Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_K20
(780 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8TC41|IBR1_HUMAN IBR domain containing protein 1 114 2e-25
sp|O95376|ARI2_HUMAN Ariadne-2 protein homolog (ARI-2) (Tri... 79 1e-14
sp|Q9Z1K6|ARI2_MOUSE Ariadne-2 protein homolog (ARI-2) (Tri... 75 3e-13
sp|Q9Y4X5|ARI1_HUMAN Ariadne-1 protein homolog (ARI-1) (Ubi... 72 1e-12
sp|Q9Z1K5|ARI1_MOUSE Ariadne-1 protein homolog (ARI-1) (Ubi... 72 1e-12
sp|Q22431|ARI2_CAEEL Probable ariadne-2 protein (Ari-2) 68 2e-11
sp|O76924|ARI2_DROME Ariadne-2 protein (Ari-2) 67 5e-11
sp|Q8IWT3|PARC_HUMAN p53-associated parkin-like cytoplasmic... 67 7e-11
sp|P36113|YKZ7_YEAST Hypothetical 63.6 kDa protein in YPT52... 66 9e-11
sp|Q80TT8|PARC_MOUSE p53-associated parkin-like cytoplasmic... 64 4e-10
>sp|Q8TC41|IBR1_HUMAN IBR domain containing protein 1
Length = 275
Score = 114 bits (286), Expect = 2e-25
Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 1/197 (0%)
Frame = +1
Query: 193 LGRIHVECPSMNCHKPIRFQSIWIRLSENNRKIYEKMKNSHEQTDYKKLCPHCMQFYELT 372
LG++ ++CP C + + ++ L+ + Y+ K CP C F T
Sbjct: 5 LGQVEIKCPITECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHF--TT 62
Query: 373 NEEKNQLTHXXXXXXXXXGFNVKCHMCNWEWCFKCQTPVHN-LSCKKNLSTDKLLMKWAN 549
++K H + ++C C + WCFKC +P H ++CK+ DKLL WA+
Sbjct: 63 FKKKG---HIPTPSRSESKYKIQCPTCQFVWCFKCHSPWHEGVNCKEYKKGDKLLRHWAS 119
Query: 550 SPAETIQSSVKKARKCPKCHVLVERNGGCPHMECSKCKCSWCYDCGRRRIKVKHIPFMNH 729
I+ + A+KCPKC + ++R GC HM CS+C ++CY CG R +++ F +H
Sbjct: 120 E----IEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRF--FGDH 173
Query: 730 DSKFFILGCSKNFLASK 780
S I GC +L +
Sbjct: 174 TSNLSIFGCKYRYLPER 190
>sp|O95376|ARI2_HUMAN Ariadne-2 protein homolog (ARI-2) (Triad1 protein)
Length = 493
Score = 79.3 bits (194), Expect = 1e-14
Identities = 52/212 (24%), Positives = 94/212 (44%), Gaps = 13/212 (6%)
Frame = +1
Query: 88 CSICYETHGAFVKR------CCDMIVCEQCYTQYLNYQVSNLGRIHVECPSMNCHKPIRF 249
C++C + FV++ C C C+ Q+ + V + + V C + +C P+R
Sbjct: 139 CAVCMQ----FVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDC--PLRT 192
Query: 250 QSIWIRLSENNRKIYEKMKN----SHEQTDYK-KLCP--HCMQFYELTNEEKNQLTHXXX 408
++ N ++ EK + + ++ Y+ +LCP C + +
Sbjct: 193 PEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARR------ 246
Query: 409 XXXXXXGFNVKCHMCNWEWCFKCQTPVHNLSCKKNLSTDKLLMKWANSPAETIQSSVKKA 588
V+C+ CN +CFKC+ H + +T + + +ET
Sbjct: 247 ---------VQCNRCNEVFCFKCRQMYH---APTDCATIRKWLTKCADDSETANYISAHT 294
Query: 589 RKCPKCHVLVERNGGCPHMECSKCKCSWCYDC 684
+ CPKC++ +E+NGGC HM+CSKCK +C+ C
Sbjct: 295 KDCPKCNICIEKNGGCNHMQCSKCKHDFCWMC 326
>sp|Q9Z1K6|ARI2_MOUSE Ariadne-2 protein homolog (ARI-2) (Triad1 protein)
