Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_H07
(319 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P12023|A4_MOUSE Amyloid beta A4 protein precursor (APP) ... 38 0.006
sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (A... 38 0.006
sp|P05067|A4_HUMAN Amyloid beta A4 protein precursor (APP) ... 37 0.014
sp|Q5IS80|A4_PANTR Amyloid beta A4 protein precursor (APP) ... 37 0.014
sp|P79307|A4_PIG Amyloid beta A4 protein precursor (APP) (A... 37 0.014
sp|P53601|A4_MACFA Amyloid beta A4 protein precursor (APP) ... 37 0.014
sp|Q60495|A4_CAVPO Amyloid beta A4 protein precursor (APP) ... 37 0.014
sp|Q95241|A4_SAISC Amyloid beta A4 protein precursor (APP) ... 37 0.018
sp|O73683|A4_TETFL Alzheimer's disease amyloid A4 protein h... 33 0.26
sp|O93279|A4_FUGRU Alzheimer's disease amyloid A4 protein h... 32 0.45
>sp|P12023|A4_MOUSE Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) (Amyloidogenic glycoprotein)
(AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid
protein 42 (Beta-APP42); Beta-amyloid protein 40
(Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59)
(Gamma-secretase C-terminal fragment 59) (Amyloid
intracellular domain 59) (AID(59)) (APP-C59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57)
(Amyloid intracellular domain 57) (AID(57)) (APP-C57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50)
(Amyloid intracellular domain 50) (AID(50)); C31]
Length = 770
Score = 38.1 bits (87), Expect = 0.006
Identities = 20/62 (32%), Positives = 28/62 (45%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 DS 219
DS
Sbjct: 194 DS 195
>sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (Alzheimer's disease
amyloid protein homolog) (Amyloidogenic glycoprotein)
(AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
APP-beta (S-APP-beta); C99; Beta-amyloid protein 42
(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83;
P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase
C-terminal fragment 59); Gamma-CTF(57) (Gamma-secretase
C-terminal fragment 57); Gamma-CTF(50) (Gamma-secretase
C-terminal fragment 50); C31]
Length = 770
Score = 38.1 bits (87), Expect = 0.006
Identities = 20/62 (32%), Positives = 28/62 (45%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 DS 219
DS
Sbjct: 194 DS 195
>sp|P05067|A4_HUMAN Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein) (Cerebral vascular amyloid peptide)
(CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4)
[Contains: Soluble APP-alpha (S-APP-alpha); Soluble
APP-beta (S-APP-beta); C99; Beta-amyloid protein 42
(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83;
P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase
C-terminal fragment 59) (Amyloid intracellular domain
59) (AID(59)); Gamma-CTF(57) (Gamma-secretase C-terminal
fragment 57) (Amyloid intracellular domain 57)
(AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal
fragment 50) (Amyloid intracellular domain 50)
(AID(50)); C31]
Length = 770
Score = 37.0 bits (84), Expect = 0.014
Identities = 19/62 (30%), Positives = 28/62 (45%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 DS 219
D+
Sbjct: 194 DN 195
>sp|Q5IS80|A4_PANTR Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); C99;
Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid
protein 40 (Beta-APP40); C83; P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50);
C31]
Length = 770
Score = 37.0 bits (84), Expect = 0.014
Identities = 19/62 (30%), Positives = 28/62 (45%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 DS 219
D+
Sbjct: 194 DN 195
>sp|P79307|A4_PIG Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); C99;
Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid
protein 40 (Beta-APP40); C83; P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50);
C31]
Length = 770
Score = 37.0 bits (84), Expect = 0.014
Identities = 19/62 (30%), Positives = 28/62 (45%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 DS 219
D+
Sbjct: 194 DN 195
>sp|P53601|A4_MACFA Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); C99;
Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid
protein 40 (Beta-APP40); C83; P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50);
C31]
Length = 770
Score = 37.0 bits (84), Expect = 0.014
Identities = 19/62 (30%), Positives = 28/62 (45%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 DS 219
D+
Sbjct: 194 DN 195
>sp|Q60495|A4_CAVPO Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); CTF-alpha;
CTF-beta; Beta-amyloid protein 42 (Beta-APP42);
Beta-amyloid protein 40 (Beta-APP40); P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
C31]
Length = 770
Score = 37.0 bits (84), Expect = 0.014
Identities = 19/62 (30%), Positives = 28/62 (45%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 DS 219
D+
Sbjct: 194 DN 195
>sp|Q95241|A4_SAISC Amyloid beta A4 protein precursor (APP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); C99;
Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid
protein 40 (Beta-APP40); C83; P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50);
C31]
Length = 751
Score = 36.6 bits (83), Expect = 0.018
Identities = 19/61 (31%), Positives = 27/61 (44%)
Frame = +1
Query: 34 CLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCPKLDAY 213
C T W AK CS T+L +GML C I ++ +++VCCP +
Sbjct: 144 CETHLHWHTVAKETCSEK----STNLHDYGMLLPCGIDK------FRGVEFVCCPLAEES 193
Query: 214 D 216
D
Sbjct: 194 D 194
>sp|O73683|A4_TETFL Alzheimer's disease amyloid A4 protein homolog precursor [Contains:
Beta-amyloid protein (Beta-APP) (A-beta)]
Length = 780
Score = 32.7 bits (73), Expect = 0.26
Identities = 16/57 (28%), Positives = 26/57 (45%)
Frame = +1
Query: 28 NPCLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCP 198
N C + W AK C + + +L +GML C I ++ +++VCCP
Sbjct: 143 NQCESHLHWHTVAKESCGDRAM----NLHDYGMLLPCGID------RFRGVEFVCCP 189
>sp|O93279|A4_FUGRU Alzheimer's disease amyloid A4 protein homolog precursor [Contains:
Beta-amyloid protein (Beta-APP) (A-beta)]
Length = 737
Score = 32.0 bits (71), Expect = 0.45
Identities = 16/57 (28%), Positives = 26/57 (45%)
Frame = +1
Query: 28 NPCLTEEEWEIKAKSLCSNNLVGVQTDLVKFGMLFKCDISDNKPVITYKSIQYVCCP 198
N C + W AK C + + +L +GML C I ++ +++VCCP
Sbjct: 143 NQCESHLHWHTVAKESCGDRSM----NLHDYGMLLPCGID------RFRGVKFVCCP 189
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,117,404
Number of Sequences: 369166
Number of extensions: 626123
Number of successful extensions: 1429
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1415
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1429
length of database: 68,354,980
effective HSP length: 74
effective length of database: 54,684,590
effective search space used: 1695222290
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)