7Z4W1|DCXR_HUMAN L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase) (Kidney
dicarbonyl reductase) (kiDCR) (Carbonyl reductase II)
(Sperm surface protein P34H)
Length = 244
Score = 191 bits (486), Expect = 1e-48
Identities = 102/228 (44%), Positives = 144/228 (63%)
Frame = +3
Query: 87 GKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKCDISKWD 266
G+ VLVTG KGIG+ VQ L +GARV+++SR+ S+ E IE V D+ W+
Sbjct: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-PGIEPVCVDLGDWE 65
Query: 267 EVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVASDWKTR 446
+ S+ PVD LVNNAA+ L F E+ + D F N++A+I +SQ+VA R
Sbjct: 66 ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR 125
Query: 447 HIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNPTAILTD 626
+ G IVNVSSQ SQRAV + YC+ K A+D +T+ MALELGP IRVN+VNPT ++T
Sbjct: 126 GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTS 185
Query: 627 MGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
MG+ WS+P + + +R+PL + EV VV+ I+FLL++ + TG+
Sbjct: 186 MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233
>sp|Q91X52|DCXR_MOUSE L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase)
Length = 244
Score = 191 bits (486), Expect = 1e-48
Identities = 99/234 (42%), Positives = 145/234 (61%)
Frame = +3
Query: 69 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 248
++ G+ LVTG KGIG+ V L +GA+V+++SR+ + E +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDLDDLVREC-PGVEPVCV 59
Query: 249 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 428
D++ W+ + ++ PVD LVNNAA+ L F E+ + D FN N++A+I +SQ+VA
Sbjct: 60 DLADWEATEQALSNVGPVDLLVNNAAVALLQPFLEVTKEACDTSFNVNLRAVIQVSQIVA 119
Query: 429 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 608
R + G IVNVSSQASQRA+ + YC+ K A+D +T+ MALELGP IRVN+VNP
Sbjct: 120 KGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLTKMMALELGPHKIRVNAVNP 179
Query: 609 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL+N + TG+
Sbjct: 180 TVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDTILFLLSNRSGMTTGS 233
>sp|Q8JIS3|DER_CHICK D-erythrulose reductase
Length = 246
Score = 189 bits (481), Expect = 5e-48
Identities = 96/236 (40%), Positives = 152/236 (64%)
Frame = +3
Query: 63 MTLNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEV 242
M + +F G+ LVTG KGIG+ + L ++GARV +LSR+ S+ E IE +
Sbjct: 1 MEPDLSFRGRRALVTGAGKGIGRAVAVALCKAGARVTALSRTAADLESLVREC-PGIEPL 59
Query: 243 KCDISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQV 422
D++ WD + V + P + LVNNAA+ L F ++ ++ F+ N +A++++SQ+
Sbjct: 60 CLDLADWDATEAAVGAAGPFELLVNNAAVAMLQPFLQVTREAVERSFDVNFRAVLHVSQI 119
Query: 423 VASDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSV 602
VA + + G IVNVSSQASQRA+ D YC+ K+A+D +++ MA+ELGP IRVN+V
Sbjct: 120 VARQMIAQGLPGAIVNVSSQASQRALRDHAVYCSTKSALDMLSKVMAMELGPHKIRVNTV 179
Query: 603 NPTAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
NPT ++TDMG++ WS+P + +R+PL + EV++VV+ I+FLL++ + TG+
Sbjct: 180 NPTVVMTDMGRINWSDPQKSAAMINRIPLGKFAEVDDVVNSILFLLSDKSAMTTGS 235
>sp|Q920N9|DCXR_CAVPO L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase)
(Protein P26h)
Length = 244
Score = 183 bits (464), Expect = 5e-46
Identities = 96/234 (41%), Positives = 142/234 (60%)
Frame = +3
Query: 69 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 248
++ G+ LVTG KGIG+ V L +GA+V+++SR+ + E +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDLDDLVREC-PGVEPVCV 59
Query: 249 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 428
D++ W+ + ++ P D LVNNAA+ L F E+ + FN N++A+I +SQ+VA
Sbjct: 60 DLADWEATEQALSNVGPADLLVNNAAVALLQPFLEVTKEACVTSFNVNLRAVIQVSQIVA 119
Query: 429 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 608
R + G IVNVSSQASQRA+ + YC+ K A+ +T+ MALELGP IRVN+VNP
Sbjct: 120 KGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALYMLTKMMALELGPHKIRVNAVNP 179
Query: 609 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL+N + TG+
Sbjct: 180 TVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDTILFLLSNRSGMTTGS 233
>sp|P08074|CBR2_MOUSE Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl
reductase) (LCR) (Adipocyte P27 protein) (AP27)
Length = 244
Score = 175 bits (444), Expect = 1e-43
Identities = 95/233 (40%), Positives = 140/233 (60%)