(UbcM4-interacting protein 48)
Length = 492
Score = 74.7 bits (182), Expect = 3e-13
Identities = 51/215 (23%), Positives = 92/215 (42%), Gaps = 16/215 (7%)
Frame = +1
Query: 88 CSICYETHGAFVKR------CCDMIVCEQCYTQYLNYQVSNLGRIHVECPSMNCHKPIRF 249
C++C + FV++ C C C+ Q+ + V + + + C + +C P+R
Sbjct: 138 CAVCMQ----FVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDC--PLRT 191
Query: 250 QSIWIRLSENNRKIYEKMKN--------SHEQTDYKKLCP--HCMQFYELTNEEKNQLTH 399
++ N ++ +K + SH Q +LCP C + +
Sbjct: 192 PEDFVFPLLPNEELRDKYRRYLFRDYVESHFQL---QLCPGADCPMVIRVQEPRARR--- 245
Query: 400 XXXXXXXXXGFNVKCHMCNWEWCFKCQTPVHNLSCKKNLSTDKLLMKWANSPAETIQSSV 579
V+C+ C+ +CFKC+ H + +T + + +ET
Sbjct: 246 ------------VQCNRCSEVFCFKCRQMYH---APTDCATIRKWLTKCADDSETANYIS 290
Query: 580 KKARKCPKCHVLVERNGGCPHMECSKCKCSWCYDC 684
+ CPKC++ +E+NGGC HM+CSKCK +C+ C
Sbjct: 291 AHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMC 325
>sp|Q9Y4X5|ARI1_HUMAN Ariadne-1 protein homolog (ARI-1) (Ubiquitin-conjugating enzyme
E2-binding protein 1) (UbcH7-binding protein)
(UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6)
Length = 557
Score = 72.4 bits (176), Expect = 1e-12
Identities = 53/211 (25%), Positives = 88/211 (41%), Gaps = 9/211 (4%)
Frame = +1
Query: 79 DATCSICYETH--GAFVKRCCDMIVCEQCYTQYLNYQVSNLGRIH-VECPSMNCHKPIRF 249
D C ICY + F C C QC+++YL ++ G + CP+ C +
Sbjct: 183 DMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDD 242
Query: 250 QSIWIRLSENNRKIYEKMKNSHEQTDYKKLCPHCMQFYELTNEEKNQLTHXXXXXXXXXG 429
++ ++++ K+K H T+ C +++ + H
Sbjct: 243 NTVMRLITDSK----VKLKYQHLITNSFVECNRLLKWCPAPD------CHHVVKVQYPDA 292
Query: 430 FNVKCHMCNWEWCFKCQTPVHN-LSCKKNLSTDKLLMKW---ANSPAETIQSSVKKARKC 597
V+C C ++CF C H+ + CK L KW + +ET ++C
Sbjct: 293 KPVRCK-CGRQFCFNCGENWHDPVKCK-------WLKKWIKKCDDDSETSNWIAANTKEC 344
Query: 598 PKCHVLVERNGGCPHMEC--SKCKCSWCYDC 684
PKCHV +E++GGC HM C CK +C+ C
Sbjct: 345 PKCHVTIEKDGGCNHMVCRNQNCKAEFCWVC 375
>sp|Q9Z1K5|ARI1_MOUSE Ariadne-1 protein homolog (ARI-1) (Ubiquitin-conjugating enzyme
E2-binding protein 1) (UbcH7-binding protein)
(UbcM4-interacting protein 77)
Length = 555
Score = 72.4 bits (176), Expect = 1e-12
Identities = 53/211 (25%), Positives = 88/211 (41%), Gaps = 9/211 (4%)
Frame = +1
Query: 79 DATCSICYETH--GAFVKRCCDMIVCEQCYTQYLNYQVSNLGRIH-VECPSMNCHKPIRF 249
D C ICY + F C C QC+++YL ++ G + CP+ C +
Sbjct: 181 DMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDD 240
Query: 250 QSIWIRLSENNRKIYEKMKNSHEQTDYKKLCPHCMQFYELTNEEKNQLTHXXXXXXXXXG 429
++ ++++ K+K H T+ C +++ + H
Sbjct: 241 NTVMRLITDSK----VKLKYQHLITNSFVECNRLLKWCPAPD------CHHVVKVQYPDA 290
