Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_L05
(570 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, deca... 229 5e-60
sp|P00349|6PGD_SHEEP 6-phosphogluconate dehydrogenase, deca... 227 1e-59
sp|Q9DCD0|6PGD_MOUSE 6-phosphogluconate dehydrogenase, deca... 220 2e-57
sp|P41570|6PGD_CERCA 6-phosphogluconate dehydrogenase, deca... 213 4e-55
sp|Q17761|6PGD_CAEEL 6-phosphogluconate dehydrogenase, deca... 212 6e-55
sp|P41572|6PGD_DROME 6-phosphogluconate dehydrogenase, deca... 207 1e-53
sp|O60037|6PGD_CUNEL 6-phosphogluconate dehydrogenase, deca... 207 1e-53
sp|P41573|6PGD_DROSI 6-phosphogluconate dehydrogenase, deca... 205 6e-53
sp|P78812|6PGD_SCHPO 6-phosphogluconate dehydrogenase, deca... 204 1e-52
sp|Q8CP47|6PGD_STAES 6-phosphogluconate dehydrogenase, deca... 200 2e-51
>sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 229 bits (583), Expect = 5e-60
Identities = 112/189 (59%), Positives = 141/189 (74%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
++ AF DWN +EL+SFLIEIT++I KF+ DG +L+ I DSAGQKGTGKWTAI+AL++G
Sbjct: 216 MAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYG 275
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
VPVTLI E+VFAR LS+LK R++ASK+ F GDK FL I+ ALYASKIISY
Sbjct: 276 VPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISY 335
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGFM+++ A+ EF W L+ G IALMWRGGCIIRS FL IKDA+++N L LL D FF
Sbjct: 336 AQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFF 395
Query: 542 QSEILKCHE 568
+S + C +
Sbjct: 396 KSAVENCQD 404
>sp|P00349|6PGD_SHEEP 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 227 bits (579), Expect = 1e-59
Identities = 112/189 (59%), Positives = 142/189 (75%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
++ AF +WN +EL+SFLIEIT+SI KF+ DG +L+ I DSAGQKGTGKWTAI+AL++G
Sbjct: 216 MAKAFEEWNKTELDSFLIEITASILKFQDADGKHLLPKIRDSAGQKGTGKWTAISALEYG 275
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
VPVTLI E+VFAR LS+LK R++ASK+ + F GDK FL I+ ALYASKIISY
Sbjct: 276 VPVTLIGEAVFARCLSSLKDERIQASKKLKGPQNIPFEGDKKSFLEDIRKALYASKIISY 335
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGFM+++ A+ EF W L+ G IALMWRGGCIIRS FL IKDA+++N L LL D FF
Sbjct: 336 AQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPGLQNLLLDDFF 395
Query: 542 QSEILKCHE 568
+S + C +
Sbjct: 396 KSAVENCQD 404
>sp|Q9DCD0|6PGD_MOUSE 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 220 bits (561), Expect = 2e-57
Identities = 108/189 (57%), Positives = 140/189 (74%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
++ AF +WN +EL+SFLIEIT++I K++ DG L+ I DSAGQKGTGKWTAI+AL++G
Sbjct: 216 MAQAFEEWNKTELDSFLIEITANILKYRDTDGKELLPKIRDSAGQKGTGKWTAISALEYG 275
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
+PVTLI E+VFAR LS+LK RV+AS++ ++ G K FL I+ ALYASKIISY
Sbjct: 276 MPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISY 335
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGFM+++ A+ EF W L+ G IALMWRGGCIIRS FL IKDA+E+N L LL D FF
Sbjct: 336 AQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFF 395
Query: 542 QSEILKCHE 568