Frame = +3
Query: 69 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 248
+ NF+G LVTG KGIG+ V+ L SGA+V++++R+ S+ E IE V
Sbjct: 1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKEC-PGIEPVCV 59
Query: 249 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 428
D+ WD + + PVD LVNNAA++ + F E+ + D F+ N++++ +SQ+VA
Sbjct: 60 DLGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVA 119
Query: 429 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 608
D R + G IVNVSS + + +TY + K A+ +T+ MA+ELGP IRVNSVNP
Sbjct: 120 RDMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLTKAMAMELGPHKIRVNSVNP 179
Query: 609 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTG 767
T +LTDMGK ++P KL R PLR+ EV +VV+ I+FLL++ +G
Sbjct: 180 TVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSDRSASTSG 232
>sp|Q29529|CBR2_PIG Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl
reductase) (LCR)
Length = 244
Score = 169 bits (428), Expect = 8e-42
Identities = 93/234 (39%), Positives = 136/234 (58%)
Frame = +3
Query: 69 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 248
+ NF+G LVTG KGIG+ V+ L SGARV++++R+ G S+ E IE V
Sbjct: 1 MQMNFSGLRALVTGAGKGIGRDTVKALHVSGARVVAVTRTNGDLVSLSQEC-PGIEPVCV 59
Query: 249 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 428
D+ W+ + + PVD LVNNAA+ + F + + D FN N++++ +SQ+VA
Sbjct: 60 DLGDWEATERALGGVGPVDLLVNNAAVALMQPFLDTTKEVFDRSFNVNLRSVFQVSQIVA 119
Query: 429 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 608
R + G IVNVSS S Y + K A+ +T++MA+ELGP IRVNSVNP
Sbjct: 120 RSMIERGVPGSIVNVSSMVSHVTYPGLAAYSSTKGAMTMLTKSMAMELGPHKIRVNSVNP 179
Query: 609 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
T +LT MG+ S+P KL R P+R+ EV +VV+ I+FLL++ +G+
Sbjct: 180 TVVLTAMGRSVTSDPELARKLKERHPMRKFAEVEDVVNSILFLLSDRSASTSGS 233
>sp|Q21929|CBR2_CAEEL Probable carbonyl reductase [NADPH] (NADPH-dependent carbonyl
reductase)
Length = 251
Score = 169 bits (428), Expect = 8e-42
Identities = 94/221 (42%), Positives = 142/221 (64%), Gaps = 4/221 (1%)
Frame = +3
Query: 120 GIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVS---NIEEVKCDISKWDEVN-SIVK 287
GIGK + LA++GA+VI+ +R+ S+ E S I + D+S +EV ++
Sbjct: 20 GIGKEICLSLAKAGAQVIAFARNEANLLSLVKETTSLRYTIIPIVGDVSANEEVLFKLIV 79
Query: 288 SLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVASDWKTRHIEGVIV 467
P+ LVNNA I + G+I + ID F NV+ I I+Q+VA ++ R I+G IV
Sbjct: 80 PHFPIHGLVNNAGIATNHAIGQITQQSIDRTFAVNVRGPILIAQLVARNFVDRQIKGSIV 139
Query: 468 NVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNPTAILTDMGKLYWS 647
N+SSQA+ R + + YCA+KAA+D +TR +A ELG IRVNSVNPT ++TDMG+ WS
Sbjct: 140 NISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQNIRVNSVNPTVVMTDMGRDNWS 199
Query: 648 EPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTGA 770
+P K+K+ RMP++R EV+EVV+ ++FLL++ ++ TG+
Sbjct: 200 DPDKKKKMLDRMPIKRFAEVDEVVNAVLFLLSDNASMTTGS 240
>sp|Q8CPI3|FABG_STAES 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 244
Score = 111 bits (278), Expect = 2e-24
Identities = 76/235 (32%), Positives = 121/235 (51%), Gaps = 9/235 (3%)
Frame = +3
Query: 90 KTVLVTGGSKGIGKYLVQELAESGARVI-----SLSRSIGTSFSIKSEAVSNIEEVKCDI 254
K+ LVTG S+GIG+ + +LAE G V S ++ IK++ V + ++ ++
Sbjct: 3 KSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKDKAEAVVEEIKAKGVESFA-IQANV 61
Query: 255 SKWDEVNSIVKSLLP----VDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQV 422
+K DEV ++K ++ VD LVNNA I K N + E E D+V +TN+K + N Q
Sbjct: 62 AKGDEVKEMIKEVVSQFGSVDVLVNNAGITKDNLLMRMKEQEWDDVIDTNLKGVFNCIQK 121
Query: 423 VASDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSV 602
V R G I+N++S Y A KA V +T+ A EL GI VN+V
Sbjct: 122 VTPQ-MLRQRSGAIINLTSIVGAMGNPGQANYVATKAGVIGLTKTAARELASRGITVNAV 180
Query: 603 NPTAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIMFLLTNCCTLVTG 767
P I++DM K+++ ++PL+R GE ++ + + FL ++ +TG
Sbjct: 181 APGFIVSDMTNAL--SDDLKDQMLEQIPLKRFGEDTDIANTVAFLASDKAKYITG 233
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,894,034
Number of Sequences: 369166
Number of extensions: 1644333
Number of successful extensions: 5861
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5311
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5506
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)