Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_G06
(806 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y6W6|DUS10_HUMAN Dual specificity protein phosphatase ... 162 8e-40
sp|Q9ESS0|DUS10_MOUSE Dual specificity protein phosphatase ... 162 8e-40
sp|Q05923|DUS2_HUMAN Dual specificity protein phosphatase 2... 115 1e-25
sp|Q05922|DUS2_MOUSE Dual specificity protein phosphatase 2... 115 2e-25
sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6... 114 2e-25
sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (... 114 2e-25
sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6... 114 2e-25
sp|P28562|DUS1_HUMAN Dual specificity protein phosphatase 1... 113 5e-25
sp|Q99956|DUS9_HUMAN Dual specificity protein phosphatase 9... 113 7e-25
sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7... 111 2e-24
>sp|Q9Y6W6|DUS10_HUMAN Dual specificity protein phosphatase 10 (Mitogen-activated protein
kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)
Length = 482
Score = 162 bits (411), Expect = 8e-40
Identities = 78/151 (51%), Positives = 107/151 (70%), Gaps = 2/151 (1%)
Frame = +1
Query: 7 NATISEILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYRED--LFIYKRLSATDC 180
NA ++ ILPFLFLGNE D+ D++ +Q I +++NVTT++P Y + LF YKRL ATD
Sbjct: 319 NAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDS 378
Query: 181 NKQDMRAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFL 360
NKQ++R Y+ EA +FI+EA+ +L+HC AGVSRSATIV AYL+KHT++ + F+
Sbjct: 379 NKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFV 438
Query: 361 QSKRPIVEPNFNFLGQLERYYCDLERGVESR 453
+ KRPI+ PN NF+GQL + DL GV R
Sbjct: 439 KGKRPIISPNLNFMGQLLEFEEDLNNGVTPR 469
>sp|Q9ESS0|DUS10_MOUSE Dual specificity protein phosphatase 10 (Mitogen-activated protein
kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)
Length = 483
Score = 162 bits (411), Expect = 8e-40
Identities = 78/151 (51%), Positives = 107/151 (70%), Gaps = 2/151 (1%)
Frame = +1
Query: 7 NATISEILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYRED--LFIYKRLSATDC 180
NA ++ ILPFLFLGNE D+ D++ +Q I +++NVTT++P Y + LF YKRL ATD
Sbjct: 320 NAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDS 379
Query: 181 NKQDMRAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFL 360
NKQ++R Y+ EA +FI+EA+ +L+HC AGVSRSATIV AYL+KHT++ + F+
Sbjct: 380 NKQNLRRYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFV 439
Query: 361 QSKRPIVEPNFNFLGQLERYYCDLERGVESR 453
+ KRPI+ PN NF+GQL + DL GV R
Sbjct: 440 KGKRPIISPNLNFMGQLLEFEEDLNNGVTPR 470
>sp|Q05923|DUS2_HUMAN Dual specificity protein phosphatase 2 (Dual specificity protein
phosphatase PAC-1)
Length = 314
Score = 115 bits (288), Expect = 1e-25
Identities = 57/133 (42%), Positives = 89/133 (66%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYREDLFIYKRLSATDCNKQDMRA 201
EILP+LFLG+ S+D++ LQ IT +LNV+ + P + E LF YK + D ++ A
Sbjct: 175 EILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISA 234
Query: 202 YYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRPIV 381
++ EAI FID + G+VLVHC AG+SRSATI AYL++ ++ + + F++ +R ++
Sbjct: 235 WFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVI 294
Query: 382 EPNFNFLGQLERY 420
PNF+F+GQL ++
Sbjct: 295 SPNFSFMGQLLQF 307
>sp|Q05922|DUS2_MOUSE Dual specificity protein phosphatase 2 (Dual specificity protein
phosphatase PAC-1)
Length = 318
Score = 115 bits (287), Expect = 2e-25
Identities = 56/130 (43%), Positives = 87/130 (66%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYREDLFIYKRLSATDCNKQDMRA 201
EILP+L+LG+ S+D++ LQ IT +LNV+ + P + E LF YK + D ++ A
Sbjct: 179 EILPYLYLGSCNHSSDLQGLQACGITAVLNVSASCPNHFEGLFHYKSIPVEDNQMVEISA 238
Query: 202 YYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRPIV 381
++ EAI FID + G+VLVHC AG+SRSATI AYL++ ++ + + F++ +R ++
Sbjct: 239 WFQEAISFIDSVKNSGGRVLVHCQAGISRSATICLAYLIQSHRVRLDEAFDFVKQRRGVI 298
Query: 382 EPNFNFLGQL 411
PNF+F+GQL
Sbjct: 299 SPNFSFMGQL 308
>sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
(Dual specificity protein phosphatase PYST1)
Length = 381
Score = 114 bits (286), Expect = 2e-25
Identities = 60/132 (45%), Positives = 86/132 (65%), Gaps = 2/132 (1%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYREDLFIYKRLSATDCNKQDM 195
EILPFL+LG DS +++VL+E I +ILNVT N+P F F YK++ +D Q++