+S + C +
Sbjct: 396 KSAVDNCQD 404
>sp|P41570|6PGD_CERCA 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 213 bits (541), Expect = 4e-55
Identities = 111/184 (60%), Positives = 134/184 (72%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
++ F WN+ EL+SFLIEIT I ++ + G YL+E I D+AGQKGTGKWTAI+AL +G
Sbjct: 215 MATEFEKWNSEELDSFLIEITRDILNYQDDRG-YLLERIRDTAGQKGTGKWTAISALQYG 273
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
VPVTLI E+VF+R LSALK RV ASK+ N+ D KFLN IK+ALY SKI+SY
Sbjct: 274 VPVTLIGEAVFSRCLSALKDERVAASKQLKGPNVNAKVEDLPKFLNHIKHALYCSKIVSY 333
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGFM+M+ A+ E WNL+ G IALMWRGGCIIRS FL NIKDAY +N LS LL D FF
Sbjct: 334 AQGFMLMREAAKENNWNLNYGGIALMWRGGCIIRSVFLGNIKDAYTRNPQLSNLLLDDFF 393
Query: 542 QSEI 553
+ I
Sbjct: 394 KKAI 397
>sp|Q17761|6PGD_CAEEL 6-phosphogluconate dehydrogenase, decarboxylating
Length = 484
Score = 212 bits (539), Expect = 6e-55
Identities = 109/185 (58%), Positives = 132/185 (71%), Gaps = 2/185 (1%)
Frame = +2
Query: 20 DWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLI 199
DWN ELESFLIEIT++I K++ G +V I DSAGQKGTGKWT AL++G+PVTLI
Sbjct: 221 DWNKGELESFLIEITANILKYRDEQGEPIVPKIRDSAGQKGTGKWTCFAALEYGLPVTLI 280
Query: 200 AESVFARSLSALKSLRVEASKRFPSNNLLNFT--GDKTKFLNQIKYALYASKIISYTQGF 373
E+VFAR LSALK RV ASK+ P + T DK F+ QI ALYASKI+SY QGF
Sbjct: 281 GEAVFARCLSALKDERVRASKQLPRPQVSPDTVVQDKRVFIKQISKALYASKIVSYAQGF 340
Query: 374 MMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEI 553
M++ AS +F WNL+ G IALMWRGGCIIRSRFL +I+ A++KNK LS LL D FF I
Sbjct: 341 MLLAEASKQFNWNLNFGAIALMWRGGCIIRSRFLGDIEHAFQKNKQLSNLLLDDFFTKAI 400
Query: 554 LKCHE 568
+ +
Sbjct: 401 TEAQD 405
>sp|P41572|6PGD_DROME 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 207 bits (527), Expect = 1e-53
Identities = 108/184 (58%), Positives = 132/184 (71%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
+++ F WN++EL+SFLIEIT I K+K G YL+E I D+AGQKGTGKWTAI AL +G
Sbjct: 215 MADEFGKWNSAELDSFLIEITRDILKYKDGKG-YLLERIRDTAGQKGTGKWTAIAALQYG 273
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
VPVTLI E+VF+R LSALK RV+AS + + TKFL+ IK+ALY +KI+SY
Sbjct: 274 VPVTLIGEAVFSRCLSALKDERVQASSVLKGPSTKAQVANLTKFLDDIKHALYCAKIVSY 333
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGFM+M+ A+ E KW L+ G IALMWRGGCIIRS FL NIKDAY LS LL D FF
Sbjct: 334 AQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPELSNLLLDDFF 393
Query: 542 QSEI 553
+ I
Sbjct: 394 KKAI 397
>sp|O60037|6PGD_CUNEL 6-phosphogluconate dehydrogenase, decarboxylating
Length = 485
Score = 207 bits (527), Expect = 1e-53
Identities = 103/189 (54%), Positives = 133/189 (70%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
+++ F +WN +L+SFLIEIT I +FK DG LV I D+AGQKGTGKWTAI +LD G
Sbjct: 218 MADIFEEWNKGDLDSFLIEITRDILRFKDTDGQPLVTKIRDTAGQKGTGKWTAIDSLDRG 277
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
+PVTLI E+V++R LS+LK RV ASK + FTGDK F+ Q+ ALYA+KI+SY
Sbjct: 278 IPVTLIGEAVYSRCLSSLKDERVRASKILQGPSSSKFTGDKKTFIAQLGQALYAAKIVSY 337
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QG+M+M+ A+ +++W L+ IALMWRGGCIIRS FL I+DAY KN L LLFD FF