Query: 430 FNVKCHMCNWEWCFKCQTPVHN-LSCKKNLSTDKLLMKW---ANSPAETIQSSVKKARKC 597
V+C C ++CF C H+ + CK L KW + +ET ++C
Sbjct: 291 KPVRCK-CGRQFCFNCGENWHDPVKCK-------WLKKWIKKCDDDSETSNWIAANTKEC 342
Query: 598 PKCHVLVERNGGCPHMEC--SKCKCSWCYDC 684
PKCHV +E++GGC HM C CK +C+ C
Sbjct: 343 PKCHVTIEKDGGCNHMVCRNQNCKAEFCWVC 373
>sp|Q22431|ARI2_CAEEL Probable ariadne-2 protein (Ari-2)
Length = 482
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/210 (24%), Positives = 84/210 (40%), Gaps = 11/210 (5%)
Frame = +1
Query: 88 CSIC-YETHGAFVKRCCDMIVCEQCYTQYLNYQVSNLGRIHVECPSMNC--HKPIRFQSI 258
CS+C + + C CE C+ ++ ++S +EC C + P F
Sbjct: 129 CSVCAMDGYTELPHLTCGHCFCEHCWKSHVESRLSEGVASRIECMESECEVYAPSEFVLS 188
Query: 259 WIRLSENNRKIYEK-----MKNSHEQTDY--KKLCPHCMQFYELTNEEKNQLTHXXXXXX 417
I+ S + YE+ M NSH + CP ++ E+ +
Sbjct: 189 IIKNSPVIKLKYERFLLRDMVNSHPHLKFCVGNECPVIIRSTEVKPKR------------ 236
Query: 418 XXXGFNVKCHMCNWEWCFKCQTPVHN-LSCKKNLSTDKLLMKWANSPAETIQSSVKKARK 594
V C C+ +C KC H SC+ T K M +ET +
Sbjct: 237 ------VTCMQCHTSFCVKCGADYHAPTSCE----TIKQWMTKCADDSETANYISAHTKD 286
Query: 595 CPKCHVLVERNGGCPHMECSKCKCSWCYDC 684
CP+CH +E+ GGC H++C++C+ +C+ C
Sbjct: 287 CPQCHSCIEKAGGCNHIQCTRCRHHFCWMC 316
>sp|O76924|ARI2_DROME Ariadne-2 protein (Ari-2)
Length = 509
Score = 67.0 bits (162), Expect = 5e-11
Identities = 49/205 (23%), Positives = 76/205 (37%), Gaps = 6/205 (2%)
Frame = +1
Query: 88 CSICYETH--GAFVKRCCDMIVCEQCYTQYLNYQVSNLGRIHVECPSMNCHKPIRFQSIW 261
C +C + F C C+ C+T Y Q+ + C + C+ + +
Sbjct: 153 CPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLV- 211
Query: 262 IRLSENNRKIYEKMKNSHEQTDYKKLCPHCMQFYELTNEEKNQLTHXXXXXXXXXGFNVK 441
L+ R + DY K P ++F N
Sbjct: 212 --LTLVTRPVMRDKYQQFAFKDYVKSHPE-LRFCPGPN------CQIIVQSSEISAKRAI 262
Query: 442 CHMCNWEWCFKCQTPVHNLSCKKNLSTD-KLLMKWANSPA---ETIQSSVKKARKCPKCH 609
C C+ +CF+C H TD +++ KW A ET + CPKCH
Sbjct: 263 CKACHTGFCFRCGMDYH-------APTDCQVIKKWLTKCADDSETANYISAHTKDCPKCH 315
Query: 610 VLVERNGGCPHMECSKCKCSWCYDC 684
+ +E+NGGC HM+C CK +C+ C
Sbjct: 316 ICIEKNGGCNHMQCFNCKHDFCWMC 340
>sp|Q8IWT3|PARC_HUMAN p53-associated parkin-like cytoplasmic protein (UbcH7 associated
protein 1)
Length = 2517
Score = 66.6 bits (161), Expect = 7e-11
Identities = 47/213 (22%), Positives = 79/213 (37%), Gaps = 14/213 (6%)
Frame = +1
Query: 88 CSICYETHGA---FVKRCCDMIVCEQCYTQYLNYQVSNLGRIHVECPSMNCHKPIRFQSI 258
C +C G CC C+ C+ +YL ++ ++ CP +C P +
Sbjct: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADC--PAQPTGA 2127
Query: 259 WIRLSENNRKIYEKMKNSHEQTDYKKLCPHCMQFYELTNEEKNQLTHXXXXXXXXXGFNV 438
+IR ++ ++ K +E+ + C TN + G
Sbjct: 2128 FIRAIVSSPEVISK----YEKALLRGYVESCSNLTWCTNPQGCD----RILCRQGLGCGT 2179
Query: 439 KCHMCNWEWCFKCQTPV--HNLSCKKNLSTDKLLMKWANSPAETIQSSVKK--------- 585