Sbjct: 209 EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNL 268
Query: 196 RAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRP 375
++ EAI FIDEA +N VLVHC AG+SRS T+ AYL++ L++ ++ K+
Sbjct: 269 SQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS 328
Query: 376 IVEPNFNFLGQL 411
+ PNFNF+GQL
Sbjct: 329 NISPNFNFMGQL 340
>sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 114 bits (286), Expect = 2e-25
Identities = 60/132 (45%), Positives = 86/132 (65%), Gaps = 2/132 (1%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYREDLFIYKRLSATDCNKQDM 195
EILPFL+LG DS +++VL+E I +ILNVT N+P F F YK++ +D Q++
Sbjct: 209 EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNL 268
Query: 196 RAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRP 375
++ EAI FIDEA +N VLVHC AG+SRS T+ AYL++ L++ ++ K+
Sbjct: 269 SQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS 328
Query: 376 IVEPNFNFLGQL 411
+ PNFNF+GQL
Sbjct: 329 NISPNFNFMGQL 340
>sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 114 bits (286), Expect = 2e-25
Identities = 60/132 (45%), Positives = 86/132 (65%), Gaps = 2/132 (1%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYREDLFIYKRLSATDCNKQDM 195
EILPFL+LG DS +++VL+E I +ILNVT N+P F F YK++ +D Q++
Sbjct: 209 EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNL 268
Query: 196 RAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRP 375
++ EAI FIDEA +N VLVHC AG+SRS T+ AYL++ L++ ++ K+
Sbjct: 269 SQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS 328
Query: 376 IVEPNFNFLGQL 411
+ PNFNF+GQL
Sbjct: 329 NISPNFNFMGQL 340
>sp|P28562|DUS1_HUMAN Dual specificity protein phosphatase 1 (MAP kinase phosphatase 1)
(MKP-1) (Protein-tyrosine phosphatase CL100) (Dual
specificity protein phosphatase hVH1)
Length = 367
Score = 113 bits (283), Expect = 5e-25
Identities = 56/147 (38%), Positives = 92/147 (62%), Gaps = 7/147 (4%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYREDLFIYKRLSATDCNKQDMRA 201
EILPFL+LG+ ++ ++L IT ++NV+ N P + E + YK + D +K D+ +
Sbjct: 176 EILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISS 235
Query: 202 YYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRPIV 381
+++EAI FID + G+V VHC AG+SRSATI AYL++ ++ + + F++ +R I+
Sbjct: 236 WFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSII 295
Query: 382 EPNFNFLGQLERY-------YCDLERG 441
PNF+F+GQL ++ +C E G
Sbjct: 296 SPNFSFMGQLLQFESQVLAPHCSAEAG 322
>sp|Q99956|DUS9_HUMAN Dual specificity protein phosphatase 9 (Mitogen-activated protein
kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)
Length = 384
Score = 113 bits (282), Expect = 7e-25
Identities = 67/156 (42%), Positives = 96/156 (61%), Gaps = 5/156 (3%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYREDLFIYKRLSATDCNKQDM 195
+ILP L+LG+ DS ++E L + I +ILNVT N+P F + F YK++ +D Q++
Sbjct: 206 QILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNL 265
Query: 196 RAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRP 375
++ EAI+FIDEA SQN VLVHC AGVSRS T+ AYL++ L++ ++ K+
Sbjct: 266 SRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKS 325
Query: 376 IVEPNFNFLGQLERYYCDLERGV---ESRSKEFAFG 474
+ PNFNF+GQL D ER + E S+E G
Sbjct: 326 NISPNFNFMGQL----LDFERSLRLEERHSQEQGSG 357
>sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7 (Dual specificity protein
phosphatase PYST2)
Length = 368
Score = 111 bits (278), Expect = 2e-24
Identities = 58/132 (43%), Positives = 86/132 (65%), Gaps = 2/132 (1%)
Frame = +1
Query: 22 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYREDLFIYKRLSATDCNKQDM 195
+ILP+L+LG DS +++VL + I +ILNVT N+P F F YK++ +D Q++
Sbjct: 196 QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNL 255
Query: 196 RAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRP 375
++ EAI FIDEA S+ VLVHC AG+SRS T+ AYL++ L++ F++ K+
Sbjct: 256 SQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKS 315
Query: 376 IVEPNFNFLGQL 411
+ PNFNF+GQL
Sbjct: 316 NISPNFNFMGQL 327
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,160,302
Number of Sequences: 369166
Number of extensions: 1549248
Number of successful extensions: 3700
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3566
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3672
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)