Sbjct: 338 AQGYMLMRQAAKDYEWKLNNAGIALMWRGGCIIRSVFLGKIRDAYTKNPELENLLFDDFF 397
Query: 542 QSEILKCHE 568
+ K +
Sbjct: 398 KDATAKAQD 406
>sp|P41573|6PGD_DROSI 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 205 bits (522), Expect = 6e-53
Identities = 107/184 (58%), Positives = 132/184 (71%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
+++ F WN++EL+SFLIEIT I K+K G +L+E I D+AGQKGTGKWTAI AL +G
Sbjct: 215 MADEFGKWNSAELDSFLIEITRDILKYKDGKG-HLLERIRDTAGQKGTGKWTAIAALQYG 273
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
VPVTLI E+VF+R LSALK RV+AS + + TKFL+ IK+ALY +KI+SY
Sbjct: 274 VPVTLIGEAVFSRCLSALKDERVQASSVLKGPSTKAEVANLTKFLDDIKHALYCAKIVSY 333
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGFM+M+ A+ E KW L+ G IALMWRGGCIIRS FL NIKDAY LS LL D FF
Sbjct: 334 AQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPQLSNLLLDDFF 393
Query: 542 QSEI 553
+ I
Sbjct: 394 KKAI 397
>sp|P78812|6PGD_SCHPO 6-phosphogluconate dehydrogenase, decarboxylating
Length = 492
Score = 204 bits (520), Expect = 1e-52
Identities = 103/186 (55%), Positives = 136/186 (73%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
I++ F WN +L+SFLIEIT + ++KA+DG LVE I D+AGQKGTGKWTA AL+ G
Sbjct: 219 IADVFEKWNTGKLDSFLIEITRDVLRYKADDGKPLVEKILDAAGQKGTGKWTAQNALEMG 278
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
PV+LI E+VFAR LS+LKS RV ASK+ N FTGDK + ++ ++ ALYASKIISY
Sbjct: 279 TPVSLITEAVFARCLSSLKSERVRASKKLTGPN-TKFTGDKKQLIDDLEDALYASKIISY 337
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGFM+M+ A+ E+ W L+ IALMWRGGCIIRS FL++I +A+ ++ NL +LF FF
Sbjct: 338 AQGFMLMREAAKEYGWKLNNAGIALMWRGGCIIRSVFLKDITEAFREDPNLESILFHPFF 397
Query: 542 QSEILK 559
+ + K
Sbjct: 398 TNGVEK 403
>sp|Q8CP47|6PGD_STAES 6-phosphogluconate dehydrogenase, decarboxylating
sp|Q5HP42|6PGD_STAEQ 6-phosphogluconate dehydrogenase, decarboxylating
Length = 468
Score = 200 bits (509), Expect = 2e-51
Identities = 101/186 (54%), Positives = 132/186 (70%)
Frame = +2
Query: 2 ISNAFADWNNSELESFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFG 181
IS F +WN ELES+LIEIT I +D LVE I D+AGQKGTGKWT+I AL+ G
Sbjct: 214 ISQTFKEWNAGELESYLIEITGDIFNKLDDDNEALVEKILDTAGQKGTGKWTSINALELG 273
Query: 182 VPVTLIAESVFARSLSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISY 361
VP+T+I ESVFAR +S++K RV ASK +F GDK FL +I+ ALY SKI SY
Sbjct: 274 VPLTIITESVFARFISSIKEERVTASKSLKGPKA-HFEGDKKTFLEKIRKALYMSKICSY 332
Query: 362 TQGFMMMKSASHEFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFF 541
QGF M+ AS + +WNL LG++A++WR GCIIR++FLQ IKDAY+ N+NL LL D +F
Sbjct: 333 AQGFAQMRKASEDNEWNLKLGELAMIWREGCIIRAQFLQKIKDAYDNNENLQNLLLDPYF 392
Query: 542 QSEILK 559
++ +++
Sbjct: 393 KNIVME 398
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,657,714
Number of Sequences: 369166
Number of extensions: 1252010
Number of successful extensions: 3384
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3272
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3333
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4177115900
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)