C C W CF C P + SC + +W + SV+
Sbjct: 2180 TCSKCGWASCFNCSFPEAHYPASCGH-------MSQWVDDGGYYDGMSVEAQSKHLAKLI 2232
Query: 586 ARKCPKCHVLVERNGGCPHMECSKCKCSWCYDC 684
+++CP C +E+N GC HM C+KC +C+ C
Sbjct: 2233 SKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRC 2265
>sp|P36113|YKZ7_YEAST Hypothetical 63.6 kDa protein in YPT52-GCN3 intergenic region
Length = 551
Score = 66.2 bits (160), Expect = 9e-11
Identities = 66/255 (25%), Positives = 104/255 (40%), Gaps = 11/255 (4%)
Frame = +1
Query: 34 NDRLRPIEYEGLWESDATCSICYETHGAFVKRC-CDMIVCEQCYTQYLNYQVSNLGRIHV 210
N R +E++ +D TC IC + C C CY Y+ ++ G I +
Sbjct: 165 NSHFREVEFK----NDFTCIICCDKKDTETFALECGHEYCINCYRHYIKDKLHE-GNI-I 218
Query: 211 ECPSMNCHKPIRFQSI-WIRLSENNRKIYEKMKNSHEQTDYK--KLCPH--CMQFYELTN 375
C M+C ++ + I + ++ K+ + S Q + K CP C L +
Sbjct: 219 TC--MDCSLALKNEDIDKVMGHPSSSKLMDSSIKSFVQKHNRNYKWCPFADCKSIVHLRD 276
Query: 376 E----EKNQLTHXXXXXXXXXGFNVKCHMCNWEWCFKCQTPVHN-LSCKKNLSTDKLLMK 540
E +L + VKC+ + +CF C VH+ CK + +K
Sbjct: 277 TSSLPEYTRLHYSPF---------VKCNSFH-RFCFNCGFEVHSPADCKITTAW----VK 322
Query: 541 WANSPAETIQSSVKKARKCPKCHVLVERNGGCPHMECSKCKCSWCYDCGRRRIKVKHIPF 720
A +E + + ++CPKC V +E+NGGC HM CS CK +C+ C P+
Sbjct: 323 KARKESEILNWVLSHTKECPKCSVNIEKNGGCNHMVCSSCKYEFCWIC--------EGPW 374
Query: 721 MNHDSKFFILGCSKN 765
H FF KN
Sbjct: 375 APHGKNFFQCTMYKN 389
>sp|Q80TT8|PARC_MOUSE p53-associated parkin-like cytoplasmic protein
Length = 1865
Score = 64.3 bits (155), Expect = 4e-10
Identities = 46/213 (21%), Positives = 79/213 (37%), Gaps = 14/213 (6%)
Frame = +1
Query: 88 CSICYET---HGAFVKRCCDMIVCEQCYTQYLNYQVSNLGRIHVECPSMNCHKPIRFQSI 258
C +C H CC C+ C+ +YL ++ ++ CP +C P +
Sbjct: 1409 CPVCVTPLGPHDDSPSLCCLHCCCKSCWNEYLTTRIEQNFVLNCTCPIADC--PAQPTGA 1466
Query: 259 WIRLSENNRKIYEKMKNSHEQTDYKKLCPHCMQFYELTNEEKNQLTHXXXXXXXXXGFNV 438
+IR ++ ++ K +E+ + C TN + G
Sbjct: 1467 FIRNIVSSPEVISK----YEKALLRGYVESCSNLTWCTNPQGCD----RILCRQGLGSGT 1518
Query: 439 KCHMCNWEWCFKCQTPV--HNLSCKKNLSTDKLLMKWANSPAETIQSSVKK--------- 585
C C W CF C P + SC + +W + SV+
Sbjct: 1519 TCSKCGWASCFSCSFPEAHYPASCGH-------MSQWVDDGGYYDGMSVEAQSKHLAKLI 1571
Query: 586 ARKCPKCHVLVERNGGCPHMECSKCKCSWCYDC 684
+++CP C +E+N GC HM C++C +C+ C
Sbjct: 1572 SKRCPSCQAPIEKNEGCLHMTCARCNHGFCWRC 1604
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,971,263
Number of Sequences: 369166
Number of extensions: 1868963
Number of successful extensions: 5401
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5102
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5365
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7308943600